Chinese yam oxygen lipid with aromatase inhibitory activity as well as application and analysis and identification method of Chinese yam oxygen lipid
By extracting the compound (Z)-9-ethoxy-6,10-dihydroxyoctadec-7-enoic acid from yam, a drug with aromatase inhibitory activity was prepared, solving the problems of selectivity and systemic effects of existing aromatase inhibitors, and realizing effective treatment of estrogen-dependent diseases and quality analysis of yam.
Patent Information
- Application Number
- CN202610451876.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-04-08
- Publication Date
- 2026-06-02
AI Technical Summary
Existing aromatase inhibitors have selective and systemic effects in treating estrogen-dependent diseases and regulating local estrogen levels, making it difficult to meet the needs of health management and cosmetic medicine. Furthermore, long-term use carries risks such as osteoporosis.
A novel compound, (Z)-9-ethoxy-6,10-dihydroxyoctadec-7-enoic acid, was extracted from yam and prepared into a drug with aromatase inhibitory activity. This drug was then applied to inhibit excessive estrogen production and treat estrogen-dependent breast cancer. The compound was identified using a combination of thin-layer chromatography, liquid chromatography, liquid chromatography-mass spectrometry, and nuclear magnetic resonance analysis.
This compound significantly inhibits aromatase activity, showing promising application prospects. It can effectively inhibit excessive estrogen production for the treatment of estrogen-dependent breast cancer and provides a rapid and efficient method for the quality analysis of yam.