Packaging assisted actuation for intraocular lens cartridges

Abstract

Provided are systems, methods and devices for storing and / or transporting an intraocular lens (IOL) box. The system includes a package having a passage. The IOL box is removably arranged in the passage. The IOL box includes a mouth and a compartment configured to receive an IOL. The mouth is in fluid communication with the compartment. The IOL box further includes a knob configured to rotate when the IOL box is taken out of the passage, wherein the inner surface of the knob is exposed to the compartment. The knob is configured to fold the IOL and release the IOL box from the package when the knob is rotated.

Description

Technical Field

[0001] The present disclosure relates generally to ophthalmic surgery, and more specifically, some embodiments may generally relate to systems, methods, and apparatus for removably attaching a drive mechanism handpiece to an intraocular lens (IOL) box that is actuated with the assistance of packaging that holds the IOL box. Background Art

[0002] There are many diseases that can occur in the human eye, ranging from mild deterioration to complete loss of vision. While contact lenses and glasses can compensate for some diseases, others may require eye surgery. In general, eye surgery can be categorized into posterior segment surgery, such as vitreoretinal surgery, and anterior segment surgery, such as cataract surgery.

[0003] For cataract surgery, the surgery may require making an incision in the eye and inserting a tool into the eye to replace the cloudy lens with an IOL. An insertion tool may be used to deliver the IOL into the eye. For example, the insertion tool may include a plunger for pushing the IOL out of the nozzle of the insertion tool. In some cases, the IOL may be preloaded into the insertion tool. In other cases, a separate carriage may be loaded into the insertion tool. The plunger may engage the IOL to advance the IOL from the carriage through the nozzle and into the eye. Summary of the invention

[0004] In an exemplary embodiment, the present disclosure provides a system for storing and / or transporting an intraocular lens (IOL) box. The system includes a packaging material having a passage. The IOL box is removably arranged in the passage. The IOL box includes a mouth and a compartment configured to receive an IOL. The mouth is in fluid communication with the compartment. The IOL box further includes a knob configured to rotate when the IOL box is taken out of the passage. The knob is configured to fold the IOL and release the IOL box from the packaging material when the knob is rotated.

[0005] In another exemplary embodiment, the present disclosure provides a system for storing and / or transporting an IOL box. The system includes a packaging material having a passage, wherein a crosspiece is arranged in the passage. The IOL box is removably arranged in the passage. The IOL box includes a mouth and a compartment configured to receive an IOL. The mouth is in fluid communication with the compartment. The IOL box further includes a knob configured to rotate when the IOL box is taken out of the passage. The knob includes a protrusion adjacent to the crosspiece. The inner surface of the knob is exposed to the compartment. The knob is configured to fold the IOL and release the IOL box from the packaging material when the knob is rotated. The IOL box further includes a plunger barrel in fluid communication with the compartment, wherein the plunger is movably arranged in the plunger barrel.

[0006] In another exemplary embodiment, the present disclosure provides a method for delivering an IOL into an eye. The method includes inserting a handpiece into a package including an IOL box. The IOL box includes a mouth and a compartment containing the IOL. The mouth is in fluid communication with the compartment. The IOL box further includes a knob, wherein the inner surface of the knob is exposed to the compartment. The IOL box further includes a plunger barrel in fluid communication with the compartment, wherein the plunger is movably arranged in the plunger barrel. The method further includes rotating the handpiece to removably attach the handpiece to the IOL box to form an insertion tool; and removing the insertion tool from the package, thereby rotating the knob to release the IOL box from the package and folding the IOL.

[0007] It should be understood that the above general description and the following detailed description are exemplary and explanatory in nature, and are intended to provide an understanding of the present disclosure without limiting the scope of the present disclosure. In this regard, additional aspects, features and advantages of the present disclosure will be apparent to those skilled in the art through the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] These drawings illustrate certain aspects of some embodiments of the disclosure and should not be used to limit or define the disclosure.

[0009] Figure 1 shows a top elevation view of a package containing an IOL box with a knob according to some embodiments of the present disclosure;

[0010] Figure 2A shows a cut-away top view of a package according to some embodiments of the present disclosure, wherein the knob is in an initial, unrotated position;

[0011] Figure 2B shows a side cross-sectional view of a package containing an IOL cartridge according to some embodiments of the present disclosure;

[0012] Figure 3 shows a cut-away view of components beneath a knob of an IOL box according to some embodiments of the present disclosure;

[0013] Figure 4 A side elevation view showing an edge roller of an IOL box according to some embodiments of the present disclosure;

[0014] Figure 5 shows a cross-sectional view of an IOL box according to some embodiments of the present disclosure, wherein the knob is in an unrotated position;

[0015] Figure 6shows a cut-away top view of an IOL cartridge extracted from packaging according to some embodiments of the present disclosure;

[0016] Figure 7 shows a cross-sectional view of an IOL box according to some embodiments of the present disclosure, wherein the knob is in a rotated position;

[0017] Figure 8 An IOL cartridge is shown removably attached to a handpiece according to some embodiments of the present disclosure; and

[0018] Fig.9A and Fig. 9B Implantation of an IOL according to some embodiments of the present disclosure is demonstrated. DETAILED DESCRIPTION

[0019] For the purpose of promoting understanding of the principles of the present disclosure, reference will now be made to the implementations shown in the accompanying drawings, and specific language will be used to describe them. However, it should be understood that it is not intended to limit the scope of the present disclosure. Those skilled in the art in the technical field involved in the present disclosure are generally fully able to envision any changes and further modifications to the described devices, instruments, methods, and any further applications of the principles of the present disclosure. Specifically, it is fully conceivable that the features, components and / or steps described with reference to one or more implementations can be combined with the features, components and / or steps described with reference to other implementations of the present disclosure. For simplicity, in some cases, the same reference numerals are used in all drawings to refer to the same or similar parts.

[0020] Embodiments of the present disclosure provide an intraocular lens box ("IOL box") that is actuated with the aid of a packaging material. The IOL box can initially be contained in a packaging material for storage and / or transportation. The IOL box includes a knob that rotates when the IOL box is removed from the packaging material, thereby releasing the IOL box from the packaging material. The rotation of the knob can also actuate the folding or unfolding mechanism of the IOL box. The IOL box can be a pre-loaded box with a pre-loaded IOL. The IOL box can be part of a modular delivery system that includes a universal interface for removably attaching to various handpieces including different types of drive mechanisms.

[0021] Particular embodiments of the present disclosure allow for interchange between different handpieces (such as disposable and reusable handpieces) and IOL box designs. Disposable handpieces may include a non-electric manual drive mechanism (e.g., manually actuated by pushing or twisting, and / or manually actuated by a fluid or elastic member such as a spring). Reusable handpieces may include a manual drive mechanism as well as an electric drive mechanism (e.g., a stator winding). It should be noted that these types of handpieces are examples, and other types of handpieces or drive mechanisms may be utilized according to particular embodiments of the present disclosure.

[0022] Certain embodiments of the present disclosure allow for assembly of a handpiece to an IOL box, delivery of an IOL, and, when desired, disengagement of the handpiece from the used IOL box. The universal interface allows different types of handpieces to be easily paired and used with the IOL box for IOL implantation. After IOL implantation, the IOL box can be easily detached from the reusable handpiece.

[0023] The handpiece can be fixed to the IOL box by sliding the end of the handpiece into the packaging and sliding on the plunger barrel of the IOL box. Then, the handpiece can be rotated to fix the handpiece to the IOL box to form an insertion tool. In certain embodiments, the IOL box may include a projection that cooperates with the slot of the handpiece to lock the handpiece to the IOL box when the handpiece rotates. Then, the insertion tool can be removed from the packaging (e.g., pulled out). The pulling motion causes the knob to rotate so that the IOL box is unlocked and released from its initial locking position in the packaging. In addition, as previously mentioned, the rotation of the knob can fold the IOL or partially unfold the IOL in the IOL box.

[0024] Once the insertion tool is formed and removed from the packaging, the IOL can be delivered into the eye. Once the IOL delivery is completed, the handpiece can be disconnected from the used IOL box by rotating the handpiece in the opposite direction and pulling the handpiece away from the IOL box.

[0025] Figure 1 A top elevation view of a package 10 for storing and / or transporting an IOL box 12 according to some embodiments of the present disclosure is shown. In this exemplary embodiment, the package 10 is shown as transparent to show the IOL box 12 arranged in the package 10. The package 10 can be made of plastic and can include a passage 14 extending into a cavity 20. The cavity 20 can be located at the distal end of the package 10 and can be in fluid communication with the passage 14. As shown, the passage 14 can be the only opening extending from the outside of the package 10 into the package 10 to allow the IOL box 12 to be extracted.

[0026] The IOL box 12 may include a housing 18 including a compartment 24 in fluid communication with a plunger barrel 26. In some examples, the compartment 24 may be preloaded with or contain an IOL 16. The IOL box 12 may also include a mouth 22 extending from the housing 18. The mouth 22 may be in fluid communication with the compartment 24. When the IOL box is positioned in the packaging 10, the mouth 22 may be positioned in the cavity 20. The cavity 20 may prevent damage to the mouth 22 during transportation and / or storage of the IOL box 12. The mouth 22 provides a delivery channel for the IOL 16. The IOL box 12 may also include a knob 30, which may be located in the passage 14 when the IOL box 12 is arranged in the packaging 10. The knob 30 may be arranged above the compartment 24 and may be rotated to fold the IOL 16 when the IOL box 12 is extracted from the packaging 10.

[0027] IOL 16 can include a lens portion 32 and haptic extensions 34. Haptic extensions 34 can be side struts (or other suitable extensions) extending from lens portion 32 that can stabilize IOL 16 when it can be placed in the patient's eye. It should be understood that IOL 16 is merely exemplary and the technology disclosed herein can be used with any suitable IOL. For example, a modular IOL (not shown) can also be used that includes a lens portion that can be placed in a base with haptic extensions.

[0028] The IOL cartridge 12 may also include a protrusion 37 disposed on the housing 18 of the IOL cartridge 12 for insertion into the slot 38 of the handpiece 40. When the handpiece 40 is rotated (e.g., 90°), the protrusion 37 of the IOL cartridge 12 may be received and fixed in the slot 38 of the handpiece 40. It should be noted that various handpieces may be used with different types of IOL cartridges. The handpiece 40 may include an electric or non-electric drive mechanism that may include a push rod 42 extending along the length of the handpiece 40. The push rod 42 may be movably disposed within the handpiece 40 and may be manually actuated via a rotatable knob 44 that may cooperate with a fluid or elastic member (such as a spring 46) or another actuation mechanism. In general, for the purpose of discussing and describing the various components and features of the handpiece 40 and the IOL cartridge 12, reference to a proximal or proximal direction may refer to a direction that is more toward the end of the handpiece 40 that includes the rotatable knob 44 according to the directional arrow 47. Likewise, reference to a distal end or distal direction may refer to a direction more toward the end of the IOL cartridge 12 including the mouth 22 according to the directional arrow 49 .

[0029] In the illustrated embodiment, the knob 30 is in an initial unrotated position to lock the IOL box 12 in place within the packaging 10. The passage 14 includes a ledge 58 that is aligned with a projection 60 of the knob 30 to contact and rotate the knob 30 when the IOL box 12 is pulled from the packaging 10, thereby releasing the IOL box 12 from its initial locked position within the packaging 10. The rotation of the knob 30 also folds the IOL 16. In some additional embodiments, the rotation of the knob can straighten or unfold one or more haptic extensions 34 of the IOL 16. In some embodiments, the projection 60 can extend orthogonally to the longitudinal axis L of the IOL box 12 to lock the knob 30 against the ledge 58.

[0030] The plunger barrel 26 may be a hollow and rigid member extending from the housing 18. The plunger 36 may be movably disposed within the plunger barrel 26 to deliver the IOL 16. The plunger 36 may be an elongated member configured to deliver the IOL 16. Although only the trailing end of the plunger 36 is shown, the plunger 36 extends lengthwise within the plunger barrel 26. The plunger barrel 26 may include an end 66. The end 66 of the plunger barrel 26 may include a rotatable locking cap 64 having an orifice 68. When the locking cap 64 is rotated, the orifice 68 may receive the distal end 70 of the push rod 42, which may be movably disposed within the housing 73 of the handpiece 40. In some examples, the orifice 68 may be shaped so that the push rod 42 can enter the orifice 68 only when rotated. When actuated, the push rod 42 drives the plunger 36 forward.

[0031] Figure 2A Shown the cutaway top view of the insertion tool 51 positioned in the packaging material 10 according to some embodiments of the present disclosure.Insertion tool 51 comprises IOL box 12, and this box is removably connected to handpiece 40.As shown in the figure, the projection 37 of IOL box 12 has cooperated with the slot 38 of handpiece 40.In the embodiment shown, mouth 22 is in the initial position in the cavity 20 of packaging material 10.As shown in the figure, knob 30 is in the initial non-rotated position.The projection 60 of knob 30 extends in the passage 14 of packaging material 10 and abuts with its crosspiece 58.When taking out from passage 14, the rotation of knob 30 moves by direction arrow 69 indication.The take-out direction of insertion tool 51 from packaging material 10 is indicated by direction arrow 71.

[0032] Figure 2BShown is a cross-sectional side view of an insertion tool 51 arranged in a packaging material 10 according to some embodiments of the present disclosure. As shown in the figure, in some examples, a knob 30 is arranged just above a compartment 24 that accommodates an IOL 16, so that the knob 30 forms a boundary of the compartment 24. A mouth 22 can be arranged in the cavity 20. In some examples, the passage 14 can include an inner surface 52 that can match the profile of the insertion tool 51 to allow the insertion tool 51 to fit snugly in the packaging material 10. The inner surface 52 can also be smooth to cause the insertion tool 51 to slide during removal from the packaging material 10.

[0033] Figure 3 A cutaway top view of the compartment 24 of the IOL box 12 according to some embodiments of the present disclosure is shown. The knob 30 (e.g., Figure 1 ) to show an unobstructed top view of components located directly below the knob 30. The compartment 24 may include edge rollers 84 that are pivotally disposed within the compartment 24. The edge rollers 84 may be used to fold the IOL 16. As shown, the IOL 16 may be disposed between the edge rollers 84. The edge rollers 84 may include a top pin 91 extending laterally from an upper portion of the edge rollers 84. The top pin 91 is positioned to contact the knob 30 when the knob 30 is rotated (e.g., Figure 1 The rotation knob 30 is configured to rotate the edge rollers 84 upward and inward, thereby folding the IOL 16. The compartment 24 may also include a recess 94 that serves as a pivot point for the edge rollers 84. The rotation knob 30 may be disposed directly above the compartment 24 and may be supported by the inner portion 76 of the housing 18 of the IOL cartridge 12. In some examples, the inner portion 76 surrounds, surrounds, or generally defines the boundaries of the compartment 24.

[0034] The compression arm 92 can be pivotally coupled to the interior portion 76 of the housing 18 via the connecting pin 77 and can extend into the compartment 24. The compression arm 92 can include a protrusion 90 extending from the upper surface 85 of the compression arm 92 to contact the knob 30 when the knob 30 is rotated (e.g., Figure 1 The inner surface (not shown) of the IOL 16 is folded and compressed by the compression arms 92. The rotation of the knob 30 causes the compression arms 92 to move inwardly, thereby folding or compressing the haptic extensions 34 of the IOL 16. The inward movement of the compression arms 92 can be simultaneous with the inward and upward movement of the edge rollers 84 to fold and compress the IOL 16 for delivery into the eye.

[0035] Figure 4 84 according to some embodiments of the present disclosure. The edge roller 84 may include a cam 96 extending along the length of the edge roller 84. The cam 96 may include a cam pin 98 that allows the edge roller 84 to be moved in a recess 94 (e.g., Figure 3The top pin 91 can be rotated by the knob 30 (e.g., Figure 1 The edge rollers 84 may also include a guide roller 86 for receiving an IOL 16 (e.g., Figure 3 For example, IOL 16 ( Figure 3 The edge rollers 84 may include a tail portion 83 that may be positioned at the knob 30 (e.g., Figure 1 The edge roller 84 is prevented from rotating backward when the edge roller 84 is rotated upward and inward (as shown).

[0036] Figure 5 Some embodiments according to the present disclosure are shown Figure 2A 1 and 1 . The knob 30 can be disposed just above the compartment 24 and can be supported by the inner portion 76 of the housing 18 of the IOL cartridge 12. The knob 30 can rotate about the inner portion 76 and can include a lip 78 that corresponds with a groove 80 of the inner portion 76 to secure the knob 30 to the inner portion 76 of the housing 18. An inner surface 82 of the knob 30 can be exposed to the compartment 24. The inner surface 82 can be shaped to contact a top pin 91 (e.g., Figure 3 The edge rollers 84 may rotate upward and inwardly when the knob 30 is rotated, thereby folding the IOL 16. The inner surface 82 may also be shaped to contact the compression arms 92 (e.g., Figure 3 ) of the protrusion 90 (eg, Figure 3 Rotation of the knob 30 causes the compression arms 92 to move inwardly to compress the haptic extensions 34 of the IOL 16 (e.g., Figure 3 1 ). The tail portion 83 contacts the tapered wall 87 of the compartment 24 and extends upwardly therefrom. The tail portion 83 can prevent the edge roller 84 from rotating backward when the knob 30 is rotated to rotate the edge roller 84 upwardly via interaction with one or more features of the tapered wall 87. The passage 75 can extend from the compartment 24 through the mouth 22 to receive the IOL 16 in the folded state.

[0037] Figure 6A cutaway top view of pulling the insertion tool 51 from the package 10 according to some embodiments of the present disclosure is shown. As shown, the knob 30 has been rotated (e.g., 90°) to release the insertion tool 51 from its locked position against the crossbar 58 in the package 10. The rotation of the knob 30 is indicated by the directional arrow 89, and the pulling direction is indicated by the directional arrow 71. As shown, the knob 30 has been rotated so that the protrusion 60 of the knob 30 is away from the crossbar 58 and rotated toward the longitudinal axis L, thereby releasing the IOL box 12 and therefore releasing the insertion tool 51 from its initial locked position in the passage 14. In addition, the rotation of the knob 30 folds or otherwise manipulates the IOL 16 (e.g., Figure 3 as shown) for delivery through the mouth 22.

[0038] Figure 7 Some embodiments according to the present disclosure are shown Figure 6 1. A cross-sectional view of a portion of an IOL cartridge 12. As shown, the knob 30 has been rotated such that the edge roller 84 has been rotated to fold the IOL 16. Also, the compression arm 92 (e.g., Figure 3 ) has been rotated inwardly to compress the haptic extensions 34 of the IOL 16 ( Figure 3 shown).

[0039] Figure 8 A side view cross section of an insertion tool 51 according to a particular embodiment of the present disclosure is shown, the insertion tool including an IOL cartridge 12 removably attached to a handpiece 40. The plunger barrel 26 can be inserted into the housing 73 of the handpiece 40. The protrusion 37 of the IOL cartridge 12 can be received and locked in the slot 38 of the handpiece 40, thereby fixing the IOL cartridge 12 to the handpiece 40. The plunger barrel 26 can be in fluid communication with the compartment 24. As previously described, the plunger 36 can be movably arranged in the plunger barrel 26. The push rod 42 of the handpiece 40 can be actuated to advance the plunger 36 forward, thereby delivering the IOL 16 in a folded state from the compartment 24 through the passage 75 and the mouth 22 to the patient's eye. After delivering the IOL 16, the mouth 22 can be removed from the patient's eye, and the handpiece 40 is rotated in the opposite direction to disengage the IOL cartridge 12 from the handpiece 40. Then, the used IOL cartridge 12 can be disposed.

[0040] refer to Figures 1 to 8 , the following describes a method for inserting an IOL box 12 (eg, Figure 1 ) is assembled to a handpiece (e.g., Figure 1 The hand piece 40 shown in the figure is used to form an insertion tool 51 (e.g., Figure 8 An exemplary technique is shown).

[0041] First, a packaging material 10 (e.g., Figure 2A ). IOL box 12 (eg, Figure 2A 2) can be removably disposed within the packaging 22. The knob 30 of the IOL box 12 can be in an initial, unrotated position, wherein a portion of the knob 30 (e.g., Figure 1 and Figure 2A The protrusion 60 shown in FIG. 1 is adjacent to and / or in contact with the crosspiece 58 of the internal passage 14 of the package 10. Second, the handpiece 40 is inserted into the passage 14 of the package 10 (see, for example, Figure 2A ) and rotates it so that a portion of the IOL box 12 (eg, Figure 2A The projection 37 shown may be received in a slot 38 (e.g., Figure 2A ), thereby fixing the IOL box 12 to the handpiece 40 to form an insertion tool 51. Then, the handpiece 40 can be pulled out of the packaging 10 (for example, see Figure 6 ) to remove the insertion tool 51 from the package 10. Pulling the insertion tool 51 rotates the knob 30 of the IOL box 12, thereby releasing the IOL box 12 from the passage 14 of the package 10 (see, for example, Figure 6 ), while folding the IOL 16 (see, for example, Figure 7 As previously described, in additional or alternative embodiments, rotation of knob 30 may additionally or alternatively cause one or more portions of IOL 16 (e.g., haptic extensions 34) to be straightened or expanded. Figure 8 1), the plunger 36 is advanced forward to deliver the IOL 16 from the compartment 24 of the IOL box 12 through the mouth 22 to the patient's eye. In order to remove the insertion tool 51 (e.g., Figure 8 ), the handpiece 40 can be rotated in the opposite direction, thereby disengaging the protrusion 37 of the IOL box 12 from the slot 38 of the handpiece 40. Next, the IOL box 12 can be pulled out of the handpiece 40.

[0042] Fig.9A and Fig. 9B Exemplary techniques for implanting IOL 16 into patient's eye 124 are presented in accordance with certain embodiments of the present disclosure. Fig.9AAn incision 128 is shown that a surgeon may create in the eye 124. For example, the incision 128 may be created through the sclera of the eye 124. The incision 128 may be of a suitable width or length. Without limitation, a suitable width and / or length may be less than 3 mm, and in some cases may be less than 2 mm. After creating the incision 128, the mouth 22 of the insertion tool 51 may be inserted through the incision 128 into the eye 124. The insertion tool 51 may be actuated to dispense the IOL 16 into the capsular bag 136 of the eye 124, as shown in FIG. Fig. 9B shown.

[0043] The IOL 16 can be delivered in a folded (or rolled) configuration and allowed to unfold after being ejected from the insertion tool 51. After dispensing, the IOL 16 should unfold and seat within the capsular bag 136 of the eye 124, as shown in FIG. Fig. 9B For example, the haptic extension 34 can be manipulated to engage the equatorial portion of the capsular bag 136. The haptic extension 34 can engage the capsular bag 136 to secure the IOL 16 in the capsular bag 136.

[0044] Compared with other IOL delivery systems, using the method and system described herein can provide many benefits and advantages.For example, the unpacking of IOL box and the folding or other manipulation of IOL can be simplified.In addition, the integrated function that the packager makes the knob rotate to actuate the IOL folding or straightening mechanism can ensure that the IOL delivery system is correctly used and can prevent user errors.For example, when the IOL box is removed from the packager, the built-in automatic and simultaneous actuation of the knob can ensure that the IOL is correctly folded or otherwise manipulated before the IOL pops out from the IOL box.In addition, positioning the IOL box in the packager can ensure that the handpiece or driving mechanism is properly attached to the IOL box before the user can remove the IOL box from the packager and actuate the push rod of the handpiece.In a word, these features and designs can ensure that the user follows the appropriate sequence of steps to properly operate the IOL delivery system.

[0045] In addition, the interchangeable use between different drive mechanisms and preloaded IOL boxes provides a simplified and unified process for pairing drive mechanisms with preloaded IOL boxes. Therefore, various handpieces using different types of drive mechanisms can be used with each of a plurality of different types of IOL boxes, and therefore can be used with different types of IOLs. For example, depending on the type of IOL and / or the type of IOL box, a user can easily choose between the multiple types of drive mechanisms he or she wishes to use. In addition, while one user may prefer to use a first type of drive mechanism handpiece for a given IOL box, a different user may choose to use a second type of drive mechanism handpiece for the same given type of IOL box. Importantly, by allowing the handpiece to be fixed to the IOL box with a universal or standard interface, the user experience of fixing the handpiece to the IOL box can be substantially the same, regardless of the type of drive mechanism used or the IOL box and therefore the type of IOL, which can also improve the operator's ease of use and simplify the IOL delivery procedure.

[0046] It is believed that the operation and construction of the present disclosure will be apparent from the foregoing description.While the apparatus and methods shown or described above have been characterized as being preferred, various changes and modifications may be made therein without departing from the spirit and scope of the present disclosure as defined in the appended claims.

Claims

1. A system for storing or transporting an intraocular lens (IOL), the system comprising: Packages with access openings; as well as an IOL cartridge removably disposed within the passageway, the IOL cartridge comprising: a compartment configured to receive an IOL; and a knob configured to be rotated when the IOL cartridge is removed from the passage, wherein rotation of the knob configures the IOL for delivery and releases the IOL cartridge from the packaging, wherein: Rotation of the knob causes the IOL to fold. The compartment of the IOL box includes edge rollers configured to rotate and fold the IOL, the IOL being arranged between the edge rollers, wherein a surface of each edge roller is configured to contact an inner surface of the knob, wherein the inner surface of the knob is exposed to the compartment, and The IOL box further includes a compression arm configured to compress a haptic extension of the IOL, the compression arm being configured to contact an inner surface of the knob.

2. The system of claim 1, wherein: The passageway includes internal features adapted to interact with the knob and cause the knob to rotate when the IOL cartridge is removed from the packaging.

3. The system of claim 2, wherein: The internal features of the passageway include rungs, and The knob includes a protrusion adjacent the rung, the protrusion being configured to be actuated upon contacting the rung.

4. The system of claim 3, further comprising a plunger barrel in fluid communication with the compartment, wherein: The plunger barrel includes a protrusion configured for attaching the plunger barrel to a handpiece, wherein a plunger is movably disposed within the plunger barrel.

5. The system of claim 1, wherein: The IOL box further includes a mouth; and The package further includes a cavity in fluid communication with the passageway, the cavity being configured to receive a mouth of the IOL cartridge.

6. The system of claim 1, wherein: The rotation of the knob causes at least one haptic extension of the IOL to be straightened.

7. The system of claim 1, wherein: The passageway is configured to receive a handpiece to removably attach the handpiece to the IOL box.

8. A system for storing or transporting an intraocular lens (IOL) box, the system comprising: A package having a passageway, wherein the crosspiece is disposed within the passageway; and An IOL cartridge is removably disposed within the passageway, the IOL cartridge comprising: a compartment for receiving an IOL; and A knob having a protrusion, the knob being configured to be rotated from a first position to a second position due to interaction between the protrusion of the knob and a rung of the passage, wherein: Rotation of the knob from the first position to the second position causes the IOL to fold, The compartment of the IOL box includes edge rollers configured to rotate and fold the IOL, the IOL being arranged between the edge rollers, wherein a surface of each edge roller is configured to contact an inner surface of the knob, wherein the inner surface of the knob is exposed to the compartment, and The IOL box further includes a compression arm configured to compress a haptic extension of the IOL, the compression arm being configured to contact an inner surface of the knob.

9. The system of claim 8, wherein: The protrusion of the knob extends away from the longitudinal axis of the IOL box.

10. The system of claim 9, wherein: In the first position, the projection of the knob extends orthogonally to the longitudinal axis of the IOL box.

11. The system of claim 10, wherein: The protrusion of the knob is configured to rotate inwardly toward a longitudinal axis of the IOL cartridge when the IOL cartridge is removed from the packaging.

12. The system of claim 11, wherein: The projection of the knob is configured to rotate inwardly and away from the crosspiece of the passageway.

13. The system of claim 8, wherein: In the first position, the projection of the knob is configured to lock the IOL box against the ledge of the passageway until the knob is rotated.

14. A method of preparing an intraocular lens (IOL) for delivery using the system of any one of claims 1-13, comprising: inserting the handpiece into a package including the IOL box; rotating the hand piece to removably attach the hand piece to the IOL box to form an insertion tool; as well as The insertion tool is removed from the packaging, thereby causing the knob to be actuated to configure the IOL for delivery and release the IOL cartridge from the packaging.

15. The method of claim 14, wherein: Actuating the knob rotates the knob from a first locked position to a second unlocked position.

16. The method of claim 15, wherein: The knob includes a first feature; and The package includes a second feature configured to engage the first feature of the knob to rotate the knob from the first locked position to the second unlocked position when the insertion tool is removed from the package.

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