Method for preparing 5-amino-2,4,6-triiodoisophthalic acid

By carrying out the reaction of iodide metal salt and iodine oxyacid under polar solvent and acidic conditions, the problems of high iodination reagent consumption and incomplete reaction in the existing technology are solved, and high purity and high efficiency 5- The preparation of amino-2,4,6-triiodoisophthalic acid is suitable for large-scale industrial production.

CN110105233AActive Publication Date: 2019-08-09XILING LAB CO LTD
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Patent Information

Application Number
CN201910465412.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2018-06-01
Filing Date
2019-05-30
Publication Date
2019-08-09
Estimated Expiration
2039-05-30

AI Technical Summary

Technical Problem

When preparing 5-amino-2,4,6-triiodoisophthalic acid, the existing technology has problems such as high consumption of iodinated reagents, high salt content in the product, incomplete reactions, poor corrosion resistance of the equipment, and many by-products. Moreover, electrochemical methods and oxidant-activated iodine methods present many challenges before large-scale industrial production.

Method used

Use iodide metal salt or hydrogen iodide to react with iodine-containing acid or its salt, and perform iodization under polar solvent and acidic conditions to generate high-purity 5-amino-2,4,6-triiodoisophenylene. Formic acid, by adjusting the reaction conditions and step sequence to achieve efficient iodination.

Benefits of technology

The preparation of 5-amino-2,4,6-triiodoisophthalic acid with high yield and high purity is achieved, and the main shortcomings of the existing technology are overcome. The reaction speed is accelerated, the yield is increased, and the process is stable, safe, and Economical and suitable for large-scale industrial production.

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Abstract

The invention relates to a method for preparing iodized aniline. The method specifically comprises the steps that an iodized metal salt or hydrogen iodide is taken to react with iodoxylic acid or a salt thereof, and then subjected to an iodine reaction with the compound shown in the formula (I) in a polar solvent under acidic conditions, purification is conducted, and 5-amino-2,4,6-triiodophthalicacid as shown in the formula (II) is obtained. The 5-amino-2,4,6-triiodophthalic acid is an intermediate which can be used for synthesizing an iodic contrast medium widely applied to medical imaging.According to the preparation method, the raw materials are stable, the process is simple, and the yield is very high, large-scale industrial production can be achieved, and industrial application andpopularization are facilitated.
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