Reagents and methods for the highly-efficient synthesis and purification of biopolymers

Modified trityl protecting groups with reactive linker moieties facilitate the capture and release of biopolymers, addressing scalability and purity issues in existing synthesis and purification methods, enhancing yield and reducing costs and environmental impact.

AU2024394451A1Pending Publication Date: 2026-07-23OLIGO FOUNDRY INC
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Patent Information

Application Number
AU2024394451
Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-12-08
Filing Date
2024-12-07
Publication Date
2026-07-23

AI Technical Summary

Technical Problem

Current methods for synthesizing and purifying synthetic biopolymers, particularly oligonucleotides and polypeptides, face challenges in scalability, efficiency, and purity, especially for modified chemistries or unconventional backbones, with existing purification techniques like trityl-on methods showing limited selectivity and leading to incomplete removal of truncated sequences.

Method used

The use of modified trityl protecting groups with selectively-reactive linker moieties that allow for the capture and release of full-length biopolymers using complementary reactive linker moieties on a capture support, enabling purification in aqueous media without the need for costly organic solvents and reducing chemical waste.

Benefits of technology

This approach enhances yield, reduces costs, and increases purity of biopolymers, making it suitable for large-scale synthesis and reducing environmental impact, while maintaining high throughput and efficiency.

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Abstract

The present disclosure provides reagent compounds, reactive biopolymeric compounds, and methods of making and using these materials for the rapid and efficient synthesis and purification of biopolymeric compounds at low cost. The materials and methods yield highly pure synthetic biopolymeric compounds, including synthetic oligonucleotides and polypeptides, and reduce or eliminate the need for toxic solvents in the synthetic process.
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