SISTEMA DE DETECÇÃO DE MÚLTIPLOS PARÂMETROS PARA AMOSTRAS DE SANGUE HUMANO E VETERINÁRIO

Abstract

The present disclosure discloses a multiparameter detection system (100) and method (900) thereof. The multiparameter detection system (100) comprises a container (1), a ferromagnetic member (2), a magnetic source (3), an inductive proximity detector (4), at least one light source (5), at least one light detector (6), a control unit (8) and a printing unit (9). The system (100) determines multiple parameters of an analyte in the blood sample in the container (1) by operating at least one of a magnetic source (3), an inductive proximity detector (4), at least one light source (5), at least one light detector (6) based on plurality of input signals received from a user interface (7). With such configuration, the system (100) may reduce the cost of testing blood samples and further the maintenance associated with the multiparameter detection systems may be reduced.

Description

[001] This disclosure generally relates to a field of medical devices. Specifically, but not exclusively, this disclosure relates to a multi-parameter detection system for human and veterinary blood samples. Additionally, the embodiments of this disclosure relate to the multi-parameter detection system for human and veterinary blood samples for the accurate determination of multiple parameters of blood samples. TECHNICAL BACKGROUND OF THE DISCLOSURE

[002] Blood tests are frequently prescribed by physicians to determine various biochemical, enzymatic, and coagulation values ​​in individuals for routine health assessment, such as routine pre / post-surgical examination or when performing other invasive medical procedures. Conventional laboratory approaches involve the use of dedicated systems to measure parameters specifically within a given measurement system and cannot accommodate other test parameters using a different technology / method.

[003] The physical detection of a change in the state of a given liquid cannot be extended to certain investigations that require the study of a change in the liquid that is beyond physical observation and is microscopic in nature, and it is not possible to observe this change with the naked eye. Such tests are classified as optical chromogenic, optical nephelometric, optical absorbance, optical immunoassay, and so on. Some examples of such important investigations included in these categories are the AT III test, the Protein C Chromogenic test or the Anti-Xa Heparin test, the Immunolatex test, such as a D test. Petition 870250082277, dated 12 / 09 / 2025, pp. 163 / 194 2 / 27 Dimer, a simple test like HB that can be measured by absorbance, PT and APTT tests that can be measured for change in turbidity, and enzymatic and protein host tests.

[004] In some analyzers, an optical methodology-based test is used where tests within the scope of biochemistry-based tests, nephelometry, turbidimetry, or coagulation-based tests can be performed. However, such analyzers are not suitable for testing whole blood or samples (extremely turbid / lipemic / cloudy / hemolyzed samples, etc.) where the samples are not clear, and results are not displayed by the optical system due to its inability to detect the clot at such pre-existing absorbance. In such scenarios, the analyzer may provide results that may be compromised and erroneous.

[005] For example, coagulation analyzers may often rely on a single test method to test coagulation in blood samples. However, test results for blood samples based on a single method may not be accurate. For better accuracy, blood samples may be tested by multiple methods using different coagulation analyzers with different technologies, such as optical coagulation, mechanical coagulation, viscosity coagulation, etc., which is laborious and costly. Additionally, testing blood samples on multiple devices is too time-consuming.

[006] Another example is that a coagulation analyzer cannot perform hemoglobin testing or measure a hematocrit value. For this, the user has to rely on another system with different methodologies that support such investigations and test reports.

[007] This disclosure is aimed at overcoming one or more Petition 870250082277, dated 12 / 09 / 2025, pages 164 / 194 3 / 27 limitations established above or any other limitations associated with conventional multiple system models and mechanisms. SUMMARY OF THE DISCLOSURE

[008] One or more deficiencies of the prior art are overcome by a system and method as claimed, and additional advantages are provided through the method and system as claimed in the present disclosure. Additional attributes and advantages are realized through the techniques of the present disclosure. Other embodiments and aspects of the disclosure are described in detail in the present invention and are considered a part of the claimed disclosure.

[009] In a non-limiting embodiment of the present disclosure, a multi-parameter detection system for blood is disclosed. The multi-parameter detection system comprises a container, a ferromagnetic member, a magnetic source, an inductive proximity detector, at least one light source, at least one light detector, a control unit, and a printing unit. The container is configured to receive a blood sample, whether plasma, serum, or whole blood, said container being defined by a wall portion and a bottom portion. The ferromagnetic member is movably positioned in the container and is configured to move around an inner perimeter in the bottom portion of the container. The magnetic source positioned adjacent to the container is configured to generate a periodic magnetic field to move the ferromagnetic member in the container.The inductive proximity detector is positioned below / at the bottom of the container and is configured to detect variations in amplitude and / or frequency of movement of the ferromagnetic member around the inner perimeter of the container. At least one light source is positioned near the container so that light passes through it. Petition 870250082277, dated 12 / 09 / 2025, pages 165 / 194 4 / 27 blood sample. At least one light detector is positioned opposite at least one light source to detect light passing through the blood sample. The control unit is communicatively coupled to the magnetic source, the inductive proximity detector, at least one light source, and at least one light detector, and configured to selectively operate at least one of the magnetic source and the inductive proximity detector, at least one light source, and at least one light detector. Additionally, the control unit is configured to receive a plurality of input signals. Then, the control unit controls at least one of the magnetic source and at least one light source based on the plurality of input signals.The control unit receives a plurality of detection signals from at least one inductive proximity detector and at least one light detector and determines an analyte to be measured from the blood sample based on selective control by the control unit. The printing unit is communicatively coupled to the control unit and is configured to print the analyte reading determined from the blood sample by the control unit.

[010] In one embodiment, the container is transparent and is positioned between the magnetic source and the inductive proximity detector and additionally, the container is positioned between at least one light source and at least one light detector to allow light to pass through the blood sample.

[011] In one embodiment, the periodic magnetic field imparts a sustained pendulum motion along a curvilinear path to the ferromagnetic member around the inner perimeter at the bottom of the container.

[012] In one embodiment, the periodic magnetic field having a frequency period substantially equivalent to the natural period of pendulum motion of the ferromagnetic member along the path Petition 870250082277, dated 12 / 09 / 2025, pages 166 / 194 5 / 27 curved within the blood sample.

[013] In one embodiment, the system comprises an incubator for storing a plurality of blood samples for determining multiple blood parameters.

[014] In one embodiment, the system comprises a heater controlled by the control unit to maintain optimal temperature for blood samples in the incubator.

[015] In one embodiment, the control unit is configured to operate the heater when the incubator temperature falls below a first threshold temperature and in which the control unit is configured to deactivate the heater when the incubator temperature rises above a second threshold temperature.

[016] In one embodiment, a user interface is configured for the multi-parameter detection system, the user interface is configured to receive a plurality of input signals from a user.

[017] In one embodiment, the user interface allows the user to view the measurement determined in units from the tested blood sample.

[018] In one embodiment, the inner perimeter of the container is defined by a depression in the bottom portion of the container to allow oscillation of the ferromagnetic member.

[019] In one modality, depression is defined by a lower portion and at least two higher portions.

[020] In one embodiment, the lowest portion of the depression is at the bottom of the container and the at least two highest portions are along the wall of the container. Petition 870250082277, dated 12 / 09 / 2025, pp. 167 / 194 6 / 27

[021] In one embodiment, the light from at least one light source is substantially tangential to the ferromagnetic member when the ferromagnetic member is located at the lowest point of the curvilinear path.

[022] In another non-limiting embodiment of the present disclosure, a method for operating a multi-parameter blood detection system is disclosed. The method includes the steps of receiving, by a control unit, a plurality of input signals, wherein the control unit is communicatively coupled to a magnetic source, an inductive proximity detector, at least one light source and at least one light detector to selectively operate at least one of a magnetic source, an inductive proximity detector, at least one light source and at least one light detector to determine multiple parameters of a blood sample.

[023] The control unit controls at least one of the magnetic source and at least one of the light sources based on the plurality of input signals. The control unit then receives a plurality of detection signals from at least one of the inductive proximity detector and at least one of the light detectors and determines the multiple parameters of the blood sample analyte based on selective control by the control unit.

[024] In one embodiment, the control unit controls a heater to maintain an optimal temperature in an incubator of the multi-parameter detection system based on the incubator temperature and a first threshold temperature and a second threshold temperature to maintain optimal temperature for the blood samples.

[025] The preceding summary is for illustrative purposes only and is not intended to be exhaustive in any way. In addition to aspects, modalities and attributes Petition 870250082277, dated 12 / 09 / 2025, pp. 168 / 194 7 / 27 illustrative aspects described above, additional aspects, modalities and attributes will become evident by reference to the drawings and detailed description below. BRIEF DESCRIPTION OF THE ATTACHED DRAWINGS

[026] The innovative attributes and characteristics of the disclosure are set forth in the appended claims. The disclosure itself, however, as well as a preferred mode of use, objectives and additional advantages thereof, will be better understood by reference to the following detailed description of an illustrative embodiment when read in conjunction with the appended figures. One or more embodiments are described below by way of example only, with reference to the appended figures where equal numerical references represent equal elements and where:

[027] Figure 1 is a block diagram illustrating an exemplary multi-parameter detection system according to an embodiment of the present disclosure.

[028] Figure 2 illustrates first cutaway views of a container of the multi-parameter detection system of Figure 1, according to an embodiment of the present disclosure.

[029] Figure 3 illustrates a top view of a multi-parameter detection device of the multi-parameter test system of Figure 1, illustrating an incubator and a user interface, according to an embodiment of the present disclosure.

[030] Figure 4 illustrates a cross-section depicting the arrangement of a magnetic source and an inductive proximity detector in relation to the container in the multi-parameter detection system of Figure 1, according to an embodiment of the present disclosure.

[031] Figure 5 illustrates a cross-section depicting the arrangement of at least one light source and at least one light detector in relation to Petition 870250082277, dated 12 / 09 / 2025, pp. 169 / 194 8 / 27 container in the multi-parameter detection system of Figure 1, according to an embodiment of the present disclosure.

[032] Figure 6 illustrates an isometric view of a multi-parameter detection device of the multi-parameter detection system of Figure 1, according to an embodiment of the present disclosure.

[033] Figure 7 is a plot depicting a plurality of absorbance curves of different solutions in the visible range, according to an embodiment of the present disclosure.

[034] Figure 8 is a plot depicting the positions of different solutions in a color diagram, according to one embodiment of this disclosure.

[035] Figure 9 is a flow diagram depicting a method for operating a multi-parameter detection system, according to an embodiment of the present disclosure.

[036] The figures depict embodiments of the disclosure for illustrative purposes only. A person skilled in the art will readily recognize from the following description that alternative embodiments of the system and method illustrated in the present invention can be employed without departing from the principles of the disclosure described in the present invention. DETAILED DESCRIPTION

[037] Although the modalities in disclosure are subject to various modifications and alternative forms, the specific modality shown as an example in the figures will be described below. It should be understood, however, that this is not intended to limit disclosure to the particular forms disclosed, but rather, disclosure should encompass all modifications, equivalents, and alternatives included within the scope of disclosure.

[038] The terms include, including or any other Petition 870250082277, dated 12 / 09 / 2025, pp. 170 / 194 9 / 27 variations of the same used in the disclosure are intended to encompass a non-exclusive inclusion, so that a device, assembly, mechanism, system, or method comprising a list of components does not include only those components, but may include other components not expressly listed or inherent to such system, assembly, or device. In other words, one or more elements in a system followed by "comprises... a" do not, without further restriction, exclude the existence of other elements or additional elements in the system or method.

[039] The embodiments of the present disclosure disclose a multi-parameter detection system. The multi-parameter detection system comprises a container, a ferromagnetic member, a magnetic source, an inductive proximity detector, at least one light source, at least one light detector, a control unit, and a printing unit. The container is configured to receive a blood sample, the container being defined by a wall portion and a bottom portion. The ferromagnetic member is movably positioned in the container and is configured to move around an inner perimeter in the bottom portion of the container. The magnetic source is positioned adjacent to the container and configured to generate a periodic magnetic field to move the ferromagnetic member in the container.The inductive proximity detector is positioned below / at the bottom of the container and is configured to detect variations in amplitude and / or frequency of movement of the ferromagnetic member around the inner perimeter of the container. At least one light source is positioned near the container to allow light to pass through the blood sample. At least one light detector is positioned opposite the at least one light source to detect light passing through the blood sample. The control unit is coupled in a communicative manner. Petition 870250082277, dated 12 / 09 / 2025, pp. 171 / 194 10 / 27 to the magnetic source, to the inductive proximity detector, to at least one light source and to at least one light detector. The control unit is configured to operate selectively with at least one of the magnetic source and the inductive proximity detector, with at least one light source and with at least one light detector.

[040] Additionally, the control unit is configured to receive a plurality of input signals. Then, the control unit controls at least one of the magnetic source and at least one of the light sources based on the plurality of input signals. The control unit receives the plurality of detection signals from at least one of the inductive proximity detector and at least one light detector and determines the multiple parameters of the blood sample based on selective control by the control unit. The printing unit is communicatively coupled to the control unit and is configured to print the multiple parameters determined from the blood sample by the control unit. With such a configuration, the system can reduce the cost of testing blood samples and additionally the maintenance associated with multi-parameter detection systems can be reduced.

[041] The disclosure is described in the following paragraphs with reference to Figures 1 to 9. In the figures, the same element or elements having the same functions are indicated by the same reference signs. A person skilled in the art will appreciate that the system and method, as disclosed in this disclosure, can be used in any sample analyzer including, but not limited to, manual multiparameter blood analyzers, semi-automatic multiparameter blood analyzers, and automatic multiparameter blood analyzers and the like. The system and method of this disclosure can also be implemented in Petition 870250082277, dated 12 / 09 / 2025, pages 172 / 194 11 / 27 fluid sample analyzers that detect fluid state changes without deviating from the principles of this disclosure.

[042] Figure 1 is an exemplary embodiment of the present disclosure illustrating a block diagram illustrating an exemplary multi-parameter detection system (100) [hereinafter referred to simply as the system]. The system (100) can be configured to perform multiparametric testing including Chromogenic, Immunotest, Nephelometric, to detect bleeding or coagulation disorders, biochemical parameters, enzymes and proteins from a blood sample when performing tests including, but not limited to, Glucose, Hemoglobin, Urea, Uric Acid, ATIII, AST, ALT, Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Absorbance Panel Thrombin Time (TT), Fibrinogen (FIB), C-Reactive Protein, Rheumatoid Arthritis, ASO, Hematocrit Factor Assay Test, Lupus Test (LA Panel), Protein C, Protein S, Activated Protein C Resistance (APCR) and the like.The multi-parameter detection system (100) comprises a container (1), a ferromagnetic member (2), a magnetic source (3), an inductive proximity detector (4), at least one light source (5), at least one light detector (6), a control unit (8), and a printing unit (9). The container (1) can be configured to receive a blood sample, the container (1) being defined by a wall portion and a bottom portion. In one embodiment, the container (1) may comprise an upper portion wherein the upper portion may be wider than the lower portion and the upper portion may be exposed to receive the blood sample. In one embodiment, the container (1) may be configured to receive the blood sample and a plurality of reagents required to determine the multiple parameters of the blood sample. In one embodiment, the multiple analyte parameters in the blood sample may include Glucose, Petition 870250082277, dated 12 / 09 / 2025, pp. 173 / 194 12 / 27 Hemoglobin, General Colorimetric Readings, PT, APTT, D-Dimer, Cholesterol, Triglycerides, Whole Blood Coagulation, ACT, CRP, Chromogenic tests such as AT3, which test various Enzymes and Proteins and the like. The container (1) may include an orifice in the upper portion to allow the blood sample into the container (1). The lower portion may be a parallelepiped portion with a curved profile around the inner periphery in the bottom portion to allow movement of the ferromagnetic member (2) in the blood sample. The ferromagnetic member (2) may be movably positioned in the container (1) and may be configured to move around an inner perimeter in the bottom portion of the container (1). In one embodiment, the ferromagnetic member (2) may include a spherical shaped member produced from a ferromagnetic material including, but not limited to, iron, cobalt, nickel and other ferromagnetic materials thereof.In one embodiment, the inner perimeter of the container (1) can be defined by a depression (12) in the bottom portion of the container (1) to allow oscillation of the ferromagnetic member (2). The depression (12) can be defined by a lower portion (12c) and at least two higher portions (12a & 12b) that form a curvilinear path for the ferromagnetic member (2). In one embodiment, the lower portion (12c) of the depression (12) can be in the bottom portion of the container (1) and the at least two higher portions (12a) can be along the wall portion of the container (1).

[043] In one embodiment, the magnetic source (3) positioned adjacent to the container (1) can be configured to generate a periodic magnetic field to move the ferromagnetic member (2) in the container (1). The magnetic source (3) may include a temporary magnet, such as an electromagnet and the like. The inductive proximity detector (4) can be positioned opposite the magnetic source (3) along the container (1) and can be configured Petition 870250082277, dated 12 / 09 / 2025, pages 174 / 194 13 / 27 to detect variations in amplitude and / or frequency of movement of the ferromagnetic member (2) around the inner perimeter of the container (1). In one embodiment, the inductive proximity detector (4) may include an inductive proximity sensor (4) to detect variation in movement of the ferromagnetic member (2). In one embodiment, the periodic magnetic field from the magnetic source (3) may impart a sustained pendulum motion along the curvilinear path to the ferromagnetic member (2) around the inner perimeter in the bottom portion of the container (1). The periodic magnetic field may have a frequency period substantially equivalent to the natural period of pendulum motion of the ferromagnetic member (2) along the curvilinear path within the blood sample.In the illustrative embodiment, the pendular motion of the ferromagnetic member (2) may include, but is not limited to, reciprocating motion of the ferromagnetic member (2) between the lowest portion (12c) and at least the two highest portions (12a) of the depression (12). Additionally, the ferromagnetic member (2) may initially rest in the lowest portion (12c) of the depression (12). In one embodiment, the inductive proximity detector (4) may detect the number of times the ferromagnetic member (2) passes around the inductive proximity detector (4) and may be configured to transmit to the control unit (8) to determine multiple parameters of an analyte in the blood sample.

[044] Referring to Figures 4 and 5, at least one light source (5) can be positioned close to the container (1) so that light passes through the blood sample. At least one light detector (6) can be positioned opposite at least one light source (5) to detect light passing through the blood sample. In one embodiment, the light source (5) may include an LED light and the light detector (6) may include a photodiode to detect the light passing through the blood sample. In one embodiment Petition 870250082277, dated 12 / 09 / 2025, pp. 175 / 194 14 / 27 illustrative, the container (1) is transparent and is positioned between the magnetic source (3) and the inductive proximity detector (4) and additionally, the container (1) is positioned between at least one light source (5) and at least one light detector (6) to allow light to pass through the blood sample. In one embodiment, the container (1) may be positioned within a retainer (13) defined with multiple provisions for positioning the magnetic source (3), the inductive proximity detector (4), the light source (5) and the light detector (6).

[045] In one embodiment, the control unit (8) can be communicatively coupled to the magnetic source (3), the inductive proximity detector (4), at least one light source (5) and at least one light detector (6) and configured to operate selectively at least one of the magnetic source (3) and the inductive proximity detector (4), at least one light source (5) and at least one light detector (6).

[046] In one embodiment, the control unit (8) is configured to receive a plurality of input signals from at least one of the inductive proximity detector (4) and at least one light detector (6). A user interface (7) may be configured for the multi-parameter detection system (100), wherein the user interface (7) may be configured to receive a plurality of input signals from a user. In the illustrative embodiment, the user interface (7) may allow the user to view the multiple parameters determined of the analyte in the blood sample by the control unit (8). In one embodiment, the user interface (7) coupled to the system (100) may comprise, including but not limited to, a touch screen interface configured to allow the user to input the plurality of input signals as shown in Figure 6. In one embodiment, the user may input a plurality of signals from Petition 870250082277, dated 12 / 09 / 2025, pages 176 / 194 15 / 27 input to select the method (900) for detecting multiple parameters of the blood sample or select similar test parameters. In one embodiment, the user interface (7) can be configured to provide a plurality of indications to the user that correspond to a plurality of actions related to the test of multiple parameters of the blood sample, including, but not limited to, starting incubation of blood samples, adding reagent to blood samples and the like, whereby the user manually performs the indicated plurality of actions.

[047] The control unit (8) can control at least one of the magnetic source (3) and at least one light source (5) based on the plurality of input signals. The control unit (8) can receive the plurality of detection signals from at least one of the inductive proximity detector (4) and at least one light detector (6) and can determine multiple analyte parameters in the blood sample based on selective control by the control unit (8). In one embodiment, the control unit (8) can selectively operate the magnetic source (3) and the inductive proximity detector (4) based on the plurality of input signals, wherein the user enters the detection method as a physical state change detection method to detect multiple parameters of the blood samples.The control unit (8) can selectively operate the light source (5) and the light detector (6) based on the plurality of input signals, wherein the user enters the detection method as an optical detection method to detect multiple parameters of the blood samples. In one embodiment, the light from at least one light source (5) is substantially tangential to the ferromagnetic member (2) when the ferromagnetic member (2) is located at the lowest point of the curvilinear path.

[048] In an illustrative embodiment, the system (100) detects multiple Petition 870250082277, dated 12 / 09 / 2025, pp. 177 / 194 16 / 27 parameters of the blood sample using at least one of two methodologies, including, but not limited to, a physical state change detection method and an optical detection method. The system (100) can detect multiple parameters by at least one of the two methods and can enhance the accuracy of the first method, for example, the physical state change detection method, by using the second method, for example, the optical detection method. However, the system (100) can be configured to determine multiple parameters of the analytes in blood samples by both methodologies. In one embodiment, the control unit (8) can be configured to receive the plurality of detection signals from at least one inductive proximity detector (4) if the user selects the physical state change detection method.Similarly, the control unit (8) can be configured to receive a plurality of detection signals from at least one light detector (6) if the user selects an optical detection method. The control unit (8) can be configured to determine multiple analyte parameters in the blood sample based on selective control by the control unit (8). In one embodiment, the system (100) may comprise at least one timer communicatively coupled to the magnetic sensor, the light detector (6), and the control unit (8) to determine the time spent by the magnetic sensor and the light detector (6) to generate the plurality of detection signals. In one embodiment, the system (100) may operate at least one timer upon receiving the plurality of input signals through the user interface (7).

[049] After determination, the control unit (8) can be configured to store and transmit the multiple determined parameters of the analyte in the blood sample to the user interface (7), wherein the user interface (7) can be configured to display the multiple determined parameters of Petition 870250082277, dated 12 / 09 / 2025, pages 178 / 194 17 / 27 analyte in the blood sample. Additionally, the printing unit (9) can be communicatively coupled to the control unit (8) and can be configured to print the multiple parameters determined of the analyte in the blood sample by the control unit (8).

[050] In one embodiment, the system (100) may comprise an incubator (11) for storing a plurality of blood samples for determining multiple blood parameters. The incubator (11) may comprise a test channel configured to receive a plurality of containers for testing multiple blood samples in batch mode. In the illustrative embodiment, the incubator (11) is capable of receiving at least five containers for testing the blood samples as best observed in Figure 3. The incubator (11) may additionally include an additional provision for receiving a plurality of pre-incubated containers at room temperature. In one embodiment, the system (100) comprises a heater controlled by the control unit (8) to maintain optimal temperature for the blood samples in the incubator (11).In one embodiment, the control unit (8) is configured to operate the heater when the temperature of the incubator (11) falls below a first threshold temperature and in which the control unit (8) is configured to deactivate the heater when the temperature of the incubator (11) rises above a second threshold temperature.

[051] In one embodiment, the control unit (8) can be configured to control at least one stirrer motor coupled to a stirrer of the system (100) to mix the plurality of reagents for testing the blood sample. Additionally, the system (100) can comprise an automatic start switch for automatic operation of the system (100) to reduce timer activation errors during multiple testing. Petition 870250082277, dated 12 / 09 / 2025, pp. 179 / 194 18 / 27 blood sample parameters.

[052] In one embodiment, the multi-parameter detection system (100) includes analytical techniques such as physical state change analysis, optical analysis, and the like. Supporting methods for detecting multiple blood parameters include absorbance, turbidimetry, coagulation, and immunolatex. The system (100) may further assist in the physical detection of blood state changes aided by an inductive proximity sensor (4). The multi-parameter detection system (100) may include two magnetic coils aided by the inductive proximity sensor (4) for the physical detection of a change in the state of the blood sample and measuring / quantifying the detected change by displaying it in clinical units. The present invention also uses an LED to support absorbance, turbidimetry, coagulation, and immunolatex testing.

[053] In general, a colorimeter or spectrometer is used to measure the absorbance of a given blood sample using Beer-Lambert's law, which is also referred to as Beer's law, which describes the relationship between absorbance (A), molar solute concentration in M ​​(c), and the path length that light travels to reach the sample in centimeters (l). Absorbance is directly proportional to concentration and length. A = ε^ Equation 1

[054] Where ε is the wavelength-dependent molar absorptivity coefficient and is constant for a particular substance. ε has units of L mol- 1cm- 1. Beer's law illustrates a linear relationship between concentration and absorbance that can be plotted to produce a user-friendly graph. The multi-parameter detection system (100) supports the absorbance of samples and reflects the absorption and scattering of suspended particles to incident light which can determine the turbidity of solutions. In Petition 870250082277, dated 12 / 09 / 2025, pages 180 / 194 19 / 27 In one modality, light absorption experiments for different turbidity solutions are performed to explore the absorption and scattering of suspended particles. As shown in Figure 7, the loss of light intensity became greater with the physical state change methodology test due to the increase in turbidity in the visible region. Furthermore, the change in absorbance is greater when the wavelength is shorter. Therefore, the chromaticity coordinate of solutions can reflect turbidity. The xyz color coordinates are normalizations of XYZ values; the XYZ values ​​of different turbidity solutions are calculated. The black squares shown in Figure 8 represent the positions in the chromaticity diagram of turbidity solutions of 0, 2, 5, 10, 20, 30, 40, 50 NTU from bottom to top.

[055] Referring to Figure 9, which is a flow diagram illustrating a method (900) for operating a multi-parameter detection system (100) according to a disclosure embodiment.

[056] In one embodiment, the control unit (8) may comprise a processing unit. The processing unit may comprise at least one data processor to execute program components to perform user-generated or system-generated requirements (100). The processing unit may be a specialized processing unit, such as integrated system controllers (bus), memory management control units, floating-point units, graphics processing units, digital signal processing units, etc. The processing unit may include a microprocessor, such as AMD Athlon, Duron or Opteron, ARM application, embedded or protected processors, IBM PowerPC, Intel's Core, Itanium, Xeon, Celeron or other processor line, etc. The processing unit may be implemented using a mainframe architecture, Petition 870250082277, dated 12 / 09 / 2025, pages 181 / 194 20 / 27 distributed processor, multiple cores, parallel, grid or other architectures. Some models may utilize embedded technologies such as application-specific integrated circuits (ASICs), digital signal processors (DSPs), field-programmable gate arrays (FPGAs), etc.

[057] The control unit (8) may be arranged in communication with one or more memory devices (e.g., RAM, ROM, etc.) via a storage interface. The storage interface may connect to memory devices including, without limitation, memory drives, removable disk drives, etc., employing connection protocols such as Serial Technology Advanced Connection (SATA), Integrated Drive Electronics (IDE), IEEE1394, Universal Serial Bus (USB), Fibre Channel, Small Computer System Interface (SCSI), etc. Memory drives may additionally include a drum, magnetic disk drive, magneto-optical drive, optical drive, Redundant Array of Independent Disks (RAID), solid-state memory devices, solid-state drives, etc.

[058] Method (900) can describe in the general context of executable instructions in the processor in the control unit (8). In general, executable instructions can include routines, programs, objects, components, data structures, procedures, modules, and functions, which perform particular functions or implement particular abstract data types.

[059] The order in which the method is described is not intended to be interpreted as a limitation, and any number of the described method blocks may be combined in any order to implement the method. Additionally, individual blocks may be omitted from the methods without departing from the scope of the subject matter described in the present invention. Furthermore, the method may be implemented on any suitable hardware, software, firmware, or combination thereof. Petition 870250082277, dated 12 / 09 / 2025, pages 182 / 194 21 / 27

[060] The method (900) includes the steps of receiving, by a control unit (8), a plurality of input signals in block 901. In one embodiment, the plurality of input signals may be received from a user interface (7) configured for the multi-parameter detection system (100) entered by a user. In one embodiment, the user interface (7) configured for the system (100) may comprise, including but not limited to, a touch screen interface configured to allow the user to enter a plurality of input signals. In one embodiment, the user may enter a plurality of input signals to select the method of detecting the multiple parameters of the blood sample or select other similar test parameters.In one embodiment, the user interface (7) can be configured to provide a plurality of indications to the user corresponding to a plurality of actions related to testing multiple parameters of the blood sample, including, but not limited to, starting incubation of blood samples, adding reagent to blood samples and the like, whereby the user manually performs the indicated plurality of actions. The control unit (8) can be communicatively coupled to a magnetic source (3), an inductive proximity detector (4), at least one light source (5) and at least one light detector (6) to selectively operate at least one of a magnetic source (3), an inductive proximity detector (4), at least one light source (5) and at least one light detector (6) to determine multiple parameters of an analyte in the blood sample.

[061] In block 902, the control unit (8) can control at least one of the magnetic source (3) and at least one light source (5) based on the plurality of input signals. In one embodiment, the control unit (8) can selectively operate the magnetic source (3), the proximity detector Petition 870250082277, dated 12 / 09 / 2025, pages 183 / 194 22 / 27 inductive (4) based on plurality of input signals, wherein the user enters the detection method as a physical state change detection method to detect multiple parameters of blood samples. In a similar mode, the control unit (8) can selectively operate the light source (5), the light detector (6) based on plurality of input signals, wherein the user enters the detection method as an optical detection method to detect multiple parameters of blood samples.

[062] The control unit (8) can then receive a plurality of detection signals from at least one of the inductive proximity detector (4) and at least one light detector (6) in block 903. The control unit (8) can be configured to receive the plurality of detection signals from at least one inductive proximity detector (4) if the user selects the physical state change method. Similarly, the control unit (8) can be configured to receive a plurality of detection signals from at least one light detector (6) if the user selects the light detection method. The control unit (8) can be configured to determine the multiple analyte parameters in the blood sample based on selective control by the control unit (8) in block 904.The control unit (8) can be configured to determine various parameters of blood samples including, but not limited to, clotting time, change in blood sample viscosity and the like to diagnose various conditions associated with the various parameters of an individual's blood sample. The control unit (8) can be configured to convert the detection signals received from at least one of the light detector (6) and the inductive proximity detector (4) into readable data, such as numerical values, such as mg / dl, g / l, ng / ml, seconds, % activity, clotting time calculation enabled by factor the same. Petition 870250082277, dated 12 / 09 / 2025, pages 184 / 194 23 / 27

[063] Additionally, the control unit (8) can be configured to print the determined analyte parameters on the blood samples using a thermal printer connected communicatively to the control unit (8), upon receiving a plurality of input signals from the user interface (7) that correspond to printing the determined plurality of analyte parameters on the blood samples. In one embodiment, the control unit (8) can be configured to display the determined plurality of analyte parameters on the blood samples via the user interface (7) and store the determined plurality of parameters in a system memory unit (100) upon receiving a plurality of input signals from the user interface (7).

[064] In one embodiment, the control unit (8) can control the heater to maintain an optimum temperature in an incubator (11) of the multi-parameter detection system (100) based on the incubator temperature (11) and a first threshold temperature and a second threshold temperature to maintain optimum temperature for blood samples. In one embodiment, the control unit (8) can receive at least one detection signal from a temperature sensor (10) that can be configured to detect the incubator temperature (11). In one embodiment, the control unit (8) can be configured to maintain the temperature in the incubator (11) in the range of 30°C to 40°C. In one embodiment, the first threshold temperature can be less than 30°C and the second threshold temperature can be greater than 40°C. In the illustrative embodiment, the control unit (8) can be configured to operate the heater at 37°C to maintain the incubator temperature (11) at an optimum value.

[065] In one embodiment, the multi-parameter detection system (100) supports multiple measurement modes using a single Petition 870250082277, dated 12 / 09 / 2025, pages 185 / 194 24 / 27 disposable sample processing retainer that can test the analyte selected by the user in the graphical user interface [GUI (Test Screen)] and thus can enable various test methods for multiple measurements, such as absorbance, turbidimetry, coagulation, immunolatex which can be further extended to Fluorimetry readings and Flocculation studies. In one embodiment, the multi-parameter detection system (100) assists the physical detection of analyte state change through an inductive proximity sensor. EQUIVALENTS

[066] Regarding the use of substantially any plural and / or singular terms in the present invention, those skilled in the art may translate from plural to singular and / or from singular to plural as appropriate to the context and / or application. The various singular / plural permutations may be expressly set forth in the present invention for the sake of clarity.

[067] It will be understood by those skilled in the art that, in general, terms used in the present invention, and especially in the appended claims (e.g., bodies of the appended claims), are intended, in general, as encompassing terms (e.g., the term including should be interpreted as including, but without limitation, the term having should be interpreted as having at least, the term includes should be interpreted as includes, but without limitation, etc.). It will further be understood by those skilled in the art that if a specific number of an introduced claim citation is intended, such intention will be explicitly stated in the claim and, in the absence of such a statement, no such intention is present. For example, as an aid to understanding, the following appended claims may contain use of the introductory expressions at least one and one or more to introduce claim citations. However, the use of such Petition 870250082277, dated 12 / 09 / 2025, pp. 186 / 194 25 / 27 expressions should not be interpreted as implying that the introduction of a claim citation by the indefinite articles a or an limits any particular claim containing such an introduced claim citation to inventions containing only one such citation, even when the same claim includes the introductory expressions a or more or at least one and indefinite articles such as a or an (e.g., a and / or an should typically be interpreted as meaning at least one or one or more); the same is true for the use of definite articles used to introduce claim citations.Furthermore, even if a specific number from an introduced claim citation is explicitly cited, those skilled in the art will recognize that such a citation should typically be interpreted as meaning at least the cited number (e.g., the simple citation of two citations, without other modifiers, typically means at least two citations, or two or more citations). Additionally, in those instances where a convention analogous to at least one of A, B, and C, etc. is used, in general, such a construction is intended in the sense that a person skilled in the art will understand the convention (e.g., a system (100) having at least one of A, B, and C will include, but not be limited to, systems that have A only, B only, C only, A and B together, A and C together, B and C together, and / or A, B, and C together, etc.). In those instances where a convention analogous to at least one of A, B, or C, etc.It is generally used, such a construction is intended in the sense that a person skilled in the art will understand the convention (for example, a system (100) having at least one of A, B or C will include, but without limitation, systems that have A only, B only, C only, A and B together, A and C together, B and C together and / or A, B and C together, etc.). It will be further understood by those skilled in the art that virtually any word and / or expression. Petition 870250082277, dated 12 / 09 / 2025, pp. 187 / 194 26 / 27 A disjunctive clause that presents two or more alternative terms, whether in the description, claims, or drawings, should be understood as encompassing the possibilities of including one of the terms, any of the terms, or both terms. For example, the expression “A or B” will be understood to include the possibilities of A or “B” or “A and B”.

[068] Furthermore, when attributes or aspects of the disclosure are described in terms of Markush groups, those skilled in the art will recognize that the disclosure is also described in terms of any individual member or subgroup of members of the Markush group.

[069] Although various aspects and embodiments have been disclosed in the present invention, other aspects and embodiments will be apparent to those skilled in the art. The various aspects and embodiments disclosed in the present invention are for illustrative purposes only and are not intended to be limiting, the true scope and spirit being indicated by the appended claims. Numerical Reference: System 100 container 1 ferromagnetic member 2 magnetic source 3 inductive proximity detector 4 light source 5 light detector 6 user interface 7 control unit 8 printing unit 9 Petition 870250082277, dated 12 / 09 / 2025, pages 188 / 194 27 / 27 temperature sensor10 incubator11 depression12 at least two higher portions 12a and 12b lower portion12c retainer13

Claims

1. Multi-parameter detection system (100) for blood, characterized in that it comprises: a container (1) configured to receive a blood sample, said container (1) defined by a wall portion and a bottom portion; a ferromagnetic member (2) positioned in a movable manner in the container (1), the ferromagnetic member (2) configured to move around an inner perimeter in the bottom portion of the container (1); a magnetic source (3) positioned adjacent to the container (1) configured to generate a periodic magnetic field to move the ferromagnetic member (2) in the container (1); an inductive proximity detector (4) positioned below / bottom of the container (1) to detect variations in amplitude and / or frequency of movement of the ferromagnetic member around the inner perimeter of the container (1); at least one light source (5) positioned near the container (1) so that light passes through the blood sample;at least one light detector (6) positioned opposite to at least one light source (5) to detect light passed through the blood sample; a control unit (8) communicatively coupled to the magnetic source (3), the inductive proximity detector (4), at least one light source (5) and at least one light detector (6) and configured to operate selectively at least one of the magnetic source (3) and the inductive proximity detector (4), at least one light source (5) and at least one light detector (6), wherein the control unit (8) is configured to: Petition 870250082277, dated 12 / 09 / 2025, page 190 / 194 2 / 5 receive a plurality of input signals; control at least one of the magnetic source (3) and at least one light source (5) based on the plurality of input signals;and receive a plurality of detection signals from at least one of the inductive proximity detector (4) and at least one light detector (6) and determine multiple parameters of an analyte in the blood sample based on selective control by the control unit (8); and a printing unit (9) communicatively coupled to the control unit (8) configured to print the multiple determined parameters of the analyte in the blood sample.

2. Multi-parameter detection system (100) for blood, according to claim 1, characterized in that the container (1) is transparent.

3. Multi-parameter detection system (100) for blood, according to claim 1, characterized in that the container (1) is positioned between the magnetic source (3) and the inductive proximity detector (4) and in that the container (1) is positioned between at least one light source (5) and at least one light detector (6) to allow light to pass through the blood sample.

4. Multi-parameter detection system (100) for blood, according to claim 1, characterized in that the periodic magnetic field imparts a sustained pendulum motion along a curvilinear path to the ferromagnetic member (2) around the inner perimeter in the bottom portion of the container (1).

5. Multi-parameter detection system (100) for blood, according to claim 4, characterized in that the periodic magnetic field Petition 870250082277, dated 12 / 09 / 2025, page 191 / 194 3 / 5 having a frequency period substantially equivalent to the natural pendular motion period of the ferromagnetic member (2) along the curvilinear path within the blood sample.

6. Multi-parameter detection system (100) for blood, according to claim 1, characterized in that the system comprises an incubator (11) for storing a plurality of blood samples to determine multiple blood parameters.

7. Multi-parameter detection system (100) for blood, according to claim 6, characterized in that it comprises a heater controlled by the control unit (8) to maintain optimal temperature for blood samples in the incubator (11).

8. Multi-parameter detection system (100) for blood, according to claim 7, characterized in that the control unit (8) is configured to operate the heater when the temperature of the incubator (11) falls below a first threshold temperature and in that the control unit (8) is configured to deactivate the heater when the temperature of the incubator (11) rises above a second threshold temperature.

9. Multi-parameter detection system (100) for blood, according to claim 1, characterized in that a user interface (7) is configured for the multi-parameter detection system, the user interface (7) is configured to receive a plurality of input signals from a user.

10. Multi-parameter detection system (100) for blood, according to claim 9, characterized in that the user interface (7) allows the user to view the multiple parameters determined of the analyte in the blood sample. Petition 870250082277, dated 12 / 09 / 2025, pp. 192 / 194 4 / 5 11. Multi-parameter detection system (100) for blood, according to claim 1, characterized in that the inner perimeter of the container (1) is defined by a depression in the bottom portion of the container (1) to allow oscillation of the ferromagnetic member (2).

12. Multi-parameter detection system (100) for blood, according to claim 11, characterized in that the depression is defined by a lower portion (12c) and at least two higher portions (12a and 12b).

13. Multi-parameter detection system (100) for blood, according to claim 11, characterized in that the lowest portion (12c) of the depression is in the bottom portion of the container (1) and in that the at least two highest portions are along the wall portion of the container (1).

14. Multi-parameter detection system (100) for blood, according to claim 1, characterized in that the light from at least one light source (5) is substantially tangential to the ferromagnetic member (2) when the ferromagnetic member (2) is located in the lowest portion (12c) of the depression.

15. Method (900) for operating a multi-parameter detection system (100) for blood, the method characterized in that it comprises: receiving, by a control unit (8), a plurality of input signals, wherein the control unit (8) is communicatively coupled to a magnetic source (3), an inductive proximity detector (4), at least one light source (5) and at least one light detector (6) to selectively operate at least one of the magnetic source (3), the inductive proximity detector (4), at least one light source (5) and at least one Petition 870250082277, dated 12 / 09 / 2025, page.193 / 194 5 / 5 light detector (6) to determine multiple parameters of an analyte in the blood sample; control, by the control unit (8), at least one of the magnetic source (3) and at least one light source (5) selectively based on the plurality of input signals; and receive, by the control unit (8), a plurality of detection signals from at least one of the inductive proximity detector (4) and at least one light detector (6) and determine multiple parameters of the analyte in the blood sample based on selective control by the control unit (8).

16. Method (900), according to claim 15, characterized in that it comprises controlling a heater to maintain an optimum temperature in an incubator (11) of the multi-parameter detection system (100) based on the temperature of the incubator (11) and a first threshold temperature and a second threshold temperature to maintain optimum temperature for the blood samples.

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