Islet cell cryopreservation and transport device for islet transplantation

Abstract

The application discloses a kind of islet cell cryopreservation and transport device for islet transplantation, and it relates to the field of medical apparatus and instruments.The container and the box body provided with refrigeration cavity are included, and the oscillation assembly is arranged in the refrigeration cavity.The oscillation assembly includes the gear ring fixed in the refrigeration cavity, and the driving gear and the driven gear are arranged in the gear ring.The first rotating disc is arranged above the driving gear, and each driven gear is connected with the driven shaft, and the first rotating disc is rotatably connected with the driven shaft.The first rotating disc is provided with the fixing assembly, and the container is fixed on the first rotating disc by the fixing assembly.The islet cell cryopreservation and transport device for islet transplantation provides the low temperature required for islet cell transport through the refrigeration cavity, and the liquid in the container is continuously oscillated or stirred through the oscillation assembly, which can avoid the agglomeration of islet cells in the culture medium and improve the survival rate of islet cells.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a device for transporting and storing pancreatic islet cells. BACKGROUND

[0002] Pancreatic islet cells are used in the human body to synthesize glucagon and insulin, which together regulate blood glucose levels. Transplanted islet cells are used to treat diabetes, and the cells are often stored in a special storage device.

[0003] Pancreatic islet cells are often transported to various locations for patient treatment. The islet cells need to be stored in a low-temperature environment. The existing transport box cannot continue to shake the container, resulting in the islet cells being prone to clumping in the culture medium. SUMMARY

[0004] In view of the defects in the prior art, the present application provides a device for transporting and storing pancreatic islet cells to solve the above problems.

[0005] To achieve the above-mentioned purposes, the technical solution adopted by the present application is as follows: a device for transporting and storing pancreatic islet cells, comprising a container and a box body provided with a refrigeration cavity, wherein an oscillation assembly is arranged in the refrigeration cavity; the oscillation assembly comprises a gear ring fixed in the refrigeration cavity, a driving gear and a driven gear are arranged in the gear ring, the driving gear is coaxially arranged with the gear ring and connected with a driving motor, the driven gears are two and symmetrically arranged on both sides of the driving gear, and each driven gear is engaged with the driving gear and the gear ring; a first rotating disc is arranged above the driving gear, each driven gear is connected with a driven shaft, and the two driven shafts are rotatably connected with the first rotating disc; a fixing assembly is arranged on the first rotating disc, and the container is fixed to the first rotating disc by the fixing assembly.

[0006] Preferably, the container is a bag, the upper end of each driven shaft penetrates the first rotating disc and is connected with a reciprocating lead screw, a lifting block is threadedly connected to each reciprocating lead screw, each lifting block is connected with a top holding piece through a connecting rod, the top holding piece abuts against the end face of the bag, and the two lifting blocks are connected by a limiting rod.

[0007] Preferably, the fixing assembly comprises a second rotating disc, an upper clamping piece and a lower clamping piece, the upper end of each reciprocating lead screw is rotatably connected with the second rotating disc, the upper clamping piece and the lower clamping piece are arranged on the lower end face of the second rotating disc and the upper end face of the first rotating disc respectively, and the upper clamping piece and the lower clamping piece are four and are respectively used to clamp the four corners of the bag.

[0008] Preferably, the first rotating disc is provided with a first magnetic attraction element, and each of the lower clamping elements is provided with a second magnetic attraction element, and the first magnetic attraction element and the second magnetic attraction element constitute a magnetic attraction cooperation.

[0009] Preferably, the top supporting element comprises a fixed shaft, the lifting blocks are connected with U-shaped frames, the two ends of the fixed shaft are connected with the two ends of the U-shaped frames respectively, and a roller is sleeved on the fixed shaft.

[0010] The beneficial effects of the present application are as follows:

[0011] The islet cell cryopreservation and transportation device for islet transplantation can provide low temperature required for islet cell transportation through the refrigeration cavity, and continuously shake or stir the liquid in the container through the oscillation assembly, so that the islet cells are prevented from being easily agglomerated in the culture medium, and the survival rate of the islet cells is improved. BRIEF DESCRIPTION OF DRAWINGS

[0012] Figure 1 It is a structural schematic view of the islet cell cryopreservation and transportation device for islet transplantation;

[0013] Figure 2 It is a structural schematic view of the oscillation assembly;

[0014] Figure 3 It is a structural schematic view of the fixing assembly;

[0015] In the drawings, 1 is a bag, 2 is a refrigeration cavity, 3 is a box body, 4 is a gear ring, 5 is a driving gear, 6 is a driven gear, 7 is a driving motor, 8 is a driven shaft, 9 is a first rotating disc, 10 is a reciprocating lead screw, 11 is a lifting block, 13 is a limiting rod, 14 is a second rotating disc, 15 is an upper clamping element, 16 is a lower clamping element, 17 is a first magnetic attraction element, 18 is a second magnetic attraction element, 19 is a U-shaped frame, and 20 is a roller. DETAILED DESCRIPTION

[0016] In order to enable those skilled in the art to better understand the technical solutions of the present application, the present application will be further described in detail below with reference to the drawings and specific embodiments.

[0017] Embodiment 1:

[0018] The islet cell cryopreservation and transportation device for islet transplantation comprises a container and a box body provided with a refrigeration cavity 2, wherein the refrigeration cavity 2 is used to provide low temperature required for islet cell transportation, specifically, the refrigeration cavity 2 can be refrigerated by a compressor or liquid nitrogen, preferably, a refrigeration pipe is arranged in the box body 3, the refrigeration pipe is filled with liquid nitrogen, more preferably, a serpentine refrigeration pipe is used to increase the contact area between air in the refrigeration cavity 2 and the refrigeration pipe.

[0019] In the embodiment, for the convenience of carrying, the bottom of the box 3 is provided with a roller, and the side wall is provided with a pull rod.

[0020] The refrigeration cavity 2 is provided with an oscillation assembly for continuously oscillating or stirring the liquid in the container for storing the culture medium and the pancreatic islet cells, and the culture medium is CMRL 1066 culture medium.

[0021] The oscillation assembly comprises a gear ring 4 fixed in the refrigeration cavity 2, the gear ring 4 is provided with a driving gear 5 and two driven gears 6, the driving gear 5 is coaxially arranged with the gear ring 4 and connected with a driving motor 7, the two driven gears 6 are symmetrically arranged on the two sides of the driving gear 5 and each driven gear 6 is engaged with the driving gear 5 and the gear ring 4; a first rotating disc 9 is arranged above the driving gear 5, each driven gear 6 is connected with a driven shaft 8, and the two driven shafts 8 are rotatably connected with the first rotating disc 9; the first rotating disc 9 is provided with a fixing assembly, and the container is fixed on the first rotating disc 9 through the fixing assembly; in use, the driving motor 7 drives the driving gear 5 to rotate, and the gear ring 4 limits the rotation to make the driven gear 6 perform revolution motion around the driving gear 5 while performing rotation motion, the two driven gears 6 drive the first rotating disc 9 to rotate through the corresponding driven shafts 8, and then drive the container fixed on the first rotating disc 9 through the fixing assembly to rotate, so that the liquid in the container is continuously vibrated or stirred.

[0022] Preferably, the container is a bag 1, the upper end of each driven shaft 8 penetrates the first rotating disc 9 and is connected with a reciprocating screw rod 10, the reciprocating screw rod 10 is threadedly connected with a lifting block 11, each lifting block 11 is connected with a supporting piece through a connecting rod, the supporting piece abuts against the end surface of the bag 1, the two lifting blocks 11 are connected through a limiting rod 13, in work, the rotation of the rotating shaft drives the reciprocating screw rod 10 to rotate and makes the lifting block 11 move along the axis direction of the reciprocating screw rod 10 (up and down), through the synchronous movement of the two supporting pieces, the bag 1 is deformed and the liquid in the bag 1 is moved, further improving the oscillation efficiency of the liquid, in the embodiment, the bag 1 stores the culture medium and the pancreatic islet cells, and the container is not easy to be damaged when the box 3 receives external force, so the transportation safety is high.

[0023] Preferably, the fixing assembly comprises a second rotating disc 14, upper clamping pieces 15 and lower clamping pieces 16, the upper end of each of the reciprocating lead screws 10 is rotationally connected with the second rotating disc 14, the upper clamping pieces 15 and the lower clamping pieces 16 are arranged on the lower end surface of the second rotating disc 14 and the upper end surface of the first rotating disc 9 respectively, the upper clamping pieces 15 and the lower clamping pieces 16 are all four and are respectively used for clamping the four corners of the bag 1, specifically, the upper clamping pieces 15 and the lower clamping pieces 16 can be clamps or other components with clamping function, the four corners of the bag 1 are clamped through the upper clamping pieces 15 and the lower clamping pieces 16, which has good stability performance and the bag 1 is not easy to be irregularly deformed, further improving the oscillation effect of the vibration assembly.

[0024] Preferably, the first rotating disc 9 is provided with a first magnetic attraction piece 17, each of the lower clamping pieces 16 is provided with a second magnetic attraction piece 18, the first magnetic attraction piece 17 and the second magnetic attraction piece 18 constitute a magnetic attraction cooperation, specifically, the lower clamping piece 16 is adsorbed on the first magnetic attraction piece 17 of the first rotating disc 9 through the first magnetic attraction piece 17, which facilitates the user to install and disassemble the bag 1.

[0025] Preferably, the top holding piece comprises a fixed shaft, the lifting blocks 11 are all connected with U-shaped frames 19, the two ends of the fixed shaft are respectively connected with the two ends of the U-shaped frames 19, a roller 20 is sleeved on the fixed shaft, specifically, the roller 20 is used to reduce the friction with the surface of the bag 1 and reduce the risk of damage of the bag 1, preferably, the roller 20 can be made of elastic material, further reducing the risk of damage of the bag 1.

[0026] It should be noted that, for the above-mentioned various method embodiments, in order to simply describe, they are all expressed as a series of action combinations, but those skilled in the art should know that the present application is not limited by the action sequence described, because according to the present application, some steps can be performed in other order or simultaneously. Secondly, those skilled in the art should know that the embodiments described in the specification all belong to preferred embodiments, and the actions and units involved are not necessarily necessary for the present application.

Claims

1. An islet cell cryopreservation and transport device for islet transplantation, characterized in that: The container and the box (3) provided with the refrigeration cavity (2) are included, the oscillation assembly is arranged in the refrigeration cavity (2), the oscillation assembly includes the gear ring (4) fixed in the refrigeration cavity (2), the driving gear (5) and the driven gear (6) are arranged in the gear ring (4), the driving gear (5) is coaxially arranged with the gear ring (4) and is connected with the driving motor (7), the driven gear (6) is two and is symmetrically arranged on the two sides of the driving gear (5), and each driven gear (6) is engaged with the driving gear (5) and the gear ring (4); the first rotating disc (9) is arranged above the driving gear (5), each driven gear (6) is connected with the driven shaft (8), and the two driven shafts (8) are rotatably connected with the first rotating disc (9); the first rotating disc (9) is provided with a fixing assembly, and the container is fixed on the first rotating disc (9) through the fixing assembly; The container is a bag (1), the upper end of each driven shaft (8) penetrates the first rotating disc (9) and is connected with the reciprocating lead screw (10), the reciprocating lead screw (10) is threadedly connected with the lifting block (11), each lifting block (11) is connected with a supporting piece through a connecting rod, the supporting piece abuts against the end surface of the bag (1), and the two lifting blocks (11) are connected through a limiting rod (13); The fixing assembly includes a second rotating disc (14), an upper clamping piece (15) and a lower clamping piece (16), the upper end of each reciprocating lead screw (10) is rotatably connected with the second rotating disc (14), the upper clamping piece (15) and the lower clamping piece (16) are arranged on the lower end surface of the second rotating disc (14) and the upper end surface of the first rotating disc (9) respectively, and the upper clamping piece (15) and the lower clamping piece (16) are four and are used for clamping the four corners of the bag (1) respectively; The supporting piece includes a fixed shaft, the lifting block (11) is connected with a U-shaped frame (19), and the two ends of the fixed shaft are connected with the two ends of the U-shaped frame (19); the fixed shaft is sleeved with a roller (20).

2. The device for islet cell cryopreservation and transportation according to claim 1, wherein: The first rotating disc (9) is provided with a first magnetic attraction piece (17), each lower clamping piece (16) is provided with a second magnetic attraction piece (18), and the first magnetic attraction piece (17) and the second magnetic attraction piece (18) constitute a magnetic attraction cooperation.

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