Method for detecting enantiomer in (S)-(1-hydroxypropyl-2-yl) tert-butyl carbamate by high performance liquid chromatography

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By combining high-performance liquid chromatography with a chiral CHIRALPAK IG column and a specific mobile phase, the problems of low response and poor solubility in the detection of enantiomers of amino acid compounds have been solved, realizing simple and efficient enantiomer detection and meeting the requirements for accurate determination of trace impurities.

CN122259745APending Publication Date: 2026-06-23JIANGSU HAIYUEKANG PHARM TECH CO LTD

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Patent Information

Application Number: CN202610407743.3
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Filing Date: 2026-03-31
Publication Date: 2026-06-23

Application Information

Patent Timeline

31 Mar 2026

Application

CN202610407743.3

23 Jun 2026

Publication

CN122259745A

IPC: G01N30/02; G01N30/34; G01N30/60; G01N30/74; G01N30/86; G01N30/89; B01J20/29; G01N30/88

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Application Domain

Component separation Other chemical processes

Technology Topics

Solubility Enantiomer

Technical Efficacy Phrases

efficient separationMeet the test requirements

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AI Technical Summary

Technical Problem

In existing technologies, the detection of enantiomers of amino acid compounds suffers from low response, poor sample solubility, difficulty in accurately determining trace enantiomer impurities, and complex operation.

Method used

High-performance liquid chromatography (HPLC) was employed, using a CHIRALPAK IG chiral column and a specific mobile phase system of water-acetonitrile-tetrahydrofuran, combined with an ultraviolet detector, to simplify derivatization and achieve efficient separation and detection of enantiomers.

Benefits of technology

It enables simple, rapid separation and high-sensitivity detection of enantiomers, allowing for accurate control of the enantiomer content in products.

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Abstract

The invention discloses a method for detecting an enantiomer in (S)-(1-hydroxypropyl-2-yl) tert-butyl carbamate by using a high performance liquid chromatography. Specifically, a sample to be tested is dissolved in a diluent, a high performance liquid chromatograph is adopted for detection, a chromatographic column is CHIRALPAK IG, the inner diameter of the chromatographic column is 4.6 mm, the length of the chromatographic column is 250 mm, and the particle size of filler is 5 micrometers; a mobile phase is water-acetonitrile-tetrahydrofuran, and the volume ratio of the water-acetonitrile-tetrahydrofuran is 900: 75: 25; isocratic elution is adopted. The method disclosed by the invention is simple and rapid to operate, free of derivatization treatment, high in sensitivity, good in sample solubility, accurate in result and suitable for quality control of the (S)-(1-hydroxypropyl-2-yl) tert-butyl carbamate.

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