A tripterine self-assembled nanoparticle, a preparation method thereof, a tripterine-loaded nanoparticle hydrogel, a preparation method and application thereof
By preparing triptolide nanoparticles through carrier-free self-assembly and combining them with inulin to form a hydrogel, the problems of poor water solubility and intestinal targeting of triptolide were solved, achieving intestinal targeted delivery and significantly improving the treatment effect of metabolic-related fatty liver disease.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHEJIANG PHARMA COLLEGE
- Filing Date
- 2026-04-20
- Publication Date
- 2026-07-17
AI Technical Summary
Existing triptolide has poor water solubility, unclear in vivo target, and high risk of side effects, making it difficult to effectively treat metabolic-related fatty liver disease. Furthermore, the combination of inulin hydrogel and triptolide makes it difficult to achieve intestinal targeted delivery.
Tripterygium wilfordii nanoparticles were prepared using a carrier-free self-assembly method and combined with inulin to form a hydrogel. An intestinal targeted delivery system was constructed through thermally induced phase transition and hydrogen bonding to improve solubility and intestinal targeting.
It significantly improves the solubility and intestinal targeting of triptolide, reduces systemic exposure, decreases side effects, improves hepatic steatosis, inflammation and fibrosis, regulates the intestinal FXR-GLP-1 signaling pathway, and provides a long-acting drug delivery system for the treatment of MAFLD.
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Figure CN122398732A_ABST