Rage-targeted antisense oligonucleotides

Abstract

The present invention relates to potent antisense oligonucleotides that modify splicing, modulating the alternative splicing of pre-mRNA encoding the Receptor of Advanced Glycation End Products (RAGE) or a portion thereof, and methods for treating RAGE-related disorders using such antisense oligonucleotides. In one aspect, the present invention provides an antisense oligonucleotide (AON) consisting of the nucleotide sequence TGCCGCCTTTGCCACAAG (5'-3'; SEC ID NO: 1); or GCCGCCTTTGCCACAAGA (5'-3'; SEC ID NO: 2), preferably wherein the antisense oligonucleotide comprises at least one modified nucleotide.