Systems and methods for quantifying the dynamic response of stiffened skeletal tissue

By filtering and identifying change points in the force response waveform of skeletal tissue, a dynamic contractility vector is generated, solving the problem of automated quantification of dynamic parameters of skeletal muscle tetanic contraction, and improving the accuracy and efficiency of disease research and drug discovery.

CN122422758APending Publication Date: 2026-07-17VARO HEALTH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
VARO HEALTH CO LTD
Filing Date
2024-11-06
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies struggle to quantify the dynamic parameters of skeletal muscle during tetanic contractions non-invasively and automatically, especially in computer simulations or virtual measurements.

Method used

By obtaining the force response waveform of bone tissue, applying a low-pass filter for noise reduction, identifying multiple points of change, and generating a dynamic contractility vector, the dynamic response of bone tissue is characterized, thereby determining the effect associated with specific conditions.

Benefits of technology

It enables unsupervised and non-invasive quantification of tetanic contractions in skeletal tissue, providing low-complexity quantification of dynamic responses and improving the accuracy and efficiency of disease research and drug discovery.

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Abstract

获得第一波形,所述第一波形包括在第一时间段期间经历强直性收缩的骨骼组织的力响应。从所述第一波形生成一个或多个变换波形。所述一个或多个变换波形包括至少一个变换波形,所述至少一个变换波形编码所述第一波形在所述第一时间段内的变化率。在所述一个或多个变换波形内识别变化点。所述变化点发生在所述第一时间段内的多个时间点处。基于在所述多个时间点处确定的所述第一波形的值的比较从所述第一波形生成动力学收缩性向量。所述动力学收缩性向量表征所述骨骼组织在所述第一时间段内的动力学响应。基于所述动力学收缩性向量确定效果。
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