Drug transfer device

Abstract

A drug transfer device includes: a housing; a vial attachment configured to secure the drug transfer device to a vial; a vial transfer member defining a channel; a cannula received within the housing, wherein the cannula is in fluid communication with the channel of the vial transfer member and has a first end and a second end positioned opposite the first end; a sealing device positioned within the housing, wherein the sealing device is movable within the housing between a first position and a second position, wherein in the first position the cannula is isolated from the first end of the housing, and in the second position the cannula is configured to be in fluid communication with a mating connector received at the first end of the housing; and a connecting member defining a channel in fluid communication with the channel of the vial transfer member, wherein the connecting member is configured to receive the mating connector.

Description

[0001] Cross-reference to related applications

[0002] This application claims priority to U.S. Provisional Application Serial No. 62 / 958,909, entitled “Drug Transfer Device”, filed January 9, 2020, the entire disclosure of which is incorporated herein by reference. Technical Field

[0003] This application generally relates to a drug transfer device, and more particularly to a drug transfer device and system for transferring liquid drugs between containers. Background Technology

[0004] Healthcare workers who reconstruct, transport, and administer hazardous medications, such as cancer treatments, are at risk of exposure to these drugs, posing significant hazards in the healthcare environment. For example, nurses treating cancer patients are at risk of exposure to chemotherapy drugs and their toxic effects. Accidental chemotherapy exposure can affect the nervous system, damage the reproductive system, and increase the risk of future blood cancers. To reduce the risk of healthcare workers being exposed to toxic drugs, the closed-loop transfer of these medications becomes crucial.

[0005] Some medications must be dissolved or diluted before administration, which involves transferring the solvent from a container to a sealed vial containing the powdered or liquid medication via a needle. During the removal of the needle from the vial, and while the needle is inside the vial in the presence of a pressure difference between the inside of the vial and the surrounding atmosphere, the medication can be unintentionally released into the atmosphere in gaseous form or via atomization. Summary of the Invention

[0006] In one aspect, a drug transfer device includes: a housing having a first end and a second end positioned opposite the first end; a vial attachment configured to secure the drug transfer device to a vial; a vial transfer member defining a channel, wherein the vial transfer member is configured to pierce a seal in the vial; a cannula received within the housing, wherein the cannula is in fluid communication with the channel of the vial transfer member and has a first end and a second end positioned opposite the first end; a sealing device positioned within the housing, wherein the sealing device is movable within the housing between a first position and a second position, in which the cannula is isolated from the first end of the housing, and in a second position, the cannula is configured to be in fluid communication with a mating connector received at the first end of the housing; and a connecting member defining a channel in fluid communication with the channel of the vial transfer member, wherein the connecting member is configured to receive the mating connector.

[0007] A vial attachment can be secured to a second end of the housing. A second end of a cannula can be secured to the vial attachment, wherein the cannula extends from the vial attachment toward a first end of the housing, such that the first end of the cannula is positioned between the first and second ends of the housing. A connecting member can extend from the vial attachment. The channels of the vial transfer member can include a first channel and a second channel extending along the longitudinal direction of the vial transfer member, such that the first channel is axially spaced from the second channel and in fluid communication with the cannula, and that the second channel is in fluid communication with the channel of the connecting member. A sealing device can include a clamp having a first end and a second end, and a diaphragm member received by the clamp, wherein at least a portion of the clamp is received within the housing. The clamp includes a body and a locking member connected to the body, wherein the clamp is movable from a first position to a second position, in which the locking member is open to receive a mating connector, and in which radial outward movement of the locking member is restricted. The connecting member can include a diaphragm member.

[0008] In another aspect, a system for transferring liquid medication between containers includes: a syringe adapter having a first end configured to be fixed to a syringe barrel and having a second end; an infusion adapter having a connecting member and a container access member configured to be fixed to an infusion container; and a medication transfer device. The drug transfer device includes: a housing having a first end configured to receive a connecting member of an infusion adapter and a second end positioned opposite the first end; a vial attachment configured to secure the drug transfer device to a vial; a vial transfer member defining a channel, wherein the vial transfer member is configured to puncture a seal of a drug vial; a cannula received within the housing, wherein the cannula is in fluid communication with the channel of the vial transfer member and has a first end and a second end positioned opposite the first end; a sealing device positioned within the housing, wherein the sealing device is movable within the housing between a first position and a second position when the infusion adapter is received by the first end of the housing, in the first position the cannula is isolated from the first end of the housing, and in the second position the cannula is configured to be in fluid communication with the infusion adapter; and a connecting member defining a channel in fluid communication with the channel of the vial transfer member, wherein the connecting member is configured to receive a syringe adapter.

[0009] The system may include an air delivery pump in fluid communication with a first end of a syringe adapter. The system may include a drug measuring device and a controller in communication with both the drug measuring device and the air delivery pump, wherein the controller is configured to actuate the air delivery pump based on dosage information received from the drug measuring device. The air delivery pump may be in fluid communication with the first end of the syringe adapter via a delivery tube.

[0010] In another aspect, a method for transferring a liquid drug between containers includes: attaching a drug transfer device to a drug container containing the liquid drug; attaching an infusion adapter to the drug transfer device; attaching an infusion container to the infusion adapter; and introducing air into the drug container via the drug transfer device to transfer the liquid drug from the drug container to the infusion container via the drug transfer device and the infusion adapter.

[0011] The method may further include inverting the drug container before introducing air into it. The method may also include: attaching a syringe adapter to a drug delivery device; attaching a syringe barrel to the syringe adapter; and injecting air into the drug container via the syringe barrel, syringe adapter, and drug delivery device to introduce air into the drug container. Air may be introduced into the drug container via an air delivery pump through a drug transfer device. The method may include attaching a delivery tube to the drug transfer device, wherein the delivery tube extends between the drug transfer device and the air delivery pump. The method may include: sending dosage information to a controller in communication with the air delivery pump; and actuating the air delivery pump based on the dosage information. The method may include measuring the volume and / or weight of the infusion container via a drug measuring device, wherein the drug measuring device sends one or more of the volume measurement, weight measurement, and dosage information to the controller; and actuating the air delivery pump via the controller until the infusion container receives a prescribed dose of liquid drug. Attached Figure Description

[0012] The above and other features and advantages of this disclosure, as well as the ways in which they are implemented, will become more apparent from the following description of some aspects of this disclosure in conjunction with the accompanying drawings, and the disclosure itself will be better understood, wherein:

[0013] Figure 1 This is a front view of a drug transfer device according to one aspect of this application.

[0014] Figure 2 yes Figure 1 A cross-sectional view of a drug transfer device.

[0015] Figure 3 yes Figure 1 A cross-sectional view of a drug transfer device, showing the drug transfer device fixed to a drug container.

[0016] Figure 4 yes Figure 1 A cross-sectional view of a drug transfer device, showing the drug transfer device fixed to a drug container and a syringe adapter.

[0017] Figure 5 This is a cross-sectional view of a system for transferring liquid drugs according to one aspect of this application.

[0018] Figure 6 This is a schematic diagram of a system for transferring liquid drugs according to another aspect of this application.

[0019] Figure 7 yes Figure 6 A schematic diagram of the system.

[0020] The corresponding reference numerals in all these views indicate the corresponding parts. The examples listed herein illustrate exemplary aspects of this disclosure, and these examples should not be construed as limiting the scope of this disclosure in any way. Detailed Implementation

[0021] The following description is provided to enable those skilled in the art to make and use the aspects described herein intended for carrying out the invention. However, various modifications, equivalents, variations, and substitutions will still be apparent to those skilled in the art. Any and all such modifications, variations, equivalents, and substitutions are intended to fall within the spirit and scope of the invention.

[0022] In the following description, for purposes of description, the terms “upper,” “lower,” “right,” “left,” “vertical,” “horizontal,” “top,” “bottom,” “lateral,” “longitudinal,” and their derivatives shall be used in relation to the orientation of the invention in the accompanying drawings. However, it should be understood that the invention may take various alternative variations unless expressly stated otherwise. It should also be understood that the specific devices shown in the drawings and described in the following specification are merely exemplary aspects of the invention. Therefore, specific dimensions and other physical characteristics relating to the aspects disclosed herein should not be considered limiting.

[0023] Reference Figures 1 to 4 According to one aspect of this application, a drug transfer device 10 includes a housing 12, a vial attachment 14, a vial transfer member 16, a cannula 18, a sealing device 20, and a connecting member 22. The housing 12 has a first end 24 and a second end 26 positioned opposite the first end 24 and defining a central opening 28. The vial attachment 14 is configured to secure the drug transfer device 10 to a drug container 30, such as a vial. The vial attachment 14 includes a protrusion 32 that radially deflects outward upon engagement with the drug container 30 and returns to its initial position when the protrusion 32 is positioned below the closure 34 of the drug container 30, thereby securing the drug transfer device 10 to the drug container 30. Figure 3 and Figure 4As shown. The vial transfer member 16 defines a channel 36 and is configured to pierce a closure or seal 34 of the drug container 30. The vial transfer member 16 extends from a portion of the vial attachment 14, but may also extend from the housing 12. A cannula 18 is received within the housing 12 and is in fluid communication with the channel 36 of the vial transfer member 16. The cannula 18 has a first end 38 and a second end 40 positioned opposite the first end 38. A sealing device 20 is positioned within the housing 12, wherein the sealing device 20 is movable within the housing 12 between a first position, in which the cannula 18 is isolated from the first end 24 of the housing 12, and in a second position, the cannula 18 is configured in fluid communication with a mating connector received at the first end 24 of the housing 12. A connecting member 22 defines a channel 42 in fluid communication with the channel 36 of the vial transfer member 16, wherein the connecting member 22 is configured to be received and secured to the mating connector. The connecting member 22 includes a diaphragm 44, which is configured to engage with a mating connector as a diaphragm or seal.

[0024] Refer again Figures 1 to 4 The vial attachment 14 is fixed to the second end 26 of the housing 12. The vial attachment 14 may be integrally formed with the housing 12, or it may be separately formed from and attached to the housing 12. The second end 40 of the cannula 18 is fixed to the vial attachment 14, wherein the cannula 18 extends from the vial attachment 14 toward the first end 24 of the housing 12, and the first end 38 of the cannula 18 is positioned between the first end 24 and the second end 26 of the housing 12. The connecting member 22 extends from the vial attachment 14, but the connecting member 22 may also extend from the housing 12. The connecting member 22 extends from the vial attachment 14 at a 45-degree angle relative to the longitudinal axis of the housing 12, but other suitable angles may also be used. The channel 36 of the vial transfer member 16 includes a first channel 46 and a second channel 48 extending along the longitudinal direction of the vial transfer member 16, wherein the first channel 46 and the second channel 48 are axially spaced and in fluid communication with the cannula 18 and the second channel 48 is in fluid communication with the channel 42 of the connecting member 22.

[0025] Reference Figures 2 to 4 The sealing device 20 includes a clamp 58 having a diaphragm 64 received by the clamp 58, wherein at least a portion of the clamp 58 is received within the housing 12. The clamp 58 includes a body 66 and a locking member 68 connected to the body 66, wherein the clamp 58 is movable from a first position to a second position, in which the locking member 68 is open to receive a mating connector. Figure 2 In the second position, the radial outward movement of the locking member 68 is restricted. Figure 5 The sealing device 20 also includes a spring 72 to bias the sealing device 20 toward the first end 24 of the housing 12.

[0026] As discussed in more detail below, the drug transfer device 10 is configured to facilitate the transfer of liquid drugs from drug container 30 to different drug containers—such as infusion container 70—while ensuring a sealed and closed transfer of the liquid drugs.

[0027] Reference Figure 5 A system 100 for transferring a drug between containers according to one aspect of this application includes a syringe adapter 102, an infusion adapter 104, and the above-mentioned components. Figures 1 to 4 The discussed drug transfer device 10. A syringe adapter 102 has a first end 106 configured to be secured to a syringe barrel 108 and a second end 110 positioned opposite the first end 106. The syringe adapter 102 may be one of the syringe adapters shown and described in U.S. Patent Application Publication No. 2018 / 0200147, the entire contents of which are incorporated herein by reference. An infusion adapter 104 has a connecting member 112 and a container access member 114 configured to be secured to an infusion container 70 such as an IV bag. The connecting member 112 and the container access member 114 define a first channel 116. The infusion adapter 104 also includes a port 118 in fluid communication with a second channel 120 defined by the container access member 114. A first end 24 of the housing 12 of the drug transfer device 10 is configured to receive the connecting member 112 of the infusion adapter 104. When the infusion adapter 104 is received by the first end 24 of the housing 12, the sealing device 20 of the drug transfer device 10 is movable within the housing 12 between a first position and a second position. In the first position, the cannula 18 is isolated from the first end 24 of the housing 12; in the second position, the cannula 18 is configured to be in fluid communication with the infusion adapter 104. Figure 5 As shown. The connecting member 22 of the drug transfer device 10 is configured to receive the syringe adapter 102.

[0028] Refer again Figure 5 The system 100 is used by securing the drug container 30 to the vial attachment 14 of the drug transfer device 10, securing the connecting member 112 of the infusion adapter 104 to the first end 24 of the housing 12 of the drug transfer device 10, and securing the syringe adapter 102 to the connecting member 22 of the drug transfer device 10. The syringe barrel 108 is secured to the syringe adapter 102 and the infusion container 70 is secured to the infusion adapter 104. When the drug container 30 is inverted, as... Figure 5 As shown, the plunger 130 of the syringe barrel 108 is pressed down to inject air into the drug container 30 via the syringe adapter 102 and the drug transfer device 10. This forces the liquid drug from the drug container 30 through the first channel 46 of the vial transfer member 16, through the cannula 18, and through the first channel 116 of the connecting member 112 of the infusion adapter 104 into the infusion container 70.

[0029] Reference Figure 6 and Figure 7 This illustrates a system 150 for transferring a drug between containers according to one aspect of this application. Figure 6 System 150 is similar to Figure 5 System 100 differs from system 150 in that system 150 does not manually inject air via syringe 108, but instead utilizes an air delivery pump 152, delivery tubing 154, controller 156, and drug measuring device 158. The air delivery pump 152 is fluidly connected to the first end 106 of syringe adapter 102 via delivery tubing 154 and is configured to deliver air to drug container 30, thereby delivering liquid drug from drug container 30 to infusion container 70 in the same manner as described above with syringe 108. The controller 156 communicates with drug measuring device 158 and air delivery pump 152. The controller 156 may be physically connected to drug measuring device 158 and air delivery pump 152 via communication lines and / or may be wirelessly connected. The controller 156 is configured to actuate air delivery pump 152 based on dosage information received from drug measuring device 158. Drug measuring device 158 may be a BD from Becton Dickinson. The system includes a drug measurement device. The controller 156 includes at least one processor or any other similar computing device for controlling one or more aspects of the system 150.

[0030] In one aspect, such as Figure 7 As shown, system 150 is used by scanning drug container 30 and infusion container 70 using a drug measuring device 158, such as by scanning a barcode, RFID tag, or other suitable device; and determining the amount of drug to be transferred for a specified dose, which can be stored as dosage information by the drug measuring device 158. The volume and / or weight of infusion container 70 is measured by the drug measuring device 158 and it is determined whether infusion container 70 contains the specified dose. Air delivery pump 152 is actuated via controller 156, wherein the drug measuring device 158 continues to measure the volume and / or weight of infusion container 70 until the specified dose is reached. In one aspect, controller 156 actuates air delivery pump 152 for a set time based on the desired volume of liquid drug to be transferred from drug container 30 to infusion container 70.

[0031] According to one aspect of this application, a method for transferring a liquid medication between containers includes: securing a medication transfer device 10 to a medication container 30 containing the liquid medication; securing an infusion adapter 104 to the medication transfer device 10; securing an infusion container 70 to the infusion adapter 104; and introducing air into the medication container 30 via the medication transfer device 10 to deliver the liquid medication from the medication container 30 to the infusion container 70 via the medication transfer device 10 and the infusion adapter 104. The method may include inverting the medication container 30 before introducing air into it.

[0032] In one aspect, the method includes: securing a syringe adapter 102 to a drug transfer device 10; securing a syringe barrel 108 to the syringe adapter 102; and introducing air into a drug container 30 via the syringe barrel 108, the syringe adapter 102, and the drug transfer device 10.

[0033] On the other hand, air is introduced into the drug container 30 via the drug transfer device 10 through the air delivery pump 152. The method may further include securing a delivery tube 154 to the drug transfer device 10, wherein the delivery tube 154 extends between the drug transfer device 10 and the air delivery pump 152. In another aspect, the method further includes sending dosage information to a controller 156 in communication with the air delivery pump 152 and actuating the air delivery pump 152 based on the dosage information.

[0034] In another aspect, the method includes measuring the volume and / or weight of the infusion container 70 via a drug measuring device 158, wherein the drug measuring device 158 sends one or more of the volume measurement, weight measurement, and dosage information to a controller 156, and actuates an air delivery pump 152 via the controller 156 until the infusion container 70 receives a prescribed dose of liquid drug.

[0035] While this disclosure has been described as having an exemplary design, it may be further modified within the spirit and scope of this disclosure. Therefore, this application is intended to cover any variations, applications, or adaptive modifications of this disclosure using its general principles. Furthermore, this application is intended to cover deviations from this disclosure that fall within the known or customary practice in the field to which this disclosure pertains and fall within the limitations of the appended claims.

Claims

1. A drug transfer device, comprising: A housing having a first end and a second end positioned opposite the first end; A medicine bottle attachment, the medicine bottle attachment being configured to secure a medicine transfer device to a medicine bottle; A vial transfer member with a defined channel, the vial transfer member being configured to pierce the seal of the vial; A cannula is received within the housing, the cannula being in fluid communication with the channel of the vial transfer member, the cannula having a first end and a second end positioned opposite the first end; A sealing device positioned within the housing, the sealing device being movable within the housing between a first position and a second position, in the first position being fluidly isolated from a first end of the housing, and in the second position being configured to fluidly communicate with a mating connector received at the first end of the housing; and A connecting member defining a channel in fluid communication with the channel of the vial transfer member, the connecting member being configured to receive a mating connector, wherein the connecting member is configured to allow air to flow into the vial when the sealing device is in the first position.

2. The drug transfer device as claimed in claim 1, wherein, The vial attachment is fixed to the second end of the outer casing.

3. The drug transfer device as described in claim 2, wherein, The second end of the cannula is fixed to the vial attachment, and the cannula extends from the vial attachment toward the first end of the housing, wherein the first end of the cannula is positioned between the first end and the second end of the housing.

4. The drug transfer device as described in claim 2, wherein, The connecting member extends from the vial attachment at an angle that is not parallel to the outer casing.

5. The drug transfer device as claimed in claim 1, wherein, The channels of the vial transfer member include a first channel and a second channel extending along the longitudinal direction of the vial transfer member. The first channel is axially spaced from the second channel and is in fluid communication with the cannula. The second channel is in fluid communication with the channel of the connecting member.

6. The drug transfer device as claimed in claim 1, wherein, The sealing device includes a clamp having a first end and a second end, and a diaphragm received by the clamp. At least a portion of the clamp is received within the housing. The clamp includes a body and a locking member connected to the body. The clamp is movable from a first position to a second position. In the first position, the locking member is open to receive a mating connector. In the second position, radial outward movement of the locking member is restricted.

7. The drug transfer device as claimed in claim 1, wherein, The connecting component includes a diaphragm.

8. A system for transferring a liquid drug between containers, the system comprising: A syringe adapter having a first end configured to be fixed to a syringe barrel and having a second end; An infusion adapter having a connecting member and a container access member configured to be fixed to an infusion container; and Drug transfer device, the drug transfer device comprising: A housing having a first end configured to receive the connecting member of the infusion adapter and a second end positioned opposite the first end; A medicine bottle attachment, the medicine bottle attachment being configured to secure the medicine transfer device to a medicine bottle; A vial transfer member with a defined channel, the vial transfer member being configured to pierce the seal of the vial; A cannula is received within the housing, the cannula being in fluid communication with the channel of the vial transfer member, the cannula having a first end and a second end positioned opposite the first end; A sealing device positioned within the housing, movable within the housing between a first position and a second position when the infusion adapter is received by the first end of the housing; in the first position, the cannula is fluidly isolated from the first end of the housing; in the second position, the cannula is configured to be in fluid communication with the infusion adapter. A connecting member defining a channel in fluid communication with the channel of the vial transfer member, the connecting member being configured to receive the syringe adapter, wherein the syringe adapter is configured to guide air into the vial via the connecting member when the sealing device is in the first position.

9. The system of claim 8, further comprising an air delivery pump in fluid communication with the first end of the syringe adapter.

10. The system of claim 9, further comprising a drug measuring device and a controller communicating with the drug measuring device and the air delivery pump, the controller being configured to actuate the air delivery pump based on dose information received from the drug measuring device.

11. The system of claim 9, wherein, The air delivery pump is in fluid communication with the first end of the syringe adapter via a delivery pipe.

12. The system according to claim 8, wherein, The vial attachment is fixed to the second end of the housing, the second end of the cannula is fixed to the vial attachment, the cannula extends from the vial attachment toward the first end of the housing, and the first end of the cannula is located between the first end and the second end of the housing.

13. The system according to claim 12, wherein, The connecting member extends from the vial attachment, and wherein the channel of the vial transfer member includes a first channel and a second channel extending along the longitudinal direction of the vial transfer member, the first channel being axially spaced from the second channel and in fluid communication with the cannula, and the second channel being in fluid communication with the channel of the connecting member.

14. The system of claim 8, wherein, The sealing device includes a clamp having a first end and a second end, and a diaphragm received by the clamp. At least a portion of the clamp is received within the housing. The clamp includes a body and a locking member connected to the body. The clamp is movable from a first position to a second position. In the first position, the locking member is open to receive the infusion adapter. In the second position, radial outward movement of the locking member is restricted.

15. A method for transferring a liquid drug between containers, the method comprising: A drug transfer device is attached to a drug container containing a liquid drug, the drug transfer device including a sealing device positioned therein, the sealing device being movable between a first position and a second position, in which fluid is prevented from flowing through a first channel and in the second position, fluid is allowed to flow through the first channel; Secure the infusion adapter to the drug transfer device, wherein securing the infusion adapter includes moving the sealing device from the first position to the second position; Secure the infusion container to the infusion adapter; The syringe adapter is secured to the drug transfer device such that at least a portion of the syringe adapter punctures a diaphragm disposed in the second fluid passage of the drug transfer device; Secure the syringe barrel to the syringe adapter; and Air is introduced into the drug container via the syringe barrel, the syringe adapter, and the drug transfer device to transfer liquid drug from the drug container to the infusion container via the drug transfer device and the infusion adapter.

16. The method of claim 15, further comprising: The drug container is inverted before air is introduced into it.

17. The method of claim 15, wherein, Air is introduced into the drug container via the drug transfer device using an air delivery pump.

18. The method of claim 17, further comprising: Secure the delivery tube to the drug transfer device, so that the delivery tube extends between the drug transfer device and the air delivery pump.

19. The method of claim 17, further comprising: The dosage information is sent to the controller that communicates with the air delivery pump; as well as The air delivery pump is actuated based on the dosage information.

20. The method of claim 19, further comprising: The volume and / or weight of the infusion container are measured by a drug measuring device, which sends one or more of the volume measurement, weight measurement, and dosage information to the controller. as well as The air delivery pump is actuated via the controller until the infusion container receives a predetermined dose of liquid medication.

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