A cold shield structure, a sample carrying unit and a method of using a cold shield structure

By designing the mounting section and heat sink section of the cold shielding structure, the problems of water molecule contamination and weak magnetic field in cryo-electron microscopy were solved, enabling high-resolution imaging and comprehensive observation, and simplifying the movement of the carrier net.

CN121595607BActive Publication Date: 2026-08-25GUANGZHOU NAT LAB
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Patent Information

Application Number
CN202511173450.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-08-20
Publication Date
2026-08-25
Estimated Expiration
2045-08-20

AI Technical Summary

Technical Problem

In existing technologies, the grid of cryo-electron microscopes easily absorbs water molecules from the microscope tube, leading to sample contamination; the weak magnetic field strength affects imaging resolution; the optimized grid movement path cannot achieve comprehensive observation; the thermally driven structure is not suitable for low-temperature environments; and the carrier cannot achieve cold shielding during the microscopic imaging process.

Method used

A cold shielding structure is designed, including a mounting section and a heat sink. The heat sink is located on both sides of the mounting section to absorb water molecules. The thickness of the mounting section is smaller than that of the heat sink to reduce the pole shoe spacing. The carrier net moves unidirectionally through the slit area to achieve comprehensive observation. The cold shielding structure body moves along the length of the slit to simplify the movement.

Benefits of technology

It effectively avoids sample contamination, enhances magnetic field strength, ensures imaging resolution, enables comprehensive observation, simplifies the movement of the cold shielding structure, and avoids interference with the pole shoes.

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Abstract

The application discloses a cold shielding structure, a sample bearing unit and a method for using the cold shielding structure. The cold shielding structure comprises a cold shielding structure body, the cold shielding structure body comprises a mounting portion and heat sink portions located on opposite sides of the mounting portion, the mounting portion is used for mounting a carrier net, and the heat sink portions are used for guiding cold to the mounting portion. When the carrier net is mounted on the mounting portion, the temperature of the cold shielding structure body is lower than the temperature of the carrier net. Since the temperature of the heat sink portions is lower than the temperature of the mounting portion, the heat sink portions can absorb water molecules in an electron microscope barrel, so that the sample is prevented from being polluted by the water molecules. The thickness of the mounting portion is small, and the mounting portion is located between upper and lower pole shoes of the electron microscope, so that the distance between the upper and lower pole shoes of the electron microscope is reduced, the magnetic field intensity between the upper and lower pole shoes is increased, and the imaging resolution is ensured. Meanwhile, the heat sink portions with large thickness are located on the two sides of the mounting portion, so that the space between the upper and lower pole shoes is not occupied, the distance between the upper and lower pole shoes is further reduced, and the imaging resolution is ensured.
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