Ear acupoint pressure pills for treating seizures and methods of making and using the same

Abstract

This invention discloses an auricular acupressure pellet for treating epileptic seizures, as well as its preparation and usage methods. The auricular acupressure pellet is composed of the following ingredients in the indicated weight percentages: Gastrodia elata 25-35 parts, Fritillaria cirrhosa 25-35 parts, Pinellia ternata 25-35 parts, Poria cocos 25-35 parts, Poria cocos sclerotium 25-35 parts, Bambusa textilis 10-20 parts, Acorus tatarinowii 10-20 parts, Buthus martensii 3-9 parts, Bombyx mori 3-9 parts, Amber 10-20 parts, Uncaria rhynchophylla 10-20 parts, Citrus reticulata 5-12 parts, Polygala tenuifolia 10-15 parts, Salvia miltiorrhiza 25-35 parts, Ophiopogon japonicus 25-35 parts, Margarita 25-35 parts, and Dragon bone 25-35 parts. This invention solves the problems of limited efficacy and inconvenience in use of existing technologies, providing a highly efficient and safe new option for the treatment of epileptic seizures.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine, and in particular to an auricular acupressure pill for treating epileptic seizures, and its preparation and usage methods. Background Technology

[0002] Epilepsy is one of the most common serious brain disorders, affecting more than 70 million people worldwide. Its incidence shows a bimodal distribution, with infants and the elderly at the highest risk. It is the second leading cause of death from a neurological disorder after stroke. A generalized tonic-clonic seizure, also known as a grand mal seizure, is characterized by loss of consciousness and generalized convulsions. Seizures cause temporary neurological dysfunction in the brain, ranging from mild physical injury to long-term psychological burden and impacting the patient's mental and physical health. Currently used antiepileptic drugs, such as sodium valproate and phenytoin sodium, have problems including drug resistance, toxic side effects, emotional abnormalities, and cognitive impairment.

[0003] Traditional Chinese medicine (TCM) can reduce the frequency of seizures and mitigate the toxic side effects of antiepileptic drugs in the treatment of epilepsy, thus compensating for the shortcomings of these drugs. In recent years, TCM external therapies, due to their "holistic regulation" characteristics, have been included in the supplementary treatment guidelines of the International League Against Epilepsy (ILAE). Among these, auriculotherapy has become a research hotspot due to its vagus nerve-limbic system regulatory effects. Auriculotherapy, based on TCM meridian theory, involves applying medicinal pills (such as Wang Bu Liu Xing seeds) to specific acupoints on the ear, combined with regular pressure, to regulate bodily functions. It is commonly used to relieve pain, improve sleep, and regulate endocrine function; it is simple to perform and has few side effects.

[0004] The existing solution has the following shortcomings: 1. Vague acupoint location: Traditional ear acupoint charts are based on empirical location and lack support from traditional Chinese medicine theory.

[0005] 2. The therapeutic effect needs to be improved: the existing auricular acupressure pills have insufficient therapeutic effect on acupoint stimulation.

[0006] 3. Inconvenient for patients: For example, the auricular acupoint electrostimulation therapy disclosed in CN6A requires frequent trips to the hospital, increasing the economic burden and reducing compliance.

[0007] Currently, auricular acupressure seed therapy faces three main technical bottlenecks: First, due to the hardness of the seeds and the delicacy of the auricular skin, prolonged pressure can easily lead to epidermal damage and subsequently increase the risk of infection; second, the high intensity of mechanical stimulation of acupoints by the seeds produces significant pain responses, reducing patient compliance in some cases; and most importantly, this therapy relies solely on physical stimulation mechanisms, making it difficult for the active ingredients contained in the seeds to be absorbed transdermally to form an effective local drug concentration gradient, thus limiting the therapeutic effect.

[0008] Therefore, the existing auricular acupressure for treating epileptic seizures is still insufficient and needs further improvement. Summary of the Invention

[0009] The technical problem to be solved by the present invention is to provide an auricular acupressure pellet for treating epileptic seizures, as well as its preparation and usage method, which can improve the efficiency and comfort of treatment, solve the problems of limited efficacy and inconvenience of use of the prior art, and provide a new, efficient and safe option for the treatment of epileptic seizures.

[0010] The technical solution adopted by the present invention to solve the above-mentioned technical problems is to provide an auricular acupressure pill for treating epileptic seizures, which is composed of the following ingredients in the indicated weight percentages: Gastrodia elata 25-35 parts, Fritillaria cirrhosa 25-35 parts, Pinellia ternata 25-35 parts, Poria cocos 25-35 parts, Poria cocos sclerotium 25-35 parts, Bambusa textilis 10-20 parts, Acorus tatarinowii 10-20 parts, Buthus martensii 3-9 parts, Bombyx mori 3-9 parts, Amber 10-20 parts, Uncaria rhynchophylla 10-20 parts, Citrus reticulata 5-12 parts, Polygala tenuifolia 10-15 parts, Salvia miltiorrhiza 25-35 parts, Ophiopogon japonicus 25-35 parts, Margarita 25-35 parts, and Dragon bone 25-35 parts.

[0011] Preferably, it is composed of the following ingredients in the indicated weight percentages: 30 parts Gastrodia elata, 30 parts Fritillaria cirrhosa, 30 parts Pinellia ternata, 30 parts Poria cocos, 30 parts Poria cocos sclerotium, 15 parts Bambusa textilis, 15 parts Acorus tatarinowii, 6 parts Buthus martensii, 6 parts Bombyx mori, 15 parts Amber, 15 parts Uncaria rhynchophylla, 9 parts Citrus reticulata peel, 12 parts Polygala tenuifolia, 30 parts Salvia miltiorrhiza, 30 parts Ophiopogon japonicus, 30 parts Mother-of-Pearl, and 30 parts Dragon Bone.

[0012] To solve the above-mentioned technical problems, this invention also provides a method for preparing the above-mentioned auricular acupressure pellets, comprising the following steps: S1, selection and pretreatment of medicinal materials: carefully selecting authentic medicinal materials and cleaning, drying, and pulverizing them; S2, extraction of volatile components: supercritical extraction of Gastrodia elata, Fritillaria cirrhosa, and Pinellia ternata to extract volatile effective components; S3, water extraction and alcohol precipitation to obtain water-soluble components: water extraction and alcohol precipitation of Poria cocos, Poria cocos sclerotium, and Bambusa textilis to obtain water-soluble effective components; S4, mixing and forming pellets: uniformly mixing the obtained volatile components, water-soluble components, and remaining fine powder of medicinal materials to obtain a medicinal material extract, adding an appropriate amount of excipients for concentration and pelleting; S5, embedding and molding: embedding the prepared pellets into nano-silver conductive ear patches.

[0013] Preferably, step S2 uses supercritical CO2 extraction to extract Gastrodia elata, Fritillaria cirrhosa, and Pinellia ternata.

[0014] Preferably, step S3 further includes adding nano-silver material to the extracted water-soluble component, wherein the mass ratio of the extracted water-soluble component to the nano-silver material is 10:1 to 5:1.

[0015] Preferably, in step S4, the excipient is dextrin or mannitol, and the weight ratio of the herbal extract to the excipient is 1:0.2-0.5.

[0016] Preferably, in step S5, the thickness of the nano-silver coating is 50-200 nm, and the weight content of nano-silver in the conductive ear patch is 0.5%-2%.

[0017] To solve the above-mentioned technical problems, the present invention also provides a method for using the above-mentioned auricular acupressure pellet, wherein the auricular acupressure pellet is embedded in a nano-silver conductive ear patch, the nano-silver conductive ear patch is applied to the auricular acupoint, and the ear pellet is pressed and / or rubbed by hand once every half hour, 60 times each time, and changed every 4 days, with 8 days as one course of treatment.

[0018] Preferably, the method further includes dividing the auricle into twelve regions clockwise corresponding to the twelve earthly branches, using a probe to find pain points at the Zi, Chou, Yin, Mao, Wei, Shen, You, and Xu positions for application, and adding corresponding sites according to the time of onset.

[0019] Preferably, the eight basic acupoints are Zi, Chou, Yin, Mao, Wei, Shen, You, and Xu. The following corresponding acupoints are added according to the time of epileptic seizure: 23-1 corresponds to Zi; 1-3 corresponds to Chou; 3-5 corresponds to Yin; 5-7 corresponds to Mao; 7-9 corresponds to Chen; 9-11 corresponds to Si; 11-13 corresponds to Wu; 11-13 corresponds to Wei; 15-17 corresponds to Shen; 17-19 corresponds to You; 19-21 corresponds to Xu; and 21-23 corresponds to Hai.

[0020] Compared with existing technologies, this invention offers the following advantages: The auricular acupressure pellets and auricular acupressure pellets provided by this invention for treating epileptic seizures improve treatment efficiency and comfort, solving the problems of limited efficacy and inconvenience in use of existing technologies, and providing a highly efficient and safe new option for treating epileptic seizures. Furthermore, this invention integrates spatiotemporal dimensions: for the first time, the Heavenly Stems and Earthly Branches sequence is incorporated into auricular acupressure location, breaking through the limitations of traditional static spatial location of auricular acupressure. The use of nano-silver conductive materials improves stimulation efficiency and accuracy, and enhances drug penetration. Attached Figure Description

[0021] Figure 1 The effects of auricular acupuncture on the frequency, severity, and duration of seizures in mice with temporal lobe epilepsy; Figure 2 The effect of auricular acupuncture on the local field potential of the hippocampus in a mouse model of temporal lobe epilepsy. Detailed Implementation

[0022] The present invention will be further described in detail below through specific embodiments, but it should not be construed as limiting the scope of the present invention to the following embodiments.

[0023] This invention provides an auricular acupressure pill for treating epileptic seizures, composed of the following ingredients in the indicated weight percentages: Gastrodia elata 25-35 parts, Fritillaria cirrhosa 25-35 parts, Pinellia ternata 25-35 parts, Poria cocos 25-35 parts, Poria cocos sclerotium 25-35 parts, Bambusa textilis 10-20 parts, Acorus tatarinowii 10-20 parts, Buthus martensii 3-9 parts, Bombyx mori 3-9 parts, Amber 10-20 parts, Uncaria rhynchophylla 10-20 parts, Citrus reticulata 5-12 parts, Polygala tenuifolia 10-15 parts, Salvia miltiorrhiza 25-35 parts, Ophiopogon japonicus 25-35 parts, Margarita 25-35 parts, and Dragon bone 25-35 parts.

[0024] As a preferred embodiment, the proportions of each ingredient are as follows: Gastrodia elata 30g, Fritillaria cirrhosa 30g, Pinellia ternata 30g, Poria cocos 30g, Poria cocos sclerotium 30g, Bambusa textilis 15g, Acorus tatarinowii 15g, Buthus martensii 6g, Bombyx mori 6g, Amber 15g, Uncaria rhynchophylla 15g, Citrus reticulata 9g, Polygala tenuifolia 12g, Salvia miltiorrhiza 30g, Ophiopogon japonicus 30g, Margarita 30g, and Dragon bone 30g.

[0025] The auricular acupressure pellets provided by this invention are prepared as follows: S1. Selection and Pre-processing of Medicinal Materials We carefully select authentic medicinal herbs to ensure their quality.

[0026] The medicinal materials undergo pretreatment such as washing, drying, and pulverizing to prepare for subsequent extraction.

[0027] S2, supercritical CO2 extraction technology Supercritical CO2 extraction technology is used to extract the active ingredients from medicinal materials containing volatile components, such as Gastrodia elata, Fritillaria cirrhosa, and Pinellia ternata. This technology has the advantages of high extraction efficiency, no solvent residue, and no damage to the active ingredients of the medicinal materials.

[0028] S3, water extraction and alcohol precipitation combined with nanotechnology Water-soluble active ingredients were obtained by water extraction and alcohol precipitation of medicinal materials such as Poria cocos, Poria cocos sclerotium, and Bambusa textilis.

[0029] Nano-silver materials are added to the extracted water-soluble components. The mass ratio of the extracted water-soluble components to the nano-silver materials is 10:1 to 5:1, preferably 8:1. The best synergistic effect has been verified by examples. The nano-silver materials serve as drug carriers, improving the permeability and bioavailability of drugs.

[0030] S4. Concentration and Pelletizing The extracted volatile components, water-soluble components, and remaining fine powder of medicinal materials are mixed evenly, and an appropriate amount of excipients, such as dextrin and mannitol, are added. The mixture is then concentrated and made into pills. During the pill-making process, care is taken to control the hardness and size of the pills to ensure comfort and stimulation effect when applied.

[0031] S5, Preparation of Nano-Silver Conductive Earplugs The prepared pills are embedded in specially designed nano-silver conductive ear patches. These nano-silver conductive ear patches, acting as a conductive medium, possess excellent conductivity and biocompatibility, enhancing the efficiency and accuracy of auricular acupoint stimulation. In this step, the nano-silver coating thickness is 50-200 nm (preferably 100 nm), and the nano-silver weight content in the conductive ear patch is 0.5%-2%; the lower limit of 0.5% ensures conductivity (resistance ≤100Ω), while the upper limit of 2% avoids excessive release of silver ions.

[0032] S6. Quality Inspection and Packaging The prepared nano-silver conductive ear patches underwent quality testing, including appearance, content determination, and irritation testing. Qualified products were packaged and labeled with usage instructions, precautions, and other information.

[0033] The auricular acupressure pellets prepared by this invention can form a dual therapeutic mechanism of "nano-drug delivery - conductive stimulation": 1) Material continuity: The nano-silver material combined in step S4 and the nano-silver conductive layer of the ear patch in step S5 form a synergistic system, which not only ensures transdermal drug release but also enhances the effect of auricular acupoint electrical stimulation.

[0034] 2) Complementary functions: Step S4 nano-silver promotes the stability of drug components and transdermal absorption; S5 nano-silver ear patch provides precise acupoint electrical stimulation and antibacterial effect.

[0035] Furthermore, this invention employs a stem-branch auricular acupoint spatiotemporal mapping model, analyzed dialectically as follows: The Heavenly Stems and Earthly Branches Correspondence Rule for the Auricle: Based on the *Huangdi Neijing* and *Shanghan Zabing Lun*, the auricle is divided clockwise into twelve regions: Zi, Chou, Yin, Mao, Chen, Si, Wu, Wei, Shen, You, Xu, and Hai. The twelve Earthly Branches correspond to the twelve meridians: Gallbladder, Liver, Lung, Large Intestine, Stomach, Spleen, Heart, Small Intestine, Bladder, Kidney, Triple Energizer, and Pericardium.

[0036] The loss of consciousness and limb convulsions that occur during a grand mal seizure are mainly caused by phlegm obstructing the heart orifices and internal liver wind. Treatment can begin with the Taiyin, Shaoyin, and Jueyin meridians. The Taiyin meridian's acupoints for resolution are Hai, Zi, and Chou; the Shaoyin meridian's are Zi, Chou, and Yin; and the Jueyin meridian's are Chou, Yin, and Mao. The liver governs the tendons, and limb convulsions are closely related to the liver meridian. Since Chou and Wei are in opposition, Wei should be added. Shen, You, and Xu are located in the west, which governs descent and helps the pathogenic qi sink and be expelled from the body. Grand mal seizures are caused by phlegm obstructing the heart orifices, and the pericardium takes the place of the heart in receiving the pathogenic qi; therefore, Xu should be added. In addition, the corresponding meridian should be selected based on the patient's onset time. 23:00-1:00 corresponds to the Zi position; 1:00-3:00 corresponds to the Chou position; 3:00-5:00 corresponds to the Yin position; 5:00-7:00 corresponds to the Mao position; 7:00-9:00 corresponds to the Chen position; 9:00-11:00 corresponds to the Si position; 11:00-13:00 corresponds to the Wu position; 11:00-13:00 corresponds to the Wei position; 15:00-17:00 corresponds to the Shen position; 17:00-19:00 corresponds to the You position; 19:00-21:00 corresponds to the Xu position; 21:00-23:00 corresponds to the Hai position.

[0037] Ear acupressure bean application method: Use a probe to find the pain points at the Zi, Chou, Yin, Mao, Wei, Shen, You, and Xu positions. At the same time, add the corresponding positions according to the time of the epileptic seizure. Then apply Wang Bu Liu Xing seeds. After application, instruct the patient to press and rub the ear seeds with their hands at the corresponding points according to the time of the onset. Do this once every half hour, 60 times each time. Change the seeds every 4 days. 8 days is a course of treatment.

[0038] Example 1: Grand mal seizure at 11:00-13:00 Ear acupoint selection: Prioritize Hai, Zi, Chou, Yin, Mao, Wei, Shen, You, Xu, and Wu acupoints; Stimulation plan: Locate the pain point every day at noon (11:00-13:00) and apply Wang Bu Liu Xing seeds. After application, instruct the patient to press and rub the ear seeds 60 times with their hands. Press and rub 60 times every half hour between 11:00 and 13:00. Change the seeds every 4 days. 8 days is one course of treatment.

[0039] Example 2: Grand mal seizure at 9-11 am Stimulation plan: Locate the pain point at 9-11 am every day, and then apply Wang Bu Liu Xing seeds. After application, instruct the patient to press and rub the ear seeds 60 times. Between 11 am and 1 pm, press and rub 60 times every half hour. Change the seeds every 4 days, and 8 days is one course of treatment.

[0040] The beneficial effects of this invention are as follows: Acupoint selection criteria: Compared with fixed empirical acupoints, this invention uses a dynamic stem-branch model plus the onset time, which is more accurate.

[0041] Stimulation parameter adjustment: Sequential pre-stimulation is performed in conjunction with the epileptic seizure cycle to improve treatment efficacy.

[0042] Practicality and Innovation: The preparation formula of the nano-silver conductive ear patch has significant innovation and practicality.

[0043] The key points of operation and implementation of this invention are as follows: 1) Basic application points: All patients need to have the patches applied to the 8 basic points of Zi, Chou, Yin, Mao, Wei, Shen, You, and Xu (corresponding to key meridians such as the Liver Meridian and Pericardium Meridian); 2) Time-based overlapping positions: Add corresponding positions according to the time of onset (e.g., if the onset is between 11:00 and 13:00, add the noon position); 3) Dynamic adjustment: Examples 1-2 show that stimulation needs to be strengthened during the onset period (e.g., for patients who fall ill at noon, press 60 times every half hour from 11:00 to 13:00). In Example 1, the additional stimulation of the noon point for patients who fall ill between 11:00 and 13:00 significantly increased the effectiveness rate to 88% (compared to 70% in the control group), confirming the clinical advantages of the spatiotemporal correspondence method.

[0044] For Example 1, the sample size was 100 individuals, aged 18-80 years, with a male-to-female ratio of 1:1. Approximately 70% of the sample had a history of epilepsy for 2 years or more. As sample criteria, the age range was 18-80 years. A retrospective analysis was conducted with a control group of 50 individuals and an experimental group of 50 individuals. The control group received sodium valproate three times daily, one tablet each time, for 3 months; the experimental group received the same treatment plus auricular acupuncture. According to the relevant standards established by the International League Against Epilepsy, the efficacy was assessed 3 months after treatment. Seizure-free episodes were considered clinically controlled; a reduction in seizure frequency ≥75% was considered significant; a reduction in seizure frequency <75% but ≥50% was considered effective; and a reduction in seizure frequency <50% or even an increase was considered ineffective. Efficacy evaluation: The efficacy rate of auricular acupuncture in the experimental group of Example 1 was 88%, while the efficacy rate in the control group was 70%. Clinical observation showed that the efficacy rates were nearly consistent across different age groups with epilepsy.

[0045] Typical cases of auricular acupoint application using Example 1: (1) Xu**, male, 25 years old, reported a history of epilepsy for more than 1 year. He had taken sodium valproate for treatment, but still had occasional seizures. After combining auricular acupoint application treatment, he no longer had epileptic seizures.

[0046] (2) Sun**, female, 42 years old, reported a history of epilepsy for more than 10 years, accompanied by nausea. After taking sodium valproate, she occasionally had epileptic seizures accompanied by nausea and discomfort. The day after applying auricular acupoints, she no longer had nausea and no more major epileptic seizures.

[0047] (3) Zhou**, male, 43 years old, reported a history of epilepsy for more than half a year. After taking sodium valproate, he experienced limb tremors and epileptic seizures from time to time. After applying acupoint patches, he no longer experienced limb tremors and became more energetic. He also did not experience epileptic seizures.

[0048] (4) Zhu**, female, 52 years old, reported a history of epilepsy for more than 2 years. After taking sodium valproate, she still had occasional major epileptic seizures. Since she started using auricular acupoint application, she has never had limb twitching again.

[0049] (5) Zhou**, male, 34 years old, reported a history of epilepsy for more than 3 years. After taking sodium valproate, he still had occasional major epileptic seizures. Since he started using auricular acupoint application, he has never had limb convulsions again. At the same time, his mental state and gastrointestinal condition have improved a lot.

[0050] The effects of auricular acupuncture therapy of the present invention on the frequency, severity, and duration of seizures in mice with temporal lobe epilepsy are as follows: A temporal lobe epilepsy model was established by intraperitoneal injection of kainic acid (KA). Spontaneous and status epilepticus were observed in mice 28 days later. The results are shown in the figure. Mice treated with auricular acupuncture (KA + auricular acupuncture) or administered the positive drug VPA (KA + VPA) had significantly fewer total seizures, fewer seizure grades, and shorter duration of spontaneous epilepsy compared to the epilepsy group (KA + Saline). Figure 1 (a), Table 1). Compared with the epilepsy group, the number of grade 4 and 5 seizures in the auricular acupuncture group and VPA group was also significantly reduced, and the proportion of total seizures was significantly lower in the auricular acupuncture group than in the epilepsy group ( Figure 1 (a and b) indicates that auricular acupuncture tends to suppress the severity of grand mal seizures. Therefore, it can be concluded that auricular acupuncture has the effect of intervening in the occurrence of epilepsy.

[0051] Figure 1 (a) Duration of grade 4 and 5 epileptic seizures; (b) Percentage of seizures in this instance (n=6, *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001)

[0052] Table 1. Effects of auricular acupuncture on the number, grade, and duration of seizures in mice with temporal lobe epilepsy ( ± s, n=5) (Comparison of auricular therapy group, VPA group and model group:) *P <0.05, **P <0.01, ****P <0.0001).

[0053] The auricular acupuncture treatment of this invention has the following regulatory effect on the local field potential in the hippocampus of epileptic mice: To determine the extent to which auricular therapy could alleviate temporal lobe epilepsy seizures and its effect on the power spectral density (PSD) of the hippocampal CA3 region after KA-induced epilepsy, the field potential signals of the control group, model group (KA+Saline), auricular therapy group, and VPA group after KA-induced epilepsy were compared. Changes in field potential after KA induction were represented by power spectral density values ​​and heatmaps generated using OmniPlex software. The results showed that, compared with the model group, auricular therapy could rapidly inhibit the field potential activity in KA-induced epileptic mice. Figure 2 Statistical analysis showed that the rhythmic energy of the five types of brain waves treated with auricular acupuncture was significantly lower than that of the saline group (Table 2). These results indicate that the KA-induced epilepsy model mice exhibited high-frequency, high-amplitude multi-spiky brain waves, with increased rhythmic energy intensity across all frequency bands, particularly significantly affecting low-frequency rhythms. Auricular acupuncture can significantly improve abnormal brain waves in epileptic mice and may have a certain protective effect against brain damage caused by epilepsy.

[0054] Figure 2 (a) Heat map of the effect of auricular acupuncture on the electroencephalogram (EEG) of epilepsy-induced mice; (b) Wave map of the effect of auricular acupuncture on the EEG of epilepsy-induced mice (n=5)

[0055] Table 2. Intervention of auricular acupuncture on five types of electroencephalograms in KA epilepsy model mice ( ± s, n=5) (Ratio of model group to blank group:) **P <0.01, ***P <0.001, ****P <0.0001; Ratio of auricular acupuncture treatment group, VPA group to model group: # P <0.05, ## P <0.01, ### P <0.001, #### P <0.0001).

[0056] Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications and improvements without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention shall be defined by the claims.

Claims

1. An auricular acupressure pellet for treating epileptic seizures, characterized in that, It is composed of the following ingredients in the indicated weight percentages: Gastrodia elata 25-35 parts, Fritillaria cirrhosa 25-35 parts, Pinellia ternata 25-35 parts, Poria cocos 25-35 parts, Poria cocos sclerotium 25-35 parts, Bambusa textilis 10-20 parts, Acorus tatarinowii 10-20 parts, Buthus martensii 3-9 parts, Bombyx mori 3-9 parts, Amber 10-20 parts, Uncaria rhynchophylla 10-20 parts, Citrus reticulata 5-12 parts, Polygala tenuifolia 10-15 parts, Salvia miltiorrhiza 25-35 parts, Ophiopogon japonicus 25-35 parts, Margarita 25-35 parts, and Dragon bone 25-35 parts.

2. The auricular acupressure pellet as described in claim 1, characterized in that, It is composed of the following ingredients in the indicated weight percentages: Gastrodia elata 30 parts, Fritillaria cirrhosa 30 parts, Pinellia ternata 30 parts, Poria cocos 30 parts, Poria cocos sclerotium 30 parts, Bambusa textilis 15 parts, Acorus tatarinowii 15 parts, Buthus martensii 6 parts, Bombyx mori 6 parts, Amber 15 parts, Uncaria rhynchophylla 15 parts, Citrus reticulata 9 parts, Polygala tenuifolia 12 parts, Salvia miltiorrhiza 30 parts, Ophiopogon japonicus 30 parts, Margarita 30 parts, and Dragon bone 30 parts.

3. A method for preparing auricular acupressure pellets as described in claim 1, characterized in that, Includes the following steps: S1. Selection and pretreatment of medicinal materials: Select authentic medicinal materials and clean, dry and crush them. S2. Extraction of volatile components: Supercritical extraction was performed on Gastrodia elata, Fritillaria cirrhosa, and Pinellia ternata to extract volatile active components; S3. Water-soluble components were obtained by water extraction and alcohol precipitation: Poria cocos, Poria cocos sclerotium and Bambusa textilis were extracted by water extraction and alcohol precipitation to obtain water-soluble active components; S4. Mixing and forming into pills: Mix the obtained volatile components, water-soluble components and remaining fine powder of medicinal materials evenly to obtain medicinal material extract, add an appropriate amount of excipients and concentrate to form pills. S5. Embedding and molding: Embed the prepared pills into nano-silver conductive ear patches.

4. The method for preparing auricular acupressure pellets according to claim 3, characterized in that, In step S2, supercritical CO2 extraction is used to extract Gastrodia elata, Fritillaria cirrhosa, and Pinellia ternata.

5. The method for preparing auricular acupressure pellets according to claim 3, characterized in that, Step S3 further includes adding nano-silver material to the extracted water-soluble component, wherein the mass ratio of the extracted water-soluble component to the nano-silver material is 10:1 to 5:

1.

6. The method for preparing auricular acupressure pellets according to claim 3, characterized in that, In step S4, the excipient is dextrin or mannitol, and the weight ratio of the herbal extract to the excipient is 1:0.2-0.

5.

7. The method for preparing auricular acupressure pellets according to claim 3, characterized in that, In step S5, the thickness of the nano-silver coating is 50-200 nm, and the weight content of nano-silver in the conductive ear patch is 0.5%-2%.

8. A method of using auricular acupressure balls as described in claim 1, characterized in that, Embed the auricular acupressure pellets into nano-silver conductive ear patches, apply the nano-silver conductive ear patches to the auricular acupoints, and press and / or rub the ear pellets with your hands every half hour, 60 times each time, change the patches every 4 days, and 8 days is one course of treatment.

9. The method of using auricular acupressure balls as described in claim 8, characterized in that, It also includes dividing the auricle clockwise into twelve regions corresponding to the twelve earthly branches, using probes to find pain points at the Zi, Chou, Yin, Mao, Wei, Shen, You, and Xu positions for application, and adding corresponding sites according to the time of onset.

10. The method of using auricular acupressure balls as described in claim 9, characterized in that, The eight basic acupoints for application are Zi, Chou, Yin, Mao, Wei, Shen, You, and Xu. Additional acupoints are added according to the time of epileptic seizure: 23-1 corresponds to Zi; 1-3 corresponds to Chou; 3-5 corresponds to Yin; 5-7 corresponds to Mao; 7-9 corresponds to Chen; 9-11 corresponds to Si; 11-13 corresponds to Wu; 11-13 corresponds to Wei; 15-17 corresponds to Shen; 17-19 corresponds to You; 19-21 corresponds to Xu; and 21-23 corresponds to Hai.

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