Lipid conjugates for the delivery of therapeutic agents to adipose tissue

Abstract

Disclosed herein are compounds comprising lipid PK / PD modulators for delivery of oligonucleotide-based agents, e.g., double stranded RNAi agents or antisense oligonucleotides, to certain tissues (e.g., adipose tissue) or cell types (e.g., adipocytes) in vivo. The PK / PD modulators disclosed herein, when conjugated to an oligonucleotide-based therapeutic or diagnostic agent, such as an RNAi agent, can enhance the delivery of the composition to the adipocytes in vivo to facilitate the inhibition of gene expression in those cells.