A composition comprising prothioconazole, clothianidin and mefenoxam and use thereof

Abstract

The application provides a composition containing prothioconazole, clothianidin and mefenoxam and application thereof. The dosage form of the composition is a suspension seed coating agent, and the suspension seed coating agent contains the following ingredients in the weight percentage: 0.5-3% of prothioconazole, 5-15% of clothianidin, 0.5-3% of mefenoxam, 4-16% of wetting dispersant, 0.2-2% of thickening agent, 2-8% of film forming agent, 0.1-0.5% of preservative, 1-6% of antifreeze, 0.2-1.2% of defoaming agent, 0.1-0.5% of pigment and deionized water to make up 100%. The suspension seed coating agent provided by the application has excellent preparation performance, can significantly improve the control effect of the pesticide on pests and diseases, can effectively reduce the use dosage of the active ingredient, can reduce environmental pollution and can ensure food safety.

Description

Technical Field

[0001] This invention relates to the field of pesticides, and in particular to a composition comprising prothioconazole, thiamethoxam and metalaxyl, and its application. Background Technology

[0002] Prothioconazole is a triazolylthion fungicide, belonging to the sterol demethylation (ergosterol biosynthesis) inhibitor class. It possesses selectivity, protective, curative, and long-lasting effects. It can be used to control wheat powdery mildew, Fusarium head blight, rust, and peanut white mold. Thiamethoxam is an agonist of nicotinic acetylcholine receptors, acting on the synapses of the insect's central nervous system, causing abnormal excitation, systemic paralysis, and death. It has contact, stomach poison, and systemic activity. Metalaxyl is a novel amide fungicide seed dressing agent. This product can be systemically translocated to all parts of the plant during seed germination and growth. It has a unique mechanism of action, a long-lasting effect, and is safe for seeds and seedlings.

[0003] Patent application CN202110446578.X discloses a seed treatment agent containing prothioconazole, metalaxyl, and thiamethoxam, with a weight ratio of 1-5:1-5:1-20; it can be used for crop seed treatment to prevent and control crop diseases and pests.

[0004] Patent application CN202110199348.8 discloses a ternary compound seed dressing agent for controlling pests and diseases. This ternary compound seed dressing agent comprises active ingredients A, B, and C. A is prothioconazole; B is one of azoxystrobin, oxadixyl, metalaxyl-M, metalaxyl-M, fluoxastrobin, and fludioxonil; and C is one of thiamethoxam, dinotefuran, thiamethoxam, flonicamid, bromuconamide, chlorantraniliprole, and tetrachlorantraniliprole. The application discloses that it significantly delays the development of crop resistance, reduces the number of repeated pesticide applications, lowers pesticide usage, reduces agricultural costs, and while significantly improving the fungicidal and insecticidal effects, it also increases crop yield.

[0005] The two patent applications mentioned above only studied the ability of combined active ingredients to simultaneously control diseases and pests when used for crop seed treatment; they did not investigate the performance of the formulations. In the pesticide field, selecting appropriate excipients after determining the active ingredient formulation not only gives the formulation excellent performance but also significantly improves the control effect, effectively reduces the dosage of active ingredients, mitigates environmental pollution, and ensures food safety. Summary of the Invention

[0006] The purpose of this invention is to provide a composition comprising prothioconazole, thiamethoxam, and metalaxyl, and its application. The specific solution is as follows:

[0007] A composition comprising prothioconazole, thiamethoxam, and metalaxyl, wherein the composition is in the form of a suspension seed coating agent, the suspension seed coating agent comprising the following components in weight percentage: prothioconazole 0.5-3%, thiamethoxam 5-15%, metalaxyl 0.5-3%, wetting and dispersing agent 4-16%, thickener 0.2-2%, film-forming agent 2-8%, preservative 0.1-0.5%, antifreeze 1-6%, defoamer 0.2-1.2%, pigment 0.1-0.5%, and deionized water to make up to 100%.

[0008] The wetting and dispersing agent is Dispersol TM Composed of PSR-19, Tersperse 2500, and Morwet D-450, Dispersol TM The mass ratio of PSR-19, Tersperse 2500 and Morwet D-450 is (1-5):(1-5):(1-5);

[0009] The thickener is composed of xanthan gum and magnesium aluminum silicate, with a mass ratio of xanthan gum to magnesium aluminum silicate of 1:4-4:1.

[0010] The film-forming agent is SYFMA001.

[0011] The preservative is sodium benzoate; the antifreeze is ethylene glycol; the defoamer is dimethyl silicone oil; and the pigment is Acid Red.

[0012] Preferably, the suspension seed coating agent comprises the following components in weight percentage: 1.2% prothioconazole, 10% thiamethoxam, 1% metalaxyl, and Dispersol. TM PSR-193%, Tersperse 25002%, Morwet D-4502%, Xanthan Gum 0.15%, Magnesium Aluminum Silicate 0.35%, SYFMA001 5%, Sodium Benzoate 0.2%, Ethylene Glycol 3%, Dimethyl Silicone Oil 0.5%, Acid Red 0.25%, Deionized Water to 100%.

[0013] The composition of the present invention is used for crop seed treatment, particularly for the prevention and control of crop diseases and pests; the crops are corn and peanut.

[0014] Beneficial technical effects

[0015] Compared to Examples 2-4, the wetting and dispersing agent selected in Example 1 was Dispersol. TMThe combination of PSR-19, Tersperse 2500, and Morwet D-450 can significantly improve the suspension properties of the formulation. The suspension seed coating agent provided by this invention exhibits excellent formulation performance and can significantly enhance the control effect of pesticides on pests and diseases. It can effectively reduce the dosage of active ingredients, mitigate environmental pollution, and ensure food safety. Detailed Implementation

[0016] Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0017] Example 1: A suspension seed coating agent containing prothioconazole, thiamethoxam, and metalaxyl.

[0018] Table 1 Suspension Seed Coating Agent Formulation FS

[0019]

[0020]

[0021] Preparation method: Using wet sand milling, according to the pre-calculated material mass ratio, the active ingredients, wetting and dispersing agents, thickeners, preservatives, antifreeze agents, defoamers, pigments, etc. are weighed and mixed evenly. After being sheared by a high-speed shear tissue disperser, the slurry is transferred to a sand mill for sand milling. Film-forming agents are added and stirred evenly to obtain a 12.2% suspension seed coating agent of prothioconazole, thiamethoxam and metalaxyl.

[0022] Example 2: A suspension seed coating agent containing prothioconazole, thiamethoxam, and metalaxyl.

[0023] Table 2 Suspension Seed Coating Formulation FS

[0024]

[0025]

[0026] Preparation method: Using wet sand milling, according to the pre-calculated material mass ratio, the active ingredients, wetting and dispersing agents, thickeners, preservatives, antifreeze agents, defoamers, pigments, etc. are weighed and mixed evenly. After being sheared by a high-speed shear tissue disperser, the slurry is transferred to a sand mill for sand milling. Film-forming agents are added and stirred evenly to obtain a 12.2% suspension seed coating agent of prothioconazole, thiamethoxam and metalaxyl.

[0027] Example 3: A suspension seed coating agent containing prothioconazole, thiamethoxam, and metalaxyl.

[0028] Table 3 Suspension Seed Coating Formulation FS

[0029]

[0030]

[0031] Preparation method: Using wet sand milling, according to the pre-calculated material mass ratio, the active ingredients, wetting and dispersing agents, thickeners, preservatives, antifreeze agents, defoamers, pigments, etc. are weighed and mixed evenly. After being sheared by a high-speed shear tissue disperser, the slurry is transferred to a sand mill for sand milling. Film-forming agents are added and stirred evenly to obtain a 12.2% suspension seed coating agent of prothioconazole, thiamethoxam and metalaxyl.

[0032] Example 4: A suspension seed coating agent containing prothioconazole, thiamethoxam, and metalaxyl.

[0033] Table 4 Suspension Seed Coating Agent Formulation FS

[0034]

[0035]

[0036] Preparation method: Using wet sand milling, according to the pre-calculated material mass ratio, the active ingredients, wetting and dispersing agents, thickeners, preservatives, antifreeze agents, defoamers, pigments, etc. are weighed and mixed evenly. After being sheared by a high-speed shear tissue disperser, the slurry is transferred to a sand mill for sand milling. Film-forming agents are added and stirred evenly to obtain a 12.2% suspension seed coating agent of prothioconazole, thiamethoxam and metalaxyl.

[0037] For the testing of formulation control indicators, refer to the national standard "GB / T 17768—1999 Specification for Writing Suspension Seed Coating Product Standards".

[0038] Table 5. Detection of Control Items in Formulation

[0039]

[0040] Examples 1-3 all yielded qualified suspension seed coating formulations. The formulation prepared in Example 4 had a low suspension rate and failed thermal storage stability tests. Compared to Examples 2-4, Dispersol was selected as the wetting and dispersing agent in Example 1. TM The combination of PSR-19, Tersperse2500, and Morwet D-450 can significantly improve the suspension properties of formulations.

[0041] Test Example 1: Field Efficacy Test of Suspension Seed Coating Agent against Corn Diseases and Pests

[0042] Test reagents: Examples 1-3.

[0043] Experimental Design: The experimental site consisted of sandy loam soil with moderate fertility. All plots were cultivated under identical conditions with good irrigation. The previous crop was wheat. Three treatment groups and one control group were included, with four replicates. Each plot was 100 m² in size. 2 The cells are randomly grouped. The interval between cells is 1m as a protection row.

[0044] For each pesticide treatment, seeds were mixed with an appropriate amount of water, dried, and then sown. The experimental plot was managed using standard methods, and no pesticides were applied to control non-target organisms during the experiment. The occurrence of corn pests and diseases was investigated 45 days after pesticide application.

[0045] Aphid occurrence survey: 5 points were randomly selected in each plot, and 20 corn plants were marked at each point. For each corn plant, the female ear was used as the reference, and the top and bottom 3 leaves of each corn plant were surveyed. That is, a total of 6 leaves and female ear were surveyed for each corn plant, for a total of 100 plants. The number of aphids was surveyed and the control effect was calculated.

[0046] Stalk base rot incidence survey: Five points were randomly selected from each plot, with 20 corn plants marked at each point, for a total of 100 plants. The incidence of stalk base rot was investigated, and the disease was graded according to the 7-level grading standard for stalk base rot. The disease index and control effect were calculated.

[0047] Grading standards for corn stalk rot: Grade 0: The whole plant grows normally, but the lower and middle leaves show signs of wilting and yellowing; the stalk base and ears grow normally. Grade 1: The whole plant shows signs of wilting; the stalk base and ears grow normally. Grade 3: The whole plant shows typical signs of wilting; the stalk base is discolored and slightly water-soaked; the ears are basically normal. Grade 5: The whole plant shows typical signs of wilting; the stalk base is noticeably soft but not lodging; the ears droop; and the kernels are not plump. Grade 7: The whole plant dies and looms; the vascular bundles at the stalk base rupture; and the kernels are shriveled.

[0048] Calculation formula:

[0049] (1) Control effect = [(Number of insects in the control area - Number of insects in the treatment area) / Number of insects in the control area] × 100%

[0050] (2) Disease index = [∑(number of diseased plants at each level × relative level value) / total number of plants surveyed × 7] × 100%

[0051] (3) Control effect = [(Disease index in control area - Disease index in treatment area) / Disease index in control area] × 100 Table 6 Field control efficacy of suspension seed coating agent against maize field diseases and pests

[0052]

[0053] As shown in Table 6, the suspension seed coating agent prepared by this invention can effectively control corn diseases and pests, with a control efficacy of over 80%, especially in Example 1 where the efficacy is over 90%. Furthermore, field observations have shown that it is safe for corn crops.

[0054] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it.

Claims

1. A composition comprising prothioconazole, thiamethoxam, and metalaxyl, characterized in that, The composition is a suspension seed coating agent, which contains the following components in weight percentage: 1.2% prothioconazole, 10% thiamethoxam, 1% metalaxyl, 3% Dispersol™ PSR-19, 2% Tersperse 2500, 2% Morwet D-450, 0.15% xanthan gum, 0.35% magnesium aluminum silicate, 5% SYFMA001, 0.2% sodium benzoate, 3% ethylene glycol, 0.5% dimethyl silicone oil, 0.25% Acid Red, and deionized water to make up to 100%.

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