Ceftizoxime sodium preparation and refining method
By reacting ceftizoxime acid with a salt-forming agent at a certain temperature, and using activated carbon decolorization and acetone crystallization, the problems of complex operation and high cost in the existing technology are solved, and the production of high-purity ceftizoxime sodium is achieved. preparation to ensure product quality and safety.
Patent Information
- Application Number
- CN201210452873.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2012-11-13
- Publication Date
- 2014-11-05
- Estimated Expiration
- 2032-11-13
AI Technical Summary
The existing preparation method of ceftizoxime sodium has the problems of complex operation, high cost, environmental pollution and poor product quality. In particular, the increase in the amount of anhydrous sodium carbonate leads to a shortened reaction time but a decrease in product quality, and an increase in impurity content. Some methods using alumina chromatography columns require a large amount of eluent, which affects industrial production.
At a certain temperature, dissolve ceftizoxime acid in water and add a salt-forming agent in batches. After the stirring reaction, use activated carbon to decolorize, and crystallize by adjusting the pH value and slowly adding acetone dropwise, and finally drying at room temperature to obtain high Purity of Ceftizoxime Sodium.
The preparation of ceftizoxime sodium with simple operation, high yield and high product purity has been achieved with low cost and a yield of 88.3%. The product quality has been improved through further refinement and the safety of medication has been ensured.