Application of E3 ubiquitin enzyme inhibitor in non-alcoholic fatty liver related drugs

By inhibiting the expression of TRIM23, a TRIM23 inhibitor was developed for the treatment of non-alcoholic fatty liver disease, which solves the problem of lack of specific therapeutic targets in existing technologies and achieves effective treatment of non-alcoholic fatty liver disease.

CN120884707AActive Publication Date: 2025-11-04南昌大学第一附属医院
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Patent Information

Application Number
CN202511432274.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-09
Publication Date
2025-11-04
Estimated Expiration
2045-10-09

AI Technical Summary

Technical Problem

Current technologies lack specific therapeutic targets and safe and effective drugs for non-alcoholic fatty liver disease, and existing treatments have limited efficacy and significant side effects.

Method used

By using TRIM23 inhibitors, drugs for the prevention or treatment of non-alcoholic fatty liver disease can be developed by inhibiting the mRNA and protein expression levels of TRIM23.

Benefits of technology

It significantly improved lipid accumulation in hepatocytes, reduced triglyceride levels, and alleviated the pathological progression of non-alcoholic fatty liver disease.

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Abstract

The invention relates to the technical field of biomedicine, in particular to application of an E3 ubiquitin enzyme inhibitor in non-alcoholic fatty liver related drugs. The TRIM23 has obvious influence on the non-alcoholic fatty liver disease, and hepatic cell lipid deposition induced by mixing of palmitic acid and oleic acid can be improved by inhibiting expression of the TRIM23 at the cellular level; on the contrary, promoting the expression level of the TRIM23 can aggravate hepatocyte lipid accumulation induced by mixing of palmitic acid and oleic acid. Therefore, the TRIM23 inhibitor can be used for preparing the medicine for preventing or treating the fatty liver.
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