Oral components

Abstract

To provide an oral composition that contains a water-soluble copper salt and has a reduced metallic taste.SOLUTION: An oral composition contains a water-soluble copper salt, as well as Angelica acutiloba extract, Paeonia lactiflora extract, Salvia officinalis extract, and / or Panax ginseng extract, so that a metallic taste derived from the water-soluble copper salt is reduced, and a good feeling of use is achieved.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oral composition containing a water-soluble copper salt and having suppressed metallic taste.

Background Art

[0002] Water-soluble copper salts such as copper gluconate are known to have a deodorizing effect and are widely used in oral compositions such as dentifrices and mouthwashes for the purpose of preventing bad breath. On the other hand, oral compositions containing water-soluble copper salts have the drawback of a lingering metallic taste after use.

[0003] Therefore, conventionally, various studies have been conducted on formulation techniques for suppressing the metallic taste in oral compositions containing water-soluble copper salts. For example, Patent Document 1 describes that an oral composition containing a water-soluble copper salt, benzyl alcohol, and xylitol and / or erythritol in a predetermined ratio can suppress the metallic taste. Further, Patent Document 1 describes that an oral composition containing a water-soluble copper salt and propylene glycol alginate in a predetermined ratio has an excellent persistence of bad breath suppressing effect and can suppress the metallic taste.

[0004] The required characteristics for the functionality of oral compositions are increasing year by year, and since it is also necessary to cope with the diversification of the formulations of oral compositions, the development of a new formulation capable of suppressing the metallic taste of oral compositions containing water-soluble copper salts is desired.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0007] The inventors of the present invention conducted diligent research to solve the aforementioned problems and discovered that by incorporating Angelica acutiloba extract, Paeonia lactiflora extract, Sage extract, and / or Carrot extract together with a water-soluble copper compound in an oral composition, the metallic taste caused by water-soluble copper salts can be suppressed, and an excellent user experience can be provided. The present invention was completed by further research based on this finding.

[0008] In other words, the present invention provides inventions in the following embodiments. Item 1. An oral composition comprising (A) a water-soluble copper salt, and (B) at least one plant extract selected from the group consisting of Angelica acutiloba extract, Paeonia lactiflora extract, Salvia officinalis extract, and Carrot extract. Item 2 The oral composition according to Item 1, wherein the component (A) is copper gluconate. Item 3. A method for suppressing metallic taste caused by water-soluble copper salts in an oral composition containing water-soluble copper salts, A method for suppressing metallic taste, comprising: (A) a water-soluble copper salt; and (B) at least one plant extract selected from the group consisting of Angelica acutiloba extract, Paeonia lactiflora extract, Salvia officinalis extract, and Carrot extract, in an oral composition. [Effects of the Invention]

[0009] According to the present invention, in an oral composition containing a water-soluble copper salt, the metallic taste caused by the water-soluble copper salt is suppressed, thus providing an excellent user experience. [Modes for carrying out the invention]

[0010] 1. Oral composition The oral composition of the present invention is characterized by containing (A) a water-soluble copper salt and (B) at least one plant extract selected from the group consisting of Angelica acutiloba extract, Paeonia lactiflora extract, Salvia officinalis extract, and Carrot extract. The oral composition of the present invention will be described in detail below.

[0011] [Water-soluble copper salt] The oral composition of the present invention contains a water-soluble copper salt (sometimes referred to as component (A)). A water-soluble copper salt is a water-soluble organic or inorganic salt of copper.

[0012] The type of water-soluble copper salt used in the present invention is not particularly limited, as long as it is applicable in the oral cavity, but examples include copper gluconate, copper sulfate, copper chloride, copper citrate, copper nitrate, copper acetate, copper lactate, copper butyrate, copper formate, copper phosphate, copper malate, copper succinate, copper malonate, copper maleate, and the like.

[0013] These water-soluble copper salts may be used individually or in combination of two or more. Among these water-soluble copper salts, copper gluconate is particularly preferred.

[0014] The content of component (A) in the oral composition of the present invention can be appropriately set depending on the form of the oral composition, the type of water-soluble copper salt used, the degree of deodorizing effect to be imparted, etc., but for example, the total amount of the water-soluble copper compound can be 0.0001 to 5% by weight, preferably 0.0001 to 1% by weight, and more preferably 0.001 to 0.1% by weight.

[0015] [Angelica extract, peony extract, sage extract, and / or carrot extract] The oral composition of the present invention contains, in addition to a water-soluble copper salt, at least one plant extract (sometimes referred to as component (B)) selected from the group consisting of Angelica acutiloba extract, Paeonia lactiflora extract, Salvia officinalis extract, and Carrot extract. In the oral composition of the present invention, these plant extracts play a role in suppressing the metallic taste caused by the water-soluble copper salt.

[0016] Tokuki is a perennial herb belonging to the genus Angera acutiloba of the family Apiaceae. Tokuki extract can be obtained by subjecting the roots of Tokuki or its related plants (Umbelliferae) to extraction after removing, if necessary, the soluble portions of n-hexane and / or n-butanol. That is, in the present invention, Tokuki extract includes not only extracts of Tokuki but also extracts of related plants of Tokuki.

[0017] Shakuyaku is a perennial herb belonging to the genus Paeonia of the family Paeoniaceae, with the scientific name Paeonia lactiflora. Shakuyaku extract can be obtained by subjecting the roots of Shakuyaku or its related plants (Paeoniaceae) to extraction. That is, in the present invention, Shakuyaku extract includes not only extracts of Shakuyaku but also extracts of related plants of Shakuyaku.

[0018] Sage is a perennial herb or evergreen shrub belonging to the genus Salvia of the family Lamiaceae, with the scientific name Salvia officinalis. The sage extract used in the present invention can be obtained by subjecting the whole herb or leaves (preferably leaves) of sage to extraction.

[0019] Ginseng is a perennial herb belonging to the genus Panax of the family Araliaceae, also known as Otaneninjin (Japanese name), with the scientific name Panax ginseng. Ginseng extract can be obtained by subjecting the whole herb or roots (preferably roots) of ginseng to extraction.

[0020] The extraction process for obtaining the plant extract may be any common extraction method used in the production of ordinary plant extracts. Also, the plant raw materials of the plant extract may be in their raw state as they are, or may be subjected to pretreatment such as grinding, cutting, steaming, kneading, drying, roasting, etc., if necessary.

[0021] The extraction process can be carried out by solvent extraction, supercritical extraction, steam distillation, etc. Among these, preferably solvent extraction is mentioned.

[0022] The extraction solvent used in the solvent extraction process may be appropriately selected according to the type of plant. For example, water; lower alcohols having 1 to 4 carbon atoms such as methanol, ethanol, n-propanol, isopropanol, n-butanol, etc.; polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, etc.; mixtures thereof, etc. can be mentioned. More specifically, in the case of ginger extract, peony extract, and carrot extract, as the extraction solvent, preferably, water, polyhydric alcohol, and mixtures thereof; more preferably, water, 1,3-butylene glycol, and mixtures thereof; still more preferably, a mixture of water and 1,3-butylene glycol can be mentioned. Also, in the case of sage extract, as the extraction solvent, preferably, water, lower alcohol, and mixtures thereof; more preferably, water, ethanol, and mixtures thereof; still more preferably, a mixture of water and ethanol can be mentioned.

[0023] When using a mixed solvent of water and a lower alcohol as the extraction solvent, the content of the lower alcohol in the mixed solvent is, for example, 10 to 99% by volume, preferably 20 to 99% by volume, more preferably 30 to 95% by volume, still more preferably 40 to 95% by volume. Also, when using a mixed solvent of water and a polyhydric alcohol as the extraction solvent, the content of the polyhydric alcohol in the mixed solvent is, for example, 10 to 90% by volume, preferably 20 to 80% by volume, more preferably 30 to 70% by volume, still more preferably 40 to 60% by volume.

[0024] The solvent extraction process may be carried out by immersing or refluxing the plant raw material in the extraction solvent. After the extraction process, the solid matter is removed by solid-liquid separation to obtain an extract of the plant. The obtained extract may be used as an extract as it is, or if necessary, part or all of the solvent may be removed and used as a concentrated extract or a dried extract.

[0025] In the oral composition of the present invention, component (B) may be selected from Angelica acutiloba extract, Paeonia lactiflora extract, Salvia officinalis extract, and Carrot extract and used alone, or two or more of these may be used in combination.

[0026] The content of component (B) in the oral composition of the present invention may be set appropriately depending on the form of the oral composition, the type of plant extract used, etc., but for example, 0.0001 to 1% by weight of component (B) on a dry weight basis is possible. From the viewpoint of more effectively suppressing the metallic taste caused by water-soluble copper salts, the content of component (B) in the oral composition of the present invention (on a dry weight basis) is preferably 0.001 to 0.5% by weight, more preferably 0.01 to 0.2% by weight. In the present invention, the dry weight basis of component (B) refers to the value obtained by converting the components derived from plant raw materials in the plant extract to dry weight (dry solid content), and if the plant extract contains solvents, excipients, etc., it refers to the value equivalent to the weight excluding these.

[0027] In the oral composition of the present invention, the ratio of component (A) to component (B) is determined according to the respective content of each component, but for example, per 1 part by weight of component (A), component (B) is 0.001 to 100 parts by weight, preferably 0.1 to 50 parts by weight, and more preferably 1 to 20 parts by weight on a dry weight basis.

[0028] [Other ingredients] The oral composition of the present invention may contain other pharmacoactive ingredients as needed, in addition to the components described above. Such pharmacoactive ingredients are not particularly limited as long as they can be incorporated into pharmaceuticals, oral care products, etc., but examples include bactericidal ingredients, bronchodilators, antitussives, expectorants, anti-inflammatory agents, glucosyltransferase inhibitors, plaque inhibitors, hypersensitivity inhibitors, tartar preventives, antipyretic analgesics, antihistamines, bactericides, gastric mucosal protectants, caffeines, vitamins, herbal medicines, and crude drug components.

[0029] Furthermore, the oral composition of the present invention may contain bases and additives in order to obtain a desired formulation. Such bases and additives are not particularly limited as long as they can be incorporated into pharmaceuticals, oral care products, etc., but examples include aqueous solvents (water, lower alcohols, etc.), oily components, polyhydric alcohols, surfactants, cooling agents, preservatives, thickeners, fragrances, flavoring agents, colorants, deodorizing components (other than water-soluble copper salts), pigments, buffers, pH adjusters, etc.

[0030] [Shape / Formulation] The shape of the oral composition of the present invention is not particularly limited and may be liquid, semi-solid (gel, ointment, paste), or solid, but liquid or semi-solid is preferred.

[0031] The formulation form of the oral composition of the present invention is not limited as long as it can be applied to the oral cavity and remain there for a certain period of time. Examples include oral care products such as liquid toothpaste, toothpaste, mouthwash, oral spray (including throat spray), gargle, mouth freshener, oral paste, and gum massage cream. Among these, liquid toothpaste, toothpaste, mouthwash, and gargle are preferred, and liquid toothpaste and toothpaste are more preferred.

[0032] 2. Method for suppressing metallic taste The present invention relates to a method for suppressing metallic taste in an oral composition containing a water-soluble copper salt, characterized in that the oral composition is blended with (A) a water-soluble copper salt and (B) at least one plant extract selected from the group consisting of Angelica acutiloba extract, Paeonia lactiflora extract, Salvia officinalis extract, and Carrot extract.

[0033] In the present invention's method for suppressing metallic taste, the types and amounts of ingredients used, the shape and formulation of the oral composition, etc., are as described in section "1. Oral Composition" above. [Examples]

[0034] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

[0035] The plant extracts used in the following test examples and formulation examples are as follows. The content of each plant extract shown in Tables 1-3 below represents the content as a liquid extract. • Angelica extract The roots of Angelica acutiloba are extracted with an aqueous solution containing approximately 50% by volume of 1,3-butylene glycol, resulting in a liquid extract with a dry solid content of approximately 3.8 w / v%. Peony extract A liquid extract (with a dry solid content of approximately 4 w / v%) obtained by extracting peony root with an aqueous solution containing approximately 50% by volume of 1,3-butylene glycol. • Sage extract A liquid extract (with a dry solid content of approximately 1 w / v%) obtained by extracting sage leaves with an aqueous solution containing approximately 90% ethanol by volume. Carrot extract A liquid extract (with a dry solid content of approximately 1.3 w / v%) obtained by extracting the roots of Panax ginseng with an aqueous solution containing approximately 50% by volume of 1,3-butylene glycol.

[0036] Test Example 1 The oral compositions (liquid) shown in Table 1 were prepared. The metallic taste of the obtained oral compositions was evaluated by 10 trained subjects. Specifically, one drop of each oral composition was placed in the mouth using a dropper, and the metallic taste was evaluated using a Visual Analogue Scale (VAS) questionnaire. In the questionnaire, the left end of a 10 cm straight line was designated as "very strongly metallic taste," and the right end as "no metallic taste." Subjects were asked to mark where on the straight line their sensation fell when holding each oral composition in their mouth. The distance from the left end (0 cm) of the marked position was used as the VAS measurement value. The average of the obtained VAS measurements was used as the evaluation result for metallic taste.

[0037] The results are shown in Tables 1 and 2. Oral compositions containing copper gluconate alone exhibited a strong metallic taste (Comparative Example 1), and even when glycerin or sorbitol, which are sweeteners or masking agents, were included, the metallic taste caused by copper gluconate could not be suppressed (Comparative Examples 2 and 3). In contrast, oral compositions containing copper gluconate along with Angelica acutiloba extract, Paeonia lactiflora extract, Salvia officinalis extract, or Carrot extract suppressed the metallic taste and demonstrated excellent usability (Examples 1-8).

[0038] [Table 1]

[0039] Prescription examples Toothpastes with the compositions shown in Table 2 and liquid toothpastes with the compositions shown in Table 3 were prepared. Both of these toothpastes and liquid toothpastes had suppressed metallic taste caused by water-soluble copper salts.

[0040] [Table 2]

[0041] [Table 3]

Claims

1. (A) Contains a water-soluble copper salt, and (B) contains carrot extract. The aforementioned carrot extract is a solvent-extracted extract obtained using a mixture of water and a polyhydric alcohol as the extraction solvent. An oral composition containing 0.001 to 0.2% by weight of the aforementioned carrot extract on a dry weight basis.

2. The oral composition according to claim 1, wherein component (A) is copper gluconate.

3. A method for suppressing metallic taste caused by water-soluble copper salts in an oral composition containing water-soluble copper salts, The oral composition contains (A) a water-soluble copper salt and (B) carrot extract. The aforementioned carrot extract is a solvent-extracted extract obtained using a mixture of water and a polyhydric alcohol as the extraction solvent. A method for suppressing metallic taste, wherein the amount of carrot extract used is 0.001 to 0.2% by weight on a dry weight basis.

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