Construction method of characteristic map of synovitis preparation and content determination method thereof

By using high-performance liquid chromatography (HPLC) for gradient elution of synovitis preparations, simultaneous detection of 13 key components was achieved, solving the problem of incomplete quality control in existing technologies and improving the quality control and clinical efficacy of synovitis preparations.

CN122449010APending Publication Date: 2026-07-24SHINEWAY PHARMA GRP LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHINEWAY PHARMA GRP LTD
Filing Date
2026-05-11
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Current technology cannot fully detect multiple key active ingredients in synovitis preparations, resulting in incomplete quality control and affecting clinical efficacy and safety.

Method used

High-performance liquid chromatography (HPLC) was used to simultaneously detect 13 components in synovitis preparations through gradient elution and optimized chromatographic conditions, including baseline separation of salvianolic acid derivatives, iridoid glycosides, and phenylpropanoids.

Benefits of technology

It enables comprehensive detection of multiple components in synovitis preparations, improves the scientific nature and pertinence of quality control, solves the problem of disconnect between quality control and clinical efficacy in existing technologies, and is suitable for the batch sample quality testing needs of industrial production.

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Abstract

The application provides a construction method and a content determination method of a synovitis preparation characteristic spectrum, and belongs to the technical field of drug detection. The construction method is that a test sample solution is prepared by using the synovitis preparation, then acetonitrile-0.08-0.12wt% formic acid aqueous solution is used as a mobile phase, high performance liquid chromatography detection is carried out, the characteristic spectrum of the synovitis preparation is obtained, and the content of components in the synovitis preparation is further determined. The method can comprehensively cover the key active components of core medicinal materials in the prescription of the synovitis preparation, realizes the synchronous detection of multiple categories and multiple target components, and completely solves the defects of single quality control index and incomplete coverage in the prior art.
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