Pyridazinyl thiazolecarboxamide compound

Abstract

Provided is a compound that is useful as an active ingredient of a medicinal composition for treating cancer related to immunocyte activation or cancer resistant to anti-PD-1 antibody / anti-PD-L1 antibody therapy. The present inventors studied compounds being useful as an active ingredient of a medicinal composition for treating cancer related to immunocyte activation or cancer resistant to anti-PD-1 antibody / anti-PD-L1 antibody therapy and confirmed that a pyridazinyl thiazolecarboxamide compound has an effect of inhibiting DGKξ (DGKzeta) to thereby complete the present invention. The pyridazinyl thiazolecarboxamide compound of the present invention has an effect of inhibiting DGKξ and is usable as a therapeutic agent for cancer related to immunocyte activation or cancer resistant to anti-PD-1 antibody / anti-PD-L1 antibody therapy.