Nanoemulsion cosmetic compositions and their preparation methods

Abstract

This invention relates to a nanoemulsion cosmetic composition and its preparation method. The nanoemulsion cosmetic composition comprises an oil phase and an aqueous phase. The oil phase comprises ginseng nanoparticles and oil swollen by the ginseng nanoparticles. The composition does not contain any surfactants alone, and the ginseng nanoparticles are uniformly distributed in the composition. According to the invention, the oil phase contains oil swollen by ginseng nanoparticles, thereby having the advantage of containing natural substances and providing beneficial effects to the skin.

Description

Technical Field

[0001] This invention discloses a nanoemulsion cosmetic composition and its preparation method. Background Technology

[0002] In the process of stably dispersing one liquid in another to prepare an emulsion, the addition of surfactants is essential. In particular, in oil-in-water emulsions, the oil droplets are surrounded by the surfactant under the emulsifying action of the surfactant, and the outer phase is a continuous aqueous phase, thus providing a moist feel. However, with the recent trend of increasing emphasis on safety, surfactant-free emulsions have become a demand. Korean Patent Publication No. 10-2003-0071485 discloses a surfactant-free oil-in-water emulsion composition comprising one or more oils selected from fatty acids and higher alcohols; and one or more polymers (polyvinylpyrrolidone or vinylpyrrolidone) soluble in said oils, but it uses chemically synthesized substances and does not provide beneficial effects on the skin. Therefore, there is a need to research and develop an emulsion that contains natural substances and provides beneficial effects on the skin.

[0003] [Existing Technical Documents]

[0004] [Patent Documents]

[0005] (Patent Document 1) Korean Patent Publication No. 10-2003-0071485. Summary of the Invention

[0006] Technical issues

[0007] The present invention is proposed to solve the problems mentioned above. The purpose of the present invention is to provide a nanoemulsion cosmetic composition containing natural substances and having beneficial effects on the skin, and a method for preparing the same.

[0008] Technical solution

[0009] To achieve the above objectives, in one aspect, the present invention provides a nanoemulsion cosmetic composition comprising an oil phase and an aqueous phase, wherein the oil phase comprises ginseng nanoparticles and oil swollen by the ginseng nanoparticles, the composition does not contain a single surfactant, and the ginseng nanoparticles are uniformly distributed in the composition. In another aspect, the present invention provides a method for preparing a nanoemulsion cosmetic composition, the method comprising preparing an emulsion by collisionally dispersing water, oil, and a ginseng nanoparticle precursor.

[0010] Beneficial effects

[0011] According to the present invention, ginseng nanoparticles and oil swollen by the ginseng nanoparticles are included in the oil phase, thereby having the advantage of containing natural substances and providing beneficial effects on the skin. Attached Figure Description

[0012] Figure 1 A photograph of the ginseng nanopowder precursor used in the preparation of the composition according to the example is shown.

[0013] Figure 2 A graph showing the results of the oil absorption assessment of the ginseng nanopowder precursor used in the preparation of the composition according to the example is presented.

[0014] Figures 3 and 4 show graphs of the oil phase size determination results for the example compositions.

[0015] Figure 5 The image shows photographs of ginseng nanoparticles and oil swollen by the ginseng nanoparticles. Detailed Implementation

[0016] Regarding the terminology used in this specification, widely used and common terms have been selected to the extent possible while considering the functionality of the invention. However, these terms may change based on the intent of those skilled in the art, precedents, or the emergence of new technologies. Furthermore, in some cases, terms arbitrarily chosen by the applicant may be used; in such cases, their meanings will be explained in detail in the corresponding description of the invention. Therefore, the definitions of terms used in this specification should be based on their inherent meanings and the overall content of this specification, rather than simply on the name of the term.

[0017] Unless otherwise defined, all terms used in this specification, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Terms as commonly understood should be interpreted as having the same meaning as in the context of the relevant art, and should not be construed as having an idealized or overly formal meaning unless expressly defined herein.

[0018] The numerical range includes the values ​​defined in this specification. Where a lower numerical limit is explicitly stated, all maximum numerical limits given in this specification include all lower numerical limits. Where a higher numerical limit is explicitly stated, all minimum numerical limits given in this specification include all higher numerical limits. Where a narrower numerical limit is explicitly stated, all numerical limits given in this specification are included within the wider numerical range.

[0019] The present invention will now be described in more detail with reference to the embodiments and accompanying drawings. However, it should be understood that the present invention is not limited to the following embodiments and drawings.

[0020] In one aspect, the present invention provides a nanoemulsion cosmetic composition comprising an oil phase and an aqueous phase, wherein the oil phase comprises ginseng nanoparticles and oil swollen by the ginseng nanoparticles, the composition does not contain a single surfactant, and the ginseng nanoparticles are uniformly distributed in the composition. Figure 5 The photos show ginseng nanoparticles and oil swollen by the ginseng nanoparticles.

[0021] The "ginseng" mentioned may refer to Korean ginseng, also known as Panax ginseng. Ginseng is generally classified into three types based on its condition: fresh ginseng, white ginseng, and red ginseng. Fresh ginseng is ginseng that has not been dried after harvesting and has a moisture content of approximately 75% by weight. White ginseng is fresh ginseng that has been peeled and dried. Red ginseng is fresh ginseng that has not been peeled and has been steamed and then dried. In an exemplary embodiment, the ginseng may be one or more of the seeds, roots, stems, leaves, and fruits selected from plants of the genus Panax. Specifically, plants of the genus Panax include Korean ginseng (Panax ginseng), American ginseng (Panax quinquefolium), Panax notoginseng (Panax notoginseng), bamboo ginseng (Panax japonicum), three-leaf ginseng (Panax trifolium), Himalayan ginseng (Panax pseudoginseng), or Vietnamese ginseng (Panax vietnamensis), etc., and processed or unprocessed ginseng from various growing environments, including red ginseng, water ginseng, white ginseng, cultivated ginseng, wild ginseng or wild mountain ginseng, and mountain ginseng cultured roots, etc., can be used without restriction on variety or species.

[0022] The term "ginseng nanopowder" has the same meaning as "ginseng nano powder." The ginseng can be obtained by dry or wet grinding using a sand mill, perl mill, rod mill, needle mill, hammer mill, shredder, ball mill, air jet mill, etc.

[0023] According to one embodiment of the present invention, the ginseng nanopowder can be obtained from ginseng root. The ginseng root contains polysaccharide components, especially ginsenosides, which are pharmacologically active substances.

[0024] According to multiple research results, the ginsenosides were analyzed into about 37 chemical structures. Through basic research, it is known that their effects include anti-stress, protection of brain nerve cells, anti-thrombosis, improvement of lipid metabolism, inhibition of cancer cell proliferation, anti-diabetic, and anti-fatigue effects, among other pharmacological activities [Arch. Pharm. Res., October 2000, 23(5) 518-524; Biochem Pharmacol., December 1, 2003, 66(11):2213-21; Chinese Journal of Physiology, March 31, 2003, 46(1):1-7; Shibata et al., J. Korean Med Sci. 16(Supplement) S28-37 (2001)].

[0025] Ginsenosides possess a bisdesmoside neutral glycoside structure, in which sugar molecules such as glucose, arabinose, xylose, and rhamnose are bound to the dammarane skeleton of triterpenoid compounds. Based on the binding position of sugar molecules and the shape of the basic skeleton, they are classified into panaxadiol, panaxtriol, and oleanane classes, and their pharmacological effects in vivo differ. It has been reported that panaxtriol ginsenosides, in particular, have the effects of raising blood pressure, increasing body temperature, and increasing central nervous system tension, while panaxadiol ginsenosides have the effects of lowering blood pressure, lowering body temperature, and relieving central nervous system tension [Saito et al., Jap. Pham., 22:245-259 (1974)]. Representative examples of ginsenosides of the ginsenoside triol class include ginsenosides Rg1 and Re, while representative examples of ginsenosides of the ginsenoside diol class include ginsenosides Rb1 and Rd.

[0026] According to one embodiment of the invention, the composition does not contain a surfactant alone. The presence of surfactants generally has the disadvantage of requiring the preparation of cosmetic compositions under mild conditions, and the need to avoid the use of surfactants, especially heat-sensitive surfactants. Furthermore, surfactants can be irritating to users with sensitive skin. Therefore, research is ongoing on cosmetic compositions that minimize or eliminate the need for surfactants. The significance of this invention lies in providing a composition that is stably dispersed in a substantially surfactant-free manner, stemming from the aqueous counter-collision method used in the preparation of the composition, and the type and amount of the components contained in the composition.

[0027] The phrase "substantially free of surfactants" means that the surfactants in the synthetic components are minimized or completely absent, and implies a content of 1% or less based on the total weight of the composition, preferably 0.5% or less, more preferably 0.1% or less.

[0028] The "oil phase" is a phase that does not readily miscibly mix with the aqueous phase. It can be a liquid at room temperature and pressure, such as oil, organic solvents, or mixtures thereof. The "water phase" is a phase that does not readily miscibly mix with the oil phase. It can be any substance that can readily dissolve water-soluble polymers. For example, it can include water such as purified water or distilled water, polyols, etc.

[0029] The oil can be any common oil component without restriction, and can be one or more oils selected from hydrocarbon oils, higher fatty alcohol oils, glyceride oils, silicone oils, ester oils, fluorinated oils, and natural oils (vegetable oils, animal oils, etc.). Preferably, it can be a natural oil. According to one embodiment of the present invention, the oil phase contains ginseng seed oil. Ginseng seed oil is mainly composed of unsaturated fatty acids, more specifically, mainly composed of oleic acid, linoleic acid, etc. The nanoemulsion cosmetic composition of the present invention is a nanoemulsion cosmetic composition comprising an oil phase and an aqueous phase, wherein the oil phase contains ginseng nanoparticles and oil swollen by the ginseng nanoparticles. Saponin compounds can be distributed at the interface between the oil phase and the aqueous phase. Further, the composition can be a so-called "whole cosmetic composition", wherein the oil constituting the oil phase is itself ginseng seed oil derived from ginseng. The "whole cosmetic composition" refers to a cosmetic composition made from natural ingredients without artificial preservatives, artificial pigments, or other harmful additives.

[0030] According to one embodiment of the present invention, the content of the oil phase is from 4% to 20% by weight, based on the total weight of the composition. Specifically, it may be 4% or more by weight, 4.65% or more by weight, 5% or more by weight, 5.83% or more by weight, 6% or more by weight, 6.66% or more by weight, 7% or more by weight, 8% or more by weight, 9% or more by weight, or 10% or more by weight; and 20% or less by weight, 19% or less by weight, 18% or less by weight, 17% or less by weight, 16% or less by weight, 15% or less by weight, 14% or less by weight, 13% or less by weight, 12% or less by weight, 11% or less by weight, or 10% or less by weight, but is not limited thereto.

[0031] According to one embodiment of the present invention, the average diameter of the oil phase is 500 nm or less. Specifically, it can be 500 nm or less, 450 nm or less, 400 nm or less, 350 nm or less, 300 nm or less, 250 nm or less, 200 nm or less, or 150 nm or less, but the lower limit of the average diameter of the oil phase is not particularly limited, and those skilled in the art can set it appropriately. When the average diameter of the oil phase is equal to or less than the upper limit, it can provide a visually appealing appearance and a uniform and soft feel when applied to the skin.

[0032] According to one embodiment of the present invention, the oil content is from 2.5% to 15% by weight, based on the total weight of the composition. Specifically, it may be 2.5% or more by weight, 2.65% or more by weight, 3% or more by weight, 3.5% or more by weight, 4% or more by weight, 4.76% or more by weight, 5% or more by weight, 6% or more by weight, 7% or more by weight, 8% or more by weight, 9% or more by weight, 10% or more by weight; and 15% or less by weight, 14.5% or less by weight, 14% or less by weight, 13.5% or less by weight, 13% or less by weight, 12.5% ​​or less by weight, 12% or less by weight, 11.5% or less by weight, 11% or less by weight, 10.5% or less by weight, 10% or less by weight, but is not limited thereto.

[0033] According to one embodiment of the present invention, based on the total weight of the composition, the content of the ginseng nanopowder is greater than 0% by weight and 5% by weight or less. Specifically, it may be greater than 0% by weight, 0.1% by weight or more, 0.5% by weight or more, 1% by weight or more, 1.5% by weight or more, 1.9% by weight or more, 2% by weight or more, 2.5% by weight or more, 3% by weight or more; and 5% by weight or less, 4% by weight or less, 3% by weight or less, but is not limited thereto.

[0034] In one embodiment of the present invention, the saponin compound may be distributed at the interface between the oil phase and the aqueous phase. According to another embodiment of the present invention, the saponin compound is derived from the ginseng nanoparticles. More specifically, the saponin compound distributed at the interface between the oil phase and the aqueous phase is dissolved from the particles of the ginseng nanoparticles and arranged at the interface between the oil phase and the aqueous phase. Saponin compounds are natural substances containing both hydrophilic and hydrophobic groups and possessing surface-active functions, forming a stable dispersed phase in a certain combination of saponin compounds and oil. Through the water-soluble mutual collision method used in the preparation of the composition, the type and content of the components contained in the composition, etc., the saponin compound exhibits effective surface-active effects.

[0035] According to one embodiment of the present invention, the ginseng nanoparticles are uniformly distributed in the composition. The dosage form of the composition of the present invention is not particularly limited and can be an oil-in-water emulsion, i.e., the fine phase surrounded by the saponin compounds is oil particles; or an oil-in-water emulsion, i.e., the fine phase surrounded by the saponin compounds is water particles. According to one embodiment of the present invention, the dosage form of the composition is an oil-in-water emulsion. The dosage form type of the composition of the present invention can be prepared by adjusting the constituent components of the saponin compounds, the arrangement of the saponin compounds, and the conditions of the water-soluble mutual collision method used to prepare the composition.

[0036] According to one embodiment of the present invention, the content of the ginseng nanopowder is from 1% to 5% by weight, based on the total weight of the composition. Specifically, it may be 1% or more by weight, 1.5% or more by weight, 1.9% or more by weight, 2% or more by weight, 2.5% or more by weight, or 3% or more by weight; and 5% or less by weight, 4.5% or less by weight, 4% or less by weight, 3.5% or less by weight, or 3% or less by weight, but is not limited thereto. The content of the ginseng nanopowder refers to the weight including saponin compounds dissolved from the ginseng nanopowder.

[0037] According to one embodiment of the present invention, the weight-based content ratio of the ginseng nanopowder to the oil is 1:1 to 3. Specifically, it can be 1:1 or more, 1:1.1 or more, 1:1.2 or more, 1:1.3 or more, 1:1.33 or more, 1:1.4 or more, 1:1.5 or more, 1:1.6 or more, 1:1.7 or more, 1:1.8 or more, 1:1.9 or more, 1:2 or more; and 1:3 or less, 1:2.9 or less, 1:2.8 or less, 1:2.7 or less, 1:2.6 or less, 1:2.51 or less, 1:2.5 or less, 1:2.4 or less, 1:2.3 or less, 1:2.2 or less, 1:2.1 or less, 1:2 or less, but is not limited thereto.

[0038] According to one embodiment of the present invention, the composition can be formulated by conventional methods. Formulation can be referenced to the contents published in the International Cosmetic Ingredient Dictionary published by the Cosmetic, Toiletry and Fragrance Association.

[0039] Specifically, the composition can be formulated into a softening lotion, nourishing lotion, serum, or spray, etc.

[0040] Depending on the quality or function of the final product, the composition may further include, as needed, fatty substances, organic solvents, solubilizers, concentrates, gelling agents, softeners, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, preservatives, pH adjusters, water, ionic or nonionic emulsifiers, fillers, metal ion chelators, chelating agents, preservatives, retardants, humectants, necessary oils, dyes, pigments, hydrophilic or lipophilic active agents, and any other ingredients commonly used in cosmetics or as adjuvants in the fields of cosmetics or dermatology.

[0041] In another aspect, the present invention provides a method for preparing a nanoemulsion cosmetic composition, the method comprising preparing an emulsion by collision dispersion of water, oil and ginseng nanopowder precursor.

[0042] The water may be purified water, pure water, hard water, soft water, natural water, deep seawater, electrolyzed alkaline ionized water, electrolyzed acidic ionized water, ionized water, and clustered water, but is not limited to these.

[0043] According to one embodiment of the present invention, the oil content is from 2.5% to 15% by weight, based on the total weight of the composition. Specifically, it may be 2.5% or more by weight, 2.65% or more by weight, 3% or more by weight, 3.5% or more by weight, 4% or more by weight, 4.76% or more by weight, 5% or more by weight, 6% or more by weight, 7% or more by weight, 8% or more by weight, 9% or more by weight, 10% or more by weight; and 15% or less by weight, 14.5% or less by weight, 14% or less by weight, 13.5% or less by weight, 13% or less by weight, 12.5% ​​or less by weight, 12% or less by weight, 11.5% or less by weight, 11% or less by weight, 10.5% or less by weight, 10% or less by weight, but is not limited thereto.

[0044] According to one embodiment of the present invention, based on the total weight of the composition, the content of the ginseng nanopowder precursor is greater than 0% by weight and 5% by weight or less. Specifically, it may be greater than 0% by weight, 0.1% by weight or more, 0.5% by weight or more, 1% by weight or more, 1.5% by weight or more, 1.9% by weight or more, 2% by weight or more, 2.5% by weight or more, 3% by weight or more; and 5% by weight or less, 4% by weight or less, 3% by weight or less, but is not limited thereto.

[0045] According to one embodiment of the present invention, the collision dispersion involves spraying a solution containing water, oil, and ginseng nanopowder precursor through nozzles facing each other, causing collisions. This spraying and collision is also known as a water-soluble mutual collision method. This method does not use any solvent other than water, thus it is environmentally friendly, and it eliminates the need for post-treatment when using solvents, thus making it economical.

[0046] According to one embodiment of the present invention, the angle between the opposing nozzles is 140° to 170°. Specifically, it may be 140° or above, 145° or above, 150° or above, or 155° or above; and 170° or below, 165° or below, 160° or below, or 155° or below, but is not limited thereto.

[0047] According to one embodiment of the present invention, the number of collisions is 30 to 40. Specifically, it can be 30 or more, 31 or more, 32 or more, 33 or more, 34 or more, or 35 or more; and 40 or less, 39 or less, 38 or less, 37 or less, 36 or less, or 35 or less, but is not limited thereto.

[0048] According to one embodiment of the present invention, the diameter of the nozzle is 0.2 mm to 0.45 mm. Specifically, it may be 0.2 mm or more, 0.25 mm or more, or 0.3 mm or more; and 0.45 mm or less, 0.4 mm or less, 0.35 mm or less, or 0.3 mm or less, but is not limited thereto.

[0049] The jet impact pressure is between 180 MPa and 200 MPa. Specifically, it can be 180 MPa or above, 182 MPa or above, 184 MPa or above, 186 MPa or above, 188 MPa or above, or 190 MPa or above; and 200 MPa or below, 198 MPa or below, 196 MPa or below, 194 MPa or below, 192 MPa or below, or 190 MPa or below, but is not limited thereto.

[0050] The ginseng nanopowder precursor is further pulverized by high-pressure impact to form ginseng nanopowder. The size of the ginseng nanopowder can be adjusted by regulating the angle of the nozzles facing each other, the jet impact pressure, and the number of impacts. Furthermore, since the temperature of the dispersion rises rapidly due to the impacts, it can be cooled by a cooling system to maintain a constant temperature.

[0051] According to one embodiment of the present invention, the oil is ginseng seed oil. As described above, the nanoemulsion cosmetic composition of the present invention contains ginseng nanoparticles in the oil phase, and the oil constituting the oil phase in the composition is ginseng seed oil derived from ginseng, thus forming a "complete cosmetic composition".

[0052] According to one embodiment of the present invention, the ginseng nanopowder precursor can be obtained without an extraction process using a solvent, and according to another embodiment of the present invention, the ginseng nanopowder precursor comprises particles with a D90 of less than 16 μm in a volume-based particle diameter distribution measured by laser diffraction.

[0053] Laser diffraction is a method for calculating particle size distribution or particle size distribution. The "Dx in volume-based particle diameter distribution" measured by this method refers to the diameter corresponding to x% of the cumulative percentage of particle size measurements converted to volume in a volume-based particle size distribution chart. Dx can be similarly represented as [D...]. x ]、D [x] =[Dx], D(0.x) or D[0.x] etc.

[0054] Therefore, D50 in volume-based particle diameter distribution refers to the 50% volumetric cumulative particle diameter, which is the diameter corresponding to 50% of the cumulative percentage of particle size measurements converted to volume in a volumetric particle size distribution chart. Similarly, D90 in volume-based particle diameter distribution refers to the 90% volumetric cumulative particle diameter, which is the diameter corresponding to 90% of the cumulative percentage of particle size measurements converted to volume in a volumetric particle size distribution chart.

[0055] Specifically, the D90 of the ginseng nanopowder precursor can be greater than 7μm, 7.5μm or above, 8μm or above, 8.5μm or above, 9μm or above, 9.5μm or above, 10μm or above, 10.5μm or above, 11μm or above, 11.5μm or above, 12μm or above, or 12.4μm or above; or less than 16μm, 15.5μm or below, 15μm or below, 14.5μm or below, 14μm or below, 13.5μm or below, 13μm or below, 12.5μm or below, or 12.4μm or below.

[0056]

Example

[0057] The present invention will now be described in detail with reference to embodiments. However, the following embodiments are only for the purpose of helping to fully understand the present invention, and the content of the present invention is not limited to the following embodiments.

[0058] [Preparation Example 1] Preparation of Ginseng Nanopowder Precursor

[0059] The dried ginseng (Osulloc Farm, South Korea) was coarsely pulverized using a cutting machine (SM100, Retsch) to obtain coarsely pulverized ginseng nanoparticles (cutting rate: 1,500 min). -1 Then, the coarsely pulverized ginseng nanoparticles are added to an air jet mill (SD Micronizer, Sturevant) at a rate of 3 g / min, and a supersonic airflow at a supply rate of 3 g / min is used to obtain the ginseng nanoparticle precursor.

[0060] [Experimental Example 1] Evaluation of oil absorption capacity based on the particle size of ginseng nanopowder precursor

[0061] 1. Sample preparation

[0062] By adjusting the running time of the air jet mill and using a classifier (AS 200 jet, Retsch), ginseng nanopowder precursors with D90 values ​​of 1470 μm (GB-1), 446 μm (GB-2), 176 μm (GB-3), 14 μm (GB-4), and 10 μm (GB-5) were prepared. Figure 1 Particle size analysis was performed using a particle size analyzer (Mastersizet 2000, Malvern Panalytical).

[0063] 2. Evaluation Methods

[0064] The oil absorption (oil absorption capacity) of GB-1, GB-2, GB-3, GB-4, and GB-5 will be determined according to the test method specified in Korean Industrial Standard (KS) standard number KS M ISO 787-5:2007 (JIS K 5107~1978), "General test methods for pigments and extender pigments, Part 5: Determination of oil absorption". The test method can be found at "http: / / www.kssn.net / StdKS / ks_detail.asp?k1=M&k2=ISO%20787-5&k3=2", the full text of which is incorporated herein by reference.

[0065] More specifically, the process for determining oil absorption (g / g) is as follows.

[0066] (1) Weigh 1.00g of ginseng nanopowder precursor powder raw material in a petri dish.

[0067] (2) Weigh the syringe + CSA (caprylic / capric triglyceride).

[0068] (3) Use a syringe to add an appropriate amount of CSA from (2) into the powdered raw material from (1).

[0069] (4) Use a spatula to mix the powder and oil in (3).

[0070] (5) Repeat the process of (2) and (3) until the powder in (3) aggregates due to the oil.

[0071] (6) The amount of oil added is determined by weighing the syringe + CSA.

[0072] The results are shown in Table 1 and Figure 2 .

[0073] Table 1

[0074]

[0075] 3. Evaluation Results

[0076] From Table 1 and Figure 2 It can be seen that the oil absorption capacity of GB-4 and GB-5 ginseng nanopowder precursors with D90 less than 16μm is 0.45 and 0.56, respectively. When compared with GB-1, GB-2 and GB-3 ginseng nanopowder precursors with D90 of 1470μm, 446μm and 176μm, respectively, it can be seen that the oil absorption capacity increases with the decrease of particle size.

[0077]

Preparation Example 2

[0078] 2.4 L of purified water, 450 g of ginseng seed oil, and 150 g of the ginseng nanopowder precursor prepared in Example 1 were subjected to a water-soluble mutual collision method and sprayed through facing nozzles. The spraying collision pressure was 200 MPa, and the collision was repeated 30 times. The composition of the composition prepared by the method is shown in Table 2 (unit: weight %; oil / P: ratio of ginseng seed oil to ginseng nanopowder precursor; P%: content of ginseng nanopowder).

[0079] Table 2

[0080]

[0081] [Experimental Example 2] Stability evaluation of the compositions of the examples and comparative examples

[0082] 1. Evaluation Methods

[0083] For the compositions of the examples and comparative examples in Preparation Example 2, the degree of separation between the aqueous and oil phases was observed visually at room temperature to assess the formulation stability. The results are shown in Table 3 (○: dispersion, △: precipitation, X: separation, △X: precipitation and separation).

[0084] Table 3

[0085]

[0086] 2. Evaluation Results

[0087] As shown in Table 3, Examples 1 to 8, where the oil / P (ratio of ginseng seed oil to ginseng nanopowder precursor) and P% (content of ginseng nanopowder) are within the preferred range, exhibit excellent results in terms of stability.

[0088] [Experimental Example 3] Determination of oil phase size 1

[0089] 1. Evaluation Methods

[0090] Except that the pressures of the opposing nozzles were set to 160 MPa, 180 MPa, and 200 MPa, respectively, the compositions of Examples 9, 10, and 11 were prepared using the same method as in Example 1. The average diameter (Z-Average) of the oil phase in the compositions of Examples 9, 10, and 11 was confirmed using a particle size analyzer (nanobrookomni particle size analyzer, Malvern Panalytical). The results are shown in Table 4 and Figure 3.

[0091] Table 4

[0092]

[0093] 2. Evaluation Results

[0094] As shown in Table 4 and Figure 3, when the pressure of the nozzles facing each other is set to 160 MPa, 180 MPa, and 200 MPa, compositions with average oil phase diameters of 275.6 nm, 218.2 nm, and 165.6 nm can be obtained. This indicates that the size of the oil phase in the composition can be adjusted by regulating the collision pressure between the two surfaces in the water-soluble mutual collision method.

[0095] [Preparation Example 3] Preparation of Nanoemulsion Cosmetic Composition

[0096] Except for adjusting the content of ginseng seed oil and ginseng nanopowder precursor, and also including excipients commonly used in the cosmetics field, the nanoemulsion cosmetic compositions of Examples 12 to 16 were prepared according to the same method as in Example 1. The composition of the compositions is shown in Table 5 (unit: weight %).

[0097] Table 5

[0098]

[0099] [Experimental Example 3] Determination of oil phase size 2

[0100] 1. Evaluation Methods

[0101] The average diameter (Z-Average) of the oil phase in the compositions of the preparation Example 3 was confirmed using a particle size analyzer (nanobrook omni particle size analyzer, Malvern Panalytical). The results are shown in Table 6 and Figure 4.

[0102] Table 6

[0103]

[0104] 2. Evaluation Results

[0105] As shown in Table 6 and Figure 4, based on the changes in the content of ginseng seed oil and ginseng nanopowder precursor, compositions with average oil phase diameters of 168.7 nm, 173.6 nm, 213.6 nm, 213.8 nm, and 224 nm can be obtained. This indicates that the size of the oil phase in the composition can be adjusted by regulating the content of ginseng seed oil and ginseng nanopowder precursor in the water-soluble mutual collision method.

[0106] 1. Evaluation Methods

[0107] The compositions of the Examples and Comparative Examples (Examples 17, Comparative Examples 8 and 9 were prepared to have the average diameter of the oil phase as shown in Table 7) were applied to 60 adults with an average age of 45 years. A sensory evaluation was then conducted on a 9-point scale to assess whether the participants experienced a foreign body sensation due to clumping (evaluation criteria are shown in Table 8). The total results are shown in Table 9.

[0108] Table 7

[0109]

[0110] Table 8

[0111]

[0112] Table 9

[0113]

[0114] 2. Evaluation Results

[0115] As shown in Table 9, the compositions of Examples 12 to 17 have excellent user experience. However, in Comparative Examples 8 and 9, where the average diameter of the oil phase exceeds the preferred range, poor user experience was confirmed.

[0116] In various respects, the present invention relates to and includes at least the following methods.

[0117] (Method 1) A nanoemulsion cosmetic composition comprising an oil phase and an aqueous phase, wherein the oil phase comprises ginseng nanoparticles and oil swollen by the ginseng nanoparticles, the composition does not contain a single surfactant, and the ginseng nanoparticles are uniformly distributed in the composition.

[0118] (Method 2) The composition according to Method 1, wherein the ginseng nanopowder is obtained from ginseng root.

[0119] (Method 3) The composition according to Method 1 or 2, wherein the oil is ginseng seed oil and the composition is a cosmetic product.

[0120] (Method 4) The composition according to any one of Methods 1 to 3, wherein the dosage form of the composition is an oil-in-water emulsion.

[0121] (Method 5) The composition according to any one of Methods 1 to 4, wherein the content of the oil phase is from 4% to 20% by weight based on the total weight of the composition.

[0122] (Method 6) The composition according to any one of Methods 1 to 5, wherein the average diameter of the oil phase is 500 nm or less.

[0123] (Method 7) The composition according to any one of Methods 1 to 6, wherein the oil content is from 2.5% to 15% by weight based on the total weight of the composition.

[0124] (Method 8) The composition according to any one of Methods 1 to 7, wherein the content of the ginseng nanopowder is greater than 0% by weight and 5% by weight or less based on the total weight of the composition.

[0125] (Method 9) The composition according to any one of Methods 1 to 8, wherein the weight-based content ratio of the ginseng nanopowder to the oil is 1:1 to 3.

[0126] (Method 10) A method for preparing a nanoemulsion cosmetic composition according to any one of Methods 1 to 9, comprising preparing an emulsion by collision dispersion of water, oil and ginseng nanopowder precursor.

[0127] (Method 11) The preparation method according to Method 10, wherein the collision dispersion is achieved by spraying a solution containing water, oil and ginseng nanopowder precursor through nozzles facing each other to cause collision.

[0128] (Method 12) The preparation method according to Method 11, wherein the jet impact pressure is 180 MPa to 200 MPa.

[0129] (Method 13) The preparation method according to Method 10 or 11, wherein the oil is ginseng seed oil.

[0130] (Method 14) The preparation method according to any one of Methods 10 to 13, wherein the ginseng nanopowder precursor comprises particles with a D90 of less than 16 μm in a volume-based particle diameter distribution determined by laser diffraction.

[0131] Although the present invention has been described with reference to the preferred embodiments described above, various modifications or variations can be made without departing from the spirit and scope of the invention. Therefore, the scope of protection of the appended claims includes these modifications or variations that fall within the spirit of the invention.

Claims

1. A nanoemulsion cosmetic composition comprising an oil phase and an aqueous phase, wherein the oil phase comprises ginseng nanoparticles and oil swollen by the ginseng nanoparticles, the oil being ginseng seed oil, the composition not containing any surfactant, and the ginseng nanoparticles being uniformly distributed in the composition. in, Based on the total weight of the composition, the content of the ginseng nanopowder is greater than 0% by weight and less than 5% by weight; based on the total weight of the composition, the content of the oil is 2.5% by weight to 15% by weight; and the weight-based ratio of the ginseng nanopowder to the oil is 1:1 to 3. The average diameter of the oil phase is less than 500 nm. The composition is in the form of an oil-in-water emulsion.

2. The composition according to claim 1, characterized in that, The ginseng nanopowder is obtained from ginseng roots.

3. The composition according to claim 1, characterized in that, The composition is made from natural ingredients.

4. The composition according to claim 1, characterized in that, The oil phase content is from 4% to 20% by weight, based on the total weight of the composition.

5. The composition according to claim 1, characterized in that, The average diameter of the oil phase is 150 nm to 500 nm.

6. The composition according to claim 1, characterized in that, The oil content is from 3% to 12% by weight, based on the total weight of the composition.

7. A method for preparing a nanoemulsion cosmetic composition according to any one of claims 1 to 6, the method comprising preparing an emulsion by collision dispersion of water, oil, and ginseng nanopowder precursor. in, The collision dispersion involves spraying a solution containing water, ginseng seed oil, and ginseng nanopowder precursor through facing nozzles, wherein the weight-based ratio of the ginseng nanopowder precursor to the ginseng seed oil in the solution is 1:1 to 3, and the collision pressure of the spray is 180 MPa to 200 MPa.

8. The preparation method according to claim 7, characterized in that, The impact pressure of the jet is 200 MPa.

9. The preparation method according to claim 7, characterized in that, The ginseng nanopowder precursor comprises particles with a D90 of less than 16 μm in a volume-based particle diameter distribution determined by laser diffraction.

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