Mutlifunctional drug conjugate of gemfibrozil and a mitochondrial uncoupler, and compositions and methods thereof

WO2026124387A1PCT designated stage Publication Date: 2026-06-18SHENZHEN HIGHTIDE BIOPHARM
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Patent Information

Application Number
PCT/CN2025/140597
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-12-10
Filing Date
2025-12-08
Publication Date
2026-06-18

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    Figure PCTCN2025140597-FTAPPB-I100003
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Abstract

The invention provides novel multifunctional conjugates of phenol-based mitochondrial uncoupler (e.g., 2, 4-dinitrophenol) and gemfibrozil, and derivatives thereof. The invention also provides pharmaceutical compositions comprising a compound of the invention and methods thereof for treating various diseases and disorders associated with or related to mitochondria or mitochondrial dysfunctions (e.g., neurodegenerative, metabolic and inflammatory diseases and disorders).
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