Hydroquinazoline derivatives for the treatment of a disease or disorder

Abstract

The disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.

Description

Hydroxyquinazoline Derivatives for the Treatment of Diseases or Conditions Abstract This invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein A, Ra to Rd and R4 to R7 are as described herein, and also to compositions and methods of use of such compounds.

Claims

CLAIMS What is claimed is:

1. A compound of Formula (I): or a pharmaceutically acceptable salt th 12A is NR or CR R3; R1and R2are each, independently H, (C3-C6)cycloalkyl, or (C6-C10)aryl, wherein the (C6-C10)aryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -CN, -OH, -CO2H, (C1-C6)alkyl and (C3-C6)cycloalkyl; R3is H or (C1-C6)alkyl; R4is (C6-C10)aryl or a 5- or 6-membered heteroaryl comprising 1, 2, 3, or 4 heteroatoms selected from N, O, and S, wherein the (C6-C10)aryl or the 5- or 6-membered heteroaryl are each optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, - CN, -OH, -CO2H, oxo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl-(C1- C6)alkyl, and (C1-C6)alkyl(C3-C6)cycloalkyl; R5is NR8R9; R6is selected from H, (C1-C6)alkyl, (C3-C6)cycloalkyl, and (C3-C6)cycloalkyl-(C1-C6)alkyl; R7is (C3-C6)cycloalkyl or (C6-C10)aryl, wherein the (C3-C6)cycloalkyl and (C6-C10)aryl are each optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -CN, -OH, –CO2H, and HO2C-(C1-C6)alkyl; R8and R9are each, independently H, (C1-C6)alkyl or a 3- to 6-membered heterocycle comprising 1 to 3 heteroatoms selected from N, O, and S; or R8and R9together with the N to which there are bound form a 3- to 10-membered heterocycle optionally comprising 1 or 2 additional heteroatoms selected from N, O, and S, wherein the 3- to 10- membered heterocycle is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -CN, -OH, -CO2H, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl-(C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkyl-O-(C1-C6)alkyl, (C1-C6)hydroxyalkyl, (C1-C6)alkoxy, and a 3- to 7-membered heterocycle comprising 1 to 2 heteroatoms selected from N, O, and S; and Ra, Rb, Rc, and Rdare each, independently H or (C1-C6)alkyl.

2. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein A is NR1and R1is (C3-C6)cycloalkyl or (C6-C10)aryl, wherein the (C6-C10)aryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -CN, -OH, -CO2H, (C1-C6)alkyl and (C3-C6)cycloalkyl.

3. The compound of claim 1 or claim 2 or a pharmaceutically acceptable salt thereof, wherein A is NR1and R1is (C6-C10)aryl which is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -CN, -OH, -CO2H, (C1-C6)alkyl and (C3-C6)cycloalkyl.

4. The compound of any one of claims 1 to 3 or a pharmaceutically acceptable salt thereof, wherein A is NR1and R1is (C6-C10)aryl which is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo and -CN.

5. The compound of any one of claims 1 to 4 or a pharmaceutically acceptable salt thereof, wherein A is NR1and R1is phenyl which is optionally substituted with 1 or 2 substituents independently selected from halo and -CN.

6. The compound of claim 1 or claim 2 or a pharmaceutically acceptable salt thereof, wherein A is ,7. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein A is CR2R3and R2is (C6-C10)aryl, which is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -CN, -OH, -CO2H, (C1-C6)alkyl and (C3-C6)cycloalkyl.

8. The compound of claim 1 or claim 7 or a pharmaceutically acceptable salt thereof, wherein A is CR2R3and R2is (C6-C10)aryl, which is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo.

9. The compound of any one of claims 1, 7, and 8 or a pharmaceutically acceptable salt thereof, wherein A is CR2R3and R2is phenyl which is optionally substituted with 1 or 2 substituents independently selected from halo.

10. The compound of any one of claims 1 and 7 to 9 or a pharmaceutically acceptable salt thereof, wherein A is CR2R3and R2is selected fro .

11. The compound of any one of claimthereof, wherein A is CR2R3and R3is selected from H and –CH3.

12. The compound of any one of claims 1 to 11 or a pharmaceutically acceptable salt thereof, wherein R4is (C6-C10)aryl or a 5- or 6-membered heteroaryl comprising 1, 2, 3, or 4 heteroatoms selected from N, O, and S, wherein the (C6-C10)aryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -CN, -OH, -CO2H, and (C1-C6)alkyl and the 5- or 6- membered heteroaryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -CN, -OH, -CO2H, oxo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3- C6)cycloalkyl, (C3-C6)cycloalkyl-(C1-C6)alkyl, and (C1-C6)alkyl(C3-C6)cycloalkyl.

13. The compound of any one of claims 1 to 12 or a pharmaceutically acceptable salt thereof, wherein R4is (C6-C10)aryl or a 5- or 6-membered heteroaryl comprising 1 to 2 heteroatoms selected from N and S, wherein the (C6-C10)aryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo and (C1-C6)alkyl and the 5- or 6-membered heteroaryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from oxo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, and (C3-C6)cycloalkyl-(C1-C6)alkyl.

14. The compound of any one of claims 1 to 13 or a pharmaceutically acceptable salt thereof, wherein R4is a 5- or 6-membered heteroaryl comprising 1 to 2 heteroatoms selected from N and S, which is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from oxo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, and (C3-C6)cycloalkyl-(C1-C6)alkyl.

15. The compound of any one of claims 1 to 14 or a pharmaceutically acceptable salt thereof, wherein R4is a 5-membered heteroaryl comprising 1 to 2 heteroatoms selected from N and S, which is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from oxo, (C1-C6)alkyl, (C1-C6)fluoroalkyl, (C3-C6)cycloalkyl, and (C3-C6)cycloalkyl-(C1-C6)alkyl.

16. The compound of any one of claims 1 to 13 or a pharmaceutically acceptable salt thereof, wherein R4is (C6-C10)aryl, which is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo.

17. The compound of any one of claims 1 to 13 or a pharmaceutically acceptable salt thereof, wherein R4is selected from , ,18. The compound of any one of claims 1 to 17 or a pharmaceutically acceptable salt thereof, wherein in R5is NR8R9and R8and R9together with the N to which there are bound form a 3- to 10- membered heterocycle optionally comprising 1 or 2 additional heteroatoms selected from N, O, and S, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -CN, -OH, -CO2H, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3- C6)cycloalkyl-(C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkyl-O-(C1-C6)alkyl, (C1-C6)hydroxyalkyl, (C1- C6)alkoxy, and a 3- to 7-membered heterocycle comprising 1 to 2 heteroatoms selected from N, O, and S.

19. The compound of any one of claims 1 to 18 or a pharmaceutically acceptable salt thereof, wherein R5is NR8R9and R8and R9together with the N which there are bound form a 3- to 10-membered heterocycle optionally comprising 1 to 2 additional O heteroatoms, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -CN, -OH, -CO2H, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl-(C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkyl-O-(C1-C6)alkyl, (C1-C6)hydroxyalkyl, (C1-C6)alkoxy, and a 3- to 7- membered heterocycle comprising 1 to 2 heteroatoms selected from N, O, and S.

20. The compound of any one of claims 1 to 19 or a pharmaceutically acceptable salt thereof, wherein R5is NR8R9and R8and R9together with the N which there are bound form a 3- to 10-membered heterocycle optionally comprising 1 to 2 additional O heteroatoms, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -OH, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, (C1-C6)alkyl-O-(C1-C6)alkyl, (C1-C6)hydroxyalkyl, (C1-C6)alkoxy, and a 3- to 7-membered heterocycle comprising a heteroatom selected from N, O, and S.

21. The compound of any one of claims 1 to 20 or a pharmaceutically acceptable salt thereof, wherein R5is NR8R9and R8and R9together with the N which there are bound form a 5- to 10-membered heterocycle optionally comprising 1 to 2 additional O heteroatoms, wherein the 5- to 10-membered heterocycle is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, -OH, (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, (C1-C6)alkyl-O-(C1-C6)alkyl, (C1-C6)hydroxyalkyl, (C1-C6)alkoxy, and a 3- to 7-membered heterocycle comprising a heteroatom selected from N and O.

22. The compound according to claim 21 or a pharmaceutically acceptable salt thereof, wherein the 5- to 10-membered heterocycle is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from fluoro, -OH, (C1-C6)alkyl, (C1-C6)fluoroalkyl, CH3O-(C1- C6)alkyl, (C1-C6)hydroxyalkyl, and a 5-membered heterocycle comprising a heteroatom selected from O.

23. The compound according to claim 21 or claim 22 or a pharmaceutically acceptable salt thereof, wherein the 5- to 10-membered heterocycle is optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from fluoro, -OH, -CH3, -CH2F, CF2H, -CH2CH3, -CH2OH, - OCH3, and -CH2OCH3.

24. The compound of any one of claims 1 to 23 or a pharmaceutically acceptable salt thereof, wherein R5is selected from ,,,. e co pou o a y o e o c a s o o a p a aceu ca y accep a e sa e eo , wherein R5is NR8R9and R8is selected from H and (C1-C6)alkyl.

26. The compound of any one of claims 1 to 17 and 25 or a pharmaceutically acceptable salt thereof, wherein R5is NR8R9and R9is selected from H, (C1-C6)alkyl, and a 3- to 6-membered heterocycle comprising an O heteroatom.

27. A compound of any one of claims 1 to 26 or a pharmaceutically acceptable salt thereof, wherein R6is selected from selected from (C1-C4)alkyl, (C3-C5)cycloalkyl, and (C3-C5)cycloalkyl-(C1-C4)alkyl.

28. The compound of any one of claims 1 to 27 or a pharmaceutically acceptable salt thereof, wherein R6is selected from, -CH3, –CH2CH .

29. The compound of any one of claims 1 to 28 or a pharmaceutically acceptable salt thereof, wherein R7is selected from (C3-C6)cycloalkyl or (C6-C10)aryl, wherein the (C3-C6)cycloalkyl and (C6- C10)aryl are each optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, –CO2H, and –CH2CO2H.

30. The compound of any one of claims 1 to 28 or a pharmaceutically acceptable salt thereof, wherein R7is selected from (C5-C6)cycloalkyl or (C6-C10)aryl, wherein the (C5-C6)cycloalkyl and (C6- C10)aryl are each optionally substituted with one or more (e.g., 1, 2, 3, 4, or 5) substituents independently selected from halo, –CO2H, and –CH2CO2H.

31. The compound of any one of claims 1 to 28 or a pharmaceutically acceptable salt thereof, wherein R7is selected from (C5-C6)cycloalkyl or (C6-C10)aryl, wherein the (C5-C6)cycloalkyl and (C6- C10)aryl are each optionally substituted with 1 or 2 substituents independently selected from fluoro, – CO2H, and –CH2CO2H.

32. The compound of any one of claims 1 to 31 or a pharmaceutically acceptable salt thereof, wherein R7is selected from ,.. e compoun o any one o claims 1 to 32 or a pharmaceutically acceptable salt thereof, wherein Ra, Rb, Rc, and Rdare each, independently H or –CH3.

34. The compound of any one of claims 1 to 32 or a pharmaceutically acceptable salt thereof, wherein Rais H.

35. The compound of any one of claims 1 to 32 or a pharmaceutically acceptable salt thereof, wherein Rband Rcare each H.

36. The compound of any one of claims 1 to 32 or a pharmaceutically acceptable salt thereof, wherein Rdis –CH3.

37. A compound or a pharmaceutically acceptable salt thereof selected from 3-((R)-1-(((R)-4-(((R)-2-(azepan-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)-6-(3-fluorophenyl)- 5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1-carboxylic acid;(1R,4r)-4-((R)-1-(((R)-6-(3-fluorophenyl)-6-methyl-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(azepan-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)-6-(3- fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; 3-((R)-1-(((R)-4-(((S)-2-(azepan-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)-6-(3-fluorophenyl)- 5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-6-(4-fluorophenyl)-6-methyl-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1- carboxylic acid; 3-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1-carboxylic acid; (1R,4r)-4-((R)-1-(methyl((R)-6-methyl-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin- 1-yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; 3-((R)-1-(methyl((R)-6-methyl-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; 3-((R)-1-(((R)-6-(3-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid ; (1R,4r)-4-((R)-1-(((S)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-ethyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1- carboxylic acid; 3-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(4-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1-carboxylic acid; 3-((R)-1-(((R)-4-(((R)-2-((S)-3-(fluoromethyl)piperidin-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)- 6-methyl-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; 3-((R)-1-(((R)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1-yl)ethyl)amino)-6-(3- fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid;(1R,4r)-4-((R)-1-(((R)-6-(4-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane- 1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1,5-dimethyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-ethyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-ethyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((S)-3-(fluoromethyl)piperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-6-(2-fluorophenyl)-6-methyl-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1- carboxylic acid; (1S,4r)-1-fluoro-4-((S)-1-(methyl((S)-4-(((S)-1-(1-methyl-1H-pyrazol-4-yl)-2-((R)-3-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-isopropyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-6-(3-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane- 1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1S)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(2,4-dimethylthiazol-5- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1- carboxylic acid; 3-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)- 6-(4-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid;(1R,4r)-4-((1R)-1-(((6R)-4-(((1S)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(4-methylthiazol-5- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1- carboxylic acid; 3-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-methyl-6-phenyl-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1-carboxylic acid; 3-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)- 6-methyl-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-(piperidin-1-yl)ethyl)amino)-6-(3- fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(4-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1-yl)ethyl)amino)- 6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-methyl-6-phenyl-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-6-(3-fluorophenyl)-4-(((R)-2-((S)-3-(methoxymethyl)piperidin-1-yl)-1-(1-methyl- 1H-pyrazol-4-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; 3-((S)-1-(((S)-4-(((R)-2-((R)-3-(fluoromethyl)piperidin-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)- 6-methyl-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((S)-6-(3-fluorophenyl)-4-(((R)-1-phenyl-2-(piperidin-1-yl)ethyl)amino)-5,6,7,8- tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid;(1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1R,3R,5R,7R)-2-azaadamantan-2-yl)-1-(1-ethyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; 2-((1R,4r)-4-((R)-1-(((R)-6-(3-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexyl)acetic acid; (1R,4r)-4-((R)-1-(methyl((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; 3-((R)-1-(((R)-4-(((R)-2-(9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)-6- (2-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; 3-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-ethyl-1H-pyrazol-4-yl)ethyl)amino)-6- (3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; 3-((S)-1-(((R)-4-(((R)-2-((S)-3-(fluoromethyl)piperidin-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)- 6-methyl-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; 3-((R)-1-(methyl((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1-yl)ethyl)amino)- 6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)bicyclo[1.1.1]pentane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-(piperidin-1-yl)ethyl)amino)-6-phenyl- 5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; 3-((R)-1-(((R)-4-(((R)-1-(1,5-dimethyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1-yl)ethyl)amino)-6- (3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; (1R,4r)-4-((R)-cyclopropyl(((R)-6-(3-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)methyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-6-(2-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane- 1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-phenylethyl)amino)-6-phenyl- 5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((S)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-(piperidin-1-yl)ethyl)amino)-6-(3- fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid;(1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(azepan-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)-6-phenyl- 5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((S)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-ethyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-6-(3-fluorophenyl)-4-(((R)-1-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane- 1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((S)-3-(difluoromethyl)piperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-((6-(3-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-1- yl)ethyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-1-yl)ethyl)amino)-6-phenyl- 5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(2-azabicyclo[2.2.1]heptan-2-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((3S,5R)-3,5-dimethylpiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(2-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(4-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid;(1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-((R)-2-methylpiperidin-1-yl)ethyl)amino)- 6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-ethyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(methyl((R)-6-methyl-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; 2-((1R,4r)-4-((R)-1-(methyl((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexyl)acetic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(2-azabicyclo[2.2.1]heptan-2-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-methyl-6-phenyl-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; 3-((1S)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)-6- methyl-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(7-azabicyclo[2.2.1]heptan-7-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-methyl-6-phenyl-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((5R,7R)-2-azaadamantan-2-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-6-(3-fluorophenyl)-4-(((R)-2-((S)-3-(hydroxymethyl)piperidin-1-yl)-1-(1-methyl- 1H-pyrazol-4-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((S)-2-((S)-3-methylpiperidin-1-yl)-1-(4-methylthiazol-5-yl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; 3-(1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)- 6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)-1l3-propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((S)-6-(3-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane- 1-carboxylic acid; (1R,4r)-4-((R)-1-((4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1-yl)ethyl)amino)-6-(3- fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid;3-((1R)-1-(((6R)-4-(((1S)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(2-methylthiazol-5-yl)ethyl)amino)-6-(3- fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(3-azabicyclo[4.1.0]heptan-3-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-((1R,5S)-3-hydroxy-9- azabicyclo[3.3.1]nonan-9-yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-((4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1S)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(2-methylthiazol-5- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1S,4s)-1-fluoro-4-((R)-1-(methyl((R)-4-(((S)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((S)-3-(methoxymethyl)piperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((R)-3-methylpiperidin-1-yl)ethyl)amino)- 6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-6-phenyl-4-(((R)-1-phenyl-2-(pyrrolidin-1-yl)ethyl)amino)-5,6,7,8- tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(2-azabicyclo[2.2.1]heptan-2-yl)-1-(4-fluorophenyl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((S)-3-(fluoromethyl)piperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1S)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1,5-dimethyl-1H-pyrazol-3- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid;3-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1,5-dimethyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((R)-2-methylpiperidin-1-yl)ethyl)amino)- 6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-(piperidin-1-yl)ethyl)amino)-6-(3- fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-ethyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((S)-3-(hydroxymethyl)piperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(azepan-1-yl)-1-(1-ethyl-1H-pyrazol-4-yl)ethyl)amino)-6-phenyl- 5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(3,3-dimethylpiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)- 6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((R)-2-ethylpiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)- 6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-cyclopropyl-1H-pyrazol-4-yl)-2-(piperidin-1-yl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1R,3R,5R,7R)-2-azaadamantan-2-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-((6-(3-fluorophenyl)-4-(((R)-1-phenyl-2-(pyrrolidin-1-yl)ethyl)amino)-5,6,7,8- tetrahydropyrido[4,3-d]pyrimidin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-isopropyl-1H-pyrazol-4-yl)-2-(piperidin-1-yl)ethyl)amino)-6-phenyl- 5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(methyl((S)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1,3-dimethyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid;(1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-((R)-2-(hydroxymethyl)piperidin-1- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1S)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-3- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-((6-(2-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-((1-(1-(fluoromethyl)-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-phenylethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-(2-oxa-7-azaspiro[4.5]decan-7- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-((6-(4-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; 3-((1R)-1-(((6R)-4-(((1S)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(2,4-dimethylthiazol-5-yl)ethyl)amino)-6- (3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-((1R,5S)-3-hydroxy-9-azabicyclo[3.3.1]nonan-9-yl)-1- phenylethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; 3-((1R)-1-(((6R)-4-(((1S)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(4-methylthiazol-5-yl)ethyl)amino)-6-(3- fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((S)-1-(4-methylthiazol-5-yl)-2-(piperidin-1-yl)ethyl)amino)-6-phenyl-5,6,7,8- tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid;(1R,4r)-4-((R)-1-(((S)-6-phenyl-4-(((R)-1-phenyl-2-(pyrrolidin-1-yl)ethyl)amino)-5,6,7,8- tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((S)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-(piperidin-1-yl)ethyl)amino)-6-(3- fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-((1R,5S)-3-hydroxy-9- azabicyclo[3.3.1]nonan-9-yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(methyl((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-1-yl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((S)-1-(2-methylthiazol-5-yl)-2-(piperidin-1-yl)ethyl)amino)-6-phenyl-5,6,7,8- tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-cyclopropyl(methyl((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)methyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-(4-methylpiperidin-1-yl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1R,4S)-2-azabicyclo[2.2.1]heptan-2-yl)-1-(1-ethyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-2-methylpiperidin-1-yl)ethyl)amino)- 6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-((6-(3-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(methyl((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((R)-3-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-(6-azaspiro[3.5]nonan-6-yl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic aci; (1R,4r)-4-((1R)-1-(((6R)-4-(((1S)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(2-methylthiazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(2-azabicyclo[2.2.1]heptan-2-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid;(1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((S)-3-hydroxypiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1S,4r)-4-((S)-1-(((S)-6-(3-fluorophenyl)-6-methyl-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((R)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-((6-phenyl-4-(((R)-1-phenyl-2-(pyrrolidin-1-yl)ethyl)amino)-5,6,7,8- tetrahydropyrido[4,3-d]pyrimidin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-isopropyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)(cyclopropyl)methyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((S)-3-methoxypiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-((S)-2-(hydroxymethyl)piperidin-1- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(2-azabicyclo[2.2.1]heptan-2-yl)-1-phenylethyl)amino)-6-phenyl- 5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(4,4-difluoroazepan-1-yl)-1-(1-ethyl-1H-pyrazol-4-yl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-((1R,5S)-6-hydroxy-3-azabicyclo[3.1.1]heptan-3-yl)-1-(1-methyl- 1H-pyrazol-4-yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-2-cyclopropyl-1-((6-phenyl-4-(((R)-1-phenyl-2-(pyrrolidin-1-yl)ethyl)amino)-5,6,7,8- tetrahydroquinazolin-2-yl)amino)ethyl)cyclohexane-1-carboxylic acid; 3-(1-(((R)-4-(((S)-1-(1,3-dimethyl-1H-pyrazol-5-yl)-2-((S)-3-methylpiperidin-1-yl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)-1l3-propyl)bicyclo[1.1.1]pentane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((S)-6-(2-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane- 1-carboxylic acid;(1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(4-fluoropiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(3-fluoro-3-methylpiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(methyl((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-(4-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(methyl((R)-6-phenyl-4-(((R)-1-phenyl-2-(pyrrolidin-1-yl)ethyl)amino)-5,6,7,8- tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-(cyclopropylmethyl)-1H-pyrazol-4-yl)-2-(piperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-ethyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(piperidin-1-yl)ethyl)amino)- 6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((R)-2-(hydroxymethyl)piperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(4,4-difluoroazepan-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(4-methoxypiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-((6-cyclohexyl-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; 4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-ethyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)ethyl)benzoic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-(4-hydroxypiperidin-1-yl)ethyl)amino)-6- phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; 3-((R)-1-(((R)-6-(3-fluorophenyl)-4-(((S)-1-(1-methyl-1H-pyrazol-5-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane-1- carboxylic acid;(1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(3-fluoropiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethyl)amino)- 6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-((6-(3-fluorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-1- yl)ethyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1S,4r)-4-((1S)-1-((6-phenyl-4-(((R)-1-phenyl-2-(pyrrolidin-1-yl)ethyl)amino)-5,6,7,8- tetrahydroquinazolin-2-yl)amino)ethyl)cyclohexane-1-carboxylic acid; 4-((R)-1-(((R)-6-phenyl-4-(((R)-1-phenyl-2-(pyrrolidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2- yl)amino)ethyl)benzoic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(2-azabicyclo[2.2.1]heptan-2-yl)-1-phenylethyl)amino)-6-phenyl- 5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-6-(3-fluorophenyl)-4-(((S)-1-(1-methyl-1H-pyrazol-5-yl)-2-((S)-3- methylpiperidin-1-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane- 1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-(2-oxa-7-azaspiro[4.5]decan-7- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-1-(1-ethyl-1H-pyrazol-4-yl)-2-((S)-3-hydroxypiperidin-1-yl)ethyl)amino)- 6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1S)-2-(8-azabicyclo[3.2.1]octan-8-yl)-1-(1-methyl-1H-pyrazol-5- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2- yl)(methyl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-(dimethylamino)-1-phenylethyl)amino)-6-phenyl-5,6,7,8- tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(((R)-6-phenyl-4-(((R)-1-phenyl-2-((tetrahydro-2H-pyran-4-yl)amino)ethyl)amino)- 5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-(methyl((R)-6-phenyl-4-(((R)-2-(piperidin-1-yl)-1-(1-(2,2,2-trifluoroethyl)-1H-pyrazol- 4-yl)ethyl)amino)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; 4-((R)-1-(((R)-4-(((R)-2-((1S,5S)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)ethyl)-2-fluorobenzoic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1R,5S)-3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol- 4-yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid;(1R,4r)-4-((R)-1-((6-(3-chlorophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; 4-((R)-1-(((R)-4-(((R)-1-(1-isopropyl-1H-pyrazol-4-yl)-2-(piperidin-1-yl)ethyl)amino)-6-phenyl-5,6,7,8- tetrahydroquinazolin-2-yl)amino)ethyl)benzoic acid; 3-((R)-1-(((R)-4-(((S)-2-((1R,5R)-9-azabicyclo[3.3.1]nonan-9-yl)-1-(1-methyl-1H-pyrazol-5- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)bicyclo[1.1.1]pentane- 1-carboxylic acid; (1R,4r)-4-((R)-1-(methyl((R)-4-(((R)-2-methyl-1-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-1- yl)propyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid; (1R,4r)-4-((R)-1-((6-(3-cyanophenyl)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((1R)-1-(((6R)-4-(((1R)-2-(3-(fluoromethyl)piperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-(3-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1R,6S)-2-azabicyclo[4.1.0]heptan-2-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((1S,6R)-2-azabicyclo[4.1.0]heptan-2-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((R)-3-ethyl-3-hydroxypiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((3R,4R)-4-hydroxy-3-methylpiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(methyl((R)-4-(((R)-1-(1-methyl-1H-pyrazol-4-yl)-2-(5-azaspiro[2.5]octan-5- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)amino)propyl)cyclohexane-1-carboxylic acid (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((R)-3-methoxypyrrolidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid;(1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((R)-3-hydroxy-3-methylpiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((3R,5R)-3-methoxy-5-methylpiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((3S,5S)-3-methoxy-5-methylpiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; (1R,4r)-4-((R)-1-(((R)-4-(((S)-1-(3-fluoro-1-methyl-1H-pyrazol-4-yl)-2-((S)-3-methylpiperidin-1- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid; and (1R,4r)-4-((R)-1-(((R)-4-(((R)-2-((S)-3-hydroxy-3-methylpiperidin-1-yl)-1-(1-methyl-1H-pyrazol-4- yl)ethyl)amino)-6-phenyl-5,6,7,8-tetrahydroquinazolin-2-yl)(methyl)amino)propyl)cyclohexane-1- carboxylic acid.

38. A pharmaceutical composition comprising a compound according to any one of claims 1 to 37 or a pharmaceutically acceptable salt thereof and one or more (e.g., 1, 2, 3, 4, or 5) pharmaceutically acceptable carriers.

39. The pharmaceutical composition of claim 38, further comprising at least one additional pharmaceutically active agent.

40. The pharmaceutical composition of claim 39, wherein the additional pharmaceutically active agent is selected from an ACE (angiotensin-converting-enzyme) inhibitor, an angiotensin receptor blocker (ARB), a neprilysin inhibitor, a beta blocker, a diuretic, a calcium channel blocker, a cardiac glycoside, a sodium-glucose co-transporter 2 inhibitor (SGLT2i), an angiotensin receptor-neprilysin inhibitor (ARNi), a corticosteroid, a leukotriene modifier, a bronchodilator, a beta-adrenoceptor antagonist, a carbonic anhydrase inhibitor, an alpha 2-adrenoceptor agonist, a parasympathomimetic, a prostaglandin analog, a rho kinase inhibitor, and combinations thereof.

41. A method for treating or preventing a disease or disorder comprising administering to a patient in need thereof a therapeutically effective amount of a compound according to any one of the claims 1 to 37 or a pharmaceutically acceptable salt thereof or the pharmaceutical composition of any one of claims 38 to 40.

42. The method of claim 41, wherein the disease or disorder is a cardiovascular disease or disorder.

43. The method of claim 42, wherein the cardiovascular disease or disorder is selected from hypertension, peripheral vascular disease, heart failure, coronary artery disease (CAD), ischemic heart disease (IHD), mitral stenosis and regurgitation, angina, hypertrophic cardiomyopathy, diabetic cardiomyopathy, supraventricular and ventricular arrhythmias, cardiac dysrhythmia, atrial fibrillation (AF), new onset of atrial fibrillation, recurrent atrial fibrillation, cardiac fibrosis, atrial flutter, detrimental vascular remodeling, plaque stabilization, and myocardial infarction (MI).

44. The method of claim 43, wherein the heart failure is selected from a heart failure with reduced ejection fraction (HFrEF), heart failure with preserved ejection fraction (HFpEF), heart failure after acute myocardial infarction, or acute decompensated heart failure.

45. The method of claim 41, wherein the disease or disorder is preeclampsia, asthma, glaucoma, a kidney disorder, and / or cytokine release syndrome in a subject in need of such treatment.

46. The method of claim 41, wherein the disease or disorder is a disorder or disease associated with natriuretic peptide receptor activity.