Process for the production of sclareol and / or sclareolide
By using microorganisms of the genera *Hyphozyma* or *Cryptococcus* to catalyze the production of perillaldehyde and perillyl lactone from lysine, the problems of waste disposal and unstable raw materials associated with chemical synthesis methods have been solved, achieving efficient and green biosynthesis.
CN122303330APending Publication Date: 2026-06-30CATAYA BIO (SHANGHAI) CO LTD
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- CATAYA BIO (SHANGHAI) CO LTD
- Filing Date
- 2025-12-31
- Publication Date
- 2026-06-30
AI Technical Summary
Technical Problem
Existing chemical synthesis methods for perillyl lactone and perillyl glycol suffer from problems such as high waste treatment costs and unstable raw material supply, while biological production methods are few and require further exploration.
Method used
Hyphozyma or Cryptococcus or their derivatives were used to catalyze the synthesis of lysenoside diol and/or lysenoside lactone by contacting lysenoside diol with phosphorylase. The synthesis pathway of lysenoside diol was enhanced by recombinant engineered bacteria, and the mixed culture conditions were optimized.
Benefits of technology
This study achieved efficient and green synthesis of perillaldehyde and perillyl lactone, reducing production costs and increasing yield and production stability.
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Smart Images
Figure CN122303330A_ABST
Abstract
The present invention discloses a method for producing perillaldehyde and / or perillyl lactone, comprising: contacting a first component with a second component to produce perillaldehyde and / or perillyl lactone; wherein the first component is selected from components containing lysine-2-diol, and the second component is selected from enzymes or microorganisms or their cell lysates or enzyme extracts capable of converting lysine-2-diol into perillaldehyde and / or perillyl lactone.
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