Application of clopidogrel in preparation of medicine for preventing radiation-induced hematopoietic system injury
By using clopidogrel to prevent radiation-induced hematopoietic system damage and inhibit the ferroptosis pathway, the problem of radiation-induced hematopoietic system damage was solved, achieving the protection of hematopoietic stem and progenitor cells and the restoration of blood cell counts.
CN122398792APending Publication Date: 2026-07-17THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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Patent Information
- Application Number
- CN202610599520.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-04-30
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Current technology lacks effective drugs to prevent radiation-induced hematopoietic system damage, especially drugs that inhibit ferroptosis, which increases the risk of hematologic diseases such as leukemia.
Method used
Clopidogrel was used as the drug to inhibit ferroptosis induced by ferroptosis inducers such as RSL3 or IKE by administering the drug 24 hours in advance, and to prevent radiation-induced hematopoietic system damage by utilizing the CHMP5 pathway.
Benefits of technology
It significantly reduces radiation-induced damage to mouse stem and progenitor cells, salvages cell survival, restores the number of blood cells, and reduces the risk of hematopoietic system damage after radiation.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to an application of clopidogrel in prevention and treatment of radiation-induced hematopoietic system injury, the radiation injury of a mouse hematopoietic system can be prevented by 24-hour administration in advance, the injury of mouse stem progenitor cells caused by radiation can be prevented under the radiation dose of 2Gy-6Gy, and meanwhile, the blood routine of the mouse is saved. In-vitro cell experiments show that the drug effect is realized by inhibiting ferroptosis induced by a ferroptosis inducer (such as RSL3), and the clopidogrel can partially recover cell lipid peroxidation and intracellular Fe < 2 + > content increase caused by ferroptosis. The clopidogrel disclosed by the invention has an obvious effect of inhibiting cell ferroptosis and is beneficial to preventing hematopoietic system injury caused by radiation.
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