A blood quality detection device and method

Abstract

The present invention discloses a blood quality detection device, comprising a test tube clamping device, a capacitance ruler and a processor. The solution uses the capacitance ruler to measure the capacitance value of the sample, and compares and analyzes the capacitance thresholds of blood of different quality grades stored in a database system to obtain the sample quality grade, which effectively solves the problem of affecting the recognition accuracy of blood quality due to the possibility of certain individual or batch differences in the pasting position of the barcode on the sample test tube in the prior art. In addition, the capacitance ruler described in the present invention can be divided into several equal parts, and the capacitance values ​​of each section of the sample are measured respectively by using the capacitance rulers of the several equal parts. Based on the inconsistency of dielectric constants under different media, the medium properties are reversely inferred by measuring the capacitance value, and then the liquid components of the corresponding liquid surface of the sample are analyzed.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a blood quality detection device and method. Background Art

[0002] The medical clinical testing process includes three stages: pre-analysis, analysis, and post-analysis. Pre-analysis errors account for about 70% of the total laboratory errors. Therefore, ensuring the quality of samples is a prerequisite for accurate and reliable test results.

[0003] At present, laboratories mainly manually evaluate whether the sample quality is qualified by checking whether the correct blood collection tube is used for the sample, whether the sample volume is too much or too little, whether the proportion of serum or plasma is too high, whether the sample is centrifuged, whether the sample is hemolyzed, icteric and lipemic, whether there are clots or fibers, etc. when the test personnel receive the sample at the front desk or before the instrument is manually tested. This is a large workload for the staff, and the efficiency of manual testing is low, and the error rate is also high. For this reason, some laboratories have introduced an assembly line system connected to a sample pre-treatment system to automatically realize operations such as sample identification, centrifugation, and opening, which reduces the manual intervention link to a certain extent. Among them, for the identification of sample quality, the existing technology usually adopts a camera photo identification method, and compares the sample photo taken with the preset standard sample photo to analyze the sample quality. However, for this solution, since the pasting position of the barcode on the sample tube may have certain individual or batch differences, it greatly affects the identification of blood quality. Summary of the invention

[0004] In order to overcome the deficiencies in the prior art, the present invention provides a blood quality detection device and method.

[0005] The present invention is achieved through the following technical solutions:

[0006] A blood quality detection device, characterized in that it comprises a test tube clamping device, a capacitance ruler and a processor, wherein the capacitance ruler is arranged on the inner side of the test tube clamping device, and the capacitance ruler is connected to the processor;

[0007] The test tube clamping device is used to fix the sample test tube;

[0008] The capacitance ruler is used to measure the capacitance value of the sample tube and feed the capacitance value back to the processor;

[0009] The processor is configured to receive the capacitance value and analyze a sample quality grade based on the capacitance value.

[0010] Further, it is characterized in that the processor includes a database system and an analysis system;

[0011] The database system is used to store capacitance thresholds of samples with different quality grades;

[0012] The analysis system is used for analyzing sample quality classification.

[0013] Furthermore, the method for building the database system includes:

[0014] Set the number and type of sample quality classification;

[0015] According to the sample quality classification, N samples with known sample quality classification are pre-selected, and the capacitance values ​​of the N samples with known sample quality classification are obtained, wherein N is a natural number not less than the number of sample quality classifications, and the N samples with known sample quality classifications should cover each set sample quality classification;

[0016] The capacitance threshold under each sample quality classification state is set according to the obtained capacitance values ​​of N samples with known sample quality classification.

[0017] Furthermore, the sample quality classification includes normal, mild quality abnormality and severe quality abnormality, the capacitance threshold includes normal capacitance threshold, mild capacitance threshold and severe capacitance threshold, and the method for obtaining the capacitance threshold includes:

[0018] The number of known samples of normal blood is set as n1, the number of known samples of mild quality abnormality is set as n2, and the number of known samples of severe quality abnormality is set as n3, wherein n1+n2+n3=N, and n1, n2 and n3 are all natural numbers not less than 1;

[0019] Obtaining capacitance values ​​of n1 known samples of normal blood, obtaining capacitance values ​​of n2 known samples with mild quality abnormalities, and obtaining capacitance values ​​of n3 known samples with severe quality abnormalities;

[0020] The normal capacitance threshold, the mild capacitance threshold, and the severe capacitance threshold are determined respectively according to the capacitance values ​​of the n1 known samples of normal blood, the capacitance values ​​of the n2 known samples of mild quality abnormalities, and the capacitance values ​​of the n3 known samples of severe quality abnormalities.

[0021] Furthermore, the method for analyzing sample quality classification by the analysis system includes:

[0022] Set the capacitance value of the target sample to P1;

[0023] When P1 falls within the normal capacitance threshold range, the target sample is a normal sample;

[0024] When P1 falls into the mild capacitance threshold range, the target sample is a sample with mild quality abnormality;

[0025] When P1 falls into the severe capacitance threshold range, the target sample is a sample with severe quality abnormality.

[0026] Furthermore, the capacitance ruler is divided into several equal parts, and the capacitance ruler is used to measure the capacitance value of each section of the sample, and the processor is also used to analyze the properties of the liquid components of the corresponding liquid surface of the sample. Its function is: by measuring the value of each section of the capacitance, the liquid components of the corresponding liquid surface can be analyzed. For example, when the sample is in a centrifugal state, the capacitance value of each part of the liquid in the stratified state can be measured, and then the properties / quality status of each part of the component liquid can be calculated.

[0027] Furthermore, the capacitance ruler is an electrode patch, including a left electrode patch and a right electrode patch symmetrically arranged on the inner side surfaces of the left and right sides of the test tube clamping device. Its function is to measure the capacitance value of the test tube sample placed in the test tube slot by symmetrically arranging the electrode patches on both sides of the base, and indirectly detect the sample quality through the capacitance value. According to the calculation formula of the plate capacitance C=ε*ε0*S / d, ε is the material dielectric constant, ε0 is the air dielectric constant, S is the plate area, and d is the plate distance. Because the dielectric constants under different media are inconsistent, the medium properties can be reversely inferred by measuring the capacitance value.

[0028] Furthermore, the capacitance ruler is an electrode patch made of a flexible material, which may be an FPC or an FFC, and the electrode patch is fixed on the inner side of the test tube clamping device. Its function is that in this scheme, the electrode patch is made of a flexible material and can be rolled and attached to the inner side of the test tube clamping device in a cylindrical or square column shape, which makes installation and fixing more convenient.

[0029] Furthermore, the method for the processor to analyze the liquid composition of the liquid surface corresponding to the sample includes:

[0030] The capacitance ruler is divided into 20 equal parts, and the capacitance ruler is used to measure the capacitance values ​​of the 20 sections of the sample;

[0031] The processor analyzes the liquid properties of each liquid surface according to the calculation formula of the plate capacitance C=ε*ε0*S / d, wherein ε is the material dielectric constant, ε0 is the air dielectric constant, S is the plate area, d is the plate distance, and the processor stores the capacitance setting values ​​of different liquid properties. The processor compares the capacitance values ​​of each section measured by the capacitance ruler with the capacitance setting values ​​of different liquid properties stored in the processor to analyze the liquid component properties of the corresponding liquid surface of the sample. In this embodiment, the processor stores the plasma capacitance setting value and the red blood cell capacitance setting value. Because the dielectric constants under different media are inconsistent, the medium properties can be reversely inferred by measuring the capacitance value. Its function is: for the sample after centrifugation, by analyzing the liquid capacitance values ​​of each liquid surface, the centrifugal stratification position, the serum and plasma volume after centrifugation, the centrifugal effect, etc. can be reversely inferred.

[0032] Furthermore, the blood quality detection device is applied to a fully automatic sample processing system. Its function is that the blood quality detection device is usually used for pre-processing in a fully automatic sample processing system to analyze and identify the sample quality, and solves the following problem of using a camera to identify the sample quality in the prior art: since the pasting position of the barcode on the sample test tube may have certain individual or batch differences, it greatly affects the identification of blood quality.

[0033] Combined with the structural features of the present invention, compared with the prior art, the present invention provides a blood quality detection device, including a test tube clamping device, a capacitance ruler and a processor, wherein the capacitance ruler is arranged on the inner side of the test tube clamping device, the capacitance ruler is connected to the processor, the test tube clamping device is used to fix the sample test tube, the capacitance ruler is used to measure the capacitance value of the sample test tube and feed the capacitance value back to the processor, the processor is used to receive the capacitance value and analyze the sample quality classification according to the capacitance value. This scheme uses the capacitance ruler to measure the capacitance value of the sample, and compares and analyzes the capacitance threshold of blood of different quality classifications stored in the database system to obtain the sample quality classification, which effectively solves the problem of affecting the recognition accuracy of blood quality in the prior art due to the possibility of certain individual or batch differences in the pasting position of the barcode affixed to the sample test tube. In addition, the capacitance ruler in the present invention can also be divided into several equal parts, and the capacitance values ​​of each section of the sample are measured by the capacitance rulers of the several equal parts respectively. Based on the inconsistency of the dielectric constants under different media, the medium properties are reversely inferred by measuring the capacitance value, and then the liquid components of the corresponding liquid surface of the sample are analyzed. Therefore, it can be used to analyze the centrifugal stratification position of the sample, the volume of serum and plasma after centrifugation, the centrifugal effect, and the like. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present invention. For ordinary technicians in this field, other drawings can also be obtained based on these drawings.

[0035] Figure 1 This is a schematic diagram of a blood quality detection device according to the present invention.

[0036] Figure 2 Schematic diagram of the capacitance ruler of the present invention.

[0037] Among them, 1-test tube clamping device, 2-sample test tube, 3-capacitance ruler. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical scheme and advantages of the present invention clearer, the embodiments of the present invention will be further described below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0039] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of the present invention are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0040] like Figure 1 As shown, a blood quality detection device is characterized in that it includes a test tube clamping device 1, a capacitance ruler 3 and a processor, wherein the capacitance ruler 3 is arranged on the inner side of the test tube clamping device 1, and the capacitance ruler is connected to the processor;

[0041] The test tube clamping device 1 is used to fix the sample test tube 2;

[0042] The capacitance ruler 3 is used to measure the capacitance value of the sample tube and feed the capacitance value back to the processor;

[0043] The processor is configured to receive the capacitance value and analyze a sample quality grade based on the capacitance value.

[0044] Further, it is characterized in that the processor includes a database system and an analysis system;

[0045] The database system is used to store the capacitance thresholds of blood of different quality grades;

[0046] The analysis system is used for analyzing sample quality classification.

[0047] Furthermore, the method for building the database system includes:

[0048] Set the number and type of sample quality classification; in this embodiment, the sample quality classification includes three classifications, namely normal, mild quality abnormality and severe quality abnormality, wherein mild quality abnormality and severe quality abnormality are blood samples with mild lipemia and severe lipemia, respectively;

[0049] According to the sample quality classification, 24 samples with known sample quality classification are pre-selected, wherein the 24 samples with known sample quality classification cover the three different blood quality classifications set. In this embodiment, the 24 samples with known sample quality classification include 8 normal samples, 8 samples with mild lipemia, and 8 samples with severe lipemia, and the capacitance values ​​of the 24 samples are obtained;

[0050] According to the capacitance values ​​of the 24 samples with known quality grades, the capacitance thresholds under three quality graded states, namely normal, mild quality abnormality and severe quality abnormality, are set, namely, the normal capacitance threshold, the mild capacitance threshold and the severe capacitance threshold, respectively. There is no cross-threshold between the normal capacitance threshold, the mild capacitance threshold and the severe capacitance threshold, that is, a target sample may eventually fall into only one of the quality grades. It should be noted that in this embodiment, the method of analyzing and setting the normal capacitance threshold, the mild capacitance threshold and the severe capacitance threshold by using the capacitance values ​​of known normal samples, mild lipemia and severe lipemia samples, as long as the method can set the threshold range by analyzing known data, falls within the protection scope of the present invention.

[0051] The method for analyzing sample quality classification by the analysis system comprises:

[0052] Set the capacitance value of the target sample to P1;

[0053] When P1 falls within the normal capacitance threshold range, the target sample is a normal sample;

[0054] When P1 falls into the mild capacitance threshold range, the target sample is a sample with mild quality abnormality;

[0055] When P1 falls into the severe capacitance threshold range, the target sample is a sample with severe quality abnormality.

[0056] like Figure 2 As shown, in another embodiment, the capacitance ruler is an electrode patch, which is divided into several equal parts. The capacitance ruler is used to measure the capacitance value of each section of the sample. The processor is also used to analyze the liquid composition of the corresponding liquid surface of the sample, that is, by measuring the capacitance value of each section, according to the calculation formula of the flat plate capacitance C=ε*ε0*S / d, ε is the material dielectric constant, ε0 is the air dielectric constant, S is the plate area, d is the plate distance, because the dielectric constants under different media are inconsistent, the medium properties can be reversely inferred by measuring the capacitance value, and the liquid composition of the corresponding liquid surface can be analyzed. For example, when the sample is in a centrifugal state, the capacitance value of each part of the liquid in the stratified state can be measured, and then the properties / quality status of the liquid components of each part can be inferred.

[0057] In one embodiment, the electrode patch includes a left electrode patch and a right electrode patch symmetrically arranged on the inner side surfaces of the left and right sides of the test tube clamping device.

[0058] In another embodiment, the capacitance ruler is an electrode patch made of a flexible material, which may be an FPC or an FFC, and the electrode patch is fixed on the inner side of the test tube clamping device.

[0059] In one embodiment, the processor is used to analyze the liquid composition of the sample corresponding to the liquid level:

[0060] The capacitance ruler is divided into 20 equal parts, and the capacitance ruler is used to measure the capacitance values ​​of the 20 sections of the sample;

[0061] The processor analyzes the liquid properties of each liquid surface according to the calculation formula of the flat plate capacitance C=ε*ε0*S / d, wherein ε is the material dielectric constant, ε0 is the air dielectric constant, S is the flat plate area, and d is the flat plate distance. The processor stores capacitance setting values ​​for different liquid properties. In this embodiment, the processor stores plasma capacitance setting values ​​and red blood cell capacitance setting values, wherein the plasma capacitance setting value and the red blood cell capacitance setting value are different. For samples after centrifugation, by analyzing the liquid capacitance values ​​of each liquid surface, the centrifugal stratification position, the serum and plasma volumes after centrifugation, the centrifugal effect, etc. can be reversely calculated.

[0062] The blood quality detection device of the present invention is applied to a fully automatic sample processing system.

[0063] The applicant declares that the above-described embodiments only express the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above-described embodiments, and the above-described embodiments and the specification only describe the principles of the present invention. For those skilled in the art, various changes and improvements can be made without departing from the concept and scope of the present invention, and these changes and improvements all fall within the scope of the present invention to be protected.

[0064] The present invention is not limited to the above-mentioned embodiments, and all embodiments that use structures and methods similar to the present invention to achieve the purpose of the present invention are within the protection scope of the present invention.

Claims

1. A blood quality detection device, characterized in that: It includes a test tube clamping device, a capacitance ruler and a processor, wherein the capacitance ruler is arranged on the inner side of the test tube clamping device, and the capacitance ruler is connected to the processor; The test tube clamping device is used to fix the sample test tube; The capacitance ruler is used to measure the capacitance value of the sample tube and feed the capacitance value back to the processor; The processor is used to receive the capacitance value and analyze the sample quality classification according to the capacitance value; The processor includes a database system and an analysis system; The database system is used to store capacitance thresholds of samples with different quality grades; The analysis system is used to analyze sample quality classification; The method for building the database system comprises: Set the number and type of sample quality classification; According to the sample quality classification, N samples with known sample quality classification are pre-selected, and the capacitance values ​​of the N samples with known sample quality classification are obtained, wherein N is a natural number not less than the number of sample quality classifications, and the N samples with known sample quality classifications cover each set sample quality classification; According to the obtained capacitance values ​​of N samples with known sample quality classification, the capacitance threshold under each sample quality classification state is set; The sample quality classification includes normal, mild quality abnormality and severe quality abnormality, the capacitance threshold includes normal capacitance threshold, mild capacitance threshold and severe capacitance threshold, and the method for obtaining the capacitance threshold includes: The number of known samples of normal blood is set as n1, the number of known samples of mild quality abnormality is set as n2, and the number of known samples of severe quality abnormality is set as n3, where n1 +n2+ n3=N, and n1, n2 and n3 are all natural numbers not less than 1; Obtaining capacitance values ​​of n1 known samples of normal blood, obtaining capacitance values ​​of n2 known samples with mild quality abnormalities, and obtaining capacitance values ​​of n3 known samples with severe quality abnormalities; Determine a normal capacitance threshold, a mild capacitance threshold, and a severe capacitance threshold according to the capacitance values ​​of the n1 known samples of normal blood, the capacitance values ​​of the n2 known samples of mild quality abnormality, and the capacitance values ​​of the n3 known samples of severe quality abnormality; The method for analyzing sample quality classification by the analysis system comprises: Set the capacitance value of the target sample to P1; When P1 falls within the normal capacitance threshold range, the target sample is a normal sample; When P1 falls into the mild capacitance threshold range, the target sample is a sample with mild quality abnormality; When P1 falls into the severe capacitance threshold range, the target sample is a sample with severe quality abnormality.

2. A blood quality detection device according to claim 1, characterized in that: The capacitance ruler is divided into a number of equal parts, and the capacitance ruler is used to measure the capacitance value of each section of the sample, and the processor is used to analyze the liquid component properties of the corresponding liquid surface of the sample.

3. A blood quality detection device according to any one of claims 1 or 2, characterized in that: The capacitance ruler is an electrode patch, and the capacitance ruler comprises a left electrode patch and a right electrode patch symmetrically arranged on the inner side surfaces of the left and right sides of the test tube clamping device.

4. A blood quality detection device according to any one of claims 1 or 2, characterized in that: The capacitance ruler is an electrode patch made of a flexible material, and the electrode patch is fixed on the inner side of the test tube clamping device.

5. A blood quality detection device according to claim 2, characterized in that: The method for the processor to analyze the liquid component properties of the sample corresponding to the liquid level includes: The capacitance ruler is divided into 20 equal parts, and the capacitance ruler is used to measure the capacitance values ​​of the 20 sections of the sample; The processor stores capacitance setting values ​​for different liquid properties; The processor compares the capacitance values ​​of each segment measured by the capacitance ruler with the capacitance setting values ​​of different liquid properties stored in the processor to analyze the liquid component properties of the corresponding liquid surface of the sample.

6. A blood quality detection device according to claim 1, characterized in that: The blood quality detection device is applied to a fully automatic sample processing system.

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