Topical skin preparations

Abstract

This invention provides a topical skin preparation containing niacinamide that suppresses the feeling of tightness or irritation. [Solution] The topical skin preparation contains (A) 0.1 to 6% by mass of niacinamide, (B) 0.01 to 1.0% by mass of one or more selected from polyvinylpyrrolidone, sodium polyacrylate, and xanthan gum, and (C) 0.0001 to 0.5% by mass of one or more selected from acetylglucosamine, hyaluronic acid and its derivatives, and hydrolyzed collagen solution.

Description

[Technical Field]

[0001] This invention relates to a topical skin preparation. [Background technology]

[0002] Among various skin concerns, "deep wrinkles" that appear on the skin with age are a major worry for women. Wrinkles can be divided into "shallow wrinkles" caused by dryness or minor changes in the external environment, and "deep wrinkles" caused by factors such as photoaging or natural aging, which alter the components of the dermis. The former can be easily improved with skincare such as moisturizing, while the latter are known to be difficult to improve without appropriate beauty ingredients and skincare.

[0003] For skin concerns related to deep wrinkles, niacinamide is particularly known to be a vitamin with high safety and anti-aging effects on the skin (e.g., Patent Document 1). However, it is known that high concentrations of niacinamide can result in an undesirable squeaky feeling, and efforts have been made to improve this. Examples include oil-in-water emulsion cosmetics using silicone oil and polyoxyalkylene-modified glycerin derivatives (e.g., Patent Document 2), gel-type topical skin preparations using silicone oil, polyether-modified silicone, and carboxymethylcellulose (e.g., Patent Document 3), and leave-on skincare compositions using petrolatum (e.g., Patent Document 4). [Prior art documents] [Patent Documents]

[0004] [Patent Document 1] Patent No. 3922311 [Patent Document 2] International Publication No. 2021 / 201136 [Patent Document 3] Patent No. 7256624 [Patent Document 4] Special Publication No. 2003-502435 [Overview of the Initiative] [Problems that the invention aims to solve]

[0005] The conventional topical skin preparations described above improve the squeaky feeling caused by niacinamide using oil-based methods, but methods to improve this squeaky feeling without relying on oil have not been sufficiently investigated. Given this background, there is a need for topical skin preparations containing niacinamide that suppress the squeaky feeling.

[0006] This invention has been made in view of the above circumstances, and its purpose is to provide a topical skin preparation containing niacinamide that suppresses the feeling of tightness. [Means for solving the problem]

[0007] The inventors of the present invention conducted diligent research to achieve the above objectives and, as a result, discovered that by combining niacinamide with one or more selected from polyvinylpyrrolidone, sodium polyacrylate, and xanthan gum, and one or more selected from acetylglucosamine, hyaluronic acid and its derivatives, and hydrolyzed collagen solution, it is possible to provide a topical skin preparation that does not cause any squeaking during use, has excellent moisturizing properties for the skin, and imparts firmness and elasticity to the skin, thus completing the present invention.

[0008] The topical skin preparation according to the present invention is a topical skin preparation containing the following (A) to (C). (A) Niacinamide 0.1-6% by mass (B) Select one from polyvinylpyrrolidone, sodium polyacrylate, and xanthan gum. One or more species, 0.01-1.0% by mass (C) One or more selected from acetylglucosamine, hyaluronic acid and its derivatives, and hydrolyzed collagen solution, 0.0001-0.5% by mass

[0009] The topical skin preparation according to the present invention may contain the following (D). (D) One or more vitamins selected from vitamins A, B (excluding component (A)), C, E and their derivatives: 0.0001-0.5% by mass [Effects of the Invention]

[0010] This invention makes it possible to suppress the squeaky feeling caused by niacinamide. [Modes for carrying out the invention]

[0011] The following describes in detail the topical skin preparation according to this embodiment, but the present invention is not limited to the following embodiments. The present invention is not limited to the configurations described below, and various modifications are possible within the scope of the claims, and embodiments and examples obtained by appropriately combining the technical means disclosed in different embodiments and examples are also included in the technical scope of the present invention. Furthermore, unless otherwise specified in this specification, "A~B" representing a numerical range means "A or more, B or less".

[0012] The topical skin preparation according to this embodiment contains (A) niacinamide, (B) one or more selected from polyvinylpyrrolidone, sodium polyacrylate, and xanthan gum, and (C) one or more selected from acetylglucosamine, hyaluronic acid and its derivatives, and hydrolyzed collagen solution.

[0013] <(A) Niacinamide> Component (A) used in the topical skin preparation according to this embodiment is niacinamide. Niacinamide is one of the B vitamins, which are water-soluble vitamins, and is also called nicotinamide. Niacinamide can be used without particular restrictions as long as it is commonly used in pharmaceuticals, quasi-drugs, and cosmetics, and these may be natural or synthetic. Niacinamide is known to have effects such as wrinkle improvement, blood circulation promotion, rough skin improvement, melanin production inhibition, and skin whitening.

[0014] Niacinamide is available as a commercially available cosmetic raw material. Examples of commercially available products include "Niacinamide USP PC (manufactured by Arcsada Japan)" and "Nicotinamide (manufactured by DSM)".

[0015] The skin external preparation according to this embodiment contains niacinamide as component (A) and one or more selected from (B) polyvinylpyrrolidone, sodium polyacrylate, and xanthan gum described later, thereby synergistically improving the moisturizing effect. Further, by containing one or more selected from (C) acetylglucosamine, hyaluronic acid and its derivatives, and hydrolyzed collagen solution described later, the firming elasticity effect of the skin is synergistically improved.

[0016] The blending amount of component (A) is 0.1 to 6% by mass in the total mass of the skin external preparation, preferably 0.5 to 5% by mass. If the blending amount of component (A) is 0.1% by mass or more, a sufficient moisturizing effect and an improvement effect on the firming elasticity of the skin can be obtained. On the other hand, if the blending amount of component (A) is 6% by mass or less, it is possible to suppress a harsh feeling by combining with component (C) described later.

[0017] <One or more selected from (B) polyvinylpyrrolidone, sodium polyacrylate, and xanthan gum> Component (B) used in the skin external preparation according to this embodiment is one or more selected from polyvinylpyrrolidone, sodium polyacrylate, and xanthan gum.

[0018] Polyvinylpyrrolidone is a polymer compound obtained by polymerizing N-vinyl-2-pyrrolidone and is not particularly limited as long as it is used in ordinary cosmetics, and can be used even if it is natural, semi-synthetic, or synthetic. As the degree of polymerization increases, the molecular weight increases. In the present invention, from the viewpoints of formulation stability, non-stickiness of the film, wrinkle improvement effect, and improvement of makeup effect, the weight average molecular weight is preferably 900,000 to 2,000,000, more preferably 1,200,000 to 1,700,000. These molecular weights refer to the weight average molecular weight measured by the SEC method.

[0019] Sodium polyacrylate is a polymer of acrylic acid, which has extremely strong hygroscopicity. When water is added, it gradually swells and has the property of becoming a uniform viscous solution through a transparent gel. In cosmetics, it is used for the purpose of hydrophilic thickening and is known to contribute to skin moisturization and a moist feeling. Regarding the weight average molecular weight, it is preferably 1 million to 10 million, more preferably 1.5 million to 8 million, and even more preferably 2 million to 6 million.

[0020] Xanthan gum is a polysaccharide obtained by fermenting hydrocarbons with Xanthomonas bacteria and is composed of glucose, mannose, glucuronic acid, etc. Xanthan gum is excellent in water retention, viscosity, elasticity, and gelling properties. In addition to being a stabilizer for milk products, etc., it is widely used as a laxative, surfactant dispersant, etc., and as a raw material for food, cosmetics, and pharmaceuticals.

[0021] The component (B) in the external preparation for skin according to this embodiment gives moisture (moisturizing effect) to the skin.

[0022] The blending amount of the component (B) is 0.01 to 1.0% by mass in the total mass of the external preparation for skin, and preferably 0.02 to 0.6% by mass. If the blending amount of the component (B) is 0.01% by mass or more, a sufficient moisturizing effect can be obtained. On the other hand, if the blending amount of the component (B) is 1.0% by mass or less, stickiness can be suppressed. When two or more of polyvinylpyrrolidone, sodium polyacrylate, and xanthan gum are used as the component (B) of the external preparation for skin, the blending amount of the component (B) is the total amount thereof.

[0023] <One or more selected from (C) acetylglucosamine, hyaluronic acid and its derivatives, and hydrolyzed collagen solution> The component (C) used in the external preparation for skin according to this embodiment is one or more selected from acetylglucosamine, hyaluronic acid and its derivatives, and hydrolyzed collagen solution.

[0024] Acetylglucosamine is a monosaccharide in which the hydroxyl group at the 2 position of glucose is replaced with an acetylamino group. It can be produced from any source, including synthetic compounds, fermentation products, or degradation products obtained from the chitin breakdown of crabs, shrimp, etc., and is not particularly limited to any specific source. When obtained from crustaceans such as crabs and shrimp, it can be prepared by using chitin, a polysaccharide prepared from their shells, as a raw material, partially hydrolyzing it with acid, and then further decomposing it with an enzyme such as chitinase.

[0025] Hyaluronic acid is a type of acidic mucopolysaccharide, a polysaccharide containing glucuronic acid and N-acetylglucosamine as constituent units. Hyaluronic acid can be extracted and recovered from animal tissues such as chicken combs, shark skin, umbilical cords, eyeballs, skin, and cartilage, hyaluronic acid-producing microorganisms such as Streptococcus microorganisms, and cultures of animal or plant cells. It can also be purchased commercially. Furthermore, a derivative of hyaluronic acid described above may be used as component (C) of the topical skin preparation according to this embodiment. Examples of hyaluronic acid derivatives include: Examples include derivatives obtained by etherification, esterification, acetylation, amidation, acetalization, and ketalization of the hydroxyl and carboxyl groups of hyaluronic acid, specifically acetylated hyaluronic acid and cationized hyaluronic acid. Hyaluronic acid and hyaluronic acid derivatives may also be salts of sodium, potassium, calcium, magnesium, ammonium, basic amino acid, or zinc salts.

[0026] Hydrolyzed collagen solution is a hydrolyzed product obtained by hydrolyzing collagen, a protein that mainly constitutes the dermis, ligaments, tendons, bones, and cartilage of vertebrates, in the presence of alkali, acid, or enzymes according to conventional methods. Sources of collagen for obtaining hydrolyzed collagen solution include animals (cattle, pigs, birds, etc.), fish (tilapia, etc.), shellfish, jellyfish, and sponges.

[0027] In the topical skin preparation according to this embodiment, component (C), when included with component (A), suppresses tightness and further synergistically improves the skin's firmness and elasticity.

[0028] The amount of component (C) is 0.0001 to 0.5% by mass of the total mass of the topical skin preparation, preferably 0.001 to 0.1% by mass. If the amount of component (C) is 0.0001% by mass or more, squeaking can be sufficiently suppressed. On the other hand, if the amount of component (C) is 0.5% by mass or less, unpleasant odors derived from component (C) can be suppressed. When two or more of acetylglucosamine, hyaluronic acid and its derivatives, and hydrolyzed collagen solution are used as component (C) of the topical skin preparation, the amount of component (C) is the sum of their amounts.

[0029] The topical skin preparation according to this embodiment contains (A) 0.1 to 6% by mass of niacinamide, (B) 0.01 to 1.0% by mass of one or more selected from polyvinylpyrrolidone, sodium polyacrylate, and xanthan gum, and (C) 0.0001 to 0.5% by mass of one or more selected from acetylglucosamine, hyaluronic acid and its derivatives, and hydrolyzed collagen solution. This suppresses the squeaky feeling caused by niacinamide and further provides moisture and firmness to the skin.

[0030] <(D) One or more selected from vitamins A, B (excluding the component in (A) above), C, E and their derivatives> The topical skin preparation according to this embodiment may optionally contain, as component (D), one or more selected from vitamins A, B (excluding component (A) above), C, E and their derivatives.

[0031] The topical skin preparation according to this embodiment synergistically improves the skin's firmness and elasticity by containing component (D).

[0032] If the topical skin preparation according to this embodiment contains component (D), the amount of component (D) is preferably 0.0001 to 0.5% by mass, and more preferably 0.001 to 0.1% by mass, of the total mass of the topical skin preparation. If the amount of component (D) is 0.0001% by mass or more, firmness and elasticity can be further improved. On the other hand, if the amount of component (D) is 0.5% by mass or less, unpleasant odors derived from component (D) can be suppressed. In the case where two or more vitamins A, B, C, E and their derivatives are used as component (D) of the topical skin preparation, the amount of component (D) is the total amount of those vitamins.

[0033] <Other ingredients> In addition to the components described above, the topical skin preparation according to this embodiment may contain other components, such as anionic surfactants, cationic surfactants, and amphoteric surfactants, to the extent that they do not impair the objectives of the present invention. Ingredients such as nonionic surfactants, oils, polymer compounds, thickeners, powders (dyes, resins, pigments), preservatives, fragrances, humectants, physiologically active ingredients, mineral salts, solvents, antioxidants, chelating agents, pearlescent agents, neutralizing agents, pH adjusters, plant extracts, and enzymes can be appropriately blended.

[0034] Furthermore, the topical skin preparation according to this embodiment may contain physiologically active ingredients as appropriate, as long as it does not impair the objectives of the present invention. Physiologically active substances are substances that, when applied to the skin, provide some kind of physiological activity to the skin. Examples include anti-inflammatory agents, anti-aging agents, UV protection agents, astringents, antioxidants, blood circulation promoters, antibacterial agents, disinfectants, drying agents, cooling agents, warming agents, vitamins, amino acids, wound healing promoters, irritation relievers, analgesics, and cell activators.

[0035] The topical skin preparation according to this embodiment can be manufactured according to conventional methods. Examples of topical skin preparations according to this embodiment include lotions, emulsions, creams, gels, serums, sheet masks, makeup, body lotions, body gels, body creams, and makeup bases. The dosage form can also be arbitrarily selected according to the purpose. Examples include liquids, creams, gels, emulsions, sheets, sticks, and aerosols. The topical skin preparation according to this embodiment is not limited to general cosmetics, but includes quasi-drugs, designated quasi-drugs, topical pharmaceuticals, etc. [Examples]

[0036] Next, the topical skin preparation according to this embodiment will be described in detail based on examples, but is not limited thereto. Prior to the examples, the test methods and evaluation methods used in each example will be described.

[0037] 1. Evaluation test for the absence of skin tightness. Ten expert panelists washed their forearms with lukewarm water, then allowed them to acclimate for 20 minutes in an environment of 25°C and 50% relative humidity. Afterward, appropriate amounts of the topical skin preparations of the examples and comparative examples of the present invention were applied, and sensory evaluations were conducted on the feeling of tightness in the skin during and after use, using the following scoring method. The evaluation criteria were based on the average value of the sum of the scores given by five participants regarding the lack of tightness, and were classified as follows. <Rating and content regarding the lack of creaking> 5 points... I don't feel any tightness or dryness on my skin during or after use. 4 points... I felt a slight tightness in my skin during and after use. 3 points... I felt a slight tightness in my skin during and after use. Two points... I feel a tightness in my skin during and after use. 1. I felt a strong, unpleasant tightness on my skin during and after use. (Evaluation criteria for lack of creaking) ◎: Excellent. The average score of the five participants was 4 points or higher. ○: Good. The average score of the 5 students was between 3 and 4 points. △: Slightly poor. The average score of the 5 participants was between 2 and 3 points. ×: Bad. The average score of the 5 students was less than 2 points.

[0038] 2. Skin moisture evaluation test For the evaluation panel of 10 participants, the forearms were washed with lukewarm water and then acclimatized for 20 minutes at a temperature of 25°C and a relative humidity of 50%. Afterward, appropriate amounts of the topical skin preparations of the examples and comparative examples of the present invention were applied, and the areas were again acclimatized for 20 minutes at a temperature of 25°C and a relative humidity of 50%. The stratum corneum moisture content (conductance value) was then measured using a Corneometer (MPA580, Courage+Khazaka). The moisturizing effect was evaluated by calculating the moisturizing effect (%) using the following formula, determining the average value for 5 participants, and then judging based on the following criteria. <Rating regarding skin moisturizing effect> Moisturizing effect (%) = (Skin stratum corneum moisture content after application / Stratum corneum moisture content before application) × 100 (Evaluation criteria for skin moisturizing effect) ◎: Moisturizing effect (%) was 150% or higher. ○: The moisturizing effect (%) was between 120% and 150%. △: Moisturizing effect (%) was between 100% and 120%. ×: The moisturizing effect (%) was less than 100%.

[0039] 3. Evaluation test of skin firmness and elasticity Ten expert panel members had their cheeks washed with soap, then acclimatized for 20 minutes in an environment of 25°C and 50% relative humidity, after which they applied 0.1 mL / cm³ of the aftershave agent according to the examples and comparative examples of the present invention to their cheeks. 2The product was applied. After application, the skin was allowed to acclimate for 60 minutes at a temperature of 25°C and a relative humidity of 50%, and the viscoelasticity of the skin was measured using a cutometer (MPA580, Courage+Khazaka). The effect of improving skin firmness and elasticity was evaluated by calculating the percentage of improvement in firmness and elasticity using the following formula, determining the average value for 10 subjects, and judging based on the following criteria. The results are shown in the table. <Calculation formula> Firmness and elasticity improvement effect (%) = (Skin elasticity 60 minutes after application / Skin elasticity before application) × 100 <Judgment criteria> ◎: The firmness and elasticity improvement effect (%) was 150% or more. ○: The firmness and elasticity improvement effect (%) was between 150% and 120%. △: The firmness and elasticity improvement effect (%) was between 120% and 100%. ×: The firmness and elasticity improvement effect (%) was less than 100%.

[0040] <Examples 1-4 and Comparative Examples 1-5> The topical skin preparations for each formulation in Examples 1-4 and Comparative Examples 1-5 shown in Table 1 were prepared by conventional methods and evaluated using the respective test methods. The results are also shown in Table 1.

[0041] [Table 1]

[0042] As is clear from Table 1, all of the topical skin preparations in the examples using the components of the present invention are excellent The product exhibited the desired performance. On the other hand, comparative examples lacking any of the essential components were inferior in terms of squeaky feeling during use, skin moisturizing properties, or skin firmness and elasticity, and thus failed to achieve the objective of the present invention.

[0043] The following are other examples of the topical skin preparations of the present invention as formulation examples. These formulation examples of topical skin preparations were also examined for the above-mentioned characteristics regarding squeaking during use, skin moisturizing properties, and skin firmness and elasticity, and all were found to possess excellent properties.

[0044] Formula Example 1 (Beauty Serum) (by mass) 1. Niacinamide 4.0% 2. Sodium hyaluronate 0.02% 3. Peppermint leaf extract 0.01% 4. Retinyl palmitate 0.1% 5. Ascorbic acid 2-glucoside 3.0% 6. L-Ascorbic Acid Sulfate Disodium 0.7% 7. Alaria esculenta extract 0.4% 8. Aminobutyric acid 0.3% 9. Acetylglucosamine 0.01% 10. Polyoxybutylene, polyoxyethylene, polyoxypropylene Glyceryl ether (3 B.O.) (8 E.O.) (5 P.O.) 0.2% 11. Diphenylsiloxy Phenylen Trimethicone 0.8% 12. Trimethylsiloxyphenyl dimethicone 0.5% 13. Phenylentrimethicone 0.1% 14. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 1.0% 15. Polyethylene glycol (average molecular weight 4000) 1.5% 16. Polyglycerin-6 3.0% 17. Polyoxyethylene glycerin (26 E.O.) 2.0% 18. Glycerin 10.0% 19. Dipropylene glycol 1.0% 20. Diglycerin 3.0% 21,1,3-Butylene glycol 0.5% 22. EDTA-2Na 0.01% 23. Xanthan gum 0.25% 24. Carboxyvinyl polymer 0.1% 25. Alkyl-modified carboxyvinyl polymer 0.01% 26. Hydroxyethylethylenediaminetriacetate trisodium 0.001% 27. PEG-60 Hydrogenated Castor Oil 0.5% 28. Polysorbate 20 0.2% 29. Citric acid 0.03% 30. Sodium citrate 0.03% 31.Fragrance 0.001% 32. Phenoxyethanol 0.3% 33. Hydroxyacetophenone 0.2% 34. Methylparaben 0.5% 35.Purified water remainder

[0045] (Manufacturing method) Heat (11) to (35) to 80°C and dissolve uniformly. Then, cool to 35°C, add (1) to (10) and dissolve uniformly, then fill into containers to make a beauty serum. Prepared.

[0046] Formula Example 2 (Serum) (by mass) 1. Cyanocobalamin 0.001% 2. Niacinamide 5.0% 3. Acetylglucosamine 1.0% 4. Glycine 0.5% 5. Loquat fruit extract 0.1% 6. Lactobacillus / Lotus Seed Ferment Filtrate 0.4% 7. Sodium glutamate 0.01% 8. Sage leaf extract 0.006% 9. Polyethylene glycol (average molecular weight 1000) 0.1% 10. Sodium polyacrylate 0.2% 11. Dipropylene glycol 10.0% 12. Diglycerin 2.0% 13. Methyl Gluceth-20 1.0% 14. Alkyl-modified carboxyvinyl polymer 0.15% 15. PEG-10 Glyceryl Triisostearate 0.1% 16. (PCA / Isostearate) PEG-40 Hydrogenated Castor Oil 0.1% 17. PEG-60 Hydrogenated Castor Oil 0.1% 18. Monopotassium phosphate 0.09% 19. Disodium phosphate 0.01% 20. Methylparaben 0.005% 21. Cyclohexylglycerin 0.5% 22. Squalane 0.1% 23. PEG-11 Methyl Ether Dimethicone 0.05% 24. dl-α-tocopherol nicotinate 0.1% 25. Purified water remainder

[0047] (Manufacturing method) Heat (1) to (21) and (25) to 80°C and stir to dissolve uniformly (Solution A). Heat (22) to (24) to 80°C and stir to disperse uniformly (Solution B). Add Solution B to Solution A, disperse in a homomixer until uniform, then cool to 30°C to create the beauty serum.

[0048] Formula Example 3 (Whitening Makeup Base Cream) (by mass) 1. Arginine 0.05% 2. Yuzu Ceramide 0.01% 3. Polyvinylpyrrolidone 0.1% 4. Niacinamide 4.5% 5. Hydrolyzed collagen 0.05% 6. Rosemary leaf extract 0.005% 7. Chamomile flower extract 0.0003% 8. Japanese knotweed root extract 2.5% 9. Kiwi extract 5.0% 10. Althaea root extract 0.0007% 11. Aloe vera juice 0.85% 12. Horse Chestnut Leaf Extract 1.0% 13. Fennel fruit extract 1.0% 14. Brown algae extract 0.1% 15. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.1% 16. Dipotassium glycyrrhizinate 0.2% 17. Ascorbic acid 2-glucoside 2.0% 18. Tranexamic acid 3.0% 19. N-stearoyl-L-glutamate sodium 0.3% 20. Diglycerin 1.0% 21. Sorbitan monoisostearate 0.1% 22. PEG-10 Glyceryl Triisostearate 0.2% 23. PEG-60 Hydrogenated Castor Oil 0.9% 24. Carboxyvinyl polymer 0.1% 25. Xanthan gum 0.3% 26. Hydrophobized hydroxypropyl methylcellulose 0.01% 27. Bentonite 0.3% 28. Potassium hydroxide 0.02% 29. L-Arginine 0.01% 30. Citric acid 0.01% 31. Dipotassium phosphate 0.04% 32. Triethanolamine 0.02% 33. Ethylparaben 0.05% 34. Methylparaben 0.05% 35. Phenoxyethanol 0.5% 36,3-O-Ethyl ascorbic acid 0.01% 37. Retinyl palmitate 0.11% 38. Ethylhexyl palmitate 0.5% 39. Mineral oil 8.0% 40. Octyldodecyl myristate 2.0% 41. Squalane 0.3% 42. Tri (Caprylic, Caprin, Myristic) Glyceryl stearate 0.5% 43. Zinc Oxide 0.5% 44. Dilinoleate Di(Phytosteryl / Isostearyl / (Cetyl / Stearyl / Behenyl) 0.3% 45. Bleached beeswax 0.1% 46. ​​Sodium cetyl sulfate 0.02% 47. Phenylentrimethicone 0.7% 48. Diphenyl Trimethicone 0.05% 49.Purified water remainder

[0049] (Manufacturing method) Heat (19) to (36) and a portion of (49) to approximately 80°C and stir to dissolve uniformly (Solution A). Heat (37) to (48) to approximately 80°C and stir to dissolve uniformly (Solution B). Add Solution A to Solution B and disperse using a homomixer. Then cool and add (1) to (18) dissolved in the remainder of (49) at 40°C and dissolve further to dissolve uniformly. Cool again to 30°C to prepare the whitening makeup base cream.

[0050] Formula Example 4 (Serum) (by mass) 1. Niacinamide 4.5% 2. Sodium hyaluronate (2) 0.1% 3. Glycine 0.05% 4. Alanine 0.0001% 5. γ-aminobutyric acid 0.001% 6. Lysine 0.0001% 7. Cysteine ​​0.0001% 8. L-Arginine 0.003% 9. N-acetylglucosamine 0.01% 10. Scutellaria Baicalensis Extract 0.01% 11. Hydrolyzed collagen solution (4) 0.03% 12. Yuzu Ceramide 0.002% 13. Royal Jelly Extract 0.005% 14. Grape fruit extract 0.1% 15. L-Ascorbic Acid 2-Glucoside 0.01% 16. Royal Jelly Extract 0.005% 17. Scutellaria Baicalensis Extract 0.1% 18. Soybean extract 0.003% 19. Lotus seed lactic acid bacteria fermented liquid 1.0% 20,1,3-Butylene glycol 10.0% 21. Diglycerin 1.0% 22. Polyvinylpyrrolidone 0.1% 23. Concentrated glycerin 0.1% 24. Polyoxyethylene hydrogenated castor oil 0.05% 25. Polyoxyethylene sorbitan monolaurate (20E.O.) 0.1% 26. Sodium polyacrylate 0.01% 27. Xanthan gum 0.03% 28. Tremella fuciformis polysaccharide 0.0001% 29. Carboxyvinyl polymer 0.04% 30. Disodium EDTA 0.003% 31. Phenoxyethanol 0.5% 32. Methylparaben 0.1% 33. Vitamin A oil (1,000,000 IU / g) 0.001% 34. Corn oil 0.001% 35. Jojoba seed extract 0.1% 36. Dibutylhydroxytoluene 0.0001% 37. Triethylhexanoin 1.2% 38.Purified water remainder

[0051] (Manufacturing method) (20) to (36) were heated to 80°C and dissolved uniformly. Then, they were cooled to 35°C, (1) to (19) were added and dissolved uniformly, and then filled into containers to prepare the beauty serum.

[0052] Prescription Example 5 (Gel Cream) (Mass %) 1. Niacinamide 6.0% 2. Hydrolyzed collagen 0.2% 3. Folic acid 0.005% 4. Tranexamic acid 2.0% 5. Angelica root extract 0.5% 6. Hydrolyzed elastin 1.5% 7. St. John's wort flower / leaf / stem extract 0.1% 8. Methyl Gluceth-20 0.7% 9. Sodium pyrrolidone carboxylate 0.1% 10. Sodium polyacrylate 0.01% 11. Polyethylene glycol (molecular weight 4000) 2.0% 12. Behenyl alcohol 1.0% 13. Sodium stearoyl glutamate 0.3% 14. Carboxyvinyl polymer 0.2% 15. (Acrylates / Alkyl Acrylate) (C10-30) Crosspolymer 0.2% 16. HEDTA-3Na 0.005% 17. Citric acid 0.01% 18. Potassium hydroxide 0.22% 19. Dipropylene glycol 5.0% 20,1,3-Butylene glycol 10.0% 21. Diglycerin 0.3% 22. Glyceryl Monostearate 2.0% 23. Octyldodecyl myristate 0.5% 24. Methylpolysiloxane (6CS) 1.5% 25. Beeswax 1.0% 26. Cucumber fruit extract 0.1% 27. Tocopherol 0.04% 28. Sorbitan isostearate 0.2% 29.Pure water remainder

[0053] (Manufacturing method) (9) to (21) and (29) were heated to 80°C and uniformly dissolved (Solution A). (22) to (28) were uniformly dissolved and then heated to 80°C (Solution B). Solution A was added to Solution B, dispersed using a homomixer, and then cooled to room temperature to prepare a gel cream.

[0054] Formula Example 6 (Wrinkle Concealing Cream) (Mass %) 1. Angelica keiskei leaf / stem extract 0.07% 2. Sodium Hyaluronate 0.05% 3. Niacinamide 5.0% 4. Salicylic acid 0.01% 5. Parietaria extract 0.3% 6. Green tea leaf extract 0.0008% 7. Licorice root extract 0.09% 8. Coenzyme Q10 0.001% 9. Arnica flower extract 0.45% 10. Maltose-sucrose condensate 0.5% 11. Saccharomyces / Rice Ferment Filtrate 0.012% 12. Ethanol 15.0% 13. Polyoxyethylene (2) alkyl (12-15) phosphoric acid 0.2% 14. Polyoxyethylene(2) oleyl ether 0.5% 15. PEG-60 Hydrogenated Castor Oil 0.5% 16. Polyvinylpyrrolidone 0.1% 17. Carboxyvinyl polymer 0.014% 18. Potassium hydroxide 0.15% 19. Disodium EDTA 0.05% 20.Fragrance 0.1% 21. Phenoxyethanol 0.1% 22. Liquid paraffin 10.0% 23. Methylpolysiloxane (100 cs) 1.0% 24. Vaseline 1.0% 25. Isocetyl Myristate 0.1% 26. Diphenyl Trimethicone 1.5% 27. Tocotrienol 0.01% 28.Purified water remainder

[0055] (Manufacturing method) Add (13) to (21) to (28) and heat to 70°C to dissolve uniformly (Solution A). Heat (22) to (27) to 60°C to disperse uniformly, add to Solution A, and disperse with a homomixer. Next, add (1) to (12) and stir, fill into tube containers, and prepare the wrinkle-concealing cream.

[0056] Formula Example 7 (Skin Texture Improving Serum) (by mass) 1. Niacinamide 4.0% 2. Soybean extract 0.2% 3. Lactobacillus / Lotus Seed Ferment Filtrate 0.01% 4. Sodium chondroitin sulfate 0.1% 5. Erythritol 0.3% 6. Trimethylglycine 0.5% 7. α-Glucan Oligosaccharide 0.3% 8. Aloe vera leaf extract 0.2% 9. White birch bark extract 0.01% 10. Elderflower Extract 0.005% 11. Silk hydrolyzate 0.003% 12. Red algae extract 0.1% 13. Lactobacillus / Pear Juice Ferment Filtrate 0.1% 14. Grape leaf extract 1.0% 15. Glucosylceramide 0.2% 16. Witch hazel leaf extract 0.35% 17. Heparin-like substance 0.5% 18. Sodium Hyaluronate 0.001% 19. Calendula Flower Extract 0.05% 20.Isomerized sugar 0.1% 21. Roman chamomile flower extract 0.0001% 22. Peach leaf extract 0.0005% 23. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.6% 24. (Sodium acrylate / acryloyl acrylate) Dimethyl taurate sodium copolymer 0.6% 25. Polyquaternium-52 0.5% 26. PPG-13 Decyltetradeceth-24 0.3% 27.1,3-Butylene glycol 1.0% 28. Glycerin 2.0% 29. Diglycerin 0.5% 30. Polyethylene glycol 4000 0.01% 31. Sorbitol 3.0% 32. Maltitol 3.0% 33. Diisopropanolamine 0.05% 34. Potassium hydroxide 0.015% 35. Carboxyvinyl polymer 0.2% 36. Alkyl-modified carboxyvinyl polymer 0.02% 37. Xanthan gum 0.2% 38. Disodium EDTA 0.07% 39. Sodium pyrosulfite 0.05% 40. Isononyl Isononanoate 0.01% 41. Diisostearyl malate 1.0% 42. Cholesterol 0.1% 43. Retinyl palmitate 0.01% 44.Purified water remainder

[0057] (Manufacturing method) (1) to (39) and (44) were uniformly dissolved at 80°C, (40) to (43) were uniformly dispersed at 80°C, and then these were added. The mixture was dispersed using a homomixer and then cooled to prepare the beauty serum.

[0058] Prescription Example 8 (Sunscreen) (by mass) 1. Niacinamide 4.5% 2. Polyvinylpyrrolidone 0.2% 3. Acetylglucosamine 1.0% 4. Ethanol 5.0% 5. Dipropylene glycol 2.0% 6. Diglycerin 3.0% 7. Methoxycinnamide ethylhexyl 6.0% 8. Diethylamino hydroxybenzoyl hexyl benzoate 1.0% 9. Bis-ethylhexyloxyphenol Methoxyphenyltriazine 1.0% 10. t-Butyl methoxydibenzoylmethane 6.0% 11. Aluminum starch octenyl succinate 0.5% 12. POE·POP-modified dimethylpolysiloxane 0.8% 13. Octyldodecyl myristate 3.0% 14. Tomato seed oil 1.0% 15. Methylcyclopolysiloxane 1.0% 16. Dimethylpolysiloxane 2.2% 17. Hydrogenated lecithin 0.08% 18. Phytosterols 0.08% 19. DL-α-tocopherol acetate 0.1% 20. d-δ-tocopherol 0.0001% 21. Scutellaria baicalensis root extract 0.05% 22. Wild rose fruit extract 0.5% 23. Green algae extract 0.3% 24. Royal jelly extract 0.0001% 25. Water-soluble collagen 0.001% 26. Hydrolyzed collagen 0.001% 27. Ceramide III 0.01% 28. Hedera helix extract 0.1% 29. Ceramide NG 0.35% 30. Glycine 0.2% 31. Bentonite 0.4% 32. Disteardimonium hectorite 0.1% 33. Silica-coated zinc oxide 5.0% 34.Purified water remainder

[0059] (Preparation method) Add (1) to (3) heated to 80°C to (34) and dissolve (Solution A). Add (5), (6), (17) to (32) and heat to 80°C to disperse uniformly (Solution B). 7) to (16) were heated to 70°C to dissolve uniformly (Solution C). Solution B and Solution C were added to Solution A in order and mixed uniformly with a homomixer, then cooled to 50°C. (4) and (11) were added to the mixture and mixed further uniformly with a homomixer, then cooled to obtain the sunscreen.

[0060] Prescription Example 9 (Sheet Mask) (Mass %) 1. Niacinamide 4.0% 2. Sodium hyaluronate 0.02% 3. Peppermint leaf extract 0.01% 4. Retinyl palmitate 0.1% 5. Ascorbic acid 2-glucoside 3.0% 6. L-Ascorbic Acid Sulfate Disodium 0.7% 7. Alaria esculenta extract 0.4% 8. Aminobutyric acid 0.3% 9. Acetylglucosamine 0.01% 10. Polyoxybutylene, polyoxyethylene, polyoxypropylene Glyceryl ether (3 B.O.) (8 E.O.) (5 P.O.) 0.2% 11. Diphenylsiloxy Phenylen Trimethicone 0.8% 12. Trimethylsiloxyphenyl dimethicone 0.5% 13. Phenylentrimethicone 0.1% 14. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 1.0% 15. Polyethylene glycol (average molecular weight 4000) 1.5% 16. Polyglycerin-6 3.0% 17. Polyoxyethylene glycerin (26 E.O.) 2.0% 18. Glycerin 10.0% 19. Dipropylene glycol 1.0% 20. Diglycerin 3.0% 21,1,3-Butylene glycol 0.5% 22. EDTA-2Na 0.01% 23. Xanthan gum 0.25% 24. Carboxyvinyl polymer 0.1% 25. Alkyl-modified carboxyvinyl polymer 0.01% 26. Hydroxyethylethylenediaminetriacetate trisodium 0.001% 27. PEG-60 Hydrogenated Castor Oil 0.5% 28. Polysorbate 20 0.2% 29. Citric acid 0.03% 30. Sodium citrate 0.03% 31.Fragrance 0.001% 32. Phenoxyethanol 0.3% 33. Hydroxyacetophenone 0.2% 34. Methylparaben 0.5% 35.Purified water remainder

[0061] (Manufacturing method) Heat (11) to (35) to 80°C and dissolve uniformly. Then, cool to 35°C, add (1) to (10) and dissolve uniformly, then a cupro nonwoven fabric sheet (basis weight 50g / m²) 2 A sheet mask was prepared by impregnating it with 20 mL of [the solution].

[0062] Formula Example 10 (Sheet Mask) (Mass %) 1. Cyanocobalamin 0.001% 2. Niacinamide 5.0% 3. Acetylglucosamine 1.0% 4. Glycine 0.5% 5. Loquat fruit extract 0.1% 6. Lactobacillus / Lotus Seed Ferment Filtrate 0.4% 7. Sodium glutamate 0.01% 8. Sage leaf extract 0.006% 9. Polyethylene glycol (average molecular weight 1000) 0.1% 10. Sodium polyacrylate 0.2% 11. Dipropylene glycol 10.0% 12. Diglycerin 2.0% 13. Methyl Gluceth-20 1.0% 14. Alkyl-modified carboxyvinyl polymer 0.15% 15. PEG-10 Glyceryl Triisostearate 0.1% 16. (PCA / Isostearate) PEG-40 Hydrogenated Castor Oil 0.1% 17. PEG-60 Hydrogenated Castor Oil 0.1% 18. Monopotassium phosphate 0.09% 19. Disodium phosphate 0.01% 20. Methylparaben 0.005% 21. Cyclohexylglycerin 0.5% 22. Squalane 0.1% 23. PEG-11 Methyl Ether Dimethicone 0.05% 24. dl-α-tocopherol nicotinate 0.1% 25. Purified water remainder

[0063] (Manufacturing method) Heat (1) to (21) and (25) to 80°C and stir to dissolve uniformly (Solution A). Heat (22) to (24) to 80°C and stir to disperse uniformly (Solution B). Add Solution B to Solution A and disperse in a homomixer until uniform, then cool to 30°C to form a cotton nonwoven fabric sheet (basis weight 50g / m²). 2 A sheet mask was prepared by impregnating it with 30 mL of [the solution].

[0064] Example Formulation 11 (Sheet Mask) (Mass %) 1. Arginine 0.05% 2. Yuzu Ceramide 0.01% 3. Polyvinylpyrrolidone 0.1% 4. Niacinamide 4.5% 5. Hydrolyzed collagen 0.05% 6. Rosemary leaf extract 0.005% 7. Chamomile flower extract 0.0003% 8. Japanese knotweed root extract 2.5% 9. Kiwi extract 5.0% 10. Althaea root extract 0.0007% 11. Aloe vera juice 0.85% 12. Horse Chestnut Leaf Extract 1.0% 13. Fennel fruit extract 1.0% 14. Brown algae extract 0.1% 15. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.1% 16. Dipotassium glycyrrhizinate 0.2% 17. Ascorbic acid 2-glucoside 2.0% 18. Tranexamic acid 3.0% 19. N-stearoyl-L-glutamate sodium 0.3% 20. Diglycerin 1.0% 21. Sorbitan monoisostearate 0.1% 22. PEG-10 Glyceryl Triisostearate 0.2% 23. PEG-60 Hydrogenated Castor Oil 0.9% 24. Carboxyvinyl polymer 0.1% 25. Xanthan gum 0.3% 26. Hydrophobized hydroxypropyl methylcellulose 0.01% 27. Bentonite 0.3% 28. Potassium hydroxide 0.02% 29. L-Arginine 0.01% 30. Citric acid 0.01% 31. Dipotassium phosphate 0.04% 32. Triethanolamine 0.02% 33. Ethylparaben 0.05% 34. Methylparaben 0.05% 35. Phenoxyethanol 0.5% 36,3-O-Ethyl ascorbic acid 0.01% 37. Retinyl palmitate 0.11% 38. Ethylhexyl palmitate 0.5% 39. Mineral oil 8.0% 40. Octyldodecyl myristate 2.0% 41. Squalane 0.3% 42. Tri (Caprylic, Caprin, Myristic) Glyceryl stearate 0.5% 43. Zinc Oxide 0.5% 44. Dilinoleate Di(Phytosteryl / Isostearyl / (Cetyl / Stearyl / Behenyl) 0.3% 45. Bleached beeswax 0.1% 46. ​​Sodium cetyl sulfate 0.02% 47. Phenylentrimethicone 0.7% 48. Diphenyl Trimethicone 0.05% 49.Purified water remainder

[0065] (Manufacturing method) Heat (19) to (36) and a portion of (49) to approximately 80°C and stir to dissolve uniformly (Solution A). Heat (37) to (48) to approximately 80°C and stir to dissolve uniformly (Solution B). Add Solution A to Solution B and disperse using a homomixer. Then cool and add (1) to (18) dissolved in the remainder of (49) at 40°C and dissolve further to dissolve uniformly. Cool again to 30°C to obtain a nonwoven fabric sheet made of rayon and pulp synthetic fibers (basis weight 50g / m²). 2 A sheet mask was prepared by impregnating it with 20 mL of [the solution].

[0066] Formula Example 12 (Sheet Mask) (Mass %) 1. Niacinamide 4.5% 2. Sodium hyaluronate (2) 0.1% 3. Glycine 0.05% 4. Alanine 0.0001% 5. γ-aminobutyric acid 0.1% 6. Lysine 0.0001% 7. Cysteine ​​0.0001% 8. L-Arginine 0.003% 9. N-acetylglucosamine 0.01% 10. Scutellaria Baicalensis Extract 0.01% 11. Hydrolyzed collagen solution (4) 0.0003% 12. Yuzu ceramide 0.07% 13. Royal Jelly Extract 0.01% 14. Grape fruit extract 0.0001% 15. L-ascorbic acid 2-glucoside 1.7% 16. Royal Jelly Extract 0.005% 17. Scutellaria Baicalensis Extract 0.1% 18. Soybean extract 0.003% 19. Lotus seed lactic acid bacteria fermented liquid 1.0% 20,1,3-Butylene glycol 10.0% 21. Diglycerin 1.0% 22. Polyvinylpyrrolidone 0.1% 23. Concentrated glycerin 0.1% 24. Polyoxyethylene hydrogenated castor oil 0.05% 25. Polyoxyethylene sorbitan monolaurate (20E.O.) 0.1% 26. Sodium polyacrylate 0.01% 27. Xanthan gum 0.03% 28. Tremella fuciformis polysaccharide 0.0001% 29. Carboxyvinyl polymer 0.04% 30. Disodium EDTA 0.003% 31. Phenoxyethanol 0.5% 32. Methylparaben 0.1% 33. Vitamin A oil (1,000,000 IU / g) 0.001% 34. Corn oil 0.001% 35. Jojoba seed extract 0.1% 36. Dibutylhydroxytoluene 0.0001% 37. Triethylhexanoin 1.2% 38.Purified water remainder

[0067] (Manufacturing method) (20) to (36) were heated to 80°C and uniformly dissolved. Then, they were cooled to 35°C, (1) to (19) were added and uniformly dissolved, and then filled into containers to prepare the beauty serum. After that, the prepared beauty serum was used to make a rayon nonwoven fabric sheet (basis weight 50g / m²). 2 A sheet mask was prepared by impregnating it with 20 mL of [the solution].

[0068] Formula Example 13 (Sheet Mask) (Mass %) 1. Niacinamide 6.0% 2. Hydrolyzed collagen 0.2% 3. Folic acid 0.005% 4. Tranexamic acid 2.0% 5. Angelica root extract 0.5% 6. Hydrolyzed elastin 1.5% 7. St. John's wort flower / leaf / stem extract 0.1% 8. Methyl Gluceth-20 0.7% 9. Sodium pyrrolidone carboxylate 0.1% 10. Sodium polyacrylate 0.01% 11. Polyethylene glycol (molecular weight 4000) 2.0% 12. Behenyl alcohol 1.0% 13. Sodium stearoyl glutamate 0.3% 14. Carboxyvinyl polymer 0.2% 15. (Acrylates / Alkyl Acrylate) (C10-30) Crosspolymer 0.2% 16. HEDTA-3Na 0.005% 17. Citric acid 0.01% 18. Potassium hydroxide 0.05% 19. Dipropylene glycol 5.0% 20,1,3-Butylene glycol 10.0% 21. Diglycerin 0.3% 22. Glyceryl Monostearate 2.0% 23. Octyldodecyl myristate 0.5% 24. Methylpolysiloxane (6CS) 1.5% 25. Beeswax 1.0% 26. Cucumber fruit extract 0.1% 27. Tocopherol 0.04% 28. Sorbitan isostearate 0.2% 29.Pure water remainder

[0069] (Manufacturing method) (9) to (21) and (29) were heated to 80°C and uniformly dissolved (Solution A). (22) to (28) were uniformly dissolved and then heated to 80°C (Solution B). Solution A was added to Solution B, dispersed using a homomixer, and then cooled to room temperature. After that, a cupro nonwoven fabric sheet (basis weight 50g / m²) was prepared. 2 A sheet mask was prepared by impregnating it with 20 mL of [the solution].

[0070] Prescription Example 14 (Sheet Mask) (Mass %) 1. Angelica keiskei leaf / stem extract 0.07% 2. Sodium Hyaluronate 0.05% 3. Niacinamide 5.0% 4. Salicylic acid 0.01% 5. Parietaria extract 0.3% 6. Green Tea Leaf Extract 0.8% 7. Licorice root extract 0.09% 8. Coenzyme Q10 0.001% 9. Arnica flower extract 0.45% 10. Maltose-sucrose condensate 0.5% 11. Saccharomyces / Rice Ferment Filtrate 0.012% 12. Ethanol 15.0% 13. Polyoxyethylene (2) alkyl (12-15) phosphoric acid 0.2% 14. Polyoxyethylene(2) oleyl ether 0.5% 15. PEG-60 Hydrogenated Castor Oil 0.5% 16. Polyvinylpyrrolidone 0.1% 17. Carboxyvinyl polymer 0.014% 18. Potassium hydroxide 0.15% 19. Disodium EDTA 0.05% 20.Fragrance 0.1% 21. Phenoxyethanol 0.1% 22. Liquid paraffin 10.0% 23. Methylpolysiloxane (100 cs) 1.0% 24. Vaseline 1.0% 25. Isocetyl Myristate 0.1% 26. Diphenyl Trimethicone 1.5% 27. Tocotrienol 0.01% 28.Purified water remainder

[0071] (Manufacturing method) Add (13) to (21) to (28) and heat to 70°C to dissolve uniformly (Solution A). Heat (22) to (27) to 60°C to disperse uniformly, add to Solution A, and disperse with a homomixer. Next, add (1) to (12) and stir to make a cotton nonwoven fabric sheet (basis weight 50g / m²). 2 A sheet mask was prepared by impregnating it with 30 mL of [the solution].

[0072] Formula Example 15 (Sheet Mask) (Mass %) 1. Niacinamide 4.0% 2. Soybean extract 0.002% 3. Lactobacillus / Lotus Seed Ferment Filtrate 0.01% 4. Sodium chondroitin sulfate 1.0% 5. Erythritol 0.3% 6. Trimethylglycine 0.5% 7. α-Glucan Oligosaccharide 0.3% 8. Aloe vera leaf extract 0.2% 9. White birch bark extract 0.01% 10. Elderflower Extract 0.005% 11. Silk hydrolyzate 0.003% 12. Red algae extract 0.1% 13. Lactobacillus / Pear Juice Ferment Filtrate 0.1% 14. Grape leaf extract 1.5% 15. Glucosylceramide 0.002% 16. Witch hazel leaf extract 0.35% 17. Heparin-like substance 0.5% 18. Sodium Hyaluronate 0.001% 19. Calendula Flower Extract 0.05% 20.Isomerized sugar 0.1% 21. Roman chamomile flower extract 0.0001% 22. Peach leaf extract 0.0005% 23. Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.6% 24. (Sodium acrylate / acryloyl acrylate) Dimethyl taurate sodium copolymer 0.6% 25. Polyquaternium-52 0.5% 26. PPG-13 Decyltetradeceth-24 0.3% 27.1,3-Butylene glycol 1.0% 28. Glycerin 2.0% 29. Diglycerin 0.5% 30. Polyethylene glycol 4000 0.01% 31. Sorbitol 3.0% 32. Maltitol 3.0% 33. Diisopropanolamine 0.05% 34. Potassium hydroxide 0.015% 35. Carboxyvinyl polymer 0.2% 36. Alkyl-modified carboxyvinyl polymer 0.02% 37. Xanthan gum 0.2% 38. Disodium EDTA 0.07% 39. Sodium pyrosulfite 0.05% 40. Isononyl Isononanoate 0.01% 41. Diisostearyl malate 1.0% 42. Cholesterol 0.1% 43. Retinyl palmitate 0.1% 44.Purified water remainder

[0073] (Manufacturing method) Dissolve (1) to (39) and (44) uniformly at 80°C, add (40) to (43) which have been uniformly dispersed at 80°C, disperse in a homomixer, and then cool to form a pulp nonwoven fabric sheet (basis weight 50g / m²). 2 A sheet mask was prepared by impregnating it with 20 mL of [the solution].

[0074] Formula Example 16 (Sheet Mask) (Mass %) 1. Niacinamide 4.5% 2. Polyvinylpyrrolidone 0.2% 3. Acetylglucosamine 1.0% 4. Ethanol 5.0% 5. Dipropylene glycol 2.0% 6. Diglycerin 3.0% 7. Methoxycinnamide ethylhexyl 6.0% 8. Diethylamino hydroxybenzoyl hexyl benzoate 1.0% 9. Bis-ethylhexyloxyphenol Methoxyphenyltriazine 1.0% 10. t-Butyl methoxydibenzoylmethane 6.0% 11. Aluminum starch octenyl succinate 0.5% 12. POE·POP-modified dimethylpolysiloxane 0.8% 13. Octyldodecyl myristate 3.0% 14. Neopentyl glycol dicaprate 1.0% 15. Methylcyclopolysiloxane 1.0% 16. Dimethylpolysiloxane 2.2% 17. Hydrogenated lecithin 0.08% 18. Phytosterols 0.08% 19. DL-α-tocopherol acetate 0.1% 20. d-δ-tocopherol 0.0001% 21. Scutellaria baicalensis root extract 0.05% 22. Wild rose fruit extract 0.5% 23. Green algae extract 0.3% 24. Royal jelly extract 0.0001% 25. Water-soluble collagen 0.001% 26. Hydrolyzed collagen 0.001% 27. Ceramide III 0.01% 28. Hedera helix extract 0.1% 29. Ceramide NG 0.35% 30. Glycine 0.2% 31. Bentonite 0.4% 32. Disteardimonium hectorite 0.8% 33. Silica-coated zinc oxide 1.0% 34.Purified water remainder

[0075] (Manufacturing Method) In addition to adding (34) heated to 80°C in (1) to (3), dissolve it (Solution A). Add (5), (6), and (17) to (32), heat to 80°C, and disperse uniformly (Solution B). Heat (7) to (16) to 70°C and dissolve uniformly (Solution C). Add Solution B and Solution C to Solution A in sequence, mix uniformly with a homomixer, and then cool to 50°C. Add (4) and (11) thereto, mix more uniformly with a homomixer, and then cool to impregnate a non-woven fabric sheet of the cupler (basis weight 50 g / m 2 ) with 20 mL to prepare a sheet mask.

Claims

1. A topical skin preparation containing the following (A) to (C). (A) Niacinamide 0.1-6% by mass (B) One or more selected from polyvinylpyrrolidone, sodium polyacrylate, and xanthan gum: 0.01 to 1.0% by mass (C) One or more selected from acetylglucosamine, hyaluronic acid and its derivatives, and hydrolyzed collagen solution, in a quantity of 0.0001 to 0.5% by mass.

2. A topical skin preparation according to claim 1, comprising the following (D). (D) One or more vitamins selected from vitamins A, B (excluding component (A)), C, E and their derivatives: 0.0001 to 0.5% by mass

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