Application of N-acetylneuraminic acid in the preparation of drugs for treating methamphetamine addiction

By using endogenously synthesized N-acetylneuraminic acid (Neu5Ac) as a therapeutic agent, the limitations of existing drug options and poor compatibility in the treatment of methamphetamine addiction have been overcome, achieving effective treatment of methamphetamine addiction, reducing CPP scores and minimizing toxic side effects.

CN121910745BActive Publication Date: 2026-05-26JINAN UNIVERSITY +1
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Patent Information

Application Number
CN202610353566.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2026-03-23
Publication Date
2026-05-26
Estimated Expiration
2046-03-23

AI Technical Summary

Technical Problem

The existing drug options for treating methamphetamine addiction are limited, and exogenous synthetic drugs have poor compatibility with the human body, are prone to toxic side effects, and have unsatisfactory overall efficacy.

Method used

The drug uses endogenously synthesized N-acetylneuraminic acid (Neu5Ac) as a therapeutic agent, comprising a therapeutically effective amount of Neu5Ac and pharmaceutically acceptable excipients, administered orally or by injection, for the treatment of methamphetamine addiction.

Benefits of technology

Neu5Ac can significantly reduce the CPP score in methamphetamine-induced mice, exhibiting good biocompatibility and low toxicity, and effectively alleviating methamphetamine addiction behavior.

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Abstract

This application relates to the field of biomedical technology, and in particular to the application of N-acetylneuraminic acid in the preparation of drugs for treating methamphetamine addiction. This application is the first to discover the key role of N-acetylneuraminic acid (Neu5Ac) in the treatment of methamphetamine addiction, which can significantly reduce the CPP score in methamphetamine-addicted mice, demonstrating a good therapeutic effect on methamphetamine addiction. Furthermore, Neu5Ac can be synthesized endogenously, exhibiting advantages such as good biocompatibility and low toxicity.
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