Nicotine composition, preparation method thereof and nicotine product
By combining nicotine salts, pH adjusters, binders, and disintegrants, the problems of poor raw material flowability and slow action speed of nicotine bags are solved, resulting in better preservation and rapid release, and improving the user experience.
Patent Information
- Application Number
- CN202411062146.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-02
- Publication Date
- 2026-02-03
AI Technical Summary
Existing nicotine pouches have poor fluidity, slow action, weak intoxication, and are prone to oxidation and yellowing, with a short duration of effect.
A combination of nicotine salts, pH adjusters, binders, and disintegrants is used to release free nicotine through a neutralization reaction, and the binders and disintegrants are used to improve preservation and release rate.
It enhances the retention time and release speed of nicotine, improving the intoxication and user experience.
Smart Images
Figure CN121445113A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of nicotine products, in particular to a nicotine composition, a preparation method thereof and a nicotine product. BACKGROUND
[0002] A nicotine pouch is a smokeless tobacco product composed of cellulose, nicotine, flavoring agents and other additives, which allows nicotine to be absorbed through the oral mucosa by being placed between the gums and the lips. The existing nicotine pouch has poor raw material fluidity, slow nicotine action speed and insufficient strong head feeling. SUMMARY
[0003] Therefore, the present application provides a nicotine composition, a preparation method thereof and a nicotine product, aiming to improve the slow action speed of the existing nicotine product.
[0004] In a first aspect, a nicotine composition is provided, comprising the following components: nicotine salt, pH adjuster, binder and disintegrant.
[0005] Optionally, in some embodiments of the present application, the nicotine composition is granular, and the particle size of the nicotine composition is 30-80 mesh; and / or
[0006] The mass ratio of the nicotine salt, the pH adjuster, the disintegrant and the binder is (0.6-4):(0.5-3):(3-6):(1-5).
[0007] Optionally, in some embodiments of the present application, the nicotine salt comprises one or more of nicotine tartrate, nicotine benzoate, nicotine lactate and nicotine gluconate; and / or
[0008] The pH adjuster comprises one or more of sodium carbonate and sodium bicarbonate; and / or
[0009] The pH adjuster is encapsulated in resin; and / or
[0010] The disintegrant comprises one or more of cross-linked sodium carboxymethyl cellulose, cross-linked polyvinylpyrrolidone and sodium carboxymethyl starch; and / or
[0011] The binder comprises one or more of povidone K25 and povidone K30.
[0012] Optionally, in some embodiments of the present application, the nicotine composition further comprises an additive, and the additive comprises one or more of a sweetener, a flavoring agent, a filler and a preservative.
[0013] Optionally, in some embodiments of the present application, the mass ratio of the nicotine salt, the pH adjuster, the disintegrant, the binder, the sweetener, the flavoring agent, the filler, and the preservative is (0.6-4):(0.5-3):(3-6):(1-5):(2.05-20.15):(0-5):(10-20):(0.01-0.05); and / or
[0014] The flavoring agent includes one or more of peppermint essence, cinnamon essence, watermelon essence, lemon essence, sweet orange essence, pineapple essence, and blueberry essence; and / or
[0015] The filler includes cellulose; and / or
[0016] The sweetener includes one or more of acesulfame, sucralose, maltitol, and mannitol; and / or
[0017] The preservative includes one or more of potassium sorbate, sodium benzoate, and parabens.
[0018] Correspondingly, the present application also provides a preparation method of a nicotine composition, including the following steps:
[0019] Providing a nicotine salt, a pH adjuster, a binder, a disintegrant, and a solvent, mixing, granulating, and drying to obtain a nicotine composition.
[0020] Optionally, in some embodiments of the present application,
[0021] The granulating includes: extruding through a 30-80 mesh screen; and / or
[0022] The temperature of the drying is 40-60°C, and the time of the drying is 15-25 minutes; and / or
[0023] The solvent is anhydrous ethanol, and the mass ratio of the nicotine salt, the pH adjuster, the disintegrant, the binder, and the anhydrous ethanol is (0.6-4):(0.5-3):(3-6):(1-5):(3-10).
[0024] Optionally, in some embodiments of the present application, the providing a nicotine salt, a pH adjuster, a binder, a disintegrant, and a solvent, mixing, granulating, and drying includes:
[0025] Providing a solvent and a binder, dissolving the binder in the solvent to obtain a granulating solution;
[0026] Providing a nicotine salt, a pH adjuster, and a disintegrant, mixing, and then adding the granulating solution to obtain a wet powder;
[0027] The wet powder is granulated, dried, and sieved to obtain the nicotine composition.
[0028] Optionally, in some embodiments of the present application, a flavoring agent is added to the granulation solution when preparing the granulation solution; and / or
[0029] A sweetening agent, a filler, and a preservative are added to the granulation solution when preparing the wet powder.
[0030] Correspondingly, the present application also provides a nicotine bag comprising the nicotine composition described above.
[0031] In the present application, the nicotine salt and the pH regulator will undergo a neutralization reaction in a wet environment to release free nicotine, which is then absorbed by the oral mucosa; the components in the nicotine composition can be bonded together by the binder, thereby reducing contact with water, avoiding the reaction between the nicotine salt and the pH regulator during storage, and thus reducing the upper head feeling; the bonded nicotine composition can be rapidly disintegrated when it comes into contact with saliva by adding a disintegrating agent, thereby accelerating the release of free nicotine. BRIEF DESCRIPTION OF DRAWINGS In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiment description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor. Figure 1 is a flow chart of the preparation method of the nicotine composition provided by the embodiments of the present application; Figure 2 is a finished product diagram of the nicotine composition provided by the embodiments of the present application; Figure 3 is a finished product diagram of the nicotine bag provided by the embodiments of the present application. DETAILED DESCRIPTION
[0032] The technical solutions in the embodiments of the present application will be described clearly and completely in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only some embodiments of the present application, but not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application. In addition, it should be understood that the specific embodiments described herein are only used to illustrate and explain the present application, and are not used to limit the present application.
[0033] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description herein is for describing particular embodiments only and is not intended to be limiting of the application. As used in this description, the singular forms "a", "an", and "the" include plural references unless the context clearly dictates otherwise. The term "and / or" includes any and all combinations of one or more of the associated listed items.
[0034] In the present application, the orientation words such as "upper" and "lower" are used in the description of the present application, unless otherwise specified, generally refer to the upper and lower in the actual use or working state of the device, and specifically refer to the direction of the drawing surface in the drawings; and "inner" and "outer" refer to the outline of the device. In addition, in the description of the present application, the term "comprising" means "including but not limited to". The terms first, second, third, etc. are only used as labels and do not impose numerical requirements or establish an order.
[0035] In the present application, "and / or" describes the association relationship of the associated objects, which means that there can be three kinds of relationships, for example, A and / or B, which can represent the following cases: A exists alone, A and B exist together, and B exists alone. Wherein A and B can be singular or plural.
[0036] In the present application, "at least one" means one or more, and "multiple" means two or more. "One or more", "at least one of the following", or similar expressions, means any combination of these items, including any combination of single item or multiple items. For example, "at least one of a, b, or c", or "at least one of a, b, and c", can represent a, b, c, a-b (i.e. a and b), a-c, b-c, or a-b-c, wherein a, b, and c can be single or multiple.
[0037] Various embodiments of the present application can exist in the form of a range; it should be understood that the description in the form of a range is only for the convenience and brevity, and should not be understood as a hard limit on the scope of the present application; therefore, it should be considered that the described range has been specifically disclosed all possible sub-ranges and single values within the range. For example, it should be considered that the range description from 1 to 6 has specifically disclosed sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as single numbers within the range, such as 1, 2, 3, 4, 5, and 6, regardless of the range. In addition, whenever a numerical range is indicated herein, it means that any cited number (fraction or integer) within the indicated range is included.
[0038] The existing nicotine bag raw material has poor fluidity, is easy to be oxidized and yellow, has not enough strong feeling, nicotine effect speed is not enough fast, and duration is short. And the nicotine bag raw material is mainly in the form of small size powder, the humidity is greater than 15%, and the nicotine salt directly contacts with the pH regulator.
[0039] The technical solution of the present application is as follows:
[0040] In the first aspect, as Figure 2 The present application provides a nicotine composition, which comprises the following components: nicotine salt, pH regulator, binder and disintegrant.
[0041] In the present application, the nicotine salt and the pH regulator will undergo a neutralization reaction in a humid environment, releasing free nicotine, which is then absorbed by the oral mucosa; the components in the nicotine composition can be bonded together by the binder, thereby reducing contact with water, avoiding the reaction between the nicotine salt and the pH regulator during storage, thereby increasing the storage time; the disintegrant can be added to make the bonded nicotine composition disintegrate rapidly when it comes into contact with saliva, thereby accelerating the release of free nicotine. By adding the binder and the disintegrant at the same time, the nicotine composition can be more easily stored, its effect can be more easily maintained, and its release speed can be improved.
[0042] In some embodiments, the mass ratio of the nicotine salt, the pH regulator, the disintegrant and the binder is (0.6-4):(0.5-3):(3-6):(1-5). Within the mass ratio range, the nicotine composition can be more easily stored, its effect can be more easily maintained, and its release speed can be improved.
[0043] In some embodiments, the nicotine salt comprises one or more of nicotine tartrate, nicotine benzoate, nicotine lactate and nicotine gluconate.
[0044] In some embodiments, the pH regulator comprises one or more of sodium carbonate and sodium bicarbonate.
[0045] In some embodiments, the pH regulator is encapsulated in resin. In the present application, the method of encapsulating the pH regulator in resin can adopt embedding technology, i.e. a process of wrapping the pH regulator with resin to provide performance support or chemical protection.
[0046] In some embodiments, the encapsulation method of the pH regulator comprises:
[0047] (1) providing resin and ethanol, configuring an ethanol solution of resin with a mass concentration of 20-23%, adding the pH regulator to the ethanol solution of resin, stirring at 40-45°C for 2-3h, and filtering;
[0048] (2) The filtrate obtained by filtration is frozen at -20 to -25 °C for 24-30 h, and then freeze-dried for 24-30 h to obtain the pH adjuster encapsulated in the resin.
[0049] In some embodiments, the pH adjuster is sodium carbonate encapsulated in the resin.
[0050] In some embodiments, the disintegrant includes one or more of croscarmellose sodium, cross-linked polyvinylpyrrolidone, and sodium starch glycolate.
[0051] In some embodiments, the disintegrant is sodium starch glycolate.
[0052] In some embodiments, the binder includes one or more of povidone K25 and povidone K30.
[0053] In the present application, povidone K25 and povidone K30 can be used in medical grade, safe and non-toxic.
[0054] In some embodiments, the binder is povidone K30.
[0055] In some embodiments, the nicotine composition further includes an additive, which includes one or more of a sweetener, a flavoring agent, a filler, and a preservative.
[0056] In the present application, the flavoring agent and the sweetener can be adjusted according to the taste of the nicotine composition.
[0057] In some embodiments, the mass ratio of the nicotine salt, the pH adjuster, the disintegrant, the binder, the sweetener, the flavoring agent, the filler, and the preservative is (0.6-4):(0.5-3):(3-6):(1-5):(2.05-20.15):(0-5):(10-20):(0.01-0.05).
[0058] In some embodiments, the flavoring agent includes, but is not limited to, one or more of peppermint essence, cinnamon essence, watermelon essence, lemon essence, sweet orange essence, pineapple essence, and blueberry essence.
[0059] In some embodiments, the filler includes cellulose.
[0060] In some embodiments, the filler includes at least one of microcrystalline cellulose, natural fiber, and cellulose derivative.
[0061] In some embodiments, the filler is microcrystalline cellulose.
[0062] In some embodiments, the sweetener comprises one or more of acesulfame, sucralose, maltitol and mannitol.
[0063] In some embodiments, the sweetener comprises the following components by weight: 0.05-0.15 parts by weight of acesulfame, 1-10 parts by weight of maltitol and 1-10 parts by weight of mannitol.
[0064] In some embodiments, the preservative comprises one or more of potassium sorbate, sodium benzoate and parabens.
[0065] In some embodiments, the preservative is potassium sorbate.
[0066] In some embodiments, the particle size of the nicotine composition is 30-80 mesh. The particle size of the nicotine composition is the average particle size. Within the particle size range, the nicotine release speed is faster, while the nicotine composition can be firmly bonded without generating excessive dust.
[0067] In the second aspect, as shown in Figure 1 The embodiments of the present application provide a preparation method of a nicotine composition, comprising the following steps:
[0068] S1, providing a nicotine salt, a pH adjuster, a binder, a disintegrant and a solvent, mixing, granulating, drying to obtain a nicotine composition.
[0069] In some embodiments, the solvent is anhydrous ethanol.
[0070] In the present application, the binder is soluble in ethanol and forms a bonding slurry with ethanol, so that the components can be bonded, and the nicotine composition is formed after drying. The nicotine salt can react with the pH adjuster under the condition of moisture to release free nicotine. By using anhydrous ethanol as the solvent, the problem of insufficient stability caused by using water as the solvent can be avoided. Moreover, ethanol has the characteristics of easy evaporation and easy drying. The ethanol will evaporate during the drying process to form the nicotine composition, which can improve the production efficiency of the nicotine composition. At the same time, even if a small amount of ethanol remains in the nicotine composition, it is also relatively safe for the human body. The anhydrous ethanol is food-grade anhydrous ethanol.
[0071] In some embodiments, the mass ratio of the nicotine salt, the pH adjuster, the disintegrant, the binder and the anhydrous ethanol is (0.6-4):(0.5-3):(3-6):(1-5):(3-10). Within the mass ratio range, the anhydrous ethanol can fully dissolve the binder, so that the nicotine components can be better bonded together, and at the same time, the ethanol can be fully evaporated.
[0072] In some embodiments, the mass ratio of the nicotine salt, the pH regulator, the disintegrant, the binder, and the absolute ethanol is (0.6-4):(0.5-3):(3-6):(1-5):(4-6).
[0073] In step S1,
[0074] In some embodiments, the providing the nicotine salt, the pH regulator, the binder, the disintegrant, and the solvent, and the mixing, comprises:
[0075] S11, providing a solvent, a flavoring agent, and a binder, dissolving the flavoring agent and the binder in the solvent to obtain a granulation solution;
[0076] S12, providing a nicotine salt, a pH regulator, and a disintegrant, mixing, and then adding the granulation solution to obtain a wet powder.
[0077] In the present application, by dissolving the flavoring agent in the solvent, the flavoring agent can be fully mixed with other powders, so that the aroma of the flavoring agent is uniformly dispersed, thereby improving the user experience.
[0078] In some embodiments, the providing the nicotine salt, the pH regulator, the binder, the disintegrant, and the solvent, and the mixing, comprises:
[0079] S11, providing a solvent and a binder, dissolving the binder in the solvent to obtain a granulation solution;
[0080] S12, providing a nicotine salt, a pH regulator, a disintegrant, and an additive, mixing, and then adding the granulation solution to obtain a wet powder, the additive comprising one or more of a sweetener, a filler, and a preservative.
[0081] In step S11,
[0082] In some embodiments, the mixing is performed by stirring at a speed of 150-450 r / min for 40-60 min.
[0083] In some embodiments, the wet powder is granulated and dried to obtain a nicotine composition, comprising:
[0084] The wet powder is granulated, dried, and sieved to obtain a nicotine composition.
[0085] In some embodiments, the granulation comprises: extruding through a 30-80 mesh sieve. This granulation method is simple and easy to operate.
[0086] In some embodiments, the sieving comprises: sieving through a 30-80 mesh sieve.
[0087] In the present application, the agglomeration of the nicotine composition during the drying process can be prevented by sieving to obtain a uniform size of the nicotine composition.
[0088] In some embodiments, the drying temperature is 40-60℃, and the drying time is 15-25 min.
[0089] The types of the binder, nicotine salt, pH regulator, disintegrant, sweetener, filler and preservative used in the preparation method of the nicotine composition provided in the present application are as described above.
[0090] In a third aspect, the embodiments of the present application provide a nicotine bag comprising the nicotine composition described above.
[0091] In some embodiments, as shown in Figure 3 The nicotine bag comprises a bag and the nicotine composition described above, and the nicotine composition is arranged in the bag. The bag is used to contain the nicotine composition and can be made of non-woven fabric.
[0092] The present application will be described in detail below through specific embodiments. The following embodiments are only part of the embodiments of the present application and are not limiting of the present application. The raw materials used in the following embodiments are commercially available products unless otherwise specified.
[0093] Example 1
[0094] A preparation method of a nicotine bag comprises the following steps:
[0095] (1) 3 parts of povidone K30 and 2 parts of watermelon flavor were added to 6 parts of anhydrous ethanol, and stirred uniformly at room temperature using a magnetic stirrer at a speed of 350 r / min for 50 min to obtain a granulation solution;
[0096] (2) 20 parts of microcrystalline cellulose, 5 parts of sodium carboxymethyl starch, 1 part of nicotine bitartrate salt (formed by one nicotine cation and two tartrate anions), 2.5 parts of resin-sodium carbonate (resin-encapsulated sodium carbonate), 0.08 parts of acesulfame potassium, 8 parts of maltitol, 8 parts of mannitol and 0.05 parts of potassium sorbate were stirred uniformly, and then the granulation solution was added and stirred uniformly to obtain a wet powder;
[0097] (3) The wet powder was extruded through a 50-mesh sieve to form granules, which were dried in a 60℃ air-drying oven for 20 min to obtain coarse granules, which were then sieved through a 50-mesh sieve to obtain a nicotine composition;
[0098] (4) The nicotine composition described above was loaded into a non-woven fabric bag to obtain a nicotine bag.
[0099] The preparation method of the resin-sodium carbonate comprises:
[0100] (1) Eudragit L100 acrylic resin was configured into an ethanol solution with a mass concentration of 20%, and sodium carbonate was added to an aqueous solution to obtain a mixture solution;
[0101] (2) The mixture solution was stirred in a constant-temperature magnetic stirrer at a temperature of 40°C for 2 h, and then filtered;
[0102] (3) The filtrate obtained after filtration was frozen in a refrigerator at -20°C for 24 h, and then freeze-dried in a freeze dryer for 24 h to obtain resin-sodium carbonate.
[0103] Example 2
[0104] This example is basically the same as Example 1, except that the nicotine tartrate salt in this example is replaced by a nicotine gluconate salt.
[0105] Example 3
[0106] This example is basically the same as Example 1, except that the nicotine tartrate salt in this example is replaced by a nicotine benzoate salt.
[0107] Example 4
[0108] This example is basically the same as Example 1, except that the nicotine tartrate salt in this example is replaced by a nicotine lactate salt.
[0109] Example 5
[0110] This example is basically the same as Example 1, except that the microcrystalline cellulose in this example is replaced by natural cellulose.
[0111] Example 6
[0112] This example is basically the same as Example 1, except that the povidone K30 in this example is replaced by povidone K25.
[0113] Example 7
[0114] This example is basically the same as Example 1, except that the sodium carboxymethyl starch in this example is replaced by cross-linked sodium carboxymethyl cellulose.
[0115] Example 8
[0116] This example is basically the same as Example 1, except that the sodium carboxymethyl starch in this example is replaced by cross-linked polyvinylpyrrolidone.
[0117] Example 9
[0118] This example is basically the same as example 1, the only difference is that the watermelon flavor in this example is replaced by a cinnamon flavor.
[0119] Example 10
[0120] This example is basically the same as example 1, the only difference is that the amount of sodium carboxymethyl starch in this example is 3 parts.
[0121] Example 11
[0122] This example is basically the same as example 1, the only difference is that the amount of sodium carboxymethyl starch in this example is 6 parts.
[0123] Example 12
[0124] This example is basically the same as example 1, the only difference is that the amount of nicotine tartrate in this example is 4 parts.
[0125] Example 13
[0126] This example is basically the same as example 1, the only difference is that the amount of nicotine tartrate in this example is 0.6 parts.
[0127] Example 14
[0128] This example is basically the same as example 1, the only difference is that the amount of povidone K30 in this example is 1 part.
[0129] Example 15
[0130] This example is basically the same as example 1, the only difference is that the amount of acesulfame in this example is 0.05 parts, the amount of maltitol is 5 parts, and the amount of mannitol is 5 parts.
[0131] Example 16
[0132] This example is basically the same as example 1, the only difference is that the amount of acesulfame in this example is 0.1 parts, the amount of maltitol is 5 parts, and the amount of mannitol is 10 parts.
[0133] Comparative Example 1
[0134] This example is basically the same as example 1, the only difference is that the resin-sodium carbonate in this example is replaced by sodium carbonate.
[0135] Comparative Example 2
[0136] This example is basically the same as example 1, the only difference is that sodium carboxymethyl starch is not used in this example.
[0137] Comparative Example 3
[0138] The present example is basically the same as Example 1, except that the amount of povidone K30 used in the present example is 10 parts.
[0139] The nicotine bags in the examples and comparative examples (storage temperature conditions: 22-28°C, humidity: 40-70%) were subjected to sensory quality evaluation: 10 people were used for each example and comparative example, and the nicotine bags were subjected to sensory evaluation, the sensory evaluation indexes are shown in Table 1, and the evaluation results are shown in Table 2.
[0140] Evaluation method: 10 sensory evaluators were used for evaluation, and the scoring method of blind evaluation was used, each person scored after experiencing the above products, and the average value was obtained by removing one highest score and one lowest score.
[0141] Irritation refers to the uncomfortable feeling of the nicotine bag to the oral cavity, throat, etc.
[0142] Pungent feeling refers to the painful feeling of the nicotine bag to the oral cavity, throat, etc.
[0143] The feeling of being addicted refers to the feeling of the nicotine bag acting on the brain through blood circulation after being released in the oral cavity.
[0144] Satisfaction refers to the comprehensive feeling of the strength, concentration and aroma of the nicotine bag to the inside of the oral cavity.
[0145] Flavor refers to the overall performance of the taste, mouthfeel and aroma of the nicotine bag different from other similar nicotine bags.
[0146] Table 1 Sensory evaluation indexes
[0147]
[0148] Table 2 Sensory evaluation results of the nicotine bag
[0149]
[0150]
[0151] From Table 2, it can be seen that:
[0152] The nicotine bags prepared in Examples 1-16 have good specific performance in terms of irritation, pungency, headiness, satisfaction, and flavor. Compared with the comparative examples, Examples 1-16 have better sensory requirements in terms of satisfaction and irritation by adding resin-sodium carbonate and disintegrating agent. In Comparative Example 1, the pH regulator is not encapsulated, and after the product is prepared, it is easy to have a neutralization reaction with nicotine salt, release free nicotine, and quickly dissipate the flavor, so that the overall experience is not good. In Comparative Example 2, no disintegrating agent is added, the free nicotine is released slowly, the headiness is slow, and the satisfaction is reduced. In Comparative Example 3, the amount of adhesive is excessive, the free nicotine is released slowly, the headiness is slow, and the satisfaction is reduced.
[0153] The nicotine composition, the preparation method thereof, and the nicotine product provided by the embodiments of the present application are described in detail above, and specific examples are applied to describe the principles and implementation manners of the present application. The above description of the embodiments is only used to help understand the method of the present application and its core idea; meanwhile, for those skilled in the art, the specific implementation manners and application ranges will be changed according to the idea of the present application, and the above description should not be understood as a limitation of the present application.
Claims
1. A nicotine composition, characterized in that, It includes the following components: nicotine salts, pH adjusters, binders, and disintegrants.
2. The nicotine composition according to claim 1, characterized in that, The nicotine composition is in granular form, and the particle size of the nicotine composition is 30-80 mesh; and / or The mass ratio of the nicotine salt, the pH adjuster, the disintegrant, and the binder is (0.6-4):(0.5-3):(3-6):(1-5).
3. The nicotine composition according to claim 1, characterized in that, The nicotine salt includes one or more of nicotine tartrate, nicotine benzoate, nicotine lactate, and nicotine gluconate; and / or The pH adjuster includes one or more of sodium carbonate and sodium bicarbonate; and / or The pH adjuster is encapsulated in resin; and / or The disintegrant includes one or more of croscarmellose sodium, croscarmellose polyvinylpyrrolidone, and sodium carboxymethyl starch; and / or The adhesive includes one or more of povidone K25 and povidone K30.
4. The nicotine composition according to claim 1, characterized in that, The nicotine composition further includes additives, which include one or more of sweeteners, flavoring agents, fillers, and preservatives.
5. The nicotine composition according to claim 4, characterized in that, The mass ratio of the nicotine salt, the pH adjuster, the disintegrant, the binder, the sweetener, the flavoring agent, the filler, and the preservative is (0.6-4):(0.5-3):(3-6):(1-5):(2.05-20.15):(0-5):(10-20):(0.01-0.05); and / or The flavoring agent includes one or more of the following: peppermint flavoring, cinnamon flavoring, watermelon flavoring, lemon flavoring, sweet orange flavoring, pineapple flavoring, and blueberry flavoring; and / or The filler includes cellulose; and / or The sweetener includes one or more of acesulfame potassium, sucralose, maltitol, and mannitol; and / or The preservatives include one or more of potassium sorbate, sodium benzoate, and p-hydroxybenzoate.
6. A method for preparing a nicotine composition, characterized in that, Includes the following steps: Nicotine salts, pH adjusters, binders, disintegrants, and solvents are provided, mixed, granulated, and dried to obtain a nicotine composition.
7. The method for preparing the nicotine composition according to claim 6, characterized in that, The granulation process includes: extruding granules through a 30-80 mesh sieve; and / or The drying temperature is 40℃-60℃, and the drying time is 15min-25min; and / or The solvent is anhydrous ethanol, and the mass ratio of the nicotine salt, the pH adjuster, the disintegrant, the binder and the anhydrous ethanol is (0.6-4):(0.5-3):(3-6):(1-5):(3-10).
8. The method for preparing the nicotine composition according to claim 6, characterized in that, The process of providing nicotine salts, pH adjusters, binders, disintegrants, and solvents, followed by mixing, granulation, and drying, includes: A solvent and a binder are provided, and the binder is dissolved in the solvent to obtain a granulation solution; Nicotine salt, pH adjuster and disintegrant are provided, mixed and added to the granulation solution to obtain wet powder; The wet powder is granulated, dried, and sieved to obtain a nicotine composition.
9. The method for preparing the nicotine composition according to claim 8, characterized in that, A flavoring agent is also added to the solvent during the preparation of the granulation solution; and / or Sweeteners, fillers, and preservatives are also added to the granulation solution during the preparation of the wet powder.
10. A nicotine bag, characterized in that, Includes the nicotine composition as described in any one of claims 1-5, or the nicotine composition prepared by the method described in any one of claims 6-9.