Metalaxyl-M, ipconazole and fludioxonil seed treatment suspending agent and application thereof

Abstract

The invention belongs to the field of pesticide preparations, and particularly relates to a metalaxyl-M, ipconazole and fludioxonil seed treatment suspending agent and application thereof, and the suspending agent comprises the following components: 10-20 g of metalaxyl-M, 40-60 g of ipconazole, 30-40 g of fludioxonil, 50-150 g of a wetting dispersant, 5-20 g of a thickening agent, 0.5-5 g of a film-forming agent, 20-80 g of an antifreeze agent, 0.5-5 g of a preservative, and the balance of deionized water. The seed treatment suspending agent has excellent preparation performance and has an excellent control effect on root rot, and particularly, the formula of the preparation 1 can remarkably improve the suspending performance of the seed treatment suspending agent and improve the field control effect of the agent on the root rot.

Description

Technical Field

[0001] This invention belongs to the field of pesticide formulations, specifically relating to a seed treatment suspension of metalaxyl, cymoxanil, and fludioxonil and their applications. Background Technology

[0002] Soybeans, as an important multi-purpose crop for grain, oil, and feed, are not only a core source of high-quality plant protein and oil, but also possess irreplaceable industrial value in food processing, feed production, and bioenergy. Research reports that the main pathogens causing soybean root rot are *Phytophthora sojae*, *Fusarium*, *Pythium*, and *Rhizoctonia solani*. These pathogens cause root rot, reducing the crop's ability to absorb water and nutrients, ultimately leading to the death of the entire plant and seriously threatening the productivity of crops and the timber industry. Soybean root rot can occur at any stage of soybean growth. Before seedling emergence, pathogens infect soybean seeds and seedlings, causing seed and seedling rot. After seedling emergence, pathogens infect the base of the seedling stem, causing sudden death. During soybean seed growth, pathogens can directly infect the root system and stem base, ultimately causing root rot. These pathogens can overwinter in the soil, becoming a major source of root rot outbreaks the following year.

[0003] Metalaxyl-M (internationally recognized name: Metalaxyl-M) can penetrate the seed coat and be systemically transported to all parts of the plant as the seed germinates and grows. Used for seed treatment, it can control various seed-borne and soil-borne diseases caused by lower fungi. Imidacloprid is a triazole fungicide and an inhibitor of ergosterol biosynthesis. Its mechanism of action is to inhibit the synthesis of ergosterol in pathogenic fungi at different sites of action, leading to cell membrane damage and death. Fludioxonil is a broad-spectrum contact fungicide used for seed treatment to control most seed-borne and soil-borne fungal diseases. There are currently no reports of combining Metalaxyl-M, Imidacloprid, and Fludioxonil for soybean root rot.

[0004] Seed treatment suspensions are liquid formulations that are directly diluted with water for seed treatment. Because they use water as a base, seed treatment suspensions are safe and environmentally friendly for producers and users, meeting the requirements of modern pesticide formulation development. This invention further investigates seed treatment suspensions for metalaxyl, cymoxanil, and fludioxonil. Summary of the Invention

[0005] The purpose of this invention is to provide a seed treatment suspension of metalaxyl, cymoxanil, and fludioxonil, and their applications. The specific solution is as follows: A seed treatment suspension containing metalaxyl, tebuconazole, and fludioxonil comprises the following components: 10-20g metalaxyl, 40-60g tebuconazole, 30-40g fludioxonil, 50-150g wetting and dispersing agent, 5-20g thickener, 0.5-5g film-forming agent, 20-80g antifreeze agent, 0.5-5g preservative, and deionized water to make up to 1L.

[0006] The wetting and dispersing agent is a combination of ATLOX4913, Morwet EFW and Dispersogen1494, wherein the mass ratio of ATLOX4913, Morwet EFW and Dispersogen1494 is (1-2):(1-2):(1-2); preferably, the mass ratio of ATLOX4913, Morwet EFW and Dispersogen1494 is 1:1:1.

[0007] The thickener is magnesium aluminum silicate and xanthan gum; the film-forming agent is gum arabic, the antifreeze agent is glycerol, and the preservative is sodium benzoate.

[0008] Preferably, the seed treatment suspension comprises the following components: 15g of metalaxyl, 50g of cymoxanil, 35g of fludioxonil, 30g of Atlox 4913, 30g of Morwet EFW, 30g of Dispersogen 1494, 5g of magnesium aluminum silicate, 3g of xanthan gum, 2g of gum arabic, 50g of glycerol, 2g of sodium benzoate, and deionized water to make up to 1L.

[0009] The seed treatment suspension of this invention is used for the prevention and control of root rot or stem rot. The crops mentioned are soybean, wheat, corn, rice, and peanut.

[0010] By adopting the above technical solution, the present invention has the following beneficial effects: The seed treatment suspension prepared by this invention has excellent formulation properties and excellent control effect on soybean root rot. In particular, the formulation of Formulation 1 can significantly improve the suspension performance of the seed treatment suspension and enhance the field control efficacy against soybean root rot. Detailed Implementation

[0011] Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0012] The present invention will be further explained below with reference to specific embodiments.

[0013] Example 1: 100g / L Metalaxyl·Izoxystrobin·Fluoxadiazon seed treatment suspension

[0014] Formulation 1: Contains the following ingredients in parts by weight: 15g of cymoxanil, 50g of tebuconazole, 35g of fludioxonil, 30g of Atlox 4913, 30g of Morwet EFW, 30g of Dispersogen 1494, 5g of magnesium aluminum silicate, 3g of xanthan gum, 2g of gum arabic, 50g of glycerol, 2g of sodium benzoate, and deionized water to make up to 1L.

[0015] Preparation method: Wet sand milling method is adopted. According to the type and amount of each component in the formula, the other components except the film-forming agent are mixed and pre-dispersed: metalaxyl technical, cyproconazole technical, fludioxonil technical, wetting and dispersing agent, thickener, antifreeze agent, preservative and deionized water. The sample is pretreated using a high-shear emulsifier, and then the material is transferred to a sand mill for sand milling. After sand milling for a period of time, the particle size is measured, the sand milling is stopped, and finally the film-forming agent is added, and the mixture is homogenized and stirred to obtain the final product.

[0016] Formulation 2: Contains the following ingredients in parts by weight: 15g of cymoxanil, 50g of tebuconazole, 35g of fludioxonil, 45g of Atlox 4913, 45g of Morwet EFW, 5g of magnesium aluminum silicate, 3g of xanthan gum, 2g of gum arabic, 50g of glycerol, 2g of sodium benzoate, and deionized water to make up to 1L.

[0017] Preparation method: Wet sand milling method is adopted. According to the type and amount of each component in the formula, the other components except the film-forming agent are mixed and pre-dispersed: metalaxyl technical, cyproconazole technical, fludioxonil technical, wetting and dispersing agent, thickener, antifreeze agent, preservative and deionized water. The sample is pretreated using a high-shear emulsifier, and then the material is transferred to a sand mill for sand milling. After sand milling for a period of time, the particle size is measured, the sand milling is stopped, and finally the film-forming agent is added, and the mixture is homogenized and stirred to obtain the final product.

[0018] Formulation 3: Contains the following ingredients in parts by weight: 15g of cymoxanil, 50g of tebuconazole, 35g of fludioxonil, 45g of Atlox 4913, 45g of Dispersogen 1494, 5g of magnesium aluminum silicate, 3g of xanthan gum, 2g of gum arabic, 50g of glycerol, 2g of sodium benzoate, and deionized water to make up to 1L.

[0019] Preparation method: Wet sand milling method is adopted. According to the type and amount of each component in the formula, the other components except the film-forming agent are mixed and pre-dispersed: metalaxyl technical, cyproconazole technical, fludioxonil technical, wetting and dispersing agent, thickener, antifreeze agent, preservative and deionized water. The sample is pretreated using a high-shear emulsifier, and then the material is transferred to a sand mill for sand milling. After sand milling for a period of time, the particle size is measured, the sand milling is stopped, and finally the film-forming agent is added, and the mixture is homogenized and stirred to obtain the final product.

[0020] Formulation 4: Contains the following ingredients in parts by weight: 15g of cymoxanil, 50g of tebuconazole, 35g of fludioxonil, 45g of Morwet EFW, 45g of Dispersogen 1494, 5g of magnesium aluminum silicate, 3g of xanthan gum, 2g of gum arabic, 50g of glycerol, 2g of sodium benzoate, and deionized water to make up to 1L.

[0021] Preparation method: Wet sand milling method is adopted. According to the type and amount of each component in the formula, the other components except the film-forming agent are mixed and pre-dispersed: metalaxyl technical, cyproconazole technical, fludioxonil technical, wetting and dispersing agent, thickener, antifreeze agent, preservative and deionized water. The sample is pretreated using a high-shear emulsifier, and then the material is transferred to a sand mill for sand milling. After sand milling for a period of time, the particle size is measured, the sand milling is stopped, and finally the film-forming agent is added, and the mixture is homogenized and stirred to obtain the final product.

[0022] Formulation 5: Contains the following ingredients in parts by weight: 15g of cymoxanil, 50g of tebuconazole, 35g of fludioxonil, 90g of Atlox 4913, 5g of magnesium aluminum silicate, 3g of xanthan gum, 2g of gum arabic, 50g of glycerol, 2g of sodium benzoate, and deionized water to make up to 1L.

[0023] Preparation method: Wet sand milling method is adopted. According to the type and amount of each component in the formula, the other components except the film-forming agent are mixed and pre-dispersed: metalaxyl technical, cyproconazole technical, fludioxonil technical, wetting and dispersing agent, thickener, antifreeze agent, preservative and deionized water. The sample is pretreated using a high-shear emulsifier, and then the material is transferred to a sand mill for sand milling. After sand milling for a period of time, the particle size is measured, the sand milling is stopped, and finally the film-forming agent is added, and the mixture is homogenized and stirred to obtain the final product.

[0024] Example 2: Quality control index test of 100g / L metalaxyl-mancozeb-fludioxonil seed treatment suspension

[0025] Referring to GB / T17768-1999, the product standard for suspension seed coating agents, pH, viscosity, suspension rate, and low-temperature and thermal storage stability were tested. Table 1 shows that the 100g / L metalaxyl-mancozeb-fludioxonil seed treatment suspension exhibits excellent formulation performance. The suspension concentration of active ingredients in formulations 1-4 is all above 90%, and all meet the requirements for cold and thermal storage stability. In particular, in formulation 1, compared with formulations 2-4, the combination of Atlox4913, Morwet EFW, and Dispersogen1494 as wetting and dispersing agents significantly improves the suspension performance of the seed treatment suspension.

[0026] Table 1: Quality Control Indicator Tests

[0027] Example 3: Field control efficacy of 100g / L metalaxyl-mancozeb-fludioxonil seed treatment suspension against soybean root rot

[0028] Test reagents: Formulations 1-4 in Example 1; the dosage of formulations 1-4 was 300ml / 100kg of seeds for seed dressing.

[0029] Experimental Methods: The previous crop in the experimental field was soybean, which had previously resulted in severe root rot. Cultivation conditions were identical in all plots. A randomized block design was used, with four treatments. Seeds were treated with the pesticide before sowing, dried, and then sown. A blank control was also included. The plot area was 50 m². 2 Each treatment was repeated 4 times.

[0030] Survey method: The survey was conducted 25 days after soybean emergence. Five random sampling points were taken from each plot, and 20 plants were surveyed at each point. The disease status of the roots and stem base was graded and recorded, and the control effect was calculated.

[0031] Disease severity grading method: Grade 0: No lesions on the base of the stem and main root; Grade 1: A small number of lesions on the base of the stem and main root; Grade 3: Many lesions on the base of the stem or main root, with the lesion area accounting for 1 / 4 to 1 / 2 of the total area of ​​the stem and root; Grade 5: Many and large lesions on the base of the stem and main root, with the lesion area accounting for 1 / 2 to 3 / 4 of the total area of ​​the base of the stem and root; Grade 7: Lesions on the base of the stem or main root merge together, forming a stem-encircling phenomenon, but the root system is not dead; Grade 9: Root necrosis, and the above-ground parts of the plant wilt or die.

[0032] Calculation method: , Disease control effect (%) = (disease index in blank area - disease index in drug-treated area) / disease index in blank control area × 100;

[0033] Results and Analysis

[0034] As shown in Table 2, the 100g / L metalaxyl-mancozeb-fludioxonil seed treatment suspension prepared in this invention has excellent field control efficacy against soybean root rot, especially formulation 1, which has a control efficacy of over 90% against root rot.

[0035] Table 2: Field control efficacy of 100g / L metalaxyl-mancozeb-fludioxonil seed treatment suspension against soybean root rot

[0036] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it.

Claims

1. A seed treatment suspension of metalaxyl, cymoxanil, and fludioxonil, characterized in that, It contains the following ingredients: 10-20g of metalaxyl-M, 40-60g of cymoxanil, 30-40g of fludioxonil, 50-150g of wetting and dispersing agent, 5-20g of thickener, 0.5-5g of film-forming agent, 20-80g of antifreeze agent, 0.5-5g of preservative, and deionized water to make up to 1L; the wetting and dispersing agent is a combination of ATLOX4913, Morwet EFW and Dispersogen1494, wherein the mass ratio of ATLOX4913, Morwet EFW and Dispersogen1494 is (1-2):(1-2):(1-2).

2. The seed treatment suspension according to claim 1, characterized in that, The thickener is magnesium aluminum silicate and xanthan gum; the film-forming agent is gum arabic, the antifreeze agent is glycerol, and the preservative is sodium benzoate.

3. The seed treatment suspension agent according to claim 2, characterized in that, It contains the following ingredients: 15g of cymoxanil, 50g of tebuconazole, 35g of fludioxonil, 30g of Atlox 4913, 30g of Morwet EFW, 30g of Dispersogen 1494, 5g of magnesium aluminum silicate, 3g of xanthan gum, 2g of gum arabic, 50g of glycerol, 2g of sodium benzoate, and deionized water to make up to 1L.

4. The use of the seed treatment suspension according to any one of claims 1-3 for the prevention and control of root rot or stem rot.

5. The use according to claim 4, characterized in that, The crops mentioned are soybeans, wheat, corn, rice, or peanuts.

6. The use according to claim 4, characterized in that, The crop mentioned is soybean.

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