A method for preparing an anti-tumor composition for pets

By using a core-shell structured multilayer nanoparticle design, the problems of poor water solubility and easy oxidative degradation of polyphenolic components in antitumor compositions for pets were solved. Stable co-encapsulation and simultaneous delivery of multiple components were achieved, improving bioavailability and drug administration compliance, and enhancing antitumor efficacy.

CN122376657APending Publication Date: 2026-07-14
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Patent Information

Application Number
CN202610854849.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Filing Date
2026-06-13
Publication Date
2026-07-14

AI Technical Summary

Technical Problem

In the existing technology, antitumor compositions for pets have problems such as poor water solubility of polyphenols, easy oxidation and degradation, difficulty in simultaneous delivery, and poor drug administration compliance, and have failed to form a systematic solution with high bioavailability, good stability, and convenient drug administration.

Method used

Employing a core-shell multilayer nanoparticle design, the core encapsulates curcumin and resveratrol, the middle shell adsorbs quercetin and green tea polyphenols, and the outer layer is coated with astragalus polysaccharide. Stable nanoparticles are formed through high-pressure homogenization and freeze-drying processes, achieving stable co-encapsulation and simultaneous delivery of multiple components.

Benefits of technology

It improves the oral absorption of polyphenolic components, increases the blood concentration of antitumor active ingredients, enhances stability and synergistic antitumor effects, improves drug administration compliance and immunomodulatory function, and has a stepwise release characteristic.

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Abstract

This application belongs to the field of biomedicine, specifically relating to a method for preparing an antitumor composition for pets, aiming to solve the technical problems of low bioavailability, poor stability, and poor drug administration compliance of poorly soluble active ingredients in antitumor drugs for pets. The method includes: a raw material pretreatment step, in which curcumin, resveratrol, quercetin, green tea polyphenols, and astragalus polysaccharides are pulverized and sieved separately; an organic phase preparation step, in which egg yolk lecithin and solid lipids are dissolved in an ethanol-acetone mixed solvent, and curcumin and resveratrol are added and dissolved by stirring in a water bath; an aqueous phase preparation step, in which poloxamer F68 is dissolved in purified water and dissolved in a water bath; a high-pressure homogenization step, in which a nanoemulsion containing a solid lipid core is prepared; a moderately polar component encapsulation step, in which quercetin and green tea polyphenols are ultrasonically dispersed and then added dropwise to the nanoemulsion; a freeze-drying step, in which a nano-lyophilized powder is obtained; and an outer hydrophilic component coating step, in which astragalus polysaccharides are sprayed or adsorbed onto the surface of the freeze-dried powder. The composition obtained by this method is a core-shell multilayer nanoparticle with a core consisting of curcumin and resveratrol encapsulated by solid lipids, a middle shell adsorbing quercetin and green tea polyphenols, and an outer shell coated with astragalus polysaccharides. This application utilizes the above-mentioned layered encapsulation technology to achieve stable co-encapsulation of multiple antitumor active ingredients, improve the bioavailability of poorly soluble components, optimize drug stability, and enhance antitumor effects through multi-target synergistic effects. Simultaneously, it endows the composition with immunomodulatory functions and sustained-release properties. The composition can be formulated into a nano-lyophilized powder form, making it easy to add to pet food or formulate into a paste for administration, improving pet drug compliance. Figure 2 is a schematic diagram of the three-layer core-shell nanoparticle structure of the composition of this invention.
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