Chromatographic column system

By designing a chromatographic column system with independent operation and gradient elution functions, the problems of low efficiency and poor applicability of existing high-pressure preparation chromatography systems are solved, and efficient and low-consumption product purification is achieved.

CN222623714UActive Publication Date: 2025-03-18TRUKING INGENUITY BIOTECHNOLOGY (CHANGSHA) CO LTD
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Patent Information

Application Number
CN202421235131.3
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-05-31
Publication Date
2025-03-18
Estimated Expiration
2034-05-31

AI Technical Summary

Technical Problem

The existing high-pressure preparation chromatography systems have problems such as low efficiency, large solvent consumption and low product yield, while the dual-column system has problems such as poor applicability, inability to operate independently and inability to elute gradients.

Method used

A column system including a first column, a second column, an eluent line, a modification line, a loading line and a valve set is designed to allow the first column and the second column to operate independently and support gradient elution.

Benefits of technology

The efficient operation of the chromatographic column system is achieved, the solvent consumption is reduced, the product yield is improved, and the applicability is expanded, allowing the dual-column system to be used for more types of product purification.

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Abstract

The utility model discloses a chromatographic column system which comprises a first chromatographic column, a second chromatographic column, a first eluent pipeline, a second eluent pipeline, a third eluent pipeline, a fourth eluent pipeline, a modification liquid pipeline and a sample loading pipeline, the modification liquid pipeline is connected with liquid inlets of the first chromatographic column and the second chromatographic column through a switching valve, the sample loading pipeline is connected with the liquid inlets of the first chromatographic column and the second chromatographic column through a switching valve, and liquid outlets of the first chromatographic column and the second chromatographic column are respectively provided with a first liquid discharge valve group and a second liquid discharge valve group; a liquid outlet of the first chromatographic column is connected with a liquid inlet of the second chromatographic column through a first tandem valve, and a liquid outlet of the second chromatographic column is connected with a liquid inlet of the first chromatographic column through a second tandem valve. The use method comprises the following steps: loading a sample on the first chromatographic column, eluting, connecting the two chromatographic columns in series, collecting the sample by the first chromatographic column, connecting the first chromatographic column and the second chromatographic column in series and the like. The two chromatographic columns can operate independently and perform gradient elution.
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