Two novel compounds with antitumor effects in Rubus corchorifolius leaves, preparation method and application thereof
Two new compounds with anti-tumor effects were prepared through the extraction and separation method of raspberry leaves, which solved the problem of lack of effective anti-tumor compounds in the existing technology and enabled the structure determination of the compounds and the development of anti-tumor drugs.
Patent Information
- Application Number
- CN201110222986.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2011-08-02
- Publication Date
- 2012-02-08
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
There is a lack of effective anti-tumor compounds extracted and isolated from raspberry leaves in the existing technology, making it difficult to develop methods with anti-tumor drugs.
Through crude extraction of raspberry leaves, repeated silica gel column chromatography, thin layer chromatography and crystallization methods, two new compounds were prepared: 3β, 16α, 17, 19-tetrahydroxy-enanti-kauri-19-acetate. and 3β,16α,17,19-tetrahydroxy-enanti-kauri-19-acetate-17-oxo-β-D-glucoside, whose structures were determined by spectroscopic analysis and chemical methods, followed by a gradient elution step purification.
These two compounds show significant anti-tumor effects and can be used to prepare anti-tumor drugs and health products with a good dose-effect relationship.