Preparation method of picoxystrobin

Through condensation reaction and subsequent processing steps, non-toxic raw materials are used to prepare picoxystrobin, which solves the complex process and environmental protection problems in the existing technology, and realizes high-efficiency and low-cost picoxystrobin production.

CN112679422AActive Publication Date: 2021-04-20JINZHOU SANFENG TECH CO LTD
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Patent Information

Application Number
CN202011611297.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2020-12-30
Publication Date
2021-04-20
Estimated Expiration
2040-12-30

AI Technical Summary

Technical Problem

The existing picoxystrobin preparation method uses the highly toxic drug dimethyl sulfate. The process is complex and unfavorable for industrial production, making it difficult to achieve green and environmentally friendly production.

Method used

Using 2-(6-trifluoromethylpyridin-2-yloxymethyl)phenylacetic acid methyl ester, acetic anhydride and trimethyl orthoformate for condensation reaction, combined with the steps of distillation, concentration under reduced pressure, water washing and recrystallization, Picoxystrobin is obtained, which avoids the use of highly toxic drugs and simplifies the technological process.

Benefits of technology

The high yield and purity of picoxystrobin are achieved, the process is simple, the production cost is low, it is suitable for industrial production, and it complies with green environmental protection standards.

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Abstract

The invention belongs to the technical field of bactericides, and particularly relates to a preparation method of picoxystrobin. The invention provides a preparation method of picoxystrobin, which comprises the following steps: mixing 2-(6-trifluoromethylpyridine-2-yloxymethyl) methyl phenylacetate, acetic anhydride and trimethyl orthoformate, and carrying out condensation reaction to obtain the picoxystrobin. According to the invention, 2-(6-trifluoromethylpyridine-2-yloxymethyl) methyl phenylacetate, acetic anhydride and trimethyl orthoformate are used as raw materials, and the 2-(6-trifluoromethylpyridine-2-yloxymethyl) methyl phenylacetate and trimethyl orthoformate are subjected to a condensation reaction under the action of acetic anhydride to obtain picoxystrobin; and acetic anhydride can react with a condensation reaction byproduct to reduce the content of the condensation reaction byproduct, promote the condensation reaction and improve the yield of picoxystrobin. The preparation method provided by the invention is simple in process, mild in reaction condition, low in production cost and beneficial to industrial production.
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