Leader sequence

The leader sequence from Photorhabdus Virulence Cassettes enables efficient, controlled delivery of diverse payloads into target cells using PVC Needle Complexes, addressing the limitations of existing systems and enhancing applications in medical and agricultural fields.

AU2020288380B2Pending Publication Date: 2026-07-09NANOSYRINX LTD
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Patent Information

Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
NANOSYRINX LTD
Filing Date
2020-06-05
Publication Date
2026-07-09

AI Technical Summary

Technical Problem

Current delivery systems for biological molecules, such as Type III secretion systems, are limited by their association with bacterial membranes, leading to nonspecific delivery and difficulty in controlling what molecules are transferred, especially for cytosolic targets, and lack compatibility with a range of molecular sizes and properties.

Method used

Utilization of a leader sequence from Photorhabdus Virulence Cassettes (PVC) effector proteins to package diverse payloads, including polypeptides and nucleic acids, into PVC Needle Complexes, allowing for targeted delivery independent of payload size and properties.

Benefits of technology

Enables efficient, controlled delivery of a variety of biological molecules into target cells, expanding the range of applicable targets and applications, including medical treatments and agricultural pest control.

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Abstract

The present invention provides use of a Photorhabdus Virulence Cassettes (PVC) effector leader sequence, for packaging a payload into a PVC Needle Complex, and related methods for manufacturing a packaged PVC Needle Complex. The payload is one or more selected from a polypeptide, a nucleic acid, or a combination thereof, and the leader sequence and the payload form an effector fusion that is distinct from a wild-type PVC effector protein.
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