Composition with moisturizing, soothing and repairing effects as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of cosmetics, and discloses a composition with moisturizing, soothing and repairing effects as well as a preparation method and application thereof. The composition disclosed by the invention is prepared from the following components in parts by mass: 1 to 15 parts of peach resin extract, 1 to 15 parts of saccharide isomeride, 0.1 to 2 parts of red-knees herb extract and 0.1 to 5 parts of Ectoin. According to the present invention, the formula contains the peach resin extract, the saccharide isomeride, the red-knees herb extract and the Ectoine, and through the unique formula combination and the scientific ratio, the components produce the good synergistic effect, such that the sensitive skin can be effectively relieved, the skin barrier can be effectively repaired, and the long-acting water locking and moisturizing can be effectively achieved.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics, and particularly relates to a composition with moisturizing, soothing and repairing effects and a preparation method and application thereof. BACKGROUND

[0002] A healthy skin barrier can help the skin to lock in moisture and resist external pollutants such as dust, ultraviolet rays, bacteria and other external stimuli, avoid excessive loss of moisture, and keep the skin moist and smooth. When the skin barrier is damaged, it can cause the skin to lose its ability to lock in moisture, the stratum corneum to become thin, redness, itching, stinging, swelling and other problems, and further cause various skin problems such as eczema, drooling rash and other problems.

[0003] Therefore, it is very important to provide a product that can act on the stratum corneum, enhance the skin barrier, reduce skin inflammation and erythema, and reduce skin irritation. SUMMARY

[0004] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the purpose of the present application is to provide a composition with moisturizing, soothing and repairing effects and a preparation method and application thereof, which can effectively relieve sensitive skin problems such as redness, itching, stinging, swelling and other problems, lock in skin moisture, repair the barrier function of the skin, and restore the skin to a healthy state.

[0005] In a first aspect of the present application, a composition is provided, which comprises the following components in terms of mass fraction: peach resin extract 1-15 parts, sugar isomer 1-15 parts, kaffir lily extract 0.1-2 parts and ectoine 0.1-5 parts.

[0006] In some embodiments of the present application, the composition comprises the following components in terms of mass fraction: peach resin extract 1-10 parts, sugar isomer 1-10 parts, kaffir lily extract 0.1-1 part and ectoine 0.1-3 parts.

[0007] In some embodiments of the present application, the composition comprises the following components in terms of mass fraction: peach resin extract 1-5 parts, sugar isomer 1-5 parts, kaffir lily extract 0.1-0.8 parts and ectoine 0.1-1 parts.

[0008] In some embodiments of the present application, the composition comprises the following components in terms of mass fraction: peach resin extract 5-15 parts, sugar isomer 5-15 parts, kaffir lily extract 0.8-2 parts and ectoine 1-5 parts.

[0009] Specifically, the peach (PRUNUS PERSICA) resin extract described in the present application is a resin secreted from the trunk of a Rosaceae plant naturally or due to a wound, which is beneficial to wound self-healing, and the main component is natural macromolecular polysaccharide, which is crystal clear and shaped like amber, and is a natural gum gifted by nature. The peach (PRUNUS PERSICA) resin extract itself has certain moisture absorption and water supplement effects, and when applied to skin care products, can endow the products with the effects of moisturizing, reducing skin roughness and improving the symptoms of skin desquamation. The peach (PRUNUS PERSICA) resin extract is a natural moisturizing agent, which can reduce skin irritation, deeply moisturize, and is beneficial to skin absorption, and has a natural moist feeling.

[0010] Specifically, the sugar isomer described in the present application has a composition structure similar to that of human stratum corneum, can be firmly combined with the skin like a magnet, and can maintain long-acting moisturizing.

[0011] Specifically, the polygonum hydropiper (POLYGONUM HYDROPIPER) extract described in the present application mainly contains flavonoids, sesquiterpenes and phenolic acid components, and the polygonum hydropiper has the effects of broad-spectrum antibacterial and anti-inflammatory, antioxidant and the like, and by adjusting the starting critical value of the skin dendritic cells to a suitable level, the overreaction of the cells when attacked is avoided, and the tolerance of sensitive skin is improved, without affecting the normal immune function of the skin.

[0012] Specifically, the ectoine described in the present application contains multiple polar groups in the molecular structure, can be combined with water molecules through hydrogen bonds and the like to form a hydration layer, improve the water content of the skin and lock in the water, at the same time, the ectoine can also stimulate the skin cells to synthesize natural moisturizing factors, promote the water retention effect of the skin, and is an excellent moisturizing agent. The ectoine can effectively improve the immune protection ability of skin cells, increase the cell repair ability, enable the skin to effectively resist the invasion of microorganisms and allergens, has a good repair effect on the conditions of skin peeling, redness, itching, stinging and the like, accelerates the recovery of healthy skin, and the ectoine can also relieve various stresses on the skin such as ultraviolet damage, skin aging caused by dry environment, and skin degradation caused by surfactants.

[0013] The composition described in the present application has a synergistic effect through the cooperation of the four specific components of the peach (PRUNUS PERSICA) resin extract, the sugar isomer, the polygonum hydropiper (POLYGONUM HYDROPIPER) extract and the ectoine, and under scientific proportioning, so as to achieve the purposes of relieving sensitive skin, repairing skin barrier, long-acting water locking and moisturizing, and rebuilding healthy skin.

[0014] In the second aspect of the present application, a preparation method of the composition described in the first aspect of the present application is provided, comprising the following steps: The components are mixed to obtain the composition.

[0015] In a third aspect, the present application provides use of the composition according to the first aspect of the present application in the preparation of a cosmetic product having the effects of moisturizing, soothing and repairing.

[0016] In a fourth aspect, the present application provides a cosmetic product comprising the composition according to the first aspect of the present application.

[0017] In some embodiments of the present application, the mass content of the composition in the cosmetic product is 0.01%-5%.

[0018] Specifically, the mass content of the composition in the cosmetic product can be any point value or any two-point range value between 0.01%-5%, such as 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, etc. Preferably, it is 0.1%-2%.

[0019] In some embodiments of the present application, the cosmetic product further comprises at least one of a thickening agent, a humectant, a preservative, an emulsifier and an emollient.

[0020] In some embodiments of the present application, the thickening agent comprises at least one of an acrylic copolymer, lecithin and xanthan gum.

[0021] In some embodiments of the present application, the humectant comprises glycerin.

[0022] In some embodiments of the present application, the preservative comprises p-hydroxyacetophenone and / or 1,2-hexanediol.

[0023] In some embodiments of the present application, the emulsifier comprises at least one of polyglyceryl-6 distearate, jojoba esters, polyglyceryl-3 beeswaxate, cetyl alcohol, cetearyl alcohol, cetearyl glucoside and sodium stearoyl glutamate.

[0024] In some embodiments of the present application, the emollient comprises at least one of stearic acid, cetearyl alcohol, behenyl alcohol, butyrospermum parkii butter, limnanthes alba (meadowfoam) seed oil, squalane, propylheptanol caprylate, tocopherol (vitamin E) and dimethicone.

[0025] In some embodiments of the present application, the dosage form of the cosmetic product comprises a cosmetic water, an essence, a lotion, a cream or a mask.

[0026] Compared with the prior art, the present application has the following beneficial effects: The composition of the present application contains peach (PRUNUS PERSICA) resin extract, sugar isomer, polygonum hydropiper (POLYGONUM HYDROPIPER) extract and ectoine in the formula, through the unique combination of the formula and the scientific proportion, the good synergistic effect between the components is generated, and the sensitive skin is more effectively relieved, the skin barrier is repaired, and long-acting water retention and moisturizing are achieved. DETAILED DESCRIPTION

[0027] The content of the present application is further described in detail through specific examples. The raw materials, reagents or devices used in the examples are commercially available unless otherwise specified, or can be obtained by the prior art method. Unless otherwise specified, the test or test method is the conventional method in the art.

[0028] The commercially available product LECIGEL™ used in the present application contains: acrylic acid (ester) copolymer, lecithin.

[0029] The commercially available product EMULIUM MELLIFERA MB used in the present application contains: polyglyceryl-6 distearate, jojoba esters, polyglyceryl-3 beeswaxate, cetyl alcohol.

[0030] The commercially available product MONTANOV 68 MB used in the present application contains: cetearyl alcohol, cetearyl glucoside.

[0031] The commercially available product Cetiol Sensoft used in the present application contains: propylheptyl octanoate, tocopherol (vitamin E).

[0032] Example 1 A composition, which is composed of the following components in mass fraction: peach (PRUNUS PERSICA) resin extract 15 parts, sugar isomer 15 parts, polygonum hydropiper (POLYGONUM HYDROPIPER) extract 2 parts and ectoine 5 parts.

[0033] The composition of the present application is prepared by mixing the components.

[0034] Example 2 A composition, which is composed of the following components in mass fraction: peach (PRUNUS PERSICA) resin extract 10 parts, sugar isomer 10 parts, polygonum hydropiper (POLYGONUM HYDROPIPER) extract 1 part and ectoine 3 parts.

[0035] The composition of the present application is prepared by mixing the components.

[0036] Example 3 A composition consisting of the following components in parts by mass: peach (PRUNUS PERSICA) resin extract 5 parts, sugar isomer 5 parts, knotweed (POLYGONUM HYDROPIPER) extract 0.8 parts, and ectoine 1 part.

[0037] The composition of the present embodiment is prepared by mixing the components.

[0038] Comparative Example 1 The only difference from Example 1 is that the peach (PRUNUS PERSICA) resin extract is not contained.

[0039] Comparative Example 2 The only difference from Example 1 is that the sugar isomer is not contained.

[0040] Comparative Example 3 The only difference from Example 1 is that the knotweed (POLYGONUM HYDROPIPER) extract is not contained.

[0041] Comparative Example 4 The only difference from Example 1 is that the ectoine is not contained.

[0042] Comparative Example 5 The only difference from Example 1 is that a single component, peach (PRUNUS PERSICA) resin extract, is used.

[0043] Comparative Example 6 The only difference from Example 1 is that a single component, sugar isomer, is used.

[0044] Comparative Example 7 The only difference from Example 1 is that a single component, knotweed (POLYGONUM HYDROPIPER) extract, is used.

[0045] Comparative Example 8 The only difference from Example 1 is that a single component, ectoine, is used.

[0046] Comparative Example 9 The only difference from Example 1 is that the peach (PRUNUS PERSICA) resin extract is replaced with an equivalent amount of glucan having similar efficacy.

[0047] Comparative Example 10 The only difference from Example 1 is that the sugar isomer is replaced with an equivalent amount of trehalose having similar efficacy.

[0048] Comparative Example 11 The only difference from Example 1 is that the Polygonum hydropiper extract was replaced in an equal amount with Symcalmin, which has similar effects.

[0049] Comparative Example 12 The only difference from Example 1 is that ectoine is replaced in equal amounts with panthenol, which has similar effects.

[0050] Composition efficacy test Experiment Example 1: In vitro hyaluronidase inhibition experiment Hyaluronidase is involved in type I hypersensitivity reactions and is strongly correlated with inflammation and allergies. Therefore, in vitro hyaluronidase activity inhibition experiments can serve as an indicator for studying the specific effects of anti-allergy components.

[0051] The inhibition rate of hyaluronidase activity was determined using the modified Elson-Morgan (N-methylglucosamine reaction) method. Sample solutions with a concentration of 1 mg / mL were prepared from the products of Examples 1-3 and Comparative Examples 1-12, respectively, for later use. Take 0.1 mL of 0.25 mmol / L CaCl2 solution, add 0.5 mL of hyaluronidase solution (1250 U / mL), and incubate at 37℃ for 20 min; add 0.5 mL of sample solution, and continue incubation at 37℃ for 20 min; add 0.5 mL of 0.5 g / L sodium hyaluronate solution, incubate at 37℃ for 30 min, and then let stand at room temperature for 5 min; then add 0.1 mL of 0.4 mol / L NaOH solution and 0.5 mL of acetylacetone solution, heat in a boiling water bath for 15 min, and immediately cool with cold water for 5 min; add 1 mL of Ehrlich reagent, dilute with 3 mL of anhydrous ethanol, mix well, and let stand for 20 min for color development. Use dipotassium glycyrrhizate as a positive control, and measure the absorbance using a UV-Vis spectrophotometer.

[0052] Hyaluronidase inhibition rate = [1 - (CD) / (AB)] × 100%; Wherein, A: Absorbance of the control solution (using acetate buffer instead of the sample solution); B: Absorbance of the control blank solution (using acetate buffer instead of the sample solution and enzyme solution); C: Absorbance of the sample solution; D: Absorbance of the sample blank solution (using acetate buffer instead of the enzyme solution).

[0053] Solution A was first scanned in the range of 450 nm to 700 nm to determine the maximum absorption wavelength. The experimental results of hyaluronidase inhibition rate are shown in Table 1.

[0054] Table 1

[0055] It can be seen from Table 1 that the composition with the moisturizing, soothing and repairing effect has good hyaluronidase inhibition capacity, and the four components have a synergistic effect. From the experimental data, the hyaluronidase inhibition capacity of the compositions of Examples 1-3 is obviously stronger than that of Comparative Examples 1-8, i.e. the effect of a single component or three components. In addition, the hyaluronidase inhibition experiment results of Comparative Examples 9-12 show that even if any one component of the composition of the application is replaced with other components with similar efficacy, the hyaluronidase inhibition rate is much lower than that of the compositions of Examples 1-3, which further illustrates that there is a synergistic relationship between the peach (PRUNUS PERSICA) resin extract, the sugar isomer, the polygonum hydropiper (POLYGONUM HYDROPIPER) extract and the ectoine in the composition of the application, and they are indispensable.

[0056] Evaluation of the moisturizing, soothing and repairing effect of human skin An acute skin barrier damage model was established by using the tape continuous sticking method, and a skin moisture tester (Germany CK Company) was used to test the changes of transdermal water loss TWEL value and skin erythema index EI value before and after using the sample.

[0057] 1) Subjects: 10 healthy subjects, aged 19-36 years old, with an average of (26.70±4.64) years old, mainly working indoors, no history of extensive sun exposure, no history of photosensitive diseases; no skin diseases, pigmentation, scars or systemic diseases that can affect the skin in the measurement area; no use of anti-allergic drugs, corticosteroids and other drugs affecting skin metabolism within 3 months. All subjects understand the experimental process and sign the informed consent form.

[0058] 2) Measurement conditions: The measurement was carried out under constant temperature and humidity conditions, the temperature was (22±1)℃, the humidity was (41.5±0.5)%, the tested person entered the test environment quietly 30min in advance, and the test site was exposed 10min before measurement, each parameter was measured continuously for 3 times to reduce measurement error.

[0059] 3) Experimental materials and equipment: The skin physiological non-invasive detection equipment is from Germany CK Company, CorneofixR tape, transdermal water loss measuring instrument (TewameterRTM300), corneometer (CorneometerRCM825), erythema index measuring instrument (MexameterMX18) and the like.

[0060] 4) Test method: Select a piece of skin of 2 cm x 2 cm in size on the back of the subject as the test area and mark it, and determine the baseline values of various physiological and physical indicators related to skin barrier function. Measured indicators: trans-epidermal water loss (TEWL) value, erythema index (EI). The products of Examples 1-3 and Comparative Examples 1-12 are used as test samples, and an acute skin barrier damage model is established using the adhesive tape continuous sticking method. Two test areas are randomly divided into natural repair areas and sample test areas. The sample test areas are applied with 2 mg of test sample once in the morning and once in the evening every day, and the natural repair areas are not treated and are used as blank controls to observe the natural repair process of the skin barrier. The indicators are measured every morning before the sample is applied. The repair conditions of the skin after damage by each sample are compared. The experimental results are shown in Tables 2 and 3 (in the tables, D0 represents the 0th day, D3 represents after 3 days of use, and D7 represents after 7 days of use).

[0061] Table 2 Change in average trans-epidermal water loss (TEWL) rate of the subject after 7 days of use

[0062] Table 3 Change in skin erythema index (EI) value of the subject after 7 days of use

[0063] Based on the experimental results of Tables 2 and 3, it can be concluded that the compositions of Examples 1-3 have good moisturizing and soothing functions and good skin barrier repair functions.

[0064] After the continuous tape sticking experiment, the skin barrier of the subjects was damaged, the transdermal water loss value increased significantly, and the skin had certain redness and swelling reaction, and the erythema index of the skin continued to rise in a period of time. Compared with Comparative Examples 5-8, the skin barrier function of the subjects using Examples 1-3 was greatly improved after 3 days of use, the transdermal water loss value was greatly reduced, and the erythema index EI was effectively controlled. After 7 days of use, the transdermal water loss value of the subjects was lower than before the experiment, and the erythema index EI value also reached or was lower than the level before the experiment, which indicated that the skin inflammation and erythema reaction of the subjects were effectively alleviated, the barrier function was restored, and the skin was locked and moisturized. Even better than before, compared with the single component, the moisturizing, soothing and repairing effect is not so significant. From the transdermal water loss value test data of Comparative Examples 1-4 and Comparative Examples 9-12, the composition lacking any component or using a component with similar efficacy to replace a component in the composition of the present application has a much poorer moisturizing, soothing and repairing effect than Examples 1-3, which indicates that there is a synergistic relationship between the peach (PRUNUS PERSICA) resin extract, the sugar isomer, the polygonum hydropiper (POLYGONUM HYDROPIPER) extract and the ectoine in the composition of the present application, and none of them can be omitted.

[0065] Patch test of experimental example 3 Test population: 450 volunteers, 18-45 years old, 225 female, 225 male, healthy skin, no history of skin disease and allergy. Randomly divided into 15 groups of the same number, 30 people in each group, the male to female ratio of each group is 1:1, and each group corresponds to the products of the test examples and comparative examples.

[0066] Test method: According to the human skin patch test method of "Cosmetic Safety Technology Specification" (2015 edition), patch test of the products of Examples 1-3 and Comparative Examples 1-12 was carried out, and the results were recorded according to the skin reaction grading standard. Among them, the skin reaction grading standard: (-, negative reaction, 0 level); (±, suspicious reaction, only weak erythema, 1 level); (+, weak positive reaction (erythema reaction), erythema, infiltration, edema, and may have papules, 2 level); (+++, strong positive reaction (vesicle reaction), erythema, infiltration, edema, papules, and vesicles, the reaction may exceed the test area, 3 level); (+++, very strong positive reaction (fusion vesicle reaction), obvious red rash, severe infiltration, edema, and fusion vesicles, the reaction exceeds the test area, 4 level).

[0067] The test results are shown in Table 4.

[0068] Table 4

[0069] As can be seen from Table 4, the moisturizing soothing repair composition of the present application has no obvious irritation to the skin, and is comfortable after use.

[0070] Application Example 1 The composition obtained in Application Example 1 was used to prepare a cream, and the formula of the cream is shown in Table 5.

[0071] Table 5

[0072] The preparation method of the cream of Application Example 1 is as follows: (1) Mix deionized water, glycerin, sodium stearoyl glutamate, xanthan gum and LECIGEL™, stir and dissolve, heat to 80°C and keep for 12 min to obtain phase A; (2) Mix EMULIUM MELLIFERA MB, MONTANOV 68 MB, stearic acid, cetylstearyl alcohol, behenyl alcohol, butyrospermum parkii butter, limnanthes alba (meadowfoam) seed oil, squalane and Cetiol® Sensoft, stir and dissolve, heat to 80°C to obtain phase B; and dimethicone is phase B2; (3) Mix 1,2-hexanediol and p-hydroxyacetophenone to obtain phase C; (4) Put phase B and dimethicone into phase A, stir uniformly, homogenize and keep for 8 min; after cooling to 55°C, add phase C, stir uniformly and homogenize; to obtain a mixed phase; (5) After the mixed phase is cooled to below 45°C, add the composition of Example 1, continue to stir until the temperature is reduced to below 37°C, and the cream is obtained.

[0073] Application Comparative Example 1 The only difference from Application Example 1 is that the composition of Example 1 is not contained, and other components, contents and preparation methods remain unchanged.

[0074] Experimental Example 4 Evaluation of Moisturizing, Soothing and Repairing Effects on Human Skin An acute skin barrier damage model was established by using the continuous tape sticking method, and a skin moisture tester (Germany CK Company) was used to test the changes in trans-epidermal water loss (TWEL) value and erythema index (EI) value before and after using the samples of Application Example 1 and Application Comparative Example 1.

[0075] 1) Subjects: 10 healthy subjects, aged 19-36 years, average (26.70±4.64) years, mainly indoor work, no history of sun exposure, no history of photosensitive disease; no skin disease, pigmentation, scar or systemic disease that can affect the skin in the measurement site; no use of anti-allergic drugs, corticosteroids and other drugs affecting skin metabolism within 3 months. All subjects understand the experimental process and sign the informed consent form.

[0076] 2) Measurement conditions: The test was carried out under constant temperature and humidity conditions, temperature (22±1) °C, humidity (41.5±0.5) %, the subjects entered the test environment quietly 30 min in advance, and the test site was exposed 10 min before measurement, each parameter was measured continuously for 3 times to reduce measurement error.

[0077] 3) Experimental materials and equipment: Skin physiological non-invasive detection equipment is from Germany CK company, CorneofixR tape, TewameterRTM300, CorneometerRCM825, erythema index measuring instrument, etc.

[0078] 4) Test method: Select a piece of skin with a size of 2 cm x 2 cm on the back of the subject as the test area and mark it, and determine the baseline value of each physiological and physical index related to skin barrier function. Measurement index: transdermal water loss TWEL value, erythema index (Erythemaindex, EI); establish an acute skin barrier damage model by continuous tape sticking method, randomly divide the two test areas into natural repair area and sample test area, apply 2 mg of test sample to the sample test area twice a day in the morning and evening, and the natural repair area does not need other treatment, as a blank control, to observe the natural repair process of skin barrier; measure each index before applying the sample in the morning every day; compare the repair situation of each sample after skin damage. The experimental results are shown in Tables 6 and 7 (in the table, D0 represents the 0th day, D3 represents after 3 days of use, and D7 represents after 7 days of use).

[0079] Table 6 Change of transdermal water loss rate TEWL average value of subjects after 7 days of use

[0080] Table 7 Change of skin erythema index EI value of subjects after 7 days of use

[0081] In combination with the experimental data in Table 6 and Table 7, compared with the application of Comparative Example 1, the skin trans-epidermal water loss rate and erythema index of the subject were obviously improved after using the sample of application Example 1 for 7 days, and basically returned to the level before the experiment, while the skin barrier repair of the subject using the sample of application Comparative Example 1 was relatively slow, and was only slightly better than the natural repair area, indicating that the addition of the composition of the application in the cosmetic product enables the cosmetic product to have a significant moisturizing, soothing and repairing effect.

[0082] The above describes the preferred embodiments of the present application, but the present application is not limited to the embodiments described above. Those skilled in the art can make various equivalent modifications or replacements without departing from the spirit of the present application. These equivalent modifications or replacements are all included in the scope defined by the claims of the present application.

Claims

1. A composition characterized in that, The composition comprises, by mass parts, peach resin extract 1-15 parts, sugar isomer 1-15 parts, knotweed extract 0.1-2 parts, and ectoine 0.1-5 parts.

2. The composition of claim 1, wherein, The composition comprises, by mass parts, peach resin extract 1-10 parts, sugar isomer 1-10 parts, knotweed extract 0.1-1 parts, and ectoine 0.1-3 parts.

3. The composition of claim 2, wherein, The composition comprises, by mass parts, peach resin extract 1-5 parts, sugar isomer 1-5 parts, knotweed extract 0.1-0.8 parts, and ectoine 0.1-1 parts.

4. Process for the preparation of a composition according to any one of claims 1 to 3, characterized in that, The method comprises the following steps: The components are mixed to obtain the composition.

5. Use of the composition of any one of claims 1-3 in the preparation of a cosmetic product having moisturizing, soothing, and repairing effects.

6. A cosmetic product, characterized by, The cosmetic product comprises the composition of any one of claims 1-3.

7. The cosmetic product according to claim 6, characterized in that, The mass content of the composition in the cosmetic product is 0.01%-5%.

8. The cosmetic product according to claim 7, characterized in that, The mass content of the composition in the cosmetic product is 0.1%-2%.

9. The cosmetic product according to claim 6, characterized in that, The cosmetic product further comprises at least one of a thickening agent, a humectant, a preservative, an emulsifier, and an emollient.

10. The cosmetic product according to claim 6, characterized in that, The dosage form of the cosmetic product comprises a cosmetic water, an essence, a lotion, a cream, or a mask. The dosage form of the cosmetic product comprises a cosmetic water, an essence, a lotion, a cream, or a mask.

Images