A uterine cavity sustained-release drug delivery device for assisted reproduction

Abstract

This invention discloses a uterine cavity sustained-release drug delivery device for assisted reproductive technology, belonging to the field of medical device technology. It includes a drug reservoir tube with a push rod slidably passing through its top. A piston plate is attached to the bottom of the push rod and slidably disposed within the drug reservoir tube. It also includes a leak-proof mechanism disposed on the outside of the drug reservoir tube, used to seal any gaps and completely enclose the drug within the uterine cavity; and a drug delivery mechanism disposed inside the drug reservoir tube, which improves drug coverage by adding a drug dispensing channel. This uterine cavity sustained-release drug delivery device for assisted reproductive technology can seal the gap between the device and the internal cervical os after drug administration, ensuring complete drug encapsulation within the uterine cavity. The retention time can be extended to over 30 minutes, and the addition of a drug dispensing channel achieves a drug coverage rate of over 92%, thereby improving the therapeutic effect.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a uterine intrauterine sustained-release drug delivery device for assisted reproduction. Background Technology

[0002] Intrauterine sustained-release drug delivery devices are intelligent intrauterine devices or stents designed to improve the success rate of assisted reproduction by achieving "stable, continuous, and precise" drug release within the uterine cavity. They combine assisted reproductive technology with novel drug delivery methods, offering advantages over traditional oral or injectable administration such as precise targeting, stable and long-lasting effects, and reduced side effects. Currently, some delivery devices employ a disposable structure, removing the device immediately after a single intrauterine drug infusion, leaving it outside the body. For example, the device for preventing intrauterine adhesions and administering drugs via intrauterine delivery, with announcement number CN221601022U, includes a sleeve with a push rod connected internally. One end of the push rod is connected to a push block, and the other end of the push rod has a retention mechanism. An anti-adhesion drug delivery mechanism is located on one side of the retention mechanism. This device for preventing intrauterine adhesions and administering medication intrauterinely involves first inserting the device into the patient's body. Then, a pusher is pushed by a push block, which activates the retention mechanism and the anti-adhesion medication delivery mechanism to enter the patient's body. The sleeve is then pulled outwards to detach the pusher from the retention block. Air is then injected into the second sac through the second through-hole and the second injection tube, which expands the second sac to fully dilate the uterine cavity. The plug is then inserted into the second through-hole, and medication is injected through the first through-hole, which then passes through the first injection tube to the inside of the first sac. Finally, the medication is delivered to the patient's uterine cavity through the medication delivery port. This solves the problems of insufficient uterine cavity dilation and inconvenient intrauterine medication delivery. For example, a novel intrauterine drug delivery device, with announcement number CN213077181U, belongs to the field of medical device technology. It includes an outer tube, a connecting block, and a drug delivery tubing. The upper end of the connecting block is fixedly connected to the lower end of the outer tube through a blind hole. A groove is formed at the lower end of the connecting block, and the side of the groove furthest from the groove communicates with the side of the blind hole. A rubber cap is fixedly connected inside the groove, and a cross-shaped slit is formed on the upper side of the rubber cap. A silicone head is fixedly connected to the upper end of the drug delivery tubing, and multiple drug outlet holes are formed through the side wall of the silicone head. An annular block is fixedly connected to the inner edge of the lower end of the outer tube, and the inner side of the annular block is fixedly connected to the wall of the drug delivery tubing. This device allows medical personnel to quickly and evenly deliver medication into the patient's uterine cavity, and the medication is less likely to leak out of the uterine cavity during administration. It also ensures that all the medication in the device is delivered into the uterine cavity, allowing the medication to effectively act on the lesion site. However, the above-mentioned intrauterine drug delivery device still has the following drawbacks in actual use: 1. With traditional conventional drug delivery devices, after the medication is pushed in, the medication leaks out through the gap between the catheter and the internal cervical os, with less than 50% of the medication actually remaining in the uterine cavity; 2. Furthermore, traditional drug delivery devices only have a single orifice, which can only spray the drug at a certain point in the uterine cavity. The drug mainly deposits in the center of the fundus, and it is difficult to cover the two uterine corners and the anterior and posterior walls.

[0003] To address the aforementioned issues, innovative designs are urgently needed based on existing drug delivery devices. Summary of the Invention

[0004] The purpose of this invention is to provide a uterine cavity sustained-release drug delivery device for assisted reproduction, in order to solve the problems mentioned in the background art, such as leakage of drug solution after drug delivery, and the fact that most conventional drug delivery devices can only spray at a certain point in the uterine cavity, resulting in limited coverage.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a uterine cavity sustained-release drug delivery device for assisted reproduction, comprising a drug storage tube, wherein a push rod is slidably passed through the top of the drug storage tube, and a piston plate is attached to the bottom of the push rod, and the piston plate is slidably disposed inside the drug storage tube; It also includes: a leak-proof mechanism, which is located on the outside of the drug storage tube. The leak-proof mechanism is used to seal the cavity so that the drug is completely sealed in the uterine cavity. The drug delivery mechanism is located inside the drug storage tube, and the drug delivery mechanism increases the drug coverage by increasing the amount of drug dispensed.

[0006] Preferably, the leak-proof mechanism includes a fixing plate fixed to the upper end of the push rod, and a connecting block is fixed to the lower end face of the fixing plate, and the connecting block and the limiting hole are engaged.

[0007] Preferably, the limiting hole is opened at the top of the medicine storage tube, and a corrugated pipe is fixed between the lower end face of the fixing plate and the top of the medicine storage tube, and the corrugated pipe is interconnected with the air bag through the air supply channel.

[0008] Preferably, the gas delivery channel is located on the side wall of the drug storage tube, and the airbag is fixedly installed on the outer wall of the lower end of the drug storage tube.

[0009] Preferably, the drug delivery mechanism includes a connector threaded at the bottom of the drug storage tube, and the connector has a frustum-shaped structure, with a drug dispensing channel reserved at the center of the connector.

[0010] Preferably, the bottom of the connector is provided with a fixing groove, and a movable block is provided inside the fixing groove. The upper end face of the movable block is connected to the inner top face of the fixing groove by an elastic rope. When the movable block is not in use, it is in the fixing groove.

[0011] Preferably, the movable block has a through first spray nozzle inside, and the first spray nozzle is interconnected with the inside of the drug storage tube through the drug outlet channel. A second spray nozzle is reserved on the side of the movable block. The arrangement of the first and second spray nozzles allows the drug to be sprayed out from different angles.

[0012] Preferably, the second spray nozzle is connected to the first spray nozzle, and the second spray nozzle is distributed at equal angles. The inner diameter of the upper end of the first spray nozzle is equal to the inner diameter of the discharge channel, and the inner diameter of the lower end of the first spray nozzle is smaller than the inner diameter of its upper end.

[0013] Preferably, a fixing tube is fixed to the lower end face of the piston plate, and the bottom of the fixing tube is sealed. Fixing holes are reserved on the upper and lower sides of the fixing tube, so that the fixing tube can block the first spray nozzle after it is lowered.

[0014] Preferably, the outer diameter of the fixed tube is the same as the inner diameter of the drug outlet channel, and after the fixed tube descends, it comes into contact with the upper end face of the movable block, so that the fixed tube can pass through the drug outlet channel and be inserted into the upper end of the first spray nozzle.

[0015] Compared with the prior art, the beneficial effects of the present invention are: the intrauterine sustained-release drug delivery device for assisted reproduction can seal the gap between the device and the internal cervical os after drug administration, so that the drug is completely sealed in the uterine cavity, and the retention time can be extended to more than 30 minutes. Furthermore, by adding a drug delivery channel, the drug coverage rate can reach more than 92%, thereby improving the treatment effect. The specific details are as follows: 1. As the push rod moves, it also moves the fixing plate and squeezes the bellows. This allows the gas inside the bellows to be transmitted to the airbag through the gas delivery channel. At this time, the inflated airbag blocks the uterine cavity opening to prevent the discharged drug from leaking out. 2. The connecting block on the fixed plate after the drug is pushed can engage with the limiting hole, which ensures the stability of the piston plate position after movement and prevents the drug from being sucked out. After a period of time, when the drug is absorbed, the push rod can be pulled to release the pressure on the bellows. In this way, the airbag returns to its flat state, and the piston plate does not move with the push rod and remains in the position close to the connector, which can smoothly pull out the drug storage tube. 3. When the piston plate descends to a certain position, it can pass through the drug outlet channel and insert into the upper end of the movable block, contacting the inside of the first spray nozzle. On the one hand, it blocks the first spray nozzle, and on the other hand, through the continued squeezing of the piston plate, the drug is transmitted through the upper fixed hole to the fixed tube, and then discharged from the lower fixed hole through the second spray nozzle. The drug distribution range can be improved by the equally angled distribution of the second spray nozzle. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is a schematic cross-sectional view of the overall structure of the present invention; Figure 3 This is a schematic cross-sectional view of the bellows structure of the present invention; Figure 4 This is a schematic diagram of the gas delivery channel structure of the present invention; Figure 5 This is a schematic diagram of the cross-sectional structure of the airbag of the present invention; Figure 6 This is a schematic cross-sectional view of the connector structure of the present invention; Figure 7 This is a schematic diagram of the active block structure of the present invention; Figure 8 This is a schematic diagram of the structure after the fixed tube of the present invention has been lowered; Figure 9 This is a schematic cross-sectional view of the fixed tube structure of the present invention.

[0017] In the diagram: 1. Drug storage tube; 2. Drug pusher rod; 3. Piston plate; 31. Fixing tube; 32. Fixing hole; 4. Fixing plate; 5. Connecting block; 6. Limiting hole; 7. Corrugated pipe; 8. Air delivery channel; 9. Airbag; 10. Connector; 11. Drug delivery channel; 12. Fixing groove; 13. Movable block; 14. Elastic rope; 15. First spray nozzle; 16. Second spray nozzle. Detailed Implementation

[0018] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0019] Please see Figures 1-9 The present invention provides the following technical solution: Example 1: To address the problems existing in the prior art, this example provides the following technical solution: a uterine cavity sustained-release drug delivery device for assisted reproduction, comprising a drug storage tube 1, a push rod 2 slidably passing through the top of the drug storage tube 1, and a piston plate 3 attached to the bottom of the push rod 2, and the piston plate 3 slidably disposed within the drug storage tube 1; further comprising: a leak-proof mechanism disposed on the outside of the drug storage tube 1, used to seal the cavity and completely enclose the drug within the uterine cavity; and a drug delivery mechanism disposed inside the drug storage tube 1, which increases the drug coverage by increasing the amount of drug dispensed.

[0020] With existing conventional drug delivery devices, after administration, the medication leaks out through the gap between the catheter and the internal cervical os, with less than 50% of the medication actually remaining in the uterine cavity. Figures 1-5As shown, the leak-proof mechanism includes a fixing plate 4 fixed to the upper end of the push rod 2, and a connecting block 5 fixed to the lower end face of the fixing plate 4, and the connecting block 5 and the limiting hole 6 are engaged; the limiting hole 6 is opened at the top of the drug storage tube 1, and a corrugated pipe 7 is fixed between the lower end face of the fixing plate 4 and the top of the drug storage tube 1, and the corrugated pipe 7 is interconnected with the air supply channel 8 and the air bag 9; the air supply channel 8 is set on the side wall of the drug storage tube 1, and the air bag 9 is fixedly set on the outer wall of the lower end of the drug storage tube 1; firstly, the connector 10 is removed from the drug storage tube 1, the required medication is infused into the drug storage tube 1, then the connector 10 is installed on the drug storage tube 1, and then the drug storage tube 1 is inserted into the patient's body. When the designated position is reached, the push rod 2 is pushed to drive the piston plate 3 to move inside the drug storage tube 1, which can release the medication inside. The medication is discharged through the dispensing channel 11 and the first spray nozzle 15 into the uterine cavity. As the push rod 2 moves, it drives the fixing plate 4 to move and compresses the bellows 7. This allows the gas inside the bellows 7 to be transmitted to the airbag 9 through the gas delivery channel 8, causing the airbag 9 to inflate. At this time, the inflated airbag 9 seals the uterine cavity opening to prevent the discharged medication from leaking out. After the medication is pushed out, the connecting block 5 on the fixing plate 4 can engage with the limiting hole 6, which ensures the stability of the piston plate 3 after movement and prevents the medication from being sucked out. After a period of time, once the medication is absorbed, pulling the push rod 2 releases the compression on the bellows 7, allowing the airbag 9 to return to its flat state. The piston plate 3 remains in the position close to the connector 10, allowing the storage tube 1 to be pulled out smoothly without sucking out the medication.

[0021] Example 2: Existing drug delivery devices only have a single orifice, which can only spray the drug at a specific point in the uterine cavity. The drug mainly deposits in the center of the fundus, and it is difficult to cover the lateral horns and anterior and posterior walls. Therefore, this example uses the following technical solution, such as... Figures 6-9As shown, the drug delivery mechanism includes a connector 10 threaded at the bottom of the drug storage tube 1, and the connector 10 has a frustum-shaped structure, with a drug dispensing channel 11 reserved at the center of the connector 10; a fixing groove 12 is provided at the bottom of the connector 10, and a movable block 13 is provided inside the fixing groove 12, and the upper end face of the movable block 13 is connected to the inner top face of the fixing groove 12 through an elastic rope 14; a through first spray nozzle 15 is provided inside the movable block 13, and the first spray nozzle 15 is connected to the inside of the drug storage tube 1 through the drug dispensing channel 11, and a second spray nozzle 16 is reserved on the side of the movable block 13; the second spray nozzle 16 is connected to the first spray nozzle 15, and the second spray nozzle 16 is distributed at equal angles, and the inner diameter of the upper end of the first spray nozzle 15 is equal to the inner diameter of the drug dispensing channel 11, and the inner diameter of the lower end of the first spray nozzle 15 is smaller than the inner diameter of its upper end; a fixing tube 31 is fixed to the lower end face of the piston plate 3, and the bottom of the fixing tube 31 is... For sealing purposes, fixing holes 32 are reserved on both the upper and lower sides of the fixing tube 31. The outer diameter of the fixing tube 31 is the same as the inner diameter of the drug outlet channel 11, and the fixing tube 31 is in contact with the upper end of the movable block 13 after it descends. When administering the drug, the drug is initially discharged from the first spray nozzle 15. When the piston plate 3 descends to a certain position, it can pass through the drug outlet channel 11 and insert into the upper end of the movable block 13, which abuts against the inside of the first spray nozzle 15. On the one hand, it blocks the first spray nozzle 15, and on the other hand, the drug is transmitted through the fixing hole 32 at the upper end to the fixing tube 31 by the continued squeezing of the piston plate 3, and then discharged from the fixing hole 32 at the lower end. At the same time, the fixing tube 31 pushes the movable block 13 out of the fixing groove 12 and drives the elastic rope 14 to extend. In this way, the drug can be discharged through the second spray nozzle 16. The second spray nozzle 16, which is distributed at equal angles, can increase the range of drug distribution and improve the treatment effect.

[0022] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0023] In the description of this invention, unless otherwise stated, "a plurality of" means two or more; the terms "upper," "lower," "left," "right," "inner," "outer," "front end," "rear end," "head," "tail," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the invention. Furthermore, the terms "first," "second," "third," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0024] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

Claims

1. A uterine cavity sustained-release drug delivery device for assisted reproduction, comprising a drug storage tube (1), wherein a push rod (2) is slidably passed through the top of the drug storage tube (1), and a piston plate (3) is attached to the bottom of the push rod (2), and the piston plate (3) is slidably disposed inside the drug storage tube (1); Its features are, Also includes: A leak-proof mechanism is provided on the outside of the drug storage tube (1). The leak-proof mechanism is used to seal the cavity so that the drug is completely sealed in the uterine cavity. The drug delivery mechanism is located inside the drug storage tube (1), and the drug delivery mechanism increases the drug coverage by increasing the amount of drug dispensed.

2. The intrauterine sustained-release drug delivery device for assisted reproduction according to claim 1, characterized in that: The leak-proof mechanism includes a fixing plate (4) fixed to the upper end of the push rod (2), and a connecting block (5) is fixed to the lower end face of the fixing plate (4), and the connecting block (5) and the limiting hole (6) are engaged.

3. The intrauterine sustained-release drug delivery device for assisted reproduction according to claim 2, characterized in that: The limiting hole (6) is opened at the top of the medicine storage tube (1), and a corrugated pipe (7) is fixed between the lower end face of the fixing plate (4) and the top of the medicine storage tube (1), and the corrugated pipe (7) is connected to the air bag (9) through the air supply channel (8).

4. The intrauterine sustained-release drug delivery device for assisted reproduction according to claim 3, characterized in that: The gas delivery channel (8) is located on the side wall of the drug storage tube (1), and the air bag (9) is fixedly located on the outer wall of the lower end of the drug storage tube (1).

5. The intrauterine sustained-release drug delivery device for assisted reproduction according to claim 1, characterized in that: The drug delivery mechanism includes a connector (10) with threads set at the bottom of the drug storage tube (1), and the connector (10) has a frustum-shaped structure, and a drug dispensing channel (11) is reserved at the center of the connector (10).

6. The intrauterine sustained-release drug delivery device for assisted reproduction according to claim 5, characterized in that: The bottom of the connector (10) is provided with a fixing groove (12), and a movable block (13) is provided inside the fixing groove (12). The upper surface of the movable block (13) is connected to the inner top surface of the fixing groove (12) by an elastic rope (14).

7. The intrauterine sustained-release drug delivery device for assisted reproduction according to claim 6, characterized in that: The movable block (13) has a through first spray nozzle (15) inside, and the first spray nozzle (15) is connected to the inside of the medicine outlet channel (11) and the medicine storage tube (1) through the medicine outlet channel (11). A second spray nozzle (16) is reserved on the side of the movable block (13).

8. The intrauterine sustained-release drug delivery device for assisted reproduction according to claim 7, characterized in that: The second spray nozzle (16) is connected to the first spray nozzle (15), and the second spray nozzle (16) is distributed at equal angles. The inner diameter of the upper end of the first spray nozzle (15) is equal to the inner diameter of the discharge channel (11), and the inner diameter of the lower end of the first spray nozzle (15) is smaller than the inner diameter of its upper end.

9. The intrauterine sustained-release drug delivery device for assisted reproduction according to claim 1, characterized in that: The piston plate (3) has a fixing tube (31) fixed on its lower end face, and the bottom of the fixing tube (31) is sealed. Fixing holes (32) are reserved on the upper and lower sides of the fixing tube (31).

10. The intrauterine sustained-release drug delivery device for assisted reproduction according to claim 9, characterized in that: The outer diameter of the fixed tube (31) is the same as the inner diameter of the drug outlet channel (11), and the fixed tube (31) is in contact with the upper end face of the movable block (13) after it descends.

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