Sterile needle cylinder type spleen lymphocyte separation and extraction device

By designing a sterile syringe-type spleen lymphocyte separation device, the problems of inconsistent operation and contamination in the existing spleen lymphocyte separation technology have been solved, achieving efficient and low-contamination cell separation effect, and improving the reproducibility of experiments and cell viability.

CN224411714UActive Publication Date: 2026-06-26CHENGDU MEDICAL COLLEGE
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Patent Information

Application Number
CN202520971813.9
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2025-05-16
Publication Date
2026-06-26
Estimated Expiration
2035-05-16

AI Technical Summary

Technical Problem

Existing techniques for isolating spleen lymphocytes involve fragmented procedures, low efficiency, and are prone to microbial contamination, affecting cell viability and experimental reproducibility.

Method used

A sterile syringe-type spleen lymphocyte separation device is designed, comprising a separation section, a grinding section, and a collection section. It adopts a semi-enclosed environment for tissue grinding, cell release, and impurity filtration, and uses a hand-cranked grinding pestle and a double-layer filter to reduce open operation and improve operational continuity and cell viability.

Benefits of technology

Achieving seamless operation of tissue grinding, cell release, and impurity filtration in a semi-closed environment reduces the risk of sample contamination and improves experimental reproducibility and cell viability.

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Abstract

The utility model discloses a sterile syringe type spleen lymphocyte separating and extracting device, which comprises a separating part, a grinding part and a collecting part, the separating part is in the shape of a syringe and comprises an upper barrel and a lower barrel which are detachably connected, the lower end of the upper barrel is detachably connected with a cell screen, the lower end of the lower barrel is detachably connected with the collecting part, and the grinding part comprises a push rod and a rocker. A piston head is arranged at the lower end of the push rod and is in close sliding fit with the upper barrel, continuous through holes are formed in the centers of the push rod and the piston head, the rocker penetrates through the through holes in a sliding mode, the upper end of the rocker extends out of the push rod and is connected with the rocking handle, and the lower end of the rocker extends out of the piston head and is connected with the grinding pestle. And the other end is positioned outside the upper cylinder. According to the utility model, the continuous operation of tissue grinding, cell release, impurity filtration and lymphocyte enrichment can be carried out in a semi-closed environment, the risk of sample pollution is reduced, and the repeatability of an experiment is improved.
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