Methods and systems for the rapid detection of microorganisms using recombinant infectious agents to express an indicator subunit

Recombinant indicator phages with luciferase-based detection enable rapid and sensitive identification of bacteria by amplifying a detectable signal during phage replication, addressing the inefficiencies of conventional methods and enabling quick detection of pathogens in various samples.

HK40134586APending Publication Date: 2026-07-10LABORATORY CORPORATION OF AMERICA HOLDINGS INC
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Patent Information

Authority / Receiving Office
HK · HK
Patent Type
Applications
Current Assignee / Owner
LABORATORY CORPORATION OF AMERICA HOLDINGS INC
Filing Date
2026-04-24
Publication Date
2026-07-10

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Abstract

Disclosed herein are methods and systems for rapid detection of microorganisms, such as bacteria, in a sample. Also disclosed is a genetically modified bacteriophage comprising an indicator gene encoding one subunit of an indicator protein. The specificity of the bacteriophage allows detection of specific target bacteria, and the indicator signal can be amplified to optimize assay sensitivity.
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