PORTABLE GAS SPRAY SYSTEM FOR MIXING AND DISPENSING MULTI-COMPONENT COMPOSITIONS

Abstract

Portable gas spray systems for mixing and dispensing multi-component compositions.

Description

PORTABLE GAS SPRAY SYSTEM FOR MIXING AND DISPENSING MULTI-COMPONENT COMPOSITIONS Related request This application claims priority of U.S. provisional application number 63 / 068,666 filed on August 21, 2020, the entirety of which is incorporated herein by reference. Background of the invention Dispensing devices, such as multi-component dispensing devices, are used to mix and dispense multi-component fluids. Multi-component fluids may be separate components that must be kept separate before dispensing. For example, several fluid components may be mixed to form a biological sealant or adhesive. Sealants and adhesives are manufactured by mixing each fluid component, which react with each other to harden or solidify after mixing. Often, the two fluid components react rapidly and harden into the sealant or adhesive, such as a tissue adhesive. Due to the rapid reactivity after contact with the components, mixing of fluid components occurs only when the multi-component fluid is ready to be dispensed and applied. Gas systems, or systems that use propellant gas, are intended for the atomization and application of fibrin sealant. For the sealant or adhesive to form correctly, each fluid component must be thoroughly mixed before applying the multi-component fluid. For example, partially mixed fluid components can result in a sealant that does not polymerize sufficiently after application. If the multi-component fluid hardens before dispensing, the dispensing device becomes clogged and impedes flow, which usually requires replacing a portion of the dispensing device. Furthermore, expelling hardened components or blockages can pose a hazard to a patient, and adhesive that clots prematurely may not adequately seal a wound. Unfortunately, existing methods for dispensing multi-component biological sealants are often inadequate. Brief description of the invention This disclosure provides a gas spray device for mixing and dispensing two-component compositions (e.g., sealant). Gas systems may be intended for atomizing and applying fibrin sealant using a propellant gas. Such systems are capable of generating a very fine spray of fibrin sealants. However, such systems generally require a hospital to maintain a supply of a large compressed gas cylinder and often require the setup of both tubing assemblies and a pressure or flow regulator, which increases the overall setup time. Furthermore, the equipment and setup time detract from ease of use.The purpose of this disclosure is to contain the pressurized gas source in the disposable device itself, eliminating the need for an external gas source, an external regulator, and any tubing assembly connections, thereby improving ease of use without compromising performance. The portable gas-assisted spray system described herein is expected to offer comparable convenience to non-gas-assisted fibrin spray devices. Furthermore, it is expected to deliver spray performance (i.e., very fine atomization) comparable to more traditional gas-assisted application devices. Specifically, the portable gas-assisted spray system does not rely on an external gas supply and does not require the maintenance of an external gas regulator. Additionally, the portable gas-assisted spray system described herein does not require connecting tubing between the regulator and the application device. Taken together, these advantages are expected to provide users with a more convenient alternative to traditional gas-assisted applicators with a less complicated setup. Another advantage of this disclosure is to provide a dispensing device (e.g., spray applicator) that prevents cross-contamination of the fluid components. Another advantage of the present disclosure is to provide a dispensing device (e.g., spray applicator) capable of spraying a two-component sealant, such as fibrin senders. The additional features and advantages of the disclosed, gas-assisted, multi-component portable dispensing applicators, systems, and methods are described in, and will be evident from, the following detailed description and figures. The features and advantages described herein are not exhaustive, and in particular, many additional features and advantages will be apparent to a person skilled in the art from the figures and description. Furthermore, any particular embodiment need not possess all the advantages listed herein. It should also be noted that the language used in this description has been selected primarily for readability and instruction, and not to limit the scope of the inventive subject matter. Brief description of the drawings Figure 1A is a perspective view of an exemplary portable gas spray system in accordance with this disclosure. Figure 1B is an exploded perspective view of the exemplary portable gas spraying system of Figure 1A. Figure 1C is an exploded perspective view of a trigger assembly in accordance with this disclosure. Figure 1D is an elevated side view of a portion of an exemplary portable gas spray system according to this disclosure. Figure 1E is a perspective view of a portion of a portable gas spraying system exemplary in accordance with this disclosure. Figure 2A is a perspective view of an exemplary portable gas spray system in accordance with this disclosure. Figure 2B is a side elevation view of the portable gas spraying system of Figure 2A. Figure 2C is a side elevation view of a portion of an exemplary portable gas spray system according to this disclosure. Figure 2D is a perspective view of an alternative embodiment of an exemplary portable gas spray system, according to this disclosure. Figure 2E is an exploded perspective view of the exemplary portable gas spraying system in Figure 2D. Figure 2F is a side elevation view of a portion of the exemplary portable gas spraying system of Figure 2D Figure 3A is an exploded side view of an exemplary gas valve assembly of this disclosure. Figure 3B is a front elevation view of the gas valve assembly of Figure 3A. Figure 3C is a cross-sectional elevation view taken along line 3C-3C of Figure 3B. Figure 4A is a side elevation view illustrating exemplary gas tube connections within an exemplary portable gas spray system in accordance with this disclosure. Figure 4B is a side elevation view illustrating exemplary gas tube connections within an exemplary portable gas spray system in accordance with this disclosure. Figure 4C is a side elevation view illustrating exemplary gas tube connections within an exemplary portable gas spray system in accordance with this disclosure. Figure 5A is an exploded perspective view of an exemplary fluid transport subassembly in accordance with this disclosure. Figure 5B is an exploded perspective view of an exemplary fluid transport subassembly in accordance with this disclosure. Figure 5C is an exploded perspective view of an exemplary fluid transport subassembly in accordance with this disclosure. Figure 6A is a front elevation view of an exemplary external cannula in accordance with this disclosure. Figure 6B is a side elevation view of an exemplary external cannula in accordance with this disclosure. Figure 7A is a front elevation view of an exemplary malleable tube according to this disclosure. Figure 7B is a side elevation view of an exemplary malleable tube according to this disclosure. in 17nn / Q7n7 / e / YiAi Figure 8A is a front elevation view of an exemplary malleable ring according to this disclosure. Figure 8B is a side elevation view of an exemplary malleable ring according to this disclosure. Figure 9A is a front elevation view of an exemplary sealing tube in accordance with this disclosure. Figure 9B is a side elevation view of an exemplary sealing tube in accordance with this disclosure. Figure 10A is a perspective cross-sectional view of an exemplary spray tip subassembly in accordance with this disclosure. Figure 10B is an elevation cross-sectional view of an exemplary spray tip subassembly in accordance with this disclosure. Figure 11A is a side elevation view of an exemplary spray tip body in accordance with this disclosure. Figure 11B is a cross-sectional elevation view of an exemplary spray tip body in accordance with this disclosure. Figure 11C is a partial view of detail 11C of the cross-sectional elevation view of Figure 11B. Figure 12A is a side elevation view of an exemplary spray tip insert in accordance with this disclosure. Figure 12B is an elevation cross-sectional view of an exemplary spray tip insert in accordance with this disclosure. Figure 12C is a cross-sectional elevation view taken along line 12C-12C of Figure 12A. Figure 12D is a cross-sectional elevation view taken along line 12D-12D of Figure 12B. Figure 13A is a perspective view of an exemplary threaded plug according to this disclosure. Figure 13B is a side elevation view of an exemplary threaded plug in accordance with this disclosure. Figure 13C is a rear elevation view of an exemplary threaded plug in accordance with this disclosure. Figure 13D is a front elevation view of an exemplary threaded plug according to this disclosure. Figure 13E is a cross-sectional elevation view of an exemplary threaded plug in accordance with this disclosure. Figure 13F is a cross-sectional elevation view taken along line 13F-13F of Figure 13D. en i znn / Qznz / e / viAi Figure 13G is a cross-sectional elevation view taken along line 13G-13G of Figure 13E. Figures 14A to 14F illustrate additional views of exemplary components of the portable gas spray systems described herein. Detailed description of exemplary modalities The portable gas spray systems for mixing and dispensing multi-component compositions described herein provide improved dispensing devices (e.g., spray applicators) that prevent clogging and cross-contamination of components up to the intended mixing point. They are particularly useful for applying high-viscosity, multi-component tissue adhesives to a surgical site. For example, clogging can be prevented by ensuring that the gas is the first fluid to enter the spray tip and the last fluid to exit. Clogging and cross-contamination of polymerized adhesives or sealants (e.g., fibrin sealant) are problematic because they can cause injury to a patient if expelled and may fail to adequately seal a wound or tissue.Furthermore, clogging and cross-contamination can increase the costs associated with dispensing applicators, as a clogged device may not function or may require a new dispensing tip. The multi-component dispensing applicator (e.g., a spray applicator) described herein improves the dispensing of multi-component fluids by preventing, resisting, mitigating, or reducing clogging and cross-contamination. The portable gas spray system described herein is a sterile, single-use device. A miniature gas cartridge (e.g., a CO2 cartridge) is contained within the device's handle. The gas cartridge is filled to a specified weight to ensure a two-phase vapor-liquid equilibrium system when the portable gas spray system is operated within a specified operating temperature range. Filling the cartridge in this manner advantageously reduces the likelihood of excessive mass flow through the flow restrictor due to the presence of saturated liquids when operating the system at high temperatures. Upon activation of the device by the user, CO2 flows to the patient-facing end of the device.Simultaneously, the two-component sealant is drawn from the syringe in the device to the spray tip. The pressurized gas and the two-component sealant mix within the spray tip, resulting in an atomized spray. For example, when the device trigger is released, the flow of the two-component sealant may stop first, followed by the gas flow. By providing a gas flow before the sealant flow and for a period after the two-component sealant flow stops, clogging can be prevented, avoided, or reduced. in 1 znn / Qznz / e / YiAi Spraying device with handle With reference to the drawings, Figures 1A, 1B, 1C, 1D, and 1E illustrate an exemplary embodiment of a portable gas spray system 100A. The portable gas spray system 100A is a direct-grip or handle-mounted spray device. The portable gas spray system 100A, which may also be referred to herein as a spray delivery device or spray applicator, includes a ratchet trigger 110a provided opposite a handle 120a. When pulled by a user, the trigger 110a activates a gas valve (described in more detail below) and pushes the syringe 130 to deliver two-component sealant through a fluid delivery subassembly 140 to a distal end of the portable gas spray system 100a.Unlike the direct-grip design, illustrated in Figures 2A and 2B (described in more detail below), several pulls of the 110a trigger of the 100A system may be required to deliver the entire contents of syringe 130 to a surgical site. However, one advantage of the portable gas spray system 100a, illustrated in Figures 1A, 1B, 1C, 1D, and 1E, is that the ratchet trigger 110a can provide fine user control in terms of incremental dispensing of the syringe contents with a relatively low gripping force. Figure 1B is an exploded view of the 100A portable gas spray system. As mentioned previously, the 100A gas spray system includes a trigger 110a, a housing 115 that can form a handle 120a, a syringe 130, and a fluid delivery subassembly 140. The housing 115 can include a right housing cover 102 and a left housing cover 104 (when viewing the 100a system from the spray tip). When housing covers 102 and 104 are joined to form the housing 115, a lower portion of the housing 115 creates the handle 120a, which is adapted to house a gas cartridge 106 held in place by a cartridge actuator knob 108. In the illustrated example, housing covers 102 and 104 can be joined by screws 103; however, other connectors or connection types may be possible, such as a press fit, a snap-fit ​​connection, or other plastic welding techniques (e.g., ultrasonic welding, etc.). Housing covers 102 and 104 can be adapted to provide points for the rigid assembly of the liquid transport subassembly 140 and the gas valve subassembly (discussed in more detail below) within system 100A. The cartridge actuator knob 108 can be captured within the lower portion of housing 115 (e.g., lower portions of covers 102 and 104), allowing rotation / translation of a gas cartridge 106 (e.g., a CO2 cartridge) contained within housing 115.In addition, the cartridge activator knob 108 and housing 115 are also adapted to prevent the complete removal of the gas cartridge 106 from the 100A system. The gas spray system 100A may also include a cam lever 112, a gas lever 114, a ratchet arm 116, and a ratchet 118 that operate in conjunction with a ratchet torsional spring 122 and a trigger torsional spring 124. The various components mentioned above may be mechanically joined by guide pins 126a to 126g, hereinafter referred to as guide pins 126. The gas spray system 100A may also include a pressure relief valve 132 in communication with a connector 134 and a tube 136 that is in fluid communication with the gas source or gas cartridge 106. In one example, the connector 134 is a male Luer locking pin connector. In addition, the 100A gas spray system may include a sliding rack 142 mechanically connected to the trigger to press the syringe plunger and a spacer 144 to physically restrict a smaller syringe in the vertical direction. The sliding rack 142 is illustrated in more detail in Figures 14A and 14B, which show the ratcheting features (e.g., notches or tabs) on the lower portion of the sliding rack 142 that are adapted to assist in pressing the syringe plunger. Figure 1C illustrates additional details of the trigger assembly, which is a linked series of components located within the device handle 120a and provided to connect the trigger 110a to a gas valve assembly 150 (as illustrated in Figures 1D and 1E) and syringe 130 (e.g., sealant syringe). As mentioned previously, the trigger assembly includes the trigger 110a, a cam lever 112, a ratchet arm 116, and a ratchet 118 that work together with a ratchet torsional spring 122 and a trigger torsional spring 124. As discussed earlier, the various components of the trigger assembly may be mechanically connected via pins 126. A small displacement of the trigger 110a rotates the cam lever 112 to fully activate the gas valve assembly 150 in its open state.Under additional displacement, the ratchet arm 116 and the ratchet 118, which may form a ratchet subassembly, move along a track, engaging a rack (not shown). The additional displacement also moves the rack along its track formed within the housing covers 102 and 104. For example, the track may be formed inside the housing covers 102 and 104. As the trigger 110a travels toward the grip handle 120a, the gas remains activated while the rack compresses the syringe 130 incrementally, delivering a portion of the sealant contained within the syringe 130 as a spray. As noted above, to reduce or prevent clogging, the gas may remain activated for a period of time after compression of the syringe 130 ceases.For example, the gas can remain activated by continuing to hold the 110a trigger in the engaged position for a period of time sufficient to remove residual sealant from the spray tip. Direct grip spray device Another exemplary embodiment of a portable gas spray system 100B is illustrated in Figures 2A, 2B, and 2C. The portable gas spray system 100B includes a handle 120b on a rear portion of the device, which slides when the user compresses it, pushing the charged syringe 130 to deliver the two-component sealant through a fluid-carrying subassembly 140. As the handle 120b slides when compressed, the user's grip simultaneously activates a trigger 110b to open a gas valve, allowing gas to flow to the distal end of the device to atomize the sealant. The user can continuously grip the system at 17nn / Q7n7 / e / YiAi 100B, which may also be referred to in this document as a spray delivery device or spray applicator, until all the contents of syringe 130 have been expelled or may temporarily stop the application and be delivered in several short bursts. Similar to system 100A, the housing 115 of system 100B may include a right housing cover 102 and a left housing cover 104. Housing covers 102 and 104 may be adapted to provide points for the rigid assembly of the liquid transport subassembly 140 and the gas valve subassembly (discussed in more detail below) within system 100B. Likewise, system 100B may include a cartridge actuator knob 108. The cartridge actuator knob 108 may be captured within the lower portion of the housing 115 (e.g., lower portions of covers 102 and 104), thereby enabling the rotation / translation of a gas cartridge 106 (e.g., a CO2 cartridge) contained within the housing 115.In addition, the cartridge activator knob 108 and the housing 115 are also adapted to prevent the complete removal of the gas cartridge 106 from the system 100b. The handle 120b at the rear of the system 100b is adapted to slide along a track formed inside the housing covers 102 and 104. The system 100b may also include a mechanical stop that prevents the removal of the handle 120b from the device. Figure 2B illustrates the system 100b with the trigger 110b and handle 120b extended together. The trigger 110b has two coaxially opposed round bushings on its left and right sides that rotatably engage with holes provided by housing covers 102 and 104, allowing rotation about a fixed axis. Specifically, as illustrated in Figure 2C, the trigger 110b is provided to be gripped by the user's fingers. In addition, the trigger 110b has a cam 152 that presses a valve stem (not shown herein, but valve stem 204 is shown in Figures 3A, 3B, and 3C) of the gas valve assembly 150, thereby opening the gas valve to activate the gas flow. The 120b handle on the back of the device moves simultaneously, supplying sealant to the spray tip for mixing with gas.The 110b trigger pivot position can be adjusted to ensure that the force required to actuate the gas valve does not exceed the force required to dispense sealant from the loaded syringe, allowing the gas to be activated before and after the sealant spray is delivered to help remove residual sealant from the device's spray tip. Figures 2D, 2E, and 2F illustrate an alternative embodiment of the exemplary 100B portable gas spray system. In the example illustrated in Figures 2D, 2E, and 2F, the handle 120b is connected to the housing 115 via a joint 220. The joint 220 allows the handle 120b to rotate around the joint (rather than slide as described for the embodiment in Figures 2A and 2B). Gas valve assembly Figures 3A, 3B, and 3C illustrate the gas valve assembly 150. In the illustrated example, the gas valve assembly 150 includes a valve body 202 (a cross-sectional view of the valve body 202 is illustrated in Figure 14C), a valve stem 204, a valve reed 206, and a puncture needle 208. A flow restrictor 210 is positioned between the valve body 202 and the valve reed 206. Additionally, the puncture needle 208 is connected to the valve body 202 with a ball bearing. 212 and a spring 214. The gas valve assembly 150 is adapted to allow controlled gas flow from the gas cartridge 106 (e.g., a miniature compressed gas cartridge) to the fluid transport subassembly 140 of the device or system 100A, 100B. In one example, the puncture needle 208, which may also be called a piercing needle, can be screwed into the valve body 202. Alternatively, the puncture needle 208 can be attached to the valve body 202 using other means of attachment (e.g., mechanical press fit, etc.). The puncture needle 208 is adapted to capture the spring 214 and ball 212 when it is screwed or otherwise installed into the valve body 202. Together, the ball 212 and spring 214 form a plug 216. In one example, the lower portion of the valve body 202 is sized to mate with a threaded gas cartridge 106 (e.g., a threaded CO2 cartridge).A cartridge sealing O-ring (not shown) may be included to prevent gas leakage during and after the puncture of the gas cartridge 106 by the puncture needle 208. An O-ring is provided as an exemplary sealing structure, but it should be noted that any suitable elastomeric seal may be placed in this location, provided it is sized to ensure that a proper seal forms before the needle 208 punctures the pressurized gas cartridge 106, thus ensuring a tight seal. Additionally, a valve stem 204 is installed in the upper bore of the valve body 202. The valve stem 204 may include packing glands, which may have two stem O-rings (not shown) installed therein, ensuring that the valve stem 204 is slip-fitted to the valve body 202 without leakage. For example, the two stem O-rings provide a slip-fit, leak-proof connection between the valve stem 204 and the valve body 202. The dimensions of the packing gland, the O-ring size, and the bore size may be conventional for this type of hinged interface and should be obvious to those skilled in the art. It should be noted that more or fewer than two sealing O-rings may be used to ensure a leak-proof interface between the valve stem and the valve body.The valve stem 204 is pressed in to move the valve from its normally closed condition to its open state. The reed 206 can be installed through a captured O-ring seal or other O-ring type seal in a side port of the valve body 202 to convey gas to a gas pipe (see gas pipe 302 in Figures 4A, 4B, and 4C). For example, the valve body 202 may have a facing (or other suitably designed recess) on its surface that matches a reed installation hole in the valve body 202 to ensure a proper seal. Additionally, a flow restrictor 210 can be installed within the reed 206 to control the downward flow of gas, ensuring a safe and functionally useful flow rate.Critically, the orifice of the 210 flow limiter is sized to ensure that the obstructed flow results in a mass flow rate that is at all times consistent with values ​​previously proven safe for use at a specified distance from the patient tissue, taking into account the vapor pressure of the compressed fluid cartridge, e.g., a CO2 cartridge. Figures 4A, 4B, and 4C illustrate the gas pipe connections between the gas cartridge 106 and the gas valve assembly 150 to the fluid transport subassembly 140. Figure 4A illustrates the gas pipe connections for system 100A, while Figures 4B and 4C illustrate alternative examples of the gas pipe connections for system 100B. As illustrated in Figures 4A and 4B, gas tube 302, which is connected to valve reed 206 at one end, leads to another reed 304 at the other end of gas tube 302. Reed 204 may be Luer-connected to a relief valve 308. The relief valve 308 is provided to ensure that excess pressure is safely vented to the environment. For example, if the downstream portion of device or system 100A, 100B becomes occluded when gas flow is activated, the relief valve 308 vents the excess pressure to the environment. In some examples, the 308 relief valve may be designed or specified by characterizing the normal operating pressure of system 100A, 100B. For example, the minimum bursting pressure of such a 308 relief valve may be greater than or equal to the normal operating pressure of the fluid path section in which the 308 relief valve is installed. Alternatively, the maximum bursting pressure of the 308 relief valve may be characterized or selected based on a specified safety limit (e.g., a clinically determined maximum safe operating pressure). For example, to determine the maximum pressure threshold, a range of pressures exceeding the normal operating pressure of the 106 compressed gas cartridge may be supplied to the 150 gas valve assembly, and the resulting impact pressure may be observed or measured at a specified distance from the device's spray tip.More generally, the 308 relief valve can be sized to ensure system pressure release in cases where upward pressure in the system would result in excessive pressure applied to the fabric at a specified distance from the spray tip. For example, the cracking pressure might be specified within a range of approximately 70 kilopascals to 110 kilopascals (kPa) of differential pressure. Additionally, the 308 release valve can be connected via a Luer slip fitting to a 310 gas filter. In some applications, the 310 gas filter may be intended to ensure that the gas is sterile and essentially particle-free before delivery to the patient. The 310 gas filter may comprise an appropriate membrane material selected based on the desired sealant and gas composition. For example, if the compressed gas is carbon dioxide and the sealant composition is aqueous, the 310 gas filter may be implemented to contain a hydrophobic membrane material (e.g., polytetrafluoroethylene (PTFE)) to ensure that wetting prevents, limits, or reduces the passage of the gas flow. Fluid Transport Subassembly The fluid transport subassembly 140 facilitates the delivery of the two surgical sealant components from the syringe 130 and a gas stream from the device handle 120 to the distal tip. Up to the spray tip subassembly 414, these three fluid streams are not in fluid communication. This is important for the functionality of systems 100A and 100B because polymerization of the two-component sealant begins rapidly after the two components converge. It is desirable to deliver a spray of well-mixed, but not yet polymerized, sealant to the target tissue site. The fluid transport subassembly 140 can have several configurations, three of which are illustrated in Figures 5A, 5B, and 5C. Figure 5A illustrates a first configuration of the fluid transport subassembly 140a that is adapted for open surgery. In one example, the fluid transport subassembly 140a can have an approximate working length of 6 cm and can generally comprise a rigid construction. As illustrated in Figure 5A, the fluid transport subassembly 140a includes sealing tubes 410a, 410b that run along the outer cannula 420 to the threaded plug 412. At the distal end 422 of the outer cannula 420, the outer cannula 420 can be attached to the threaded plug 412, providing a gastight or airtight seal. The 412 threaded plug can be attached to a 414 spray tip subassembly (e.g., threaded).At the proximal end 424 of the outer cannula 420, the outer cannula 420 may be attached to a distal component 430 of the Y-connector that provides a gastight or airtight seal between the outer cannula 420 and the distal component 430 of the Y-connector (additional views of the distal component 430 of the Y-connector are illustrated in Figures 14E and 14F). A proximal component 432 of the Y-connector can be ultrasonically welded to the distal component 430 of the Y-connector (a cross-sectional view of the proximal component 432 of the Y-connector is illustrated in Figure 14D). In one example, sealing tubes 410a and 410b, hereafter generally referred to as sealing tubes 410, are joined within two heads 434a, 434b located on the proximal component 432 of the Y-connector. The other ends of the sealing tubes 410 are attached to the corresponding receiving structures (described in more detail below) on the threaded plug 412. A gas connection port 440 can be provided on the bottom of the distal component of the Y-connector 430, allowing connection to the gas filter 310 described in Figures 4A and 4B. The 310 gas filter can be connected to the 440 gas connection port via a Luer lock connection.The fluid transport subassembly 140a may also include check valves 450a and 450b, which can be installed in the corresponding female Luer locking connections 436a and 436b of the Y-connector proximal component 432 to prevent backflow into syringe 130 under pressure. It should be noted that the female Luer connections 436a and 436b of the Y-connector proximal component 432 can be positioned with a predetermined axial offset corresponding to the outlet spacing of the syringe 130 to be used. Figure 5B illustrates a second configuration of the fluid transport subassembly 140b that is adapted for laparoscopic surgery. For example, laparoscopic surgical procedures may require a longer cannula 420, as illustrated in Figures 5B and 5C, while procedures closer to the skin surface may use a shorter cannula 420, as illustrated in Figure 5A. In one example, the fluid transport subassembly 140b may have an approximate working length of 40 cm and may generally comprise a rigid construction. As illustrated in Figure 5B, the fluid transport subassembly 140b includes each of the components described above in subassembly 140a. However, the sealing tubes 410a, 410b and the cannula on the outside 420 are longer, so the fluid transport subassembly 140b has a longer working length. Figure 5C illustrates a third configuration of the fluid transport subassembly 140c that is adapted for laparoscopic surgery. In one example, the fluid transport subassembly 140c may have an approximate working length of 40 cm and generally comprises a rigid construction with a malleable section that allows the device to be bent at its distal end for placement during laparoscopic surgery. As illustrated in Figure 5B, the fluid transport subassembly 140b includes each of the components described above in the subassembly 140a. However, the sealing tubes 410a, 410b, and the outer cannula 420 are longer, similar to the fluid transport subassembly 140b, so that the fluid transport subassembly 140c has a longer working length.In addition, the fluid transport subassembly 140c includes an additional malleable tube 460 and a malleable ring 470 positioned between the outer cannula 420 and the threaded plug 412. For example, instead of the distal end 422 of the outer cannula 420 being attached to the threaded plug, as in Figure 5A, the distal end 422 of the outer cannula 420 can be coupled or attached to the malleable tube 460, which is coupled or attached to the ring 470. For example, a proximal end 464 of the malleable tube 460 can be connected to the distal end 422 of the outer cannula 420, and a distal end 462 of the malleable tube 460 can be connected to a proximal end 474 of the ring 470. Furthermore, a distal end 472 of the ring 470 can be connected to the threaded plug 412. The ring 470 can be Attach to the 412 threaded plug, providing a gas-tight or airtight seal. Similar to the 140a and 140b subassemblies, the 412 threaded plug can be attached to a 414 spray tip subassembly. The entire malleable section (e.g., malleable tube 460 and ring 470) can be approximately 4.5 cm long, and therefore the outer cannula 420 is shortened relative to the sealing tubes 410a, 410b compared to the fluid transport subassembly 140b. Referring back to Figure 5B, the sealing tubes 410a, 410b, and subsequently the sealing tubes 410, can be approximately the same length as the combined length of the distal Y-connector component 430 and the outer cannula 420. However, the sealing tubes 410 in Figure 5C can be approximately the same length as the combined length of the distal Y-connector component 430, the outer cannula 420, the malleable tube 460, and the ring 470. In each of Figures 5A, 5B, and 5C, the first and second sealing tubes 410 provide seamless communication between fluid containers, such as syringe 130 and, ultimately, the spray tip subassembly 414. The fluids travel, while separated, from syringe 130, through the check valves 450, before entering the proximal Y-connector component 432 and passing through the sealing tubes 410. The fluids remain completely separated as they travel through the system to the threaded plug 412. The fluids then travel to the detachable spray tip subassembly 414, which can be removably attached to the threaded plug 412. Although systems 100A and 100B are shown with interfaces for receiving two fluid sources, it should be appreciated that systems 100A and 100B can be configured to receive more than two fluid sources (e.g., sealant).For example, systems 100A and 100B can be configured to mix and dispense an adhesive or sealant, such as a biological sealant composed of three or more component fluids. It should also be noted that systems 100A and 100B can include additional interfaces (e.g., syringe interfaces) for additional fluid containers. For example, the systems 100A and 100B illustrated herein show a two-component syringe 120 with two discrete sealing tubes 410; however, three or more fluid containers and / or sealing tubes 410 can be used. For example, some multi-component fluids may include three or more fluids that are mixed to form a sealant or adhesive. Furthermore, it should be noted that systems 100A and 100B can be configured to receive a single fluid source (e.g., a one-component sealant).For example, the 100A and 100B systems can be configured to dispense a one-component adhesive. It should be noted that the 100A and 100B systems can include a single interface for a single fluid container. For example, the 100A and 100B systems illustrated herein show a two-component syringe 120 with two discrete sealing tubes 410; however, a single fluid container and / or sealing tube 410 can be used. Outer cannula, malleable tube, sealing ring and tubes Figures 6A and 6B illustrate the end and side profiles of the outer cannula 420. The outer cannula 420 can have an inside diameter (Di) 502, an outside diameter (Do) 504, and a length (Loe) 506. The inside diameter (Di) 502 can be approximately 5 mm, and the outside diameter (Do) 504 can be approximately 5.30 mm. The length (Loe) 506 can vary depending on the configuration of the fluid transport subassembly 140. For example, the length (Loe) 506 can be approximately 63 mm, 401 mm, and 342 mm for subassemblies 140a, 140b, and 140c, respectively. In one example, the outer cannula 420 can be made from a rigid material, such as 304 stainless steel. Figures 7A and 7B illustrate an extreme and cross-sectional profile of malleable tube 460. Malleable tube 460 may have an inside diameter (Di) 512, an outside diameter (Do) 514, a length (Lmt) 516, and a wall thickness (Tw) 518. The inside diameter (Di) 512 may be approximately 4 mm, and the outside diameter (Do) 514 may be approximately 5 mm. The length (Lmt) 516 may be approximately 65 mm. The wall thickness (Tw) 518 of malleable tube 460 may be approximately 0.5 mm. In addition, malleable tube 460 may include an opening or channel 530 extending along the length of the malleable tube 460, sized and shaped to receive a cable 532. The channel 530 may have a diameter of approximately 0.75 mm. The separation (Se) 534 between a longitudinal axis 542 of the channel 530 and a longitudinal axis 544 of the tube 460 can be approximately 1.7 mm. The 532 wire can be used as reinforcing wire to add strength and support to the 460 malleable tube. Furthermore, the 532 wire can be shaped to provide malleability to the 460 tube while maintaining its shape. The 532 wire can be a malleable wire and can be made of stainless steel. The 460 malleable tube can be made of a malleable plastic or rubber material. In one example, the 460 malleable tube is made from thermoplastic polyurethane elastomer. en i znn / Qznz / e / viAi Figures 8A and 8B illustrate the end and side profiles of ring 470. Ring 470 can have an inside diameter (Di) 552, an outside diameter (Do) 554, and a length (Lmc) 556. The inside diameter (Di) 552 can be approximately 5 mm, and the outside diameter (Do) 554 can be approximately 5.30 mm. The length (Lmc) 556 can be approximately 15 mm. In one example, ring 470 can be made from a rigid material, such as 304 stainless steel. In another example, ring 470 can be made from a rigid or semi-rigid plastic material. Alternatively, ring 470 can be made from a plastic or elastomeric material similar to malleable tubing 460. Alternatively, ring 470 can be integrated as part of threaded plug 412. Figures 9A and 9B illustrate the end and side profiles of a sealing tube 410. The sealing tube 410 can have an inside diameter (Di) 562, an outside diameter (Do) 564, and a length (Lst) 566. The inside diameter (Di) 562 can be approximately 1 mm, and the outside diameter (Do) 564 can be approximately 1.78 mm. The length (Lst) 566 can vary depending on the configuration of the fluid-carrying subassembly 140. For example, the length (Lst) 566 can be approximately 93 mm, 432 mm, and 432 mm for subassemblies 140a, 140b, and 140c, respectively. In one example, the sealing tube 410 can be made from an elastic polymer, such as ethylene-vinyl acetate (EVA). Screw cap Figures 13A to 13G illustrate an exemplary embodiment of the threaded plug 412. As mentioned previously, the fluid-carrying subassembly 140a includes sealing tubes 410a, 410b that run along the outer cannula 420 to the threaded plug 412. In one example, the outer cannula 420 (or malleable ring 470) may be attached to the threaded plug 412, providing a gas-tight or airtight seal. The threaded plug 412 may be coupled to a spray tip subassembly 414. For example, the threaded plug 412 may include external threads 902 that are adapted to engage the corresponding threads (for example, the threaded portion 636 of the tip body 610). The threaded plug 412 facilitates the removable connection of the spray tip subassembly 414 to the outer cannula 420 or the malleable ring 470, depending on the configuration of the fluid delivery subassembly 140. By design, the threaded plug 412 features a cone (e.g., tapered surface 904) to seal against an internal surface of the spray tip body 610, preventing leakage of the pressurized fluid mixture. Furthermore, the threaded plug 412 may include two sealing channels 906a, 906b (hereafter generally referred to as sealing channels 906) that are adapted to receive the corresponding sealing tubes 410a, 410b at a proximal end 924 of the threaded plug 412.For example, as illustrated in Figure 13F, sealing passages 906a, 906b may include sealing tubes accepting portions 907a, 907b that are sized and shaped such that a corresponding sealing tube 410 can be press-fitted into the threaded plug 412 and / or joined within the accepting portion 907 of the threaded plug 412 to form a fluid-tight seal. The threaded plug 412 also includes one or more gas conduits 908a, 908b (hereafter generally referred to as gas conduits 908) that are adapted to allow the passage of gas from the outer cannula 420 to the spray tip subassembly 414. The gas conduits in i znn / Qznz / e / YiAi 908a, 908b and sealing channels 906a, 906b extend from the proximal end 924 to the distal end 922 of the threaded plug. At the distal end 922 of the plug 412, the gas channels 908 can be configured to open to the spray tip subassembly 414 before the sealing channels 906, thus allowing the gas to properly propagate through the spray tip before the sealant enters the spray tip, which can help to properly mix and atomize the two-component sealant. For example, as illustrated in Figure 13A, the plug 412 can include two holes 930a, 930b that allow the gas to communicate with the spray tip subassembly 414 before the sealant communicates with and enters the spray tip. In one example, each of the sealing conduits 906 and the gas conduits 908 can have a diameter of approximately 0.8 mm. The threaded plug may also include a 940 flange that is configured to serve as a plug and abut the outer cannula 420 when the threaded plug 412 is coupled to the cannula 420 (or similarly the malleable ring depending on the configuration). As the sealants travel through the sealing tubes 410a and 410b, and the gas flows through the outer cannula 420, the fluids remain completely separate as they travel through the system. This separation continues as the sealants travel through the sealing passages 906 and as the gas travels through the gas passages 908 of the threaded plug 412. Specifically, the sealing tubes 410 and the plug 412 ensure that the fluids remain isolated while traveling between the syringe 130 and the spray tip subassembly 414. The fluids (e.g., sealant components and gas) then travel to the detachable spray tip subassembly 414, which can be attached to the threaded plug 412, where the fluids begin to mix. Spray Tip Subassembly Figures 10A and 10B illustrate the spray tip subassembly 414. At the distal end of the device, the two sealant components and the gas stream are mixed within a spray tip subassembly 414, which includes a spray tip body 610 and an insert 670. The threaded plug 412 facilitates removable connection of the spray tip subassembly 414 to the outer cannula 420 or the malleable ring 470, depending on the configuration of the fluid delivery subassembly 140. By design, the threaded plug 412 has a cone to seal against an internal surface of the spray tip body 610, preventing leakage of the pressurized fluid mixture. The fluid mixture is mixed through a 670 tip insert. In one example, the 670 tip insert is non-removably assembled into the 610 spray tip body via a press fit.A turbulence chamber or spin chamber geometry (discussed in more detail below) is provided as part of the 670 tip insert, imparting rotation to the fluid mixture as it exits the 414 spray tip subassembly. The tip body 610 can be a hollow body forming a cavity 612. The size and shape of the cavity 612 together with the size and shape of the insert 670 can be selected to optimize the mixing volume and mixing characteristics of the spray tip subassembly 414. The cavity 640 can have a cavity diameter (De) 614 and a cavity depth (Cd) 616 (see Figures 11A and 11B in 17nn / Q7n7 / e / YiAi). Additionally, the 670 tip insert has a volume (Vi) and the 612 cavity has a volume (Ve), where the difference between the cavity volume (Ve) and the insert volume (Vi) creates a mixing volume (Vm) of the 414 spray tip subassembly. Adjusting the size, shape, and geometry of the components of the 414 spray tip subassembly adjusts the size of the mixing volume (Vm), as well as the geometry of the created mixing chamber.As illustrated in more detail in Figure 10B, the size and shape of the cavity 612, along with the size and shape of the insert 670, can be selected to adjust the mixing characteristics of the spray tip subassembly 414. For example, the geometry of the tip body 610 and the insert 670 can be selected to provide an optimal fluid path distance (FPdistance) 618 before the fluids impact a first contact surface 620 of the insert 670 to initiate turbulence and mixing. Adjusting the fluid path distance (FPdistance) 618, along with the geometry of the tip body 610 and the insert 670, can increase or decrease the turbulence created in the spray tip subassembly 414. Pointed body Figures 11A, 11B, and 11C illustrate various views of the tip body 610. The tip body 610 can generally be cylindrical and hollow, thus forming the cavity 612 with a wall thickness of approximately 0.4 mm. As illustrated in Figure 11B, the cavity 612 can generally be cylindrical. In some cases, the cavity 612 may be tapered such that the initial cavity diameter (De) 614a near a proximal end 624 of the tip body 610 is greater than the final cavity diameter (De) 614b near a distal end 622 of the tip body 610. The cavity diameter (De) 614a may start at approximately 4 mm and may gradually decrease as the cavity extends toward the distal end 622 of the tip body 610 until it reaches a cavity diameter (De) 614b of approximately 3.7 mm. In the illustrated example, the last section 626 of the cavity 612 may have a constant cavity diameter (De) 614b.The last section 626 may have a depth (Cdls) 628 of approximately 4 mm. As noted previously, the 100A and 100B systems may include a pre-threaded spray tip subassembly 414 and one or more replacement spray tip subassemblies 414 that are interchangeable with the original pre-threaded spray tip subassembly 414 if the original spray tip becomes clogged during use. To assist with the removal and replacement of a respective spray tip subassembly 414, the tip body 610 may include a gripping portion 630. The gripping portion 630 may include ridges, protrusions, grooves, a textured surface, or other surface finish or geometry that aids in gripping the tip body 610. In the example illustrated in Figure 11A, the gripping portion 630 may have a gripping length (Lg) 632, which may be approximately 14 mm.The distal end 622 of the tip body 610 may also include a small notch 656 projecting from an outer wall of the tip body 610 by a notch width (Wn) 658. The notch 656 may be present in the last 2 mm of the tip body 610 and may have a notch width (Wn) 658 of approximately 0.1 mm. The notch 656 may further assist the user in removing the tip subassembly from the spray gun 414. As noted above, the 610 tip body can generally be cylindrical with an outside diameter (Do) 634. In one example, the outside diameter (Do) 634 is approximately 5.3 mm. Furthermore, the threaded portion 636 can have a height (Ht) 638, where the height (Ht) 638 of the threaded portion 636 is approximately 4 mm. As illustrated in Figures 11B and 11C, the tip body 610 also includes an orifice or outlet 640 with an initial outlet diameter (Dio) 642 associated with an initial outlet portion 641, a transition outlet diameter (Dto) 644 associated with a transition outlet portion 643, and an end outlet diameter (Dfo) 646 associated with an end outlet portion 645. Similarly, each of the initial outlet portions 641, the transition outlet portion 643, and the end outlet portion 645 may have associated heights (Hip) 650, (Htp) 652, and (Hfp) 654, respectively. The height (Hip) 650 of the initial outlet portion 641 may be approximately 0.23 mm. The height (Htp) 652 of the transition outlet portion 643 can be approximately 0.6 mm. In addition, the height (Hfp) 654 of the final outlet portion 645 can be approximately 0.2 mm.The transition outlet diameter (Dto), taken in conjunction with the turbulence chamber geometry described below, can critically control the width and uniformity of the resulting spray pattern. The geometry (e.g., heights and diameters) of the outlet portions can be configured to produce a preferred spray geometry or based on the materials used in the 100A and 100B systems. Tip insert The tip insert 670 acts as a static mixing element within the spray tip subassembly 414. The tip insert 670 is illustrated in more detail in Figures 12A and 12B, which show that the insert 670 has a generally cylindrical body or stem 700 with a plurality of mixing protrusions 702 (for example, mixing protrusions 702a to 702d are visible in Figure 12A). The mixing protrusions in the illustrated example are triangular in shape with a base length (Lbase) 704 and an internal angle (β) 706. The base length (Lbase) 704 can be approximately 2.9 mm long and the internal angle (β) 706 can be approximately 60 degrees. The mixing protrusions 702 can be evenly distributed around the tip insert 670. In the illustrated example, the mixing protrusions 702 are separated by a gap (Sme) 703 (e.g., gap 703a, 703b, and 703c).The separation (Sme) 703 can be approximately 0.5 mm. In one example, the plurality of blending protrusions 702 can be positioned around the cylindrical trunk 700. In the illustrated example, the tip insert 670 includes three pairs of protrusions 720 in a staggered cross pattern such that the first set of protrusions (protrusions 702a and the other protrusion opposite 702a, but not visible in Figure 12A) form a T near the proximal end 734, and the next set of protrusions 702 (e.g., protrusions 702b and 702c) can be oriented in a different circumferential position around the tip insert 670. In one example, the second set of blending protrusions 702 can be oriented 90 degrees from the first set. In one example, the 720 blend protrusions can be oriented in different circumferential positions (e.g., 30 degrees, 45 degrees, etc.) The cylindrical stem 700 has a diameter (Db) 710 and a height (Hb) 712. The body mixing diameter (Dbm) 714, which is the diameter of the tip insert 670, including the mixing protrusions 702, can be approximately 3.6 mm. In one example, one or more of the mixing protrusions 702 may include a retention feature 720, which may be a protrusion, tab, or notch that creates a tight friction fit between the tip insert 670 and the tip body 610. In one example, the retention features 720 may be crushing ridges that ensure the insert 670 does not detach from the tip body 610 during the device's life or during use and that also ensure the tip insert 670 is able to withstand the pressure built up by the fluid within the turbulence chamber (described in more detail below). The retention features 720 may result in the insert 670 having an overall width (Retention) 795 of approximately 3.8 mm, which is greater than the diameter (De) 614b (referring to Figure 11B) by approximately 0.1 mm.The friction fit of the clamping features 720 is illustrated in more detail in Figure 10B, which shows that a portion of the tip insert 670 is oversized for the corresponding cavity 612 of the tip body 610. In the illustrated example, retention feature 720 is a rectangular structure with a retention height (Hr) 722 and a retention width (Wr) 724. In one embodiment, the retention height (Hr) 722 may be approximately 1.0 mm and the retention width (Wr) 724 may be approximately 1.2 mm. In the illustrated example, retention feature 720 is separated from the proximal end 734 of the tip insert 670 by a separation (Srf) 750, which may be approximately 7.8 mm. In addition, the retention feature 720 may include an inclined profile that aids alignment during installation by friction fit with the tip insert 670, since the tip insert 670 is press-fitted into the tip body 610. As illustrated in Figures 12A and 12B, the retention feature 720 may have an inclined portion 754 and a flat portion 756, where the flat portion has a mating surface with a height (Hes) 752. The tip insert 670 may have a proximal end 734 and a distal end 732 closer to the orifice or outlet 640 of the tip body 610. The mixing tip insert 670 may have a blunt or flat fluid contact surface at the proximal end 734, which may be the first surface of the tip insert 670 encountered by the multi-component sealant. Additionally, the tip insert 670 may include a swirl chamber portion 740 near the distal end 732 of the tip insert 670. The swirl chamber portion may have a diameter (Dsc) 742 of approximately 3.7 mm and a height (Hsc) 744 of approximately 1.5 mm. The geometry (e.g., height and diameter) of the turbulence chamber can be configured to produce a preferred spray geometry or based on the materials used in the 100A, 100B systems. As mentioned previously, the 670 mixing tip insert can have a blunt or flat fluid contact surface at the proximal end 734. For example, the contact surface can be the first surface around which both fluids come into contact and flow, which initially can create turbulence in the 414 spray tip subassembly, and where fluid mixing begins. It should be noted that other mixing geometries can be used; for example, the 670 tip insert can include helical, triangular, or rectangular features, etc. Additionally, other mixing structures such as grids or matrices can be used. Furthermore, the mixing structure can be omitted entirely, for example, when used with a sealant that requires limited mixing before application. As the gas and two-component sealant are pushed through the applicator or device (e.g., system 100A, 100B), the various components of the sealant and gas enter the spray tip subassembly 414 and begin to mix within the cavity 612 due to interactions with the tip insert 670. As more fluid (e.g., gas and sealant) enters the spray tip subassembly 414, the mixed fluid is pushed from the cavity 612 through the outlet orifice 630 of the tip body 610. Before exiting through the outlet orifice 630, the fluid travels through a turbulence chamber 800, illustrated in more detail in Figure 12C. In one example, the spray tip 414, spray tip insert 470, and threaded plug components 412 may be made from a radiopacified resin to allow visualization under X-ray imaging (e.g., 20% weight loading of barium sulfate). Turbulence chamber Returning to Figure 12A (and also visible in Figure 10A), the tip insert 670 includes the channels 780 (e.g., channels 780a and 780b visible in Figure 12A) formed within the portion 740 of the turbulence chamber. The channels 780 direct the mixed fluid toward the distal end 732 of the tip insert and into the corresponding horizontal channels 802 of the turbulence chamber 800, as illustrated in Figure 12C. The horizontal channels 802 serve as feed channels that direct the mixed fluid tangentially to the turbulence chamber 800, which may also be referred to as the spin chamber. The channels 802 or conduits may narrow as they approach the turbulence chamber 800. For example, each channel 802 may narrow at a constant velocity or angle (a) 806, which may be approximately 15 degrees. As the channels 802 reach the turbulence chamber, they may have a channel width (Wc) 808 of approximately 0.4 mm and a channel depth of approximately 0.5 mm. The channels 802 may have trapezoidal cross-sections that gradually decrease in cross-sectional area as they approach the turbulence chamber 800 of the tip body 610. The reduced cross-sectional area increases the velocity of the fluid entering the turbulence chamber 800.As the pressurized fluid mixture enters the turbulence chamber 800, the increase in speed and angular / tangential focus caused by the channels 802 advantageously forms a vortex, which improves the mixing and nozzle performance in the spray orifice 630. The number of channels 780 and 802 may depend on the preferred spray geometry or the materials used in the spray tip subassembly 414. For example, the number of channels 780 and 802 may be determined based on the viscosity and preferred volumetric flow rate of the fluid entering the swirl chamber 800. In the example illustrated in Figure 12C, the swirl chamber 800 is fed by four channels 802. For example, four feed channels 802 may be more effective compared to another channel configuration when used with a higher viscosity fluid, such as the fibrinogen in a fibrin sealant product. The turbulence chamber 800 and the corresponding channels 802 may include rounded corners to aid in malleability. For example, the edges 812 where a channel 802 meets the turbulence chamber 800 may be rounded with a radius of approximately 0.05 mm. The diameter of the turbulence chamber (Dsc) 820 can be approximately 1.6 mm. Furthermore, the diameter of the turbulence chamber (Dsc) 820, the geometry of the channels 780 and 802, along with other features of the spray tip subassembly 414, can control the velocity of the fluid exiting the spray tip. As mentioned previously, the insert 670 has a retention feature 720, such as crushing lugs, which ensure that the insert 670 does not detach from the tip body 610 during storage or use. Mingle As noted previously, the 130 syringe can be a multi-chamber syringe that includes multiple chambers or containers (e.g., first and second fluid containers, like syringes). The 130 syringe can contain reactive fluids. For example, the 130 syringe can include a first fluid and a second fluid. The fluids can react to create a sealant or adhesive, such as a biological tissue sealant. Due to the reactivity of the fluids, they are stored separately in different chambers or containers within the 130 syringe, and fluid separation is maintained through the various system components to a desired mixing point within the removable spray tip subassembly 414. Particularly reactive multi-component fluids tend to clot shortly after the fluid pathways join and mix within the applicator.For example, with reactive solutions such as biological tissue sealants, the residence time for clot formation can be short, in many cases only seconds. Therefore, it is advantageous to maintain fluid separation until the desired mixing point to prevent premature coagulation. Additionally, it is advantageous to provide a removable or detachable 414 spray tip subassembly, which can be replaced if clogging occurs during or between uses. The geometry of insert 670, and more specifically, the diameter of insert 670, as well as the geometry of the mixing protrusions 702, can control the cross-sectional area through which the fluid stream passes as it travels through the spray tip subassembly 414. The geometry can also control the fluid velocity and the injection pressure required to pass through the spray tip subassembly 414. The mixing protrusions 702 can create turbulence in the fluid path, allowing different fluid streams to mix and create a combined fluid stream before entering the turbulence chamber 800. For example, the number of mixing protrusions 702, as well as other geometric considerations of the tip body 610 and tip insert 670, can be determined based on the physical properties of the fluid (e.g., viscosity, density, etc.).) and the required mixing level before entering the turbulence chamber 800 at 17nn / Q7n7 / e / YiAi. The 100A and 100B systems described herein advantageously produce a well-mixed reactive sealant formulation that exits the 414 spray tip subassembly with a uniform spray pattern to rapidly cover a target surgical site. Components - Connections It should be noted that many of the components described herein may be components that can be assembled together. For example, each component of systems 100A and 100B may be removably attached to the other such that each component may be disassembled and reassembled. In addition, components may be joined together by chemical fasteners. Chemical fasteners may include, for example, adhesives, chemical bonds, solder joints, or molds suitable for securing components. For example, each of the components illustrated in Figures 5A, 5B, and 5C may be joined, coupled, or connected by means of a threaded fitting, press fit, adhesive, or any other suitable fastener, so that each component is connected and maintains smooth communication from the syringe 130 to the detachable spray tip subassembly 414. In other examples, component parts may be molded as a single piece. Mounting For a rigid device configuration, and more specifically when assembling the fluid transport subassembly 140, the sealing tubes 410 are cut to size and joined to the threaded plug 412. For example, the sealing tubes 410 can be joined to the threaded plug 412 by applying a small amount of adhesive, such as cyanoacrylate, to the outer surface of the sealing tube 410 and inserting the sealing tube 410 into the tube acceptance portions 907 (which may also be referred to as tube joining cavities) of the threaded plug 412. After the adhesive hardens, a small amount of adhesive can be applied to the outer surface of the threaded plug 412 before inserting the proximal end of the threaded plug 412 into the distal end 420 of the outer cannula until a flange of the threaded plug 412 is flush with the end of the outer cannula 420. Again, after allowing the adhesive to harden, a small amount of adhesive can be applied to an outer surface of the proximal end of the outer cannula 420 (opposite the threaded plug) and the distal component of the Y-connector 430 can be inserted into the cannula 420. When inserting the distal component of the Y-connector 430, the components must be aligned so that the sealing channels of the threaded plug 412 are in the plane with the horizontal plane of the distal component of the Y-connector 430. After the adhesive hardens, adhesive can be applied to the outer surface of the free sealing tube ends, which can then be inserted into the bushings 434 of the proximal component of the Y-connector 432. Next, the check valves 450 can be connected to the female Luer fittings of the proximal component of the Y-connector 432. Finally, the gas filter 310 can be connected to the female Luer fitting at the bottom of the distal component of the Y-connector 430. in 17nn / Q7n7 / e / YiAi A similar assembly process is performed for a malleable device configuration. However, instead of inserting the threaded plug 412 into the outer cannula 420, the threaded plug 412 is inserted into the malleable ring 470. A small amount of adhesive is then applied to the outer surface of one end of the malleable tube 460, which is then inserted into the malleable ring 470. During assembly, the stainless steel wire may be oriented downwards. Next, adhesive is applied to the outer surface of the free end of the malleable tube 460, which is then inserted into the outer cannula 420. The insertion depth can be determined by the exposed length of the malleable tube 460. When correctly positioned, the gap between the malleable ring 470 and the outer cannula 420 can be, for example, 45 mm. Adhesive is then applied to the outer surface of the proximal end of the outer cannula 420, which is then inserted into the distal component of the Y-connector 430. The remaining assembly steps follow the same pattern described above for rigid device assembly. For the spray tip assembly, the assembly begins by firmly inserting the spray tip insert 470 into the spray tip body 410 with the turbulence chamber geometry 800 facing down. The distal face of the insert 470 must be completely flush with the tip body 410. Next, the spray tip 414 is screwed onto the threaded plug 412 until the proximal end is flush with the flange of the plug 412. When assembling the 100A or 100B applicator device or system, the right-hand housing can be placed on a flat surface. A gas cartridge is then installed onto the gas actuator knob using a small amount of adhesive. The gas actuator knob is then screwed clockwise to partially thread the gas cartridge into the valve assembly. In one example, the gas actuator knob is screwed on three turns to ensure the cartridge is securely attached to the valve but not punctured. Next, the gas line is connected to the valve's reed outlet, and a Luer lug is installed on the free end of the gas line. The Luer lug is then connected to the release valve using a Luer lock fitting. The male Luer sliding connector of the release valve is inserted into the gas filter within the fluid transport subassembly. The gas actuator knob is placed in its corresponding slot in the housing, and the gas line and release valve are guided to align their respective features within the housing. Next, the fluid transport subassembly is installed in its corresponding groove in the housing. The coupling is then assembled, and one or more of the bolts, trigger, and / or torsion springs can be installed (depending on the system configuration being assembled). Finally, the opposite side of the housing is aligned and bolted to the other housing. The aspects of the subject matter described in this document may be useful alone or in combination with one or more additional aspects described in this document. To the extent that any of these aspects are mutually exclusive, it should be understood that such mutual exclusivity will in no way limit the combination of these aspects with any other aspect, regardless of whether that aspect is explicitly mentioned or not. Any of these aspects may be claimed, without limitation, as a system, method, apparatus, device, means, etc. The various features and advantages of this disclosure are evident from the written disclosure, and the appended claims are therefore intended to encompass all such features and advantages. Furthermore, since numerous changes and modifications will readily occur to those skilled in the art, this disclosure is not limited to the exact functioning and construction as illustrated and described. Therefore, the described embodiments should be considered illustrative and not restrictive, and the disclosure should not be limited to the details provided herein, but should be defined by the following claims and their full scope of equivalents, whether foreseeable or unforeseeable now or in the future.

Claims

1. An applicator for mixing and dispensing a multi-component fluid, the applicator comprising: a fluid transport subassembly in fluid communication with a syringe, wherein the syringe houses at least two different sealant components; a housing; a gas cartridge disposed within the housing; a gas valve assembly disposed within the housing, the gas valve assembly being in fluid communication with the gas cartridge and the fluid transport subassembly, the gas valve assembly being configured to control the flow of gas from the gas cartridge to the fluid transport subassembly; a trigger configured to actuate the gas valve assembly; and a detachable spray tip in fluid communication with the fluid transport subassembly, the detachable spray tip being configured to dispense the multi-component fluid out of the applicator.

2. The applicator according to claim 1, wherein the detachable spray tip includes: a body including an open end, a closed end and an internal cavity extending between the open end and the closed end, wherein the closed end has an inwardly oriented surface and an outlet hole.

3. The applicator according to claim 2, wherein the body has a cylindrical shape.

4. The applicator according to claim 2, wherein the detachable spray tip includes: a spray tip insert housed within the body, the insert including a plurality of outwardly projecting mixing protrusions separated radially at different positions between a proximal end and a distal end of the spray tip insert, the spray tip insert and the body forming a mixing chamber within the internal cavity.

5. The applicator according to claim 4, wherein the detachable spray tip includes: a turbulence chamber formed from the spray tip insert and the inner surface of the body, wherein the spray tip insert is configured to cause the multi-component fluid to mix within the mixing chamber before entering the turbulence chamber and exiting through the outlet orifice.

6. The applicator according to claim 1, wherein the housing is formed in the shape of a handle.

7. The applicator according to claim 1, wherein the gas valve assembly in 17nn / Q7n7 / e / YiAi includes: a valve body having a lower portion formed to engage with the gas cartridge.

8. The applicator according to claim 7, wherein the gas valve assembly includes a flow-limiting orifice sized to control or reduce the gas flow from the gas cartridge to the fluid transport subassembly, wherein the flow-limiting orifice is disposed in a side port of the valve body.

9. The applicator according to claim 8, wherein the valve body has an internal cavity extending at least between the bottom of the valve body and the side port of the valve body to carry the gas flowing from the gas cartridge to the flow-limiting orifice.

10. The applicator according to claim 8, wherein the gas valve assembly includes: a valve reed formed to connect with the valve body, the valve reed extending away from the valve body at the side port, wherein the flow-limiting orifice is disposed within the valve reed.

11. The applicator according to claim 7, wherein the gas cartridge is a threaded gas cartridge, and wherein the valve body is formed to screw onto the threaded gas cartridge.

12. The applicator according to claim 1, wherein the trigger is configured to actuate the syringe.

13. The applicator according to claim 1, further comprising: a gas filter disposed within the housing and along a fluid gas path flowing from the gas valve assembly to the fluid transport subassembly.

14. An applicator for mixing and dispensing a multi-component fluid, the applicator comprising: a fluid transport subassembly in fluid communication with a syringe, wherein the syringe houses at least two different sealant components; a housing; a gas cartridge disposed within the housing; a gas valve assembly disposed within the housing, the gas valve assembly being in fluid communication with a gas cartridge and the fluid transport subassembly, the gas valve assembly being configured to control the flow of gas from the gas cartridge to the fluid transport subassembly; and a trigger configured to actuate the gas valve assembly.

15. The applicator according to claim 14, wherein the gas valve assembly includes: a puncture needle connected to the valve body at the bottom of the valve body, the puncture needle extending into the gas cartridge to couple the valve body with the gas cartridge by piercing the gas cartridge.

16. The applicator according to claim 15, wherein the puncture needle is screwed into i znn / Qznz / e / viAi in the valve body at the bottom of the valve body to fix the puncture needle to the valve body.

17. The applicator according to claim 15, wherein the gas valve assembly includes: a plug disposed between the puncture needle and the valve body, wherein the puncture needle is shaped to capture the plug when the puncture needle is attached to the valve body.

18. The applicator according to claim 14, wherein the gas valve assembly includes: a valve stem installed in an upper bore of the valve body, wherein the valve stem is configured to move the gas valve assembly from a closed state to an open state by pressing the valve stem.

19. The applicator according to claim 14, further comprising: a release valve disposed within the housing and along a fluid path of gas flowing from the gas valve assembly to the fluid transport subassembly, wherein the release valve is configured to release, out of the fluid path, at least a portion of the gas based on a gas pressure that is greater than a threshold pressure.

20. The applicator according to claim 19, further comprising: a gas tube disposed within the housing and extending between the gas valve assembly and the release valve to carry the gas flowing out of the gas valve assembly to the release valve.

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