1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine and synthesis method thereof

Synthesis of 1-(2-(4-methoxyphenyl)thiazol-4-yl)ethylamine from 4-methoxybenzoic acid through a 9-step reaction process, solving the problems of complexity and high cost of thiazole derivative synthesis , achieving efficient and low-cost synthesis of thiazole derivatives, providing a basis for the production of pharmaceutical intermediates.

CN111848545AActive Publication Date: 2020-10-30NANTONG UNIV
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Patent Information

Application Number
CN202010765770.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2020-08-03
Publication Date
2020-10-30
Estimated Expiration
2040-08-03

AI Technical Summary

Technical Problem

The synthesis of thiazole derivatives is complicated and costly in the existing technology, making it difficult to meet the needs of pharmaceutical intermediates.

Method used

Through a 9-step reaction process, starting from 4-methoxybenzoic acid as raw material, sulfoxide chloride, ammonia, phosphorus pentasulfide, ethyl bromopyruvate, inorganic base, triethylamine, methylmagnesium bromide, sodium acetate, Hydroxylamine hydrochloride and catalyst Re-Ni and other media are used to gradually synthesize 1-(2-(4-methoxyphenyl)thiazol-4-yl)ethylamine.

Benefits of technology

It achieves efficient synthesis of thiazole derivatives, simplifies the process flow, reduces costs, and provides a solid foundation for the production of pharmaceutical intermediates.

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Abstract

The invention belongs to the technical field of organic synthesis, and discloses 1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine and a chemical synthesis method thereof. The method comprises the following steps: by taking 4-methoxybenzoic acid as a raw material, carrying out acylation, substitution, sulfonylation, substitution, hydrolysis, substitution, substitution and reduction reaction to prepare 1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine. An efficient synthesis method is provided for synthesis of the compound.
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