Establishment method and application of mesenteric artery hemorrhagic shock animal model

By severing the distal ileocolic artery and performing vascular interventional embolization in a pig model, a hemorrhagic shock model consistent with abdominal combat trauma was established. This solved the problem that existing models did not reflect actual injuries, enabling rapid diagnosis and effective hemostasis correction, reducing mortality and anesthesia risks, and improving battlefield medical efficiency.

CN120918840APending Publication Date: 2025-11-11THE 982ND HOSPITAL OF THE CHINESE PEOPLES LIBERATION ARMY JOINT LOGISTICS SUPPORT FORCE
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Patent Information

Application Number
CN202511132599.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-13
Publication Date
2025-11-11

AI Technical Summary

Technical Problem

Existing animal models of hemorrhagic shock do not accurately reflect the actual condition of abdominal combat injuries, making it difficult to accurately determine and correct shock, leading to misdiagnosis or delay in receiving optimal treatment.

Method used

Using pigs as experimental animals, a mesenteric artery hemorrhagic shock model was established by cutting the distal ileocolic artery using digital subtraction angiography of the superior mesenteric artery, artificial pneumoperitoneum, and laparoscopy, combined with vascular interventional embolization technology. Invasive arterial blood pressure, heart rate, and blood routine were monitored in real time, and auxiliary judgment and correction criteria were formulated.

Benefits of technology

A hemorrhagic shock model that more closely resembles abdominal combat trauma has been established. It is simple, easy to implement, and has controllable results. It can quickly diagnose and assess the bleeding site and risk, rapidly stop bleeding and correct shock, reduce mortality, improve treatment efficiency, and reduce reliance on surgery.

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Abstract

The invention provides an establishment method and application of a mesenteric artery hemorrhagic shock animal model, and the establishment method comprises the following steps: S1, anesthetizing an animal, performing superior mesenteric artery digital subtraction angiography, artificial pneumoperitoneum and laparoscopic surgery after anesthesia, and performing hemorrhagic operation on a target blood vessel; and S2, after the animal has hemorrhagic shock for 10-15 minutes, injecting 0.9% sodium chloride injection into the animal for fluid infusion so as to maintain the stability of the blood pressure and heart rate of the animal, thereby obtaining the animal model of the abdominal traumatic hemorrhagic shock. A pig is used as an animal for establishing a model, vital signs and hemodynamic indexes of the animal are monitored in real time, and an auxiliary judgment standard of mesenteric artery hemorrhagic shock and a judgment standard of shock correction are determined according to the change trend of the indexes. According to the method, the animal model of the abdominal traumatic hemorrhagic shock is established, various indexes of the animal are continuously recorded, the shock condition and the shock correction condition are more accurately judged, and the shocked wounded can be rescued in time.
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