Antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive interbody fusion cage

Abstract

The present disclosure relates to an antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive intervertebral fusion cage, which comprises: N edges connected end to end, adjacent edges are pivotally connected, forming a closed N-sided polygon, wherein N is an integer greater than three; an adjusting rod is adjustably arranged between a first corner and a second corner of the N-sided polygon, and forms a triangular structure with two edges between the first corner and the second corner of the N-sided polygon; the three edges of the triangular structure are pivotally connected to each other; when the adjusting rod is retracted, the other two edges of the triangular structure are close to each other to distract the fusion cage until it enters a locked position; wherein a locking mechanism is arranged on the adjusting rod, and the locking mechanism at least locks the locking position of the adjusting rod. The present disclosure can maintain a suitable shape during implantation, be implanted through a wound, and be easily operated to achieve good fixation effect at a predetermined position.

Description

TECHNICAL FIELD

[0001] The present disclosure belongs to the technical and application field of medical materials, and particularly relates to an antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive intervertebral fusion cage. BACKGROUND

[0002] Spinal infection can be primary in vertebral body, intervertebral disc, paravertebral or epidural space, or secondary after spinal surgery. Due to its atypical clinical manifestations, its diagnosis and treatment are often delayed, often requiring complex and lengthy treatment, with poor prognosis, high morbidity and mortality, causing huge economic and social burden. For patients with spinal infection caused by instability, deformity, nerve function decline or loss due to abscess or mass compression, surgical treatment of decompression and bone grafting internal fixation is needed. However, the current spinal infection-related implants lack good anti-infection and bone induction properties, etc., so there are still many concerns and problems in their clinical application, including spinal instability, bone defect at the infection site, early post-internal fixation infection recurrence, and infection persistence, etc.

[0003] Titanium alloy has excellent biocompatibility, mechanical properties and corrosion resistance, and is widely used in orthopedic implants. However, in bone reconstruction therapy, peri-implantitis and poor early bone healing at the bone / implant interface after implantation are still serious challenges in clinical application. Traditional treatment methods include systemic use of antibiotics, wound drainage, surgical debridement, implant exclusion, etc. However, these methods are less efficient and can interfere with further surgery in patients.

[0004] The mechanical properties of titanium alloy can also provide more functions and structures for the fusion cage. SUMMARY

[0005] The present patent is proposed to solve the above-mentioned needs, and the technical problem to be solved by the present patent is to provide an antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive intervertebral fusion cage to improve the implantation effect of the intervertebral fusion cage.

[0006] To solve the above problems, the technical scheme provided by the present disclosure includes:

[0007] The application discloses an antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive intervertebral fusion cage, which is characterized by comprising N edges connected end to end, adjacent edges being pivotally connected, and an enclosed N-sided polygon being formed, wherein N is an integer greater than 3; an adjusting rod is arranged between a first corner and a second corner of the N-sided polygon in a length-adjustable mode, and forms a triangular structure with two edges between the first corner and the second corner of the N-sided polygon; the three edges of the triangular structure are pivotally connected with each other; when the adjusting rod is contracted, the other two edges of the triangular structure are close to each other to expand the fusion cage until a locking position is reached; wherein a locking mechanism is arranged on the adjusting rod, and the locking mechanism at least locks the locking position of the adjusting rod.

[0008] Preferably, each of the N edges comprises an upper plate and a lower plate, the upper plate and the lower plate are spaced apart by a predetermined distance to form a bone graft cavity, and through holes are formed in the upper plate and the lower plate.

[0009] Preferably, the adjusting rod comprises a rod body, one end of the rod body is provided with a fixed part which is pivotally arranged between the upper plate and the lower plate of the first corner part, the other end of the rod is provided with an upper protrusion and a lower protrusion, a sliding part comprises an upper sliding part and a lower sliding part which are separately arranged, and the upper sliding part and the lower sliding part are pivotally arranged on the upper plate and the lower plate of the second corner part respectively, the sliding part comprises a sliding groove, a guide groove and a locking platform, the sliding groove comprises an upper sliding groove and a lower sliding groove which are separately arranged, shapes of the upper sliding groove and the lower sliding groove correspond to the rod body, the upper sliding groove and the lower sliding groove are respectively provided with through holes matched with the upper protrusion and the lower protrusion, the locking platform comprises an upper locking platform and a lower locking platform which are pivotally arranged on the upper plate and the lower plate of the second corner part respectively, the upper locking platform and the lower locking platform are respectively provided with recesses matched with the upper protrusion and the lower protrusion to position the sliding rod on the locking platform, the guide groove is arranged between the sliding groove and the locking platform, the guide groove comprises an upper guide groove and a lower guide groove, the upper guide groove transitions from the upper sliding groove to the upper locking platform, and the lower guide groove transitions from the lower sliding groove to the lower guide platform, a first distance is between the upper sliding groove and the lower sliding groove, a second distance is between the upper guide groove and the lower guide groove, and a third distance is between the upper locking platform and the lower locking platform, the first distance is greater than the second distance, and the second distance is greater than the third distance.

[0010] Preferably, the sliding rod is in a cylindrical shape, the upper sliding groove and the lower sliding groove are respectively formed in a half-cylinder shape matched with the cylindrical shape, the upper guide groove and the lower guide groove are respectively formed in a half-cone shape, the upper end of the upper locking platform is connected with an upper frame through a pivot, and the lower end of the lower locking platform is connected with a lower frame through a pivot.

[0011] Preferably, the upper frame and the lower frame are quadrilateral frame structures, and the four corners of the quadrilateral are all formed as rounded corners, and a vertical arc baffle is formed at least at one of the corners to block the position of the corner.

[0012] Preferably, a reinforcing plate is arranged between the upper frame and the lower frame, and one of the reinforcing plates between two adjacent edges extends along the length direction of the corresponding edge, and the other reinforcing plate extends along the width direction of the corresponding edge.

[0013] Preferably, the upper surface of the upper plate is formed with fixing teeth, and the lower surface of the lower plate is also formed with fixing teeth.

[0014] Preferably, the whole fusion cage is made of a copper-containing titanium alloy.

[0015] Preferably, the copper-containing titanium alloy is prepared by using a titanium alloy and pure copper as raw materials, and the mass percentage of copper in the copper-containing titanium alloy is 1-30%; the yield strength of the copper-containing titanium alloy can be 600-1200 MPa, and the tensile strength can be 700-1300 MPa.

[0016] Preferably, the titanium alloy as the raw material is Ti6Al4V.

[0017] The present disclosure uses a copper-containing titanium alloy with good performance and a polygonal hinge structure to make a fusion cage, adjusts the shape of the fusion cage by adjusting the rod, can maintain a suitable shape when implanted, and is easily operated to be expanded at a predetermined position to achieve a good fixing effect. BRIEF DESCRIPTION OF DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present specification or the prior art, the drawings needed in the embodiments or prior art description will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments described in the present specification, and other drawings can also be obtained by those skilled in the art based on these drawings.

[0019] Figure 1 is a structural schematic diagram of an antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive intervertebral fusion cage in an initial position in the present specific embodiment;

[0020] Figure 2 is a structural schematic diagram of an antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive intervertebral fusion cage after being expanded in the body in the present specific embodiment;

[0021] Figure 3 is an exploded view of an antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive intervertebral fusion cage in the present specific embodiment;

[0022] Figure 4 is a structural schematic diagram of the sliding part in the embodiment;

[0023] Figure 5 is a matching structural schematic diagram of the protrusion and the through hole in the sliding groove in the embodiment;

[0024] Figure 6 is a structural diagram of the state of the fusion cage being expanded in the embodiment.

[0025] In the figure, the structure names referred to by the reference signs are: antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive intervertebral fusion cage 1; side 2; upper plate 3; lower plate 4; connecting plate 5; hollow structure 6; opening 7; fixed tooth 8; circular arc baffle 9; adjusting rod 10; rod 11; fixed part 12; sliding part 13; protrusion 14; upper sliding groove 15; lower sliding groove 16; guide hole 17; locking table 18; baffle 19; guide groove 20; recess 21. EMBODIMENT

[0026] To make the objectives, technical solutions and advantages of the embodiments of the present application clearer, the following will be a clear and complete description of the technical solutions in the embodiments of the present application in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the scope of protection of the present application.

[0027] In the description of the embodiments of the present disclosure, it should be noted that unless otherwise explicitly specified and limited, the term “connected” should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected, which can be mechanically connected, or electrically connected, which can be directly connected, or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meaning of the above-mentioned term in the present disclosure can be understood according to the specific circumstances.

[0028] In order to facilitate the understanding of the embodiments of the present application, the following will be further explained and described in specific embodiments in conjunction with the drawings, and the embodiments do not constitute a limitation on the embodiments of the present application.

[0029] The present embodiment provides an antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive intervertebral fusion cage.

[0030] Minimally invasive spinal surgery has advantages that other kinds of surgery cannot match, that is, it has a small incision and causes less damage to the patient's body during the operation and recovers faster. The application of minimally invasive surgery in spinal surgery has gradually been recognized by people for its advantages.

[0031] For example, in intervertebral fusion surgery, minimally invasive surgery has incomparable advantages over traditional surgical methods. However, in intervertebral fusion surgery, the premise of minimally invasive surgery is to use a fusion cage that can adapt to a minimally invasive opening. Such a fusion cage can be implanted in the body and can be expanded in the body to have a good fusion effect, and it needs to be easy to operate and fixed, so an excellent intervertebral fusion cage is an important part of minimally invasive intervertebral fusion surgery.

[0032] To this end, the structure of an antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive intervertebral fusion cage provided in the specific embodiment is as shown in Figures 1-6 In the Figure 1 state, it can be folded to have a smaller cross section, and in the Figure 2 state, it can be expanded to be well fixed between the vertebral bodies, which is easy to meet the requirements of minimally invasive intervertebral fusion surgery.

[0033] In the specific embodiment, the antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive intervertebral fusion cage is formed as a plurality of long edges 2, and the plurality of edges 2 are connected end to end to form a polygon. The polygon has more than three edges. If the polygon has three edges, it becomes a triangle when connected end to end. The triangle is not conducive to having a small cross section when implanted and can be expanded to have a large cross section after being implanted in the body due to its stable shape. Therefore, the polygon in the specific embodiment refers to a polygon with more than or equal to four edges. The number of edges of the polygon is equal to the number of angles of the polygon, that is, when the polygon has N edges, it also has N angles.

[0034] The polygon with edges connected end to end can be easily stretched to reduce the cross-sectional size in one direction, and can also be easily expanded to meet the needs of the fusion cage supporting the spine. However, only the characteristic of easy deformation is not enough for the fusion cage, because the fusion cage needs to have a stable structure after being implanted in the body, and has enough strength to support the vertebral body. Therefore, how to easily deform and maintain the stability of the shape in the required state, in addition, considering the convenience of operation, and having enough structural strength and good implantation effect, in fact, it is a contradictory body in which multiple factors are restricted to some extent.

[0035] In order to facilitate understanding of the inventive concept of the present disclosure, a quadrilateral is taken as an example for description in the specific embodiment.

[0036] In the embodiment, each side of the quadrangle includes an upper plate 3 and a lower plate 4. For the sides that do not need to adjust the distance in the vertical direction, the upper plate and the lower plate can be fixedly connected through a connecting plate 5. For the sides that need to adjust the distance between the upper plate and the lower plate, the upper plate and the lower plate can be arranged separately from each other. The upper plate and the lower plate are spaced apart by a predetermined distance, so as to form a hollow structure 6 to facilitate bone grafting. The sides of the structure can form a stable shape while maintaining a certain strength.

[0037] In the embodiment, openings 7 are formed in the upper plate and the lower plate, and the openings communicate with the hollow structure between the upper plate and the lower plate to facilitate bone grafting.

[0038] Further, the upper surface of the upper plate and the lower surface of the lower plate are provided with fixing teeth 8, which are in contact with the vertebrae after the cage is implanted into the vertebral body. The fixing teeth can prevent the cage from being disengaged.

[0039] Further, in a natural state, the height of each side as a whole is basically consistent, so that each surface can be in full contact with the implant surface of the vertebrae. The end edges of each side are formed in a circular arc shape to facilitate implantation without causing additional harm to the body.

[0040] In the embodiment, the sides of the quadrangle are hingedly connected to each other to form a closed and adjustable quadrangular shape. The hingedly connected structure can be achieved by arranging a pivot at the connecting portion. The two adjacent sides can be connected by the same pivot to form the hingedly connected structure. Since the two adjacent sides include the upper plate and the lower plate, in order to facilitate the connection, in the embodiment, the upper plate and the lower plate of the first side can be accommodated between the upper plate and the lower plate of the second side, so as to facilitate the connection. When the corresponding end portions of the first side and the second side are arranged in a suitable circular arc shape, the corner arc shape can be maintained when the two sides are relatively rotated, so as to avoid harm to the body of the implant.

[0041] Further preferably, a circular arc baffle 9 is formed between the connected end portions of the first side, so as to form a substantially closed shape, which is beneficial to the implantation operation and the stability of the structure.

[0042] In the embodiment, the polygon with the hingedly connected sides can change the shape based on the hinge, but the cage should be easy to operate after being implanted to support the vertebral body and maintain a stable spread shape. Both the ease of operation and the stability of the structure have high requirements, which are contradictory to the easy deformation of the hinged structure.

[0043] In the specific embodiment, an adjusting rod 10 is provided to facilitate the distraction operation and fixation of the shape after distraction. The adjusting rod is pivotally arranged between two non-adjacent corners with adjustable length, and the overall shape of the cage is adjusted by changing the distance between the two non-adjacent corners by adjusting the length of the adjusting rod.

[0044] The adjusting rod and the two adjacent sides form a triangle, one side of the triangle is the adjusting rod, and the other two sides are the sides of the polygon, and the three sides are pivotally connected to each other. When the length of the adjusting rod is elongated, the triangle can be elongated, thereby forming a state convenient for implantation. When the length of the adjusting rod is shortened, the other two sides are distracted, thereby facilitating the support of the vertebral body.

[0045] The adjusting rod is convenient to adjust the length and can stably maintain its length at the position where distraction is required, which is beneficial to the minimally invasive surgical operation and the fixation of the cage and the vertebral body.

[0046] In the specific embodiment, preferably, the adjusting rod comprises

[0047] The rod 11 is provided with a fixing portion 12 at one end, and the fixing portion is fixedly arranged with the pivot; the other end of the rod is provided with a protrusion 14, i.e. an upper protrusion and a lower protrusion. One end of the rod is pivotally connected to the first corner of the quadrilateral, and the other end of the rod is connected to the sliding portion. In order to increase the strength, the one end of the rod can be formed into a thickened structure, which not only can strengthen the strength of the rod but also can form a support at the connection position.

[0048] The sliding portion 13 comprises an upper sliding portion and a lower sliding portion arranged in two parts. The upper sliding portion and the lower sliding portion are pivotally arranged on the lower surface of the upper plate and the upper surface of the lower plate of the second corner, respectively. The sliding portion comprises a sliding groove, a guide groove and a locking platform.

[0049] The sliding groove is formed in a cylindrical shape as a whole, and accommodates the other end of the rod, and the rod and the cylinder are connected to form a sliding connection. The sliding groove comprises an upper sliding groove 15 and a lower sliding groove 16 arranged in two parts, and the upper sliding groove and the lower sliding groove are respectively provided with guide holes 17 matched with the upper protrusion and the lower protrusion, which guide the sliding of the guide rod in the sliding groove, and the inner side end of the guide hole can limit the position of the protrusion, thereby limiting the maximum length of the adjusting rod.

[0050] The locking platform 18 comprises an upper locking platform and a lower locking platform, which are separately arranged. The upper locking platform is pivotally connected with the upper plate of the second corner, and the lower locking platform is pivotally connected with the lower plate of the second corner. In the specific embodiment, the upper locking platform and the lower locking platform are provided with recesses 21, which can be grooves or holes, for locking cooperation with the upper protrusion and the lower protrusion. The cooperation of the protrusion and the recess limits the minimum length of the sliding rod. The sliding rod is locked and positioned on the locking platform.

[0051] Further preferably, a baffle 19 is further arranged outside the locking platform. Different baffles can be arranged on the upper locking platform and the lower locking platform respectively. The baffles further block the shortest position of the rod in the sliding part.

[0052] A guide groove is arranged between the sliding groove and the locking platform. The guide groove 20 comprises an upper guide groove and a lower guide groove. The upper guide groove transitions from the upper sliding groove to the upper locking platform, and the lower guide groove transitions from the lower sliding groove to the lower locking platform.

[0053] The first distance between the upper sliding groove and the lower sliding groove, the second distance between the upper guide groove and the lower guide groove, and the third distance between the upper platform and the lower platform satisfy the relationship that the first distance is greater than the second distance, and the second distance is greater than the third distance. In this way, when the adjusting rod is shortened, the second corner is gradually stretched, and the overall shape of the cage is formed as a shape with one side being higher and the other side being lower, which is beneficial to the fusion with the vertebral body. Since the second corner in the quadrilateral can be stretched and the other corners cannot be stretched, the protrusion can be maintained in the groove / hole based on the elastic force of the material itself, which is beneficial to the fixation of the shape.

[0054] The sliding rod is in a cylindrical shape. The upper sliding groove and the lower sliding groove are respectively formed in a semicircular cylinder shape matched with the cylindrical shape. The upper guide groove and the lower guide groove are respectively formed in a semicircular conical shape. This structure is beneficial to sliding and guiding and avoids displacement and deviation.

[0055] In this way, in the minimally invasive surgery, the cage is implanted from the incision with the elongated state of the adjusting rod as the initial state. After implantation, in the process of pushing the cage, the adjusting rod is gradually shortened based on sliding until it is positioned and maintained on the locking platform. The locking platform is stretched to adapt to the shape of the vertebral body. Due to the elastic force, the protrusion is stably maintained on the platform to form a stable structure for fusion with the vertebral body. In the specific embodiment, a quadrilateral structure is preferably adopted. In this way, one adjusting rod can divide the quadrilateral into two triangles. As long as the length of the adjusting rod is fixed, the triangle has a stable structure to maintain the shape of the cage unchanged.

[0056] This structure is convenient to operate and reliable to fix, but the requirement for materials is also higher. In the specific embodiment, the fusion device can be made of a whole copper-containing titanium alloy.

[0057] Preferably, 4.8wt% of copper element is added in the titanium alloy (Ti6Al4V) to obtain the copper-containing titanium alloy Ti6Al4V-4.8Cu with uniform element distribution by repeated melting for 3 times, and the copper-containing titanium alloy rod with a length of 400 mm and a diameter of 6 mm is obtained after high-temperature heat treatment at 1100℃ and final forging at 850℃.

[0058] The obtained copper-containing titanium alloy rod is tested on a calibrated universal testing machine at a tensile speed of 1 mm / min, and the yield strength of the copper-containing titanium alloy rod is 1040 MPa and the tensile strength is 1120 MPa by a standard calculation formula.

[0059] According to the experimental requirements of YY / T 0119.4, the distance a between the two inner rollers is 76 mm, and the distance h between the outer roller and the nearest roller is 76 mm. The copper-containing titanium alloy rod is tested by four-point bending at a displacement rate of 5 mm / min, and the yield bending moment is 19 Nm and the ultimate bending moment is 26 Nm.

[0060] The gram-positive bacteria Staphylococcus aureus, which is prone to infection during the clinical service of implants, is used for antibacterial experiments on the copper-containing titanium alloy Ti6Al4V-4.8Cu, and the titanium alloy Ti6Al4V is used as a reference. Each test is repeated 10 times, and 5 parallel samples are selected each time. The antibacterial rate calculation formula is:

[0061] D(%)=(B-B1) / B×100

[0062] In the formula, D is the antibacterial rate (%), B is the average number of recovered bacteria (cfu) of the titanium alloy control sample, and B1 is the average number of recovered bacteria (cfu) of the copper-containing titanium alloy Ti6Al4V-4.8Cu sample.

[0063] The test results show that the antibacterial capacity of the copper-containing titanium alloy Ti6Al4V-4.8Cu reaches 99% compared with the titanium alloy Ti6Al4V sample.

[0064] The above specific embodiments further illustrate the purpose, technical solutions and beneficial effects of the present application. It should be understood that the above description is only a specific embodiment of the present application and is not used to limit the protection scope of the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. An antibacterial copper-containing titanium alloy three-dimensional adjustable minimally invasive interbody fusion cage, characterized in that, The fusion cage comprises: N edges connected end to end, adjacent edges are pivotally connected, forming a closed N polygon, wherein N is an integer greater than three; an adjusting rod, the adjusting rod is adjustably arranged between a first corner and a second corner of the N polygon, forming a triangular structure with two edges between the first corner and the second corner of the N polygon; the three edges of the triangular structure are pivotally connected with each other; when the adjusting rod is contracted, the other two edges of the triangular structure are close to each other to expand the fusion cage until it enters a locked position; wherein the adjusting rod is provided with a locking mechanism, the locking mechanism at least locks the locking position of the adjusting rod; each of the N edges comprises an upper plate and a lower plate, the upper plate and the lower plate are spaced apart by a predetermined distance to form a bone graft cavity, and the upper plate and the lower plate are provided with through holes. The adjusting rod comprises: a rod body, one end of the rod body is provided with a fixed part, the fixed part is pivotally arranged between the upper plate and the lower plate of the first corner; the other end of the rod is provided with an upper protrusion and a lower protrusion; a sliding part, comprising a split upper sliding part and a lower sliding part, respectively pivotally arranged on the upper plate and the lower plate of the second corner; the sliding part comprises a sliding groove, a guide groove and a locking platform; the sliding groove comprises an upper sliding groove and a lower sliding groove, the shapes of the upper sliding groove and the lower sliding groove correspond to the rod body, the upper sliding groove and the lower sliding groove are respectively provided with through holes matched with the upper protrusion and the lower protrusion; the locking platform comprises an upper locking platform and a lower locking platform, the upper locking platform and the lower locking platform are respectively pivotally arranged on the upper plate and the lower plate of the second corner; the upper locking platform and the lower locking platform are respectively provided with recesses matched with the upper protrusion and the lower protrusion for positioning the sliding rod on the locking platform; the sliding groove and the locking platform are provided with a guide groove, the guide groove comprises an upper guide groove and a lower guide groove, the upper guide groove transitions from the upper sliding groove to the upper locking platform, and the lower guide groove transitions from the lower sliding groove to the lower locking platform; the upper sliding groove and the lower sliding groove are apart by a first distance, the upper guide groove and the lower guide groove are apart by a second distance, and the upper locking platform and the lower locking platform are apart by a third distance; the first distance is greater than the second distance, and the second distance is greater than the third distance.

2. The antibacterial copper-titanium alloy containing three-dimensional adjustable minimally invasive interbody fusion cage according to claim 1, characterized in that, The sliding rod is cylindrical; the upper sliding groove and the lower sliding groove are oppositely arranged to form a semicircular cylinder matched with the cylindrical shape; the upper guide groove and the lower guide groove are oppositely arranged to form a semicircular conical guide surface; the upper end of the upper locking platform is connected with the upper frame through a pivot, and the lower end of the lower locking platform is connected with the lower frame through a pivot.

3. The antibacterial copper-titanium alloy containing three-dimensional adjustable minimally invasive interbody fusion cage of claim 2, characterized in that, The upper frame and the lower frame are quadrilateral frame structures, the four corners of the quadrilateral are formed as rounded corners, and at least one of the vertical direction circular arc baffles is formed at one of the corners to block the position of the corner.

4. The antibacterial copper-titanium alloy containing three-dimensional adjustable minimally invasive interbody fusion cage of claim 3, characterized in that, The upper frame and the lower frame are provided with reinforcing plates, one of the reinforcing plates between the adjacent two edges extends along the length direction of the corresponding edge, and the other extends along the width direction of the corresponding edge.

5. The antibacterial copper-titanium alloy containing three-dimensional adjustable minimally invasive interbody fusion cage of claim 3, characterized in that, The upper surface of the upper plate is formed with fixed teeth; the lower surface of the lower plate is also formed with fixed teeth.

6. The antibacterial copper-titanium alloy containing three-dimensional adjustable minimally invasive interbody fusion cage according to any one of claims 1-5, characterized in that, The whole of the fusion cage is made of copper-containing titanium alloy.

7. The antibacterial copper-titanium alloy containing three-dimensional adjustable minimally invasive interbody fusion cage of claim 6, characterized in that, The copper-containing titanium alloy is prepared by using titanium alloy and pure copper as raw materials, and the mass percentage of copper in the copper-containing titanium alloy is 1-30%; the yield strength of the copper-containing titanium alloy can be 600-1200 MPa, and the tensile strength can be 700-1300 MPa.

8. The antibacterial copper-titanium alloy containing three-dimensionally adjustable minimally invasive interbody fusion cage of claim 7, characterized in that, It is characterized in that, The titanium alloy as raw material is Ti6Al4V.

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