Curcumin analog and preparation method and application thereof

By modifying the molecular structure of curcumin, 1,7-bis(4-hydroxy-3-allylphenyl)-1,6-heptadiene-3,5-dione compounds were prepared, and the existing ones were solved The problem of limited inhibition of curcumin on certain cancer cells has achieved stronger anti-tumor activity and wider application potential.

CN102126938BInactive Publication Date: 2013-03-27XIAMEN UNIV
2 Cites 0 Cited by

Patent Information

Application Number
CN201010589444.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2010-12-15
Publication Date
2013-03-27
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Although existing curcumin is active in anti-tumor, its inhibitory effect on certain specific cancer cells is limited, and its structure is relatively simple, making it difficult to further modify to improve pharmacological activity.

Method used

By modifying the molecular structure of curcumin, a new compound 1,7-bis(4-hydroxy-3-allylphenyl)-1,6-heptadiene-3,5-dione was prepared. , the specific synthetic methods include the preparation of 4-allyloxybenzaldehyde, 3-allyl-4-hydroxybenzaldehyde and finally the compound is isolated by silica gel column chromatography.

Benefits of technology

This compound significantly inhibits the growth of nasopharyngeal carcinoma, cervical cancer, fibrosarcoma and liver cancer cells, has stronger anti-tumor activity than curcumin, and shows obvious inhibitory effects at different concentrations, and has a wide range of anti-tumor drugs application potential .

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention discloses a curcumin analog and a preparation method and application thereof, relates to a curcumin analog and provides a curcumin analog. The curcumin analog is red powder, and has the chemical name of 1,7-di(4-hydroxyl-3-allyl benzene)-1,6-heptadiene-3,5-diketone and the molecular weight of 388.1. The molecular structure of curcumin is modified and reformed on the basis of known active compound curcumin, so that a novel compound which is the 1,7-di(4-hydroxyl-3-allyl benzene)-1,6-heptadiene-3,5-diketone with higher antitumor activity is prepared. The curcumin analog remarkably suppresses the growth of nasopharyngeal darcinoma CNE2 cells, human cervical carcinoma Hela cells, human fibrosarcoma HT1080 cells and human liver cancer Bel-7402 cells, and can be widely applied to preparation of antitumor medicaments.
Need to check novelty before this filing date? Find Prior Art