Multilayer polymer composite vascular graft

The multilayer polymer composite vascular graft addresses mechanical weakness and clotting issues by combining biodegradable and non-biodegradable polymers, ensuring stability and compatibility with blood vessel regeneration, thus enhancing vascular graft performance.

WO2025144344A1 Publication Date: 2025-07-03ONDOKUZ MAYIS UNIVERSITESI
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Patent Information

Application Number
PCT/TR2024/051773
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Filing Date
2024-12-26
Publication Date
2025-07-03

AI Technical Summary

Technical Problem

Current vascular grafts face issues such as mechanical weakness during endothelialisation, clot formation, negative effects on blood vessel cell regeneration, and aneurysm formation due to non-biodegradability, particularly in small diameter vessels.

Method used

A multilayer polymer composite vascular graft comprising layers of PCL-Heparin, PCL, PVA-Chitosan, and TPU, produced via electrospinning, which combines biodegradable and non-biodegradable polymers to maintain mechanical strength and prevent clotting, ensuring biocompatibility and compatibility with blood vessel regeneration.

Benefits of technology

The graft achieves enhanced mechanical stability, prevents clot formation, and supports blood vessel cell regeneration, providing a reliable alternative for small diameter vessels with improved endothelialisation and reduced aneurysm risk.

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Abstract

The invention relates to a multilayer polymer composite vascular graft and a method for its manufacturing The said vascular graft comprises a first layer containing PCL-Heparin, a second layer containing PCL, a third layer containing PVA-Chitosan and a fourth layer containing TPU. The electrospinning method is used to prepare the vascular graft in question. In the vascular graft subject to the invention, both biodegradable (PCL, chitosan) and non-biodegradable polymer materials (TPU) are used. By supporting the biodegradable materials (PCL, chitosan), which lose their mechanical properties during the endothelialisation process, with the non-biodegradable polymer material (TPU), the problem caused by the potential loss of mechanical strength is eliminated. Thanks to the heparin additive in the inner layer of the vascular graft subject to the invention, clotting, which is commonly encountered in vascular graft applications, is also prevented.
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