Traditional Chinese medicine composition, its extract, preparation method and application, and medicament containing it

Abstract

The invention discloses a traditional Chinese medicinal composition, an extract, a preparation method and an application thereof as well as a medicament containing the traditional Chinese medicinal composition. The traditional Chinese medicinal composition comprises 4-10 parts of rhizoma atractylodis, 4-10 parts of coix seed, 4-10 parts of flos magnoliae, 4-10 parts of scutellaria baicalensis, 4-10 parts of acorus gramineus, 5-10 parts of selfheal, 5-10 parts of loofah sponge, 3-10 parts of thunberg fritillary bulb, 6-15 parts of raw oyster shell and 2-5 parts of liquorice. The preparation method of the traditional Chinese medicinal composition comprises that all the components of the traditional Chinese medicinal composition are mixed, namely the traditional Chinese medicinal composition is obtained, or all the components of the traditional Chinese medicinal composition are mixed and then are smashed into fine powder, namely the traditional Chinese medicinal composition is obtained. The traditional Chinese medicinal composition, the extract and the medicament containing the traditional Chinese medicinal composition have the advantages that sleep-disordered breathing, especially clinical symptoms and signs of a patient suffering from children adenoidal hypertrophy, can be effectively alleviated, recurrence rate of a patient after drug withdrawal is low, and adverse effects are fewer.

Description

technical field

[0001] The invention relates to a traditional Chinese medicine composition, its extract, preparation method and application, and medicament containing it. Background technique

[0002] Epidemiological surveys show that the incidence of obstructive sleep apnea-hypopnea syndrome (OSAHS) in children is about 2 to 7 years old, and more males than females. The exact etiology of OSAHS in children is not yet fully understood. Currently, the most common cause of OSAHS in children is upper airway obstruction. Among them, adenoid hypertrophy is an important factor in the pathogenesis of OSAHS. If hyperplasia and hyperplasia of adenoids block the posterior nostrils, sleep disorders can occur, manifested as nighttime snoring, mouth breathing, disturbed sleep, abnormal body position, excessive sweating, bedwetting and other symptoms. In addition, abnormal sleep structure due to nighttime hypoxia and frequent awakening can cause growth retardation, inattention, anxiety, ...

Examples

Embodiment 1

[0051] Take 4g of Atractylodes atractylodis, 4g of barley kernels, 4g of Magnolia magnolia, 4g of Scutellaria baicalensis, 4g of calamus calamus, 5g of Prunella vulgaris, 5g of loofah, 3g of fritillary fritillaria, 9g of raw oysters, 2g of licorice, add 440mL of water, soak for 60 minutes, and heat to a slight boil ( 100°C), keep boiling slightly for 30 minutes, filter to obtain filtrate 1; add 264 mL of water again, heat to slightly boil (100°C), keep boiling slightly for 45 minutes, filter to obtain filtrate 2; combine filtrate 1 and filtrate 2, and pass through three Separation in a foot centrifuge to obtain filtrate 3; pump the filtrate 3 into the second-effect concentration tank, start to concentrate, concentrate until the relative density is 1.21 (80°C), stop concentrating, and obtain extract. The extract is spray-dried to obtain extract powder, passed through a No. 7 sieve, and the extract powder passed through the No. 7 sieve is collected, and the extract powder is prep...

Embodiment 2

[0053] Take bran-fried Atractylodes 10g, Coix seed 10g, Magnolia 6g, Scutellaria baicalensis 10g, Shichangpu 6g, Prunella vulgaris 10g, loofah 10g, Fritillaria 10g, raw oyster 15g, licorice 3g, add water 900mL, soak for 60 minutes, heat to slightly Boil (100°C), keep boiling slightly for 30 minutes, filter to obtain filtrate 1; add 540 mL of water again, heat to slightly boiling (100°C), keep boiling slightly for 45 minutes, filter to obtain filtrate 2; combine filtrate 1 and filtrate 2, After separation by a three-legged centrifuge, the filtrate 3 was obtained; the filtrate 3 was pumped into the second-effect concentration tank, and the concentration was started until the relative density was 1.21 (80°C), and the concentration was stopped to obtain the extract. The extract is spray-dried to obtain extract powder, passed through a No. 7 sieve, and the extract powder passed through the No. 7 sieve is collected, and the extract powder is prepared into granules according to the pr...

Embodiment 3

[0055] Take 10g of Atractylodes atractylodis, 10g of coix seed, 10g of Magnolia magnolia, 10g of Scutellaria baicalensis, 10g of Shichangpu, 10g of Prunella vulgaris, 10g of towel gourd, 10g of Fritillaria japonicus, 12g of raw oyster, 3g of licorice, add 950mL of water, soak for 60 minutes, and heat to a slight boil ( 100°C), keep boiling slightly for 30 minutes, filter to obtain filtrate 1; add 570 mL of water again, heat to slightly boil (100°C), keep boiling slightly for 45 minutes, filter to obtain filtrate 2; combine filtrate 1 and filtrate 2, and pass through three Separation in a foot centrifuge to obtain filtrate 3; pump the filtrate 3 into the second-effect concentration tank, start to concentrate, concentrate until the relative density is 1.21 (80°C), stop concentrating, and obtain extract. The extract is spray-dried to obtain extract powder, passed through a No. 7 sieve, and the extract powder passed through the No. 7 sieve is collected, and the extract powder is pr...

technical field

[0001] The invention relates to a traditional Chinese medicine composition, its extract, preparation method and application, and medicament containing it. Background technique

[0002] Epidemiological surveys show that the incidence of obstructive sleep apnea-hypopnea syndrome (OSAHS) in children is about 2 to 7 years old, and more males than females. The exact etiology of OSAHS in children is not yet fully understood. Currently, the most common cause of OSAHS in children is upper airway obstruction. Among them, adenoid hypertrophy is an important factor in the pathogenesis of OSAHS. If hyperplasia and hyperplasia of adenoids block the posterior nostrils, sleep disorders can occur, manifested as nighttime snoring, mouth breathing, disturbed sleep, abnormal body position, excessive sweating, bedwetting and other symptoms. In addition, abnormal sleep structure due to nighttime hypoxia and frequent awakening can cause growth retardation, inattention, anxiety, ...

Examples

Embodiment 1

[0051] Take 4g of Atractylodes atractylodis, 4g of barley kernels, 4g of Magnolia magnolia, 4g of Scutellaria baicalensis, 4g of calamus calamus, 5g of Prunella vulgaris, 5g of loofah, 3g of fritillary fritillaria, 9g of raw oysters, 2g of licorice, add 440mL of water, soak for 60 minutes, and heat to a slight boil ( 100°C), keep boiling slightly for 30 minutes, filter to obtain filtrate 1; add 264 mL of water again, heat to slightly boil (100°C), keep boiling slightly for 45 minutes, filter to obtain filtrate 2; combine filtrate 1 and filtrate 2, and pass through three Separation in a foot centrifuge to obtain filtrate 3; pump the filtrate 3 into the second-effect concentration tank, start to concentrate, concentrate until the relative density is 1.21 (80°C), stop concentrating, and obtain extract. The extract is spray-dried to obtain extract powder, passed through a No. 7 sieve, and the extract powder passed through the No. 7 sieve is collected, and the extract powder is prep...

Embodiment 2

[0053] Take bran-fried Atractylodes 10g, Coix seed 10g, Magnolia 6g, Scutellaria baicalensis 10g, Shichangpu 6g, Prunella vulgaris 10g, loofah 10g, Fritillaria 10g, raw oyster 15g, licorice 3g, add water 900mL, soak for 60 minutes, heat to slightly Boil (100°C), keep boiling slightly for 30 minutes, filter to obtain filtrate 1; add 540 mL of water again, heat to slightly boiling (100°C), keep boiling slightly for 45 minutes, filter to obtain filtrate 2; combine filtrate 1 and filtrate 2, After separation by a three-legged centrifuge, the filtrate 3 was obtained; the filtrate 3 was pumped into the second-effect concentration tank, and the concentration was started until the relative density was 1.21 (80°C), and the concentration was stopped to obtain the extract. The extract is spray-dried to obtain extract powder, passed through a No. 7 sieve, and the extract powder passed through the No. 7 sieve is collected, and the extract powder is prepared into granules according to the pr...

Embodiment 3

[0055] Take 10g of Atractylodes atractylodis, 10g of coix seed, 10g of Magnolia magnolia, 10g of Scutellaria baicalensis, 10g of Shichangpu, 10g of Prunella vulgaris, 10g of towel gourd, 10g of Fritillaria japonicus, 12g of raw oyster, 3g of licorice, add 950mL of water, soak for 60 minutes, and heat to a slight boil ( 100°C), keep boiling slightly for 30 minutes, filter to obtain filtrate 1; add 570 mL of water again, heat to slightly boil (100°C), keep boiling slightly for 45 minutes, filter to obtain filtrate 2; combine filtrate 1 and filtrate 2, and pass through three Separation in a foot centrifuge to obtain filtrate 3; pump the filtrate 3 into the second-effect concentration tank, start to concentrate, concentrate until the relative density is 1.21 (80°C), stop concentrating, and obtain extract. The extract is spray-dried to obtain extract powder, passed through a No. 7 sieve, and the extract powder passed through the No. 7 sieve is collected, and the extract powder is pr...

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