Application of oleic acid in medicine for treating atopic dermatitis
By using oleic acid in drugs, health products, or functional foods, the problem of severe side effects from atopic dermatitis medications has been solved, achieving safe and effective treatment for itchy and inflammatory skin diseases. In particular, by regulating the IL-31 signaling pathway, it significantly improves skin inflammation and itching.
CN122005531APending Publication Date: 2026-05-12NANTONG UNIV
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Patent Information
- Application Number
- CN202610160325.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-02-04
- Publication Date
- 2026-05-12
AI Technical Summary
Technical Problem
Existing medications for treating atopic dermatitis have significant side effects, decreased efficacy with long-term use, and a high recurrence rate.
Method used
Using oleic acid as the active ingredient, pharmaceutical compositions, health products, or functional foods can be developed through oral or topical administration to target fatty acid metabolism in the treatment of itchy and inflammatory skin diseases, taking advantage of the anti-inflammatory and antipruritic properties of oleic acid.
Benefits of technology
Oleic acid significantly improves the appearance of skin inflammation and itching symptoms, has high safety and low cost, and achieves effective treatment and prevention of atopic dermatitis by regulating the IL-31 signaling pathway.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention provides application of oleic acid in a medicine for treating atopic dermatitis and relates to the technical field of biomedicine, oleic acid is common monounsaturated fatty acid, it is found for the first time through a non-targeted metabonomics technology that after peripheral sensory neurons are stimulated by an itching and inflammatory factor IL-31, the level of oleic acid (OA) in cells is remarkably increased (the VIP score gt; according to the present invention, the specific verification test results show that the oleic acid can significantly improve the symptoms of the pruritus model animal and regulate the related immune response under the specific concentration, and the new low-cost candidate scheme is provided for the treatment of the specific dermatitis;
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