Systems, methods, and computer program products for selectively modifying x-ray images of tissue specimens

Abstract

X-ray images generated by a biopsy tissue handling device are selectively modified to emphasize regions of interest and de-emphasize or eliminate image regions that are distracting, impair viewing attention, and / or cause eye strain. An image processor performs an image mask based on the geometry of a portion of a specimen tray that includes a storage compartment having a tissue specimen. A compartment mask is performed on a portion of an X-ray image that depicts the storage compartment including the tissue specimen. The compartment mask boundary substantially corresponds to the outline of the compartment. A partial structure mask is performed on a portion of the X-ray image that depicts the specimen tray and a corresponding wall of the storage compartment. The partial structure mask boundary extends along a corresponding length and partially through the corresponding wall of the specimen tray.

Description

Technical Field

[0001] The disclosed inventions generally relate to imaging of biopsy tissue specimens, and more specifically to systems, methods, and computer program products for modifying and enhancing X-ray images of tissue specimens that can be performed in real time during biopsy procedures. Background Technology

[0002] Biopsy is a well-known medical procedure involving the removal of tissue from a living body and its examination for diagnostic studies, such as determining the presence, cause, or extent of a disease. For example, a biopsy of human breast tissue may be performed to diagnose breast cancer or other diseases. The current standard of care is percutaneous biopsy, which is performed by inserting a biopsy device with needles and cutting instruments through a small incision and advancing the needles and cutting instruments to the site of tissue of interest. The cutting instrument then cuts the tissue sample, captures the tissue specimen, and removes the tissue specimen through the small incision. Various methods have been used to remove tissue specimens from percutaneous biopsy devices, such as simply removing the device with the captured tissue specimen through an incision, or transporting the tissue specimen through the device, where it can be removed or aspirated into a container via a tube. One advantage of removing tissue specimens from a biopsy device is that multiple specimens can be collected without removing the biopsy device from the patient.

[0003] X-ray imaging systems are typically used to image tissue specimens for verification. For example, a tissue specimen may be placed in an X-ray specimen tray or container and then placed in a specimen imaging device to obtain an image of the tissue. Automated biopsy and imaging systems for performing biopsies and imaging tissue specimens have also been disclosed. An example of a tissue biopsy and disposal apparatus is described in U.S. Patent No. 9,492,130, the contents of which are incorporated herein by reference as if fully described. In particular, U.S. Patent No. 9,492,130 discloses an integrated biopsy analysis system having a biopsy excision tool, a tissue specimen transport mechanism for automatically transporting the excised tissue specimen from the biopsy excision tool to an analysis / imaging unit, and an analysis / imaging system for automatically analyzing tissue specimen images acquired by an X-ray imaging device. The system excises the tissue specimen and transfers and places the excised tissue specimen into a specimen holder having multiple tissue receiving slots for placing multiple different tissue specimens. The imaging unit is configured to acquire images of tissue specimens in the tissue holder, such as by acquiring individual images of each tissue specimen in its respective tissue receiving slot.

[0004] However, known biopsy and imaging systems have some drawbacks that can be improved. For example, while X-ray images generated by known biopsy and imaging systems can be informative and useful, certain aspects of the X-ray image can be distracting and cause eye strain due to the associated specimen holder structure and the imaging of image portions with varying brightness. Some image portions will be significantly brighter than others (e.g., metallic objects), thus drawing the user's attention to these areas initially and during specimen review. Otherwise, such bright spots are in the user's field of view when reviewing X-ray images. These distractions and interferences caused by the imaging of non-specimen objects can be inconvenient, time-consuming, and impair the observer's analytical and endurance, and these drawbacks become more complex as users participate in longer review sessions and are required to review a larger number of specimen images. Such drawbacks can also disrupt review workflows by requiring additional time to review lower-quality images.

[0005] Other biopsy and imaging systems have been designed to improve fluid control during X-ray image acquisition, as fluid in the imaging field can degrade image quality. For example, when acquiring images using X-ray imaging equipment, fluid can partially or completely cover or obscure a tissue specimen and / or adhere to the top of or partially or completely cover the tissue specimen. Interfering fluids can have attenuation properties similar to the tissue specimen being imaged and obscure portions of the specimen. Therefore, the imaged tissue specimen can appear similar to cancerous tissue or tissue with features indicative of cancer, such as a mass, tumor, or calcification. Interfering fluids can also appear as shadows obscuring portions of the image of interest.

[0006] To address these drawbacks, filter tray assemblies have been designed with structures that manage fluids in the imaging field during X-ray imaging of tissue specimens. Fluid management can involve using different types of fluid control structures to prevent fluid from entering the imaging field and / or to remove fluid that has entered the imaging field.

[0007] However, these additional fluid control structures (which may be made of plastic or other radiopaque materials) are also imaged along with the specimen and ultimately appear in the resulting X-ray images. Therefore, while these additional structures can improve fluid management, they can also cause the various X-ray image defects mentioned above because these additional fluid management structures are imaged. Summary of the Invention

[0008] The embodiments of the tissue biopsy and disposal systems, methods, and imaging algorithms described herein provide improved X-ray imaging by selectively modifying X-ray images, which can be performed in real time or online with tissue extraction and processing.

[0009] The embodiments of the tissue biopsy and disposal systems, methods, and imaging algorithms described herein provide improved X-ray imaging by selectively modifying the X-ray image of a specimen tray, which includes the specimen and has additional structures for improving fluid management during X-ray imaging.

[0010] Examples of tissue biopsy and disposal systems, methods, and imaging algorithms also provide improved X-ray images of tissue specimens that are cleaner and more focused to emphasize the image portion of interest, while not emphasizing or eliminating distracting image portions to maintain the observer's attention.

[0011] Embodiments of tissue biopsy and disposal systems, methods, and imaging algorithms also provide improved X-ray images of tissue specimens that are easier on the observer's eye and thus reduce eye strain compared to raw X-ray images generated by X-ray imaging equipment.

[0012] Examples of tissue biopsy processing systems, methods, and imaging algorithms also provide improved imaging of specimens in specimen trays of various types and configurations. Specimen trays may be made of plastic and other radiopaque materials and may include various radiopaque objects (such as magnets used as compartment references or “zero” position markers and printed markings).

[0013] The embodiments also provide specimen imaging suitable for manufacturing defects and collimator offsets during imaging.

[0014] The embodiments provide improved specimen imaging by using partial structural masks, which are performed such that the outer portions of the specimen tray wall (such as separator walls) are not emphasized or eliminated, while the inner portions of the wall defining the tissue storage compartment are maintained or enhanced. In other words, the boundary of the partial structural mask does not cover the entire width or thickness of the specimen tray wall, and this partial thickness boundary may extend the length or perimeter of the wall. In this way, the partial structural mask captures a portion of the corresponding wall (the inner wall segment defining or adjacent to the tissue storage compartment) and the remaining portion of the storage compartment not used for imaging the inner compartment, which is covered or extends beyond that boundary. For example, the partial structural mask may include 25% to 50% of the inner wall, regardless of whether its shape is linear, curved, or other shapes. Thus, the embodiments illustrate selected relevant wall structures, and more specifically, the portion of the specimen tray wall closest to or adjacent to the storage compartment or specimen, without emphasizing or eliminating potentially visually distracting and unnecessary outer wall structures.

[0015] According to one embodiment, a computer-implemented method performed by a biopsy tissue disposal apparatus includes acquiring X-ray images of a tissue specimen in a storage compartment of a specimen tray by an X-ray imaging system of the biopsy tissue disposal apparatus. The method further includes generating a modified X-ray image via an image processor in communication with the X-ray imaging system performing an imaging algorithm. The modified X-ray image is generated by the image processor performing an imaging algorithm that includes performing a plurality of image masks based at least in part on the geometric configuration of at least a portion of the specimen tray including the storage compartment containing the tissue specimen. A compartment mask is performed on a portion of the X-ray image depicting the storage compartment with the cut tissue specimen. The boundaries of the compartment mask substantially correspond to the contours of the specimen tray walls defined by the storage compartment, which may be linear or curved / arc. A partial structural mask is performed on a portion of the X-ray image depicting the respective walls of the specimen tray and a portion of the storage compartment. The boundary of the partial structure mask extends along the corresponding length and partially penetrates the corresponding wall of the specimen tray, capturing a portion of the storage compartment and a portion of the wall thickness not covered by the compartment mask.

[0016] Therefore, the boundary of the partial structural mask extends along the length or perimeter of the specimen tray wall and partially extends into the specimen tray wall (e.g., into the first quarter, first third, or first half of the specimen tray wall). In other words, in such embodiments, the boundary of the partial structural mask does not cover the entire width or thickness of the specimen tray wall. In this way, the partial structural mask captures a corresponding internal segment or portion of the respective wall of the specimen tray, while also capturing the remaining portion of the storage compartment not included in and beyond the boundary of the compartment mask, thereby showing the selected relevant wall structure relative to the compartment and the specimen, without emphasizing or eliminating outer wall structures that may be uninteresting and visually distracting.

[0017] In another embodiment, the biopsy tissue disposal apparatus includes a specimen tray, a tube, an X-ray imaging system, and a display. The specimen tray defines one or more storage compartments or chambers for holding one or more tissue specimens. The tube defines a vacuum lumen communicating with the storage compartments, such that the tube can receive and deliver the excised tissue specimen, along with fluid, through the vacuum lumen into the storage compartments. The X-ray imaging system is positioned or arranged relative to the tissue storage compartments to acquire X-ray images of the excised tissue specimens in the storage compartments of the specimen tray. An image processor communicating with the X-ray imaging system is programmed or configured to execute an imaging algorithm that modifies the X-ray images by performing multiple image masks, which are at least partially based on the geometric configuration of at least a portion of the specimen tray including the storage compartments containing the tissue specimens. A compartment mask is performed on a portion of the X-ray image depicting the storage compartment with the excised tissue specimen. The boundaries of the compartment mask substantially correspond to the contours of the specimen tray walls defined by the storage compartments. Partial structural masking is also performed on a portion of the X-ray image depicting the respective walls of the specimen tray and storage compartment. The boundaries of the partial structural mask extend along the respective length and partially through the respective wall of the specimen tray, capturing a portion of the wall thickness and a portion of the storage compartment not covered by the compartment mask. Other system embodiments may include one or more of the specimen tray, tube, X-ray imaging system, and display, and combinations thereof.

[0018] In a further embodiment, a non-transitory computer-readable medium tangibly implements one or more sequences of instructions, which can be executed by one or more processors in one or more computing systems included in a biopsy tissue disposal apparatus, such that the one or more computing systems acquire and modify X-ray images by executing the computer-implemented methods and imaging algorithms of the embodiment.

[0019] In one or more embodiments or options, the compartment mask is an internal compartment mask that does not include the walls of the storage compartment, the imaged portion of the collimator of the X-ray imaging apparatus, or the magnet. The magnet can be used as a “zero” position marker for the tissue storage compartment when the specimen tray rotates about an axis. The compartment mask enhances or emphasizes at least one of the brightness and contrast of the pixels depicting the tissue specimen in the compartment in an X-ray image. The compartment mask may cover the entire specimen or a portion of the specimen, and the remaining portion of the specimen may be covered by a partial structural mask.

[0020] In one or more embodiments or options, a partial structural mask is performed to obscure, darken, or reduce at least one of the brightness and contrast of pixels in an X-ray image depicting the outer portion of the corresponding plastic wall of the specimen tray outside the boundary of the partial structural mask, and the boundary of the partial structural mask is determined based on or according to a predetermined point within the wall (e.g., the midpoint) or a predetermined distance from the boundary of the compartment mask.

[0021] In one or more embodiments or options, the boundary of the partial structural mask has substantially the same shape as the boundary of the compartment mask and encompasses the boundary of the compartment mask. In one embodiment, it includes a pair of linear boundary segments and a pair of curved / arc boundary segments extending between the linear boundary segments. Other compartment mask and partial structural mask configurations can be used.

[0022] In one or more embodiments or options, the image processor performs an irrelevant object masking on a portion of an X-ray image that depicts an object (such as a magnet embedded, fixed, or applied to a specimen tray or a printed mark). For example, a metallic magnet may be embedded within a plastic wall section of a specimen tray and may serve as a reference or “zero” position compartment marker and be used to engage another magnet to rotate the specimen tray. For these types of objects (e.g., metallic objects), the mask may substantially correspond to the outer periphery of the magnet and obscure, darken, or reduce at least one of the brightness and contrast of the pixels in the X-ray image depicting the radiopaque magnet, which initially appear as a bright white dot in the original X-ray image. Thus, the embodiments reduce or eliminate the tendency of magnets to stand out in the X-ray image and attract the observer's attention. As another example, the object may be a printed mark, such as numbers or characters printed with tungsten ink, that is associated with or identifies tissue compartments. For these types of objects, the boundaries of the irrelevant object mask (e.g., a square or rectangle surrounding the mark) define the area including the mark and to be included in the modified image. Therefore, depending on the type of object identified or indicated by the user, the object may be unemphasized or eliminated (e.g., for metallic magnets) or selected and included in the modified X-ray image.

[0023] In one or more embodiments or options, the boundaries of the compartment mask include a first linear boundary segment, a second linear boundary segment, a first arcuate boundary segment, a second arcuate boundary segment, and a third arcuate boundary segment. The first arcuate boundary segment extends between the first and second linear boundary segments, the second arcuate boundary segment extends between the first and third arcuate boundary segments, and the third boundary segment extends between the second arcuate boundary segment and the second linear boundary segment. With this compartment mask configuration, the radius of curvature of the third arcuate segment of the compartment mask (e.g., the imaged portion adjacent to the magnet) is smaller than the respective radii of curvature of the first and second arcuate boundaries of the specimen and tray structure masks. The partial structure mask may have the same shape as the compartment mask, or in other embodiments, a portion of the boundary of the tray structure mask may extend through the region defined by the boundary of an unrelated object mask (e.g., the imaged portion of the magnet), such that the boundaries of the compartment and the partial structure mask may have different shapes.

[0024] In one or more embodiments or options, the image mask executed by the image processor is a predefined region of interest mask operable to initially crop an X-ray image, for example, to eliminate portions of the X-rays that describe the metal collimator of the X-ray imaging system. In one or more embodiments or options, the predefined region of interest mask is a first image mask executed on the raw X-ray image and prior to the execution of the compartment and partial structure masks.

[0025] In one or more embodiments or options, the geometry of at least a portion of the specimen tray and / or the orientation of the applied image mask is at least partially based on the center (e.g., centroid) of a printed mark associated with the storage compartment. If desired, the X-ray image is rotated to align the center of the printed mark with a predetermined axis (e.g., a horizontal axis) so that the image mask, which registers or aligns the X-ray image with the geometry of the specimen tray and / or is initially correctly aligned, can be rotated. For these purposes, the mask orientation and associated structural or geometric specimen tray configuration can also be rotated. Therefore, embodiments can automatically compensate for and accommodate rotational or mechanical inconsistencies in the biopsy tissue disposal apparatus and allow the geometry to be used to determine corresponding segments in the X-ray image during image masking.

[0026] In one or more embodiments or options, the image processor determines the offset value of the collimator of the X-ray imaging apparatus, for example, the horizontal offset value relative to the side or left and right ends of the imaged tissue compartment, for horizontal adjustment or registration of the X-ray image or a portion thereof and / or adjustment of the position where the image mask is performed so as to apply the image mask to determine the corresponding segment in the X-ray image.

[0027] In one or more embodiments or options, the biopsy tissue disposal device stores the excised tissue specimen into the storage compartment via a vacuum lumen connected to the storage compartment.

[0028] In one or more embodiments or options, the generated or unprocessed X-ray image is modified by changing pixel values ​​according to multiple masks and combining the modified X-ray image pixel data into a Medical Digital Imaging and Communication (DICOM) object. Other data formats may also be used.

[0029] In one or more embodiments or options, image masking and X-ray image modification are performed in real time during the processing of the excised tissue specimen.

[0030] In one or more embodiments or options, the brightness values ​​of pixels in an X-ray image depicting a tissue specimen are selectively modified to adapt the corresponding brightness levels to the different thicknesses of the imaged tissue specimen. For example, portions of the X-ray image depicting thinner portions of the specimen can be identified compared to thicker portions, allowing pixel adjustments based on different specimen thicknesses. For instance, the brightness values ​​of pixels in thinner and thicker specimen portions are enhanced with corresponding brightness and contrast to depict the edges of the thinner and thicker specimen portions, while the thicker specimen portions are not overly bright. Thus, pixel values ​​can be selectively adapted across specimen thickness. Attached Figure Description

[0031] The foregoing and other aspects of the embodiments of the invention disclosed herein will be described in further detail with reference to the accompanying drawings, wherein similar reference numerals denote similar elements, and the description of similar elements shall apply to all described embodiments as long as relevant:

[0032] Figure 1 This is a block diagram of a tissue biopsy and treatment system for X-ray imaging of tissue specimens and modification of X-ray images of tissue specimens, constructed according to one embodiment.

[0033] Figure 2 This is a flowchart of a method for modifying an X-ray image of a tissue specimen according to one embodiment;

[0034] Figure 3 This is a flowchart of a method for modifying an X-ray image of a tissue specimen according to one embodiment;

[0035] Figure 4A -B describes a tissue biopsy and treatment system operable to perform embodiments and for real-time imaging of breast biopsy procedures and breast tissue specimens during biopsy procedures, wherein Figure 4A The image shows the imaging cabinet in the open position, and Figure 4B The diagram shows an imaging cabinet in its closed position;

[0036] Figure 5 An embodiment of an imaging cabinet for a tissue biopsy and treatment system constructed according to one embodiment is described;

[0037] Figure 6 Examples of tissue biopsy and disposal systems that can be used to cut tissue specimens are described in more detail, as well as tubing components through which fluids such as saline and blood can flow during biopsy procedures;

[0038] Figure 7A -M describes in more detail an example of the tissue filter assembly of the tissue biopsy and disposal system and includes a tissue storage compartment in which tissue specimens and fluids are stored during the biopsy procedure, wherein... Figure 7A -D describes an example tissue filter assembly with a rotatable specimen tray, and Figure 7E -M describes an organization filter assembly that also includes an additional fluid management structure, which includes fluid channels and flow combs;

[0039] Figure 8 This is a flowchart of a method for modifying an X-ray image of a tissue specimen according to one embodiment;

[0040] Figure 9 The illustration shows an example of how the structure or geometry of at least a portion of a specimen tray can be applied to an X-ray image;

[0041] Figure 10A -B is a visually enhanced X-ray image shown by the embodiment, wherein Figure 10A It is an unprocessed X-ray image of a portion of a specimen tray including the magnet being imaged, and Figure 10B These are modified X-ray images generated according to the embodiments; and

[0042] Figure 11A -B is a visually enhanced X-ray image shown by the embodiment, wherein Figure 11A It is an unprocessed X-ray image of a portion of a specimen tray excluding the magnet, and Figure 11B These are modified X-ray images generated according to the embodiments. Detailed Implementation

[0043] The embodiments provide tissue biopsy and disposal systems, methods, and imaging algorithms that selectively modify X-ray images of tissue specimens by performing image masking and structural or geometrical configuration of at least a portion of the specimen tray being imaged and depicted in the X-ray image. The modified X-ray images generated according to the embodiments are cleaner and more focused than conventional or unprocessed X-ray images, which can be cluttered with irrelevant and bright areas that can be highly distracting to the observer, causing observer fatigue and reducing review throughput. The modified X-ray images generated according to the embodiments emphasize or maintain relevant image segments while not emphasizing or removing image portions of irrelevant or high-attenuation objects (such as magnets and various irrelevant specimen tray structures). Therefore, the embodiments are also particularly suitable for X-ray imaging involving specimen trays having additional structures for controlling the entry and exit of fluids (such as blood, saline, anesthetics, biofluids, etc.) into and out of the imaging field and being imaged together with the specimen. The embodiments are applicable to modifying X-ray images of various types of specimen tray structures. Furthermore, given the manner in which the embodiments are performed, the embodiments can be adapted to mechanical and imaging variations of different imaging systems and components.

[0044] The embodiment is advantageously performed to generate improved X-ray images, which can be generated in real time after tissue processing or during tissue processing. For example, during the procedure, a tissue specimen is excised from the patient, aspirated through a vacuum tube along with transport and / or bodily fluids (such as saline, blood, or a combination thereof), and stored together in a storage compartment of a specimen tray. X-ray images of the excised tissue specimen are acquired, and the embodiment is performed to selectively modify the generated X-ray images. The resulting modified X-ray images, instead of the generated X-ray images, can then be presented in real time to a radiologist or other users of the tissue biopsy and disposal system via a display during the procedure. The modified X-ray images and the generated X-ray images can also be presented together for additional review and comparison. Image acquisition and embodiment execution can be performed while the patient is held on a stereotactic table, after the excised tissue specimen has been aspirated through a vacuum tube and stored in the specimen tray, before the tissue specimen is removed from the specimen tray, and before the tissue specimen is removed from the housing of the tissue biopsy and disposal system.

[0045] refer to Figure 1 A schematic diagram of a tissue biopsy and treatment system 100 (generally a tissue biopsy system 100) constructed according to one embodiment is shown. Although Figure 1 The schematic diagram illustrates certain features of the tissue biopsy system 100, but the tissue biopsy system 100 may include components and features of a tissue biopsy system as disclosed in U.S. Patent No. 9,492,130B2, the contents of which are incorporated herein by reference as if fully described.

[0046] An exemplary tissue biopsy system 100 includes a tissue filter or tissue retainer assembly 110 (generally, a tissue filter assembly 110). The tissue filter assembly 110 is attached to and connected between a biopsy excision tool 120 and an aspiration canister 130. The biopsy excision tool 120 and the tissue filter assembly 110 are in fluid communication with each other via an inlet line 122. The tissue filter assembly 110 and the aspiration canister 130 are in communication with each other via a vacuum aspiration line 132. A vacuum source ( Figure 1 (Not shown) is connected to the vacuum suction line 132 and / or suction canister 130, such that activation of the vacuum source causes the aspiration of tissue specimen 123 removed by the biopsy excision tool 120 and one or more bodily fluids or added fluids 124 through the inlet line 122 into the tissue storage compartment of the specimen tray of the tissue filter assembly 110.

[0047] The tissue biopsy system 100 includes an imaging unit 140 positioned relative to a tissue filter assembly 110 such that a removed tissue specimen 123 and fluid 124 contained in the tissue filter assembly 110 are positioned within the field of view of the imaging unit 140. It also includes an X-ray imaging device 141 that generates an X-ray image 150. The X-ray imaging device 141 utilizes photons in an energy range of approximately 10 keV to approximately 100 keV and a wavelength range of approximately ~0.01 nm to ~10 nm. The X-ray imaging device 141 communicates with an image processor 160, which receives input including data from the generated X-ray image 150.

[0048] According to an embodiment, the image processor 160 generates a modified X-ray image 150m (“m” means “modified”) by executing an imaging algorithm that utilizes an image mask 170 and the structure or geometry 172 of at least a portion of the specimen tray of the tissue filter assembly 110, which is imaged and depicted in the X-ray image 150. The image processor 160 also communicates with the display 180 of the tissue biopsy system 100 to present the modified X-ray image 150m to the user or operator of the tissue biopsy system 100.

[0049] refer to Figure 2 In general Figure 1 In one embodiment of the computer-implemented method 200 performed by the tissue biopsy system 100 shown, at 202, after the tissue specimen 123 and fluid 124 have been placed in the tissue storage compartment of the specimen tray of the tissue filter assembly 110, the X-ray imaging device 141 is activated to acquire an X-ray image 150 of the excised tissue specimen 123. At 204, the image processor 160 executes an imaging algorithm to determine the structure or geometry 172 of at least a portion of the specimen tray imaged and depicted in the X-ray image 150, and at 206, multiple image masks 170 are executed based on the structure or geometry 172 on corresponding selected portions of the X-ray image 150 generated by the X-ray imaging device 141. A selectively modified X-ray image is generated as a result by modifying certain pixels of the X-ray image 150. The modified X-ray image 150 can then be presented to a user via the UI 182 of the display 180, or otherwise transmitted or stored, at 208.

[0050] refer to Figure 3 , in the Figure 1In one embodiment of the computer-implemented method 200 performed by the tissue biopsy system 100 shown in the overall diagram, at 302, an X-ray imaging device 141 is activated to obtain an X-ray image 150 of a tissue specimen 123 in a storage compartment of a specimen tray of a tissue filter assembly 110. At 304, an image processor determines a structural or geometric configuration 172 of at least a portion of the specimen tray, which includes a storage compartment having the tissue specimen 123 imaged and depicted in the X-ray image 150. At 306, the image processor performs an image mask 170, including an internal compartment mask and a partial structural mask, based at least in part on the determined geometric configuration 171. At 308, the image processor 160 selectively modifies the X-ray image 150 based on the result of the mask execution, and at 310, the modified X-ray image 150 is displayed to a user via a UI of a display 180.

[0051] Figure 4-7M illustrates an exemplary tissue biopsy system 100 and its tissue filter assembly 110 according to certain embodiments, which can be used to implement and / or perform X-ray image modification embodiments. Aspects of the exemplary tissue biopsy system components are described with reference to Figure 4-7M, wherein... Figure 7E -M depicts embodiments with different fluid management configurations and associated additional structures. (Reference) Figure 8-1 1. Description of the use Figure 7A Further details of the X-ray modification and imaging algorithm for the exemplary tissue filter component of -M.

[0052] refer to Figure 4A -B illustrates an exemplary tissue biopsy system 100, which incorporates an X-ray image 150 for real-time modification of a tissue specimen 123. In the illustrated embodiment, the exemplary tissue biopsy system 100 includes a main housing or cabinet 400, which includes an imaging cabinet 402 and a filter drawer 430. The filter drawer 430 can be located within the imaging cabinet 402 in an open position 431 (e.g., ...). Figure 4A (as shown) and closed position 432 (as shown) Figure 4B The filter drawer 430 slides between the X-ray unit 110 and the X-ray unit 402 (as shown in the diagram). In the open position 431, the filter drawer 430 pops out or is pulled out by the radiologist to extend outward from the imaging cabinet 402, thereby allowing insertion and removal of the tissue filter assembly 110. The filter drawer 430 is pushed into or inserted into the imaging cabinet 402 and enters the closed position 432, in which the X-ray imaging device 141 (located inside the imaging cabinet 402) is positioned relative to the tissue filter assembly 110 such that the excised tissue specimen 123 contained in the tissue filter assembly 110 is positioned in the field of view of the X-ray imaging device 141.

[0053] X-ray imaging device 141 can be configured to acquire X-ray image 150, and then move or rotate the tissue filter assembly 110 containing tissue specimen 123 to position the next tissue specimen 123 in the field of view for imaging. The position of X-ray imaging device 141 can also be adjusted, but for ease of interpretation and not limitation, reference tissue filter assembly 110 or its specimen tray can be rotated to place tissue specimen 123 in the field of view of X-ray imaging device 141 in imaging cabinet 402.

[0054] exist Figure 4A In the illustrated embodiment, the biopsy excision tool 120 communicates with a remote control 410, which can be operated by a radiologist to activate and control the operating modes and other controls of the biopsy excision tool 120. Figure 4A -B also illustrates an aspiration canister 130 and associated aspiration line 132 communicating with the tissue filter assembly 110 via the main housing 400. The aspiration canister 130 may be a disposable canister used to collect, retain, and dispose of waste generated during the biopsy procedure, including one or more fluids 124, such as excess saline and / or blood aspirated through the tissue filter assembly 110. The tissue biopsy system 100 may also include a foot switch 440 that allows the surgeon to manually activate and / or control the biopsy excision tool 120, and the system mode or control status and / or system mode or control parameters may be displayed or adjusted via a technical expert control display 420.

[0055] Figure 5 A more detailed illustration shows how the imaging cabinet 402 of the tissue biopsy system 100 can be configured. In the illustrated embodiment, a tissue filter assembly 110 defining a corresponding tissue storage compartment is removably inserted into a filter drawer 430. The filter drawer 430 is slidably inserted into and removed from the imaging cabinet 402. The tissue filter assembly 110 is configured such that the tissue storage compartment is positioned in communication with and between the biopsy excision tool 120 and the aspiration container 130 via an inlet line 122 and an outlet line 132. During use, tissue specimens 123 and fluid 124 excised by the biopsy excision tool 120 are aspirated through the inlet line 122 and stored in the tissue storage compartment of the tissue filter assembly 110. Excess fluid 124 can be aspirated through the evacuation line 132 into the aspiration container 130. Imaging cabinet 402 includes or houses X-ray imaging equipment 141, and includes a detector plate 510 for detecting emitted X-rays and generating X-ray images 150. Tissue specimen 123 is positioned within the field of view of X-ray imaging equipment 141.

[0056] Image processor 160 may also be included in imaging cabinet 402, but embodiments are not limited thereto. For example, image processor 160 or components thereof may be remotely positioned relative to tissue biopsy system 100 to allow remote image processing, remote execution of image mask 170 and remote execution of machine intelligence, and object detection within tissue specimen 123. For ease of explanation, reference is made to real-time imaging and acquisition of X-ray image 150.

[0057] Filter drawer 430 defines conduit passages 520 for inlet line 122 and outlet or suction line 132. A vacuum source (not shown) is connected to suction or outlet line 132 and / or suction canister 130, such that activation of the vacuum source causes tissue specimen 123 and fluid 124 to be drawn through inlet line 122 into the tissue storage compartment of tissue filter assembly 110. Waste or excess fluid can be drawn into suction canister 130 via evacuation suction line 132.

[0058] Refer again Figure 4A -B, and continue to refer to Figure 5 The imaging cabinet 402 includes a control panel 460 having buttons or UI elements (for a touchscreen control panel) to allow a user to select or adjust various operating parameters of the biopsy system 100, such as imaging parameters or filters, and to request the generation of a modified X-ray image 150m, according to an embodiment. A display 180 is provided to present the modified X-ray image 150m generated according to an embodiment to the user. In some embodiments, these parameters can be adjusted via one or more UI elements 182 on the display 180.

[0059] For example, image processor 160 may execute imaging algorithms including one or more image masks 170, such as a predefined region of interest (ROI) mask to exclude a portion of X-ray image 150 depicting the metal collimator 142 of X-ray imaging device 141, a compartment mask executed on a portion of X-ray image 150 depicting the interior of a tissue storage compartment, a partial structure mask executed on a portion of X-ray image 150 depicting portions of the specimen tray wall and interior of the compartment not covered by the compartment mask, one or more irrelevant object masks for attaching or embedding other objects (such as magnets or printed markings) within the specimen tray, and a background image mask (e.g., for other plastic surroundings or base materials). Image processor 160 also communicates with computer display 180 of tissue biopsy system 100 to process user interactions via UI 182, such as processing user requests for modifications to X-ray images according to embodiments.

[0060] refer to Figure 6An exemplary biopsy excision tool 120 and tissue filter assembly 110 are illustrated. The distal end of the biopsy excision tool 120 includes a guide 620 for inserting a biopsy needle 622, which is attached to a driver of the biopsy excision tool 120 and configured for tissue extraction. For these purposes, the proximal end of the biopsy excision tool 120 communicates with a saline / aspiration tubing assembly 610, which includes an inlet line 122 for delivering saline 124 and fluid to the filter assembly 110. Figure 6 The exemplary saline / aspiration tubing assembly 610 shown may include an aspiration line 612 through which a tissue specimen 123 removed by the needle 622 of the biopsy excision tool 120 is aspirated along with fluid 124 (such as saline introduced via one or more inlet values ​​or saline line 614). The excised tissue specimen 123 and fluid(s) 124 are aspirated through the aspiration line 612, which is in communication with the inlet of the tissue filter assembly 110. The outlet of the tissue filter assembly 110 is in fluid communication with the aspiration canister 130 via an evacuation aspiration line 132.

[0061] Figure 7A The diagram illustrates an exemplary configuration of a tissue filter assembly 110, which is in fluid communication between a biopsy excision tool 120 and an aspiration canister 130. In the illustrated embodiment, the tissue filter assembly 110 includes a housing or cap 710 and a base 730. The cap 710 is removably attached to the base 730 to define an interior or chamber in which a tissue specimen holder or tray, or a filter holder or specimen tray 720 (generally, specimen tray 720) is enclosed. The base 730 includes a spindle 732 that receives a hub 722 of the specimen tray 720, such that the specimen tray 720 is rotatable about an axis of rotation 740 defined by the spindle 732 and is rotatable relative to the base 730 and the cap 710 about the axis 740. In other words, the base 730 and the cap 710 are stationary, while the specimen tray 720 rotates within the chamber defined by the base 730 and the cap 710. The specimen tray 720 can be rotated using any suitable actuator, including magnetic drive systems. Figure 7A (not shown in -D), wherein one or more magnetic elements are deployed on or embedded in the specimen tray 720, which is rotated by the magnetic force of a magnet in an actuator.

[0062] exist Figure 7A In the embodiment shown in -D, the base 730 includes a bottom member or surface 734 and a cylindrical circumferential outer wall 736 (generally a sidewall 736). The sidewall 736 extends upward from the bottom member 734 and has an inner diameter such that the specimen tray 720 can be rotated via the spindle 732 of the base 730 that receives the hub 722 of the specimen tray 720, such that the specimen tray 720 can be rotated about the axis of rotation 740.

[0063] exist Figure 7A In the embodiment shown in -D, the specimen tray 720 also includes a bottom member that may include a filter material 724 and a cylindrical circumferential sidewall 726 (generally a sidewall 726) extending upward from the bottom member 724. In some embodiments, the bottom surface 724 of the specimen tray 720 includes a porous filter material. The filter material may be a single filter, such as a filter plate that covers the entire bottom of the specimen tray 720 and through which excess fluid 124 flows into the aspiration canister 130. Alternatively, the filter material may be a separate filter deployed at the bottom of each tissue storage compartment 728.

[0064] The specimen tray 720 also includes a plurality of inner walls or partition walls 727 (generally partition walls 727) extending radially from the center or hub 722 to the inner surface of the sidewall 726 to define corresponding tissue storage compartments 728. In the illustrated embodiment, the specimen tray 720 defines 12 tissue storage compartments 728A-L (generally tissue storage compartments 728). In the illustrated configuration, the specimen tray 720 defines storage compartments 728 in the shape of "pie" or "wedge" segments, each segment defined by two partition walls 727 and arcuate portions of the sidewall 726. The tissue storage compartments 728 are separated and partially defined by radially extending partition walls 727. It will be understood that the specimen tray 720 may define other numbers of tissue storage compartments 728 and have other configurations, providing Figure 7A -D is for illustrative and explanatory purposes, not for limitation.

[0065] During the biopsy procedure, tissue specimen 123 and one or more fluids 124 are aspirated into the online tissue storage compartment 728 via biopsy needle 622. Tissue compartment markings or identifiers 750a-1 (generally compartment markings 750) are provided to identify the corresponding tissue storage compartment 728 and the corresponding tissue specimen 123 therein. The compartment markings 750 can be printed or engraved alphanumeric indicators. For example, radiopaque tungsten graphite can be used for the compartment markings 750, making them visible in X-ray image 151. In the illustrated embodiment, the compartment markings 750 are alpha indicators in the form of the letters AL to identify the corresponding 12 tissue storage compartments 728A-L.

[0066] Some embodiments may involve first reducing the fluid 124 in the tissue storage compartment 728 before imaging the tissue specimen 123. Image processing for the tissue specimen 123 is then performed with the remaining fluid 124 present.

[0067] According to one embodiment, a fluid management device 760 may be deployed inside a base 730. The embodiment may involve removing fluid 124 from a tissue storage compartment 728 using a mechanical device in the form of the fluid management device 760 to handle fluid 124 remaining in the tissue storage compartment 728 and continuing to interfere with imaging of the excised tissue specimen 123.

[0068] Figure 7E -M depicts another exemplary configuration of the filter assembly 110, which is in fluid communication between the biopsy excision tool 120 and the aspiration canister 130, and includes additional structures for improved fluid management and control of the removal of fluid 124 from the tissue storage compartment 728. Figure 7E -M illustrates one embodiment of a tissue filter assembly 110 for receiving multiple tissue samples and having a base 730 structurally configured to enhance fluid management.

[0069] In the illustrated embodiment, the tissue filter assembly 110 includes a housing having a base 730 and a cover 710, the cover 710 being removably attached to the base 730. The base 730 and the attached cover 710 form an interior or chamber in which a specimen tray 720 is enclosed. As discussed above with reference to Figure AD, the base 730 has a hub with a spindle that receives the hub of the specimen tray 720, such that the specimen tray 720 can be rotated about an axis 740 relative to the housing 710, for example using a magnetic drive system. The bottom of the tissue specimen tray 720 has a tissue filter 724 comprising a porous filter material.

[0070] The base 730 has a bottom surface 734 and a circumferential sidewall 736 extending upward from the bottom surface 734. The tissue filter assembly 110 also includes a platform 760 having a platform opening 762. A fluid channel 764 is located below the platform 760 (see [link]). Figure 7E (The middle line is a dashed arrow pointing to the fluid passage 764 below the platform 760). As used in this specification, the term "fluid passage" can be any pathway capable of transporting fluids such as gases (e.g., air) and / or liquids.

[0071] Platform 760 has a flat, horizontal surface. In some embodiments, the bottom of specimen tray 720 may rest on the flat, horizontal surface of platform 760 when specimen tray 720 is rotated relative to base 730. In other embodiments, the bottom of specimen tray 720 may be spaced a small distance from the flat, horizontal surface of platform 760, such as less than 0.5 mm, less than 0.2 mm, less than 0.1 mm, or less than 0.05 mm. Fluid channel 764 extends circumferentially around hub 731 of base 730 below platform 760 and is in fluid communication with pressurization chamber 766 at base 730. Suction line 132 is coupled to pressurization chamber 766 for applying suction within pressurization chamber 766 and fluid channel 764. Tissue filter assembly 110 also includes a flow comb 768 located below platform opening 762. In some embodiments, flow comb 768 may extend from platform opening 762 into fluid channel 764. During use, fluid from the specimen tray 720 is drawn into the platform opening 762 due to suction applied by the suction line 132 in the fluid channel 764. A flow comb 768 breaks up the fluid, which is then transported through the fluid channel 764 around the hub 731 of the base 730 to reach the pressurization chamber 766. The pressurization chamber 766 allows a certain amount of fluid to be collected while the suction line 132 extracts the fluid from the pressurization chamber 766 via an outlet or vacuum port 770. In some embodiments, the outlet port 770 has an inner diameter of 0.26 inches. In other embodiments, the outlet port 770 may have an inner diameter of other dimensions, which may be greater than or less than 0.26 inches.

[0072] In one embodiment, the fluid channel 764 extends circumferentially about 270° (e.g., 270° ± 20°) around the hub 731 of the base 730, such that fluid in the fluid channel 764 travels an angular distance of approximately 270° around the hub 731 to reach the pressurization chamber 766. In other embodiments, the fluid channel 764 may extend circumferentially about the hub 731 through other angular ranges. For example, the fluid channel 764 may extend about the hub 731 by at least 180°. Moreover, in the illustrated embodiment, the platform 760 extends circumferentially about most of the space between the hub 731 and the circumferential sidewall 736. In other embodiments, the platform 760 may extend about the hub 731 within a range different from that shown.

[0073] like Figure 7EAs shown, this embodiment of the tissue filter assembly 110 also includes an imaging platform 772 corresponding to the imaging position for imaging the tissue specimen 123. An imager may be located below the imaging platform 772. Specifically, when the tissue specimen 123 in the specimen tray 720 is placed above the imaging platform 772, imaging of the tissue specimen 123 can be performed by an imager below the imaging platform 772. In some embodiments, the imaging platform 772 is a molded piece with solid walls that rise above the bottom surface 734 to prevent fluid buildup in and around the imaging area. During use, one of the tissue storage compartments 728 containing the tissue specimen 123 to be imaged is placed above the imaging platform 772. In some cases, the filter or bottom surface 724 of the specimen tray 720 may be flush with the imaging platform 772. It should be noted that the imaging platform 772 is a separate piece from the platform 766 and does not define any fluid channels.

[0074] like Figure 7F As shown, the cover 710 also includes a raised portion 711 that defines an arched compartment corresponding to the imaging position of the tissue specimen 123. Specifically, imaging can then be performed to image the tissue specimen 123 when the tissue storage compartment 728 containing the tissue specimen 123 is positioned below the raised portion 711 and above the imaging platform surface 772.

[0075] In some embodiments, platform opening 762, fluid channel 764, and flow comb 768 may be considered part of a fluid removal mechanism. The fluid removal mechanism is configured to remove fluid from a bottom surface filter 734 located below the bottom of a plurality of tissue storage compartments 728 to improve image quality of tissue specimens 123 acquired in the tissue storage compartments 728. In other embodiments, structures involved in defining the fluid channel 764 may also be considered part of the fluid removal mechanism. For example, the platform 760 above the fluid channel 764 and / or the bottom member of the base 730 below the fluid channel 764 may be considered part of the fluid removal mechanism. In further embodiments, pressurization chamber 766 and / or suction line 132 may be considered part of the fluid removal mechanism.

[0076] Figure 7G The illustration shows a partially transparent view of the tissue filter assembly 110. The cover 710 of the tissue filter assembly 110 is shown partially transparent, so that the specimen tray 720 beneath the cover 710 can be seen.

[0077] Figure 7HThe illustration shows the tissue filter assembly 110 with the cap 710 removed. The circumferential sidewall 736 of the base 730 defines space for receiving the specimen tray 720. When the specimen tray 720 is rotatably attached to the base 730, the specimen tray 720 is spaced apart from the circumferential sidewall 736 by a gap 776. This allows the specimen tray 720 to rotate undisturbed relative to the base 730.

[0078] Figure 7I The illustration shows the base 730 of the tissue filter assembly 110, with the cover 710 and specimen tray 720 removed. Figure 7I As shown, the platform 760 of the base 730 of the tissue filter assembly 10 is presented in a partially transparent form to illustrate a portion of the flow comb 768 beneath the platform 760.

[0079] Figure 7J The illustration shows the base 730 of the tissue filter assembly 110, and in particular the platform 760 removed from the base 730. The extent of the imaging platform 772 and the flow comb 768 can be seen. As shown, the base 730 includes a bottom member 780 surrounded by circumferential sidewalls 736 of the base 730. The height of the bottom member 780 is less than the height of the flow comb 768. In some embodiments, the imaging platform 772 and / or the flow comb 768 may be molded together with the bottom member 780. As shown, the flow comb 768 has an arcuate shape that allows fluid 124 to be transported along a curved path from the platform opening 762 into the fluid channel 764. In the illustrated embodiment, the flow comb 768 has six parallel flow channels. In other embodiments, the flow comb 768 may have more than six parallel flow channels (e.g., seven, eight, nine channels, etc.) or fewer than six flow channels (e.g., five, four, three, two channels). In some cases, the flow comb 768 may include at least four flow channels. Furthermore, in the illustrated embodiment, the length of the flow comb 768 is longer than the dimension of the platform opening 762 measured along the longitudinal axis of the fluid channel 764. In other embodiments, the length of the flow comb 768 is shorter than or equal to the dimension of the platform opening 762 measured along the longitudinal axis of the fluid channel 764. Additionally, in the illustrated embodiment, a first portion of the flow comb 768 adjacent to the platform opening 762 may have a generally vertical first slope (e.g., 90° ± 20°), a second portion of the flow comb 768 following the first portion may have a second slope of approximately 45° ± 20°, and a third portion of the flow comb 768 following the second portion and extending within the fluid channel 764 may have a third slope of approximately 0° ± 20°. In other embodiments, the flow comb 768 may have other inclined profiles. In some embodiments, surface treatments may be applied to the flow comb 768 to facilitate the flow of fluid 124 on the flow comb 768. For example, in some embodiments, an anticoagulant coating, a hydrophobic coating, or other treatments may be applied to the surface of the flow comb 768.

[0080] like Figure 7K As shown, the bottom member 780 and the platform 760 together define a fluid channel 764. When the specimen tray 720 is coupled to the base 730, the platform 760 and the fluid channel 764 are located below the specimen tray 720. The fluid channel 764 is configured to provide suction to transport fluid 124 through the fluid channel 764.

[0081] Figure 7L A partial cross-sectional view of the tissue filter assembly 110 is illustrated, showing in particular the specimen tray 720 mounted within the interior defined by the base 730 and the lid 710. The lid 710 includes a protrusion 782 configured to mate with an opening 784 at the hub 722 of the specimen tray 720. The lower portion of the hub 722 of the specimen tray 720 has an opening for receiving a hub 731 of the base 730, and the hub 722 includes a groove for receiving a spindle 732 of the base 730. Thus, rotation of the spindle 732 will cause the specimen tray 720 to rotate relative to the base 730. The protrusion 782 from the lid 110 and the hub 731 of the base 730 extend from opposite directions into the hub 722 of the specimen tray 720, thereby stabilizing the specimen tray 720 during rotation. Therefore, the specimen tray 720 is removably coupled to the spindle 732 (drive member) at the base 730 and is configured to selectively rotate about an axis 140 that is substantially orthogonal (e.g., 90° ± 10°) relative to the bottom member 780.

[0082] like Figure 7L As shown, the inlet port 122 at the cover 110 is radially aligned with the corresponding tissue storage compartment 728 and also radially aligned with the platform opening 762, which at least partially forms the platform 760. Thus, when a tissue specimen 123 containing fluid 124 is delivered into the inlet port 122, the tissue specimen 123 and fluid 124 are stored in the corresponding tissue storage compartment 728. The tissue specimen 123 is contained by a bottom surface filter 734, while the fluid 124 flows out through the bottom surface filter 734 and through the platform opening 762 of the platform 760. During use of the tissue filter assembly 110, suction is provided within the fluid channel 764 to aid in drawing fluid 124 from the bottom of the specimen tray 720 into the platform opening 762.

[0083] Figure 7M The diagram shows... Figure 7LA partial cross-sectional view of the tissue filter assembly 110, particularly showing the direction of fluid flow. As shown, a tissue specimen 123 and fluid 124 from the biopsy device 120 enter the tissue filter assembly 110 via inlet port 122. The tissue specimen 123 is stored in one of the tissue storage compartments 728 in the specimen tray 720. A bottom surface filter 734 prevents the tissue specimen 123 from exiting through the bottom of the specimen tray 720 while allowing the fluid 124 to pass through. Due to suction provided in the fluid channel 764, the fluid 124 enters the platform opening 762 at the platform 760 and is broken up by the flow comb 768 inside the fluid channel 764. Then, due to the suction within the fluid channel 764, the fluid 124 is transported through the fluid channel 764 and exits via the outlet port 97 at the circumferential sidewall 746 into the pressurization chamber 766. The pressurization chamber 766 allows a certain amount of fluid 124 to be collected, while the fluid 124 is drawn from the pressurization chamber 766 into the suction line 132 via the outlet port.

[0084] Although it has been referenced Figure 7A -D and Figure 7E -M describes various tissue filter assembly 100 configurations, but it will be understood that embodiments may involve or utilize various tissue filter assembly 100 configurations, including those with a particularly configured mechanical fluid management device 760, as referenced. Figure 7E The -M describes a method to reduce the amount of fluid 124 being imaged. Therefore, certain fluid management devices 760 are described herein as non-limiting examples of how the fluid 124 undergoing image processing can be reduced and removed from the tissue storage compartment 728. It will also be understood that embodiments may not involve a mechanical fluid management device 760.

[0085] An exemplary tissue biopsy system 100 and its components, which can be used in conjunction with embodiments of X-ray images 150 of tissue specimen 123 to generate modified X-ray images 150m, have been described, with reference to Figure 8-1 1 and above references Figure 4A-7M The exemplary biopsy system 100 described herein is described in more detail with reference to [reference]. Figure 1-3 The image processing embodiments described.

[0086] refer to Figure 8 An embodiment of the image processor 160 of the tissue biopsy system 100 is configured or operable to selectively modify an X-ray image by executing an imaging algorithm comprising a plurality of image masks 170 based on the structure or geometry 171 of at least a portion of the specimen tray 720 imaged and depicted in the X-ray image 150.

[0087] At 802, the structure or geometry 171 or template of the specimen tray 720 is received or determined and stored by the image processor 160 for subsequent access. The structure or geometry 171 may include geometric data of the tissue storage compartment 728, sidewalls 726, and inner partition walls 727. The boundaries of the sidewalls 726, partition walls 727, and tissue specimen 123 within the tissue storage compartment 728, whether positioned in the middle of the compartment or in contact with the walls, can be determined using the structural or geometric data 171, including one or more of the component dimensions, centers, centers of rotation, and radii of curvature of various components. The structure or geometry 171 or template may also take into account the geometric data of other objects embedded or fixed to the specimen tray 720, such as predetermined typographical markings 750 and magnets or compartment “zero” position objects. The structural or geometric data 171 may include, for example, the centroid of the printed mark 750, the position of the magnet relative to the storage compartment 728, the size or dimensions of the mark 750 and the magnet, their center and radius (if applicable). While printed marks and magnets are provided as examples of such objects, other objects and their image data may be processed depending on the construction and handling of the specimen tray 720.

[0088] For the exemplary tissue biopsy system 100 described above, a single magnet is sufficient to magnetically drive the specimen tray 720 to rotate, and as an example, such a magnet can be positioned between or adjacent to the compartment 728 with the printed mark "A" and the compartment 728 with the printed mark "L" (wherein the magnet of the specimen tray 720 is imaged as...). Figure 9 (The brightest part). The magnet can be used not only to rotate the specimen tray 720, but also as a compartment "zero" or reference mark. Therefore, it will be understood that one or more storage compartments 728 may be adjacent to the magnet, while other storage compartments 728 are not adjacent.

[0089] At position 804, the tissue biopsy system 100 is activated and used to cut the tissue specimen 123. For example, as referenced above. Figure 6 This may involve inserting a biopsy needle 622 into the patient and attaching the biopsy needle 622 to a driver of a biopsy excision tool 120 for tissue extraction.

[0090] At point 806, the excised tissue specimen 123 is delivered via aspiration through the lumen of the inlet line 122 and stored in the storage compartment 728 of the specimen tray 720 of the tissue filter assembly 110. For example, as referenced above. Figure 6The proximal end of the biopsy excision tool 120 is connected to a saline / aspiration tubing assembly 610, which includes an inlet line 122 for delivering saline 124 and fluid to a filter assembly 110. The tissue specimen 123 excised by the needle 622 of the biopsy excision tool 120, together with the fluid 124, is aspirated through the aspiration line 612 connected to the inlet of the filter assembly 110 to store the excised tissue specimen 123 and fluid 124 in a storage compartment 128.

[0091] Continue to refer to Figure 8 At 808, X-ray imaging device 141 is activated to acquire X-ray images 150 of tissue specimens 123 in at least a portion of storage compartment 728 and specimen tray 720. X-ray images 150 are stored and / or provided to image processor 160.

[0092] Figure 9 An exemplary X-ray image 150 is shown, illustrating a portion of a specimen tray 720 including a storage compartment 728. Although Figure 9 It is an X-ray image 150, not the actual specimen tray 720, but... Figure 9 The accompanying drawings provide reference numerals for specimen tray 720 and other structures to identify the physical structure of specimen tray 720 depicted in X-ray image 150.

[0093] In the illustrated example, X-ray image 150 includes a complete specimen compartment 728 defined by an arc-shaped, cylindrical, or circumferential outer wall 736o (“o” means “outer”, generally referring to the outer wall 736o), an arc-shaped, cylindrical, or circumferential inner wall 736i (“i” means “inner”, generally referring to the inner wall 736i), and inner partition walls 727a-b. A tissue specimen (not shown) is placed in the storage compartment 728 and imaged by X-ray imaging device 141.

[0094] Figure 9 The illustration further shows an X-ray image 150 generated by the X-ray imaging device 141 relative to a predetermined structure or geometric frame 171, including a rotation point or rotation center (0) or axis 740 and associated x-axis 901 and y-axis 902. Figure 9 Further illustration shows how the specimen tray 720 and compartment 728 structures depicted in X-ray image 150 are expressed relative to different references and radii (such as the rotation center (0) or axis 740, x-axis 901 and y-axis 902).

[0095] Specifically, line OA 911 extends from the rotation center (0) or axis 740 through the center of the typographic mark or landmark 750 to indicate or approximate the longitudinal centerline of the storage compartment 728. Exemplary X-ray image 150 is an image of a specimen tray 720 defining 12 tissue storage compartments (AL), wherein only one complete storage compartment 728 is included in the X-ray image 150 and identified by the typographic mark 750 "A". However, it will be understood that embodiments are not limited thereto and that X-ray image 150 is provided as an example to describe how embodiments can be implemented. Figure 9 An example in which X-ray image 150 is not properly rotated and aligned is also illustrated. Line OA 911 is shifted clockwise relative to Y-axis 902. In other words, line OA-A911, marked with typographical notation 750 "A", does not coincide with Y-axis 902.

[0096] Line OB 912 extends from the rotation center (0) or axis 740 and passes approximately through the center of partition wall 727b. Line OC 913 extends from the rotation center (0) or axis 740 and passes approximately through the center of partition wall 727a. Thus, lines OB 912 and OC 913 effectively divide the imaged partition walls 727b, 727c into two image segments—an “inner” wall segment or inner wall defining at least a portion of the storage compartment 728, and an “outer” wall segment or outer wall. The arcuate sidewalls 736i, o in X-ray image 150 can also be similarly divided into “inner” and “outer” portions, as described in further detail below, but based on other structural criteria besides lines OB and OC 912, 913. As described in further detail below, according to certain embodiments, the imaging algorithm utilizes this virtual division of the specimen tray wall 727 to generate a modified X-ray image 150m.

[0097] Figure 9 Different radii and curvatures relative to the rotation center (0) or axis 740 are also illustrated, including radius R1 921 representing the virtual radius of the outer wall 736o from axis 740, radius R2 922 representing the virtual radius of the inner wall 736i from axis 740, radius R3 923 representing the virtual radius of the wall 736m (“m” refers to the magnet) relative to axis 740, and radii R4 924 and radius R5 925 representing the corresponding virtual radii of the respective boundaries of the imaging mask 170, which will be described in further detail below.

[0098] Figure 9 The X-ray image 150 also includes dark corner regions 931 and surrounding bright regions 932, which are generated by imaging a portion of the collimator 142 of the X-ray imaging device 141 that is in the field of view when the X-ray image 150 is acquired.

[0099] Refer again Figure 8 At 810, the image processor 160 executes the imaging mask 170 of the ROI mask to remove image portions 931 and 932, for example, using segmentation or other image processing or filters suitable for non-transparent / metallic objects.

[0100] Continue to refer to Figure 8 and 9 At 812, image processor 160 identifies registration and / or orientation references to determine whether X-ray image 150 is in proper lateral and / or rotational alignment to correspond to a known structure or geometry 171 of the imaged specimen tray 720. Registration and / or orientation references may include, for example, an x-axis 901, a y-axis 902, and a rotation center (0) 740. At 814, image processor 160 identifies printed markings or landmarks 750 (e.g., a printed “A”) associated with storage compartments 728 of specimen tray 720. Printed markings or landmarks 750 may be predetermined letters, shapes, or indicators (e.g., from the letters “A” to “L”) such that this limited set of predetermined characters can be identified by character recognition or selected by the user via UI 182 as markings 750 for compartments 728. At 816, having identified or received a selection of the mark or landmark 750, the image processor 160 determines the center of the printed mark 750, such as the centroid, which in the illustrated embodiment is also identified by line OA 911. Line OA 911 represents the estimated longitudinal centerline of compartment 728.

[0101] At 818, the embodiment determines whether a rotational misalignment adjustment is required. This can be accomplished by rotating the X-ray image 150 as needed based on step 816 to correct the rotational positioning of the X-ray image 150. For example, in the illustrated example, the X-ray image 150 is not in proper rotational alignment because line OA 911 is rotated clockwise relative to the Y-axis 902. In other words, line OA 911 is rotated out of alignment because it does not coincide with the Y-axis 902. In this case, the X-ray image 150 is rotated until line OA 911 is aligned or coincident with the Y-axis 902. The X-ray image 150 may already be in proper rotational alignment, thus requiring no rotational adjustment. Alternatively, in other embodiments, to accommodate rotational misalignment, the X-ray image orientation may remain as it is being imaged, and the embodiment may alternatively rotate or reposition the image mask 170 and the structure or geometry 171, as described in further detail below. Regardless of whether the rotational adjustment of the X-ray image 150 and / or the image mask 170 and the structure or geometry 171 is clockwise or counterclockwise.

[0102] Continue to refer to Figure 8 and 9At 820, image processor 160 determines X-ray collimator offsets 941, 942 within X-ray image 160, for example, a left collimator offset 941 relative to the outer edge of outer sidewall 736o and a right collimator offset relative to the outer edge of inner sidewall 736i. In the illustrated example, the left collimator offset 941 is greater than the right collimator offset 942. X-ray image 150 can be translated to the center at 822 such that the X-ray image 150 depicting specimen tray 720 or a portion thereof corresponds to a known structure or geometry 171 of specimen tray 720 or a portion thereof. There may be cases where X-ray image 150 is already correctly centered and no offset adjustment is required. Alternatively, in other embodiments, to accommodate collimator offsets, the X-ray image position may remain as imaged, and embodiments may alternatively reposition image mask 170 and structure or geometry 171. Therefore, the embodiments can accommodate manufacturing defects and collimator offsets during imaging, regardless of whether such defects result in rotation and / or offset adjustments.

[0103] Therefore, after any rotation and / or offset adjustment, the X-ray image 150 of the specimen tray 720 or a portion thereof corresponds to the known structure or geometry 171 of the actual specimen tray 720 or a portion thereof. An image mask 170 based on the structure or geometry 170 is ready to be executed on the X-ray image 150.

[0104] At 824, image processor 160 executes an imaging algorithm including compartment mask 951 on a portion of X-ray image 150 depicting the internal region of storage compartment 728. Compartment mask 951 substantially conforms to the contours of the interior of storage compartment 728 defined by a plurality of walls of specimen tray 720, which in the illustrated embodiment includes partition walls 727 and arcuate sidewalls 736, as well as arcuate wall portions 956 (generated by imaging of magnet 953). Different magnet shapes will result in different image 953 contours, such that the shape of the wall portions 956 will reflect such shapes. Furthermore, in the absence of magnets, the outer sidewall 936o will extend between partition walls 727a, b, without the wall portions 956 generated by magnet imaging. Thus, it will be understood that providing... Figure 9 It is for illustrative purposes, not restrictive ones.

[0105] The compartment mask 951 enhances at least one of the brightness and contrast of pixels in the X-ray image 150 depicting the tissue specimen 123 within the boundaries of the compartment mask 951. In the illustrated embodiment and depicted specimen tray 720 configuration, the boundaries of the compartment mask 951 include a pair of linear boundary segments and a pair of arcuate boundary segments extending between the linear boundary segments, and an arcuate segment following the contour of the wall segment 956 adjacent to a portion of the X-ray image of the imaged magnet. It will be understood that the boundaries of the compartment mask 951 can be of different shapes depending on the shape of the tissue storage compartment 728, such that the linear / arc configuration shown in the figures and described herein is provided for illustrative and explanatory purposes and not for limitation. In this way, the boundaries of the compartment mask 951 are contained within the storage compartment 728 and do not include the partition walls 727a-b, the side walls 736i, 736o, and the wall portion 56. Because the X-ray collimator 142 is within the field of view, the magnets and other objects of the specimen tray 720 are positioned outside the storage compartment 728, and the boundary of the compartment mask 951 also excludes the results or dark areas 931 and region 932.

[0106] The X-ray image 150 includes the imaged magnet. Figure 9 In the illustrated embodiment, the wall structure and shape of the compartment mask 951 are altered compared to when the adjacent storage compartment 728 does not have a magnet and is not imaged with a magnet. In either case, the compartment mask 951 substantially follows the inner contour of the compartment 728 and has an imaged magnet as shown, including a first linear boundary segment, a second linear boundary segment, a first arcuate boundary segment, a second arcuate boundary segment, and a third arcuate boundary segment. The first arcuate boundary segment of the compartment mask 951 extends between the first and second linear boundary segments, the second arcuate boundary segment of the compartment mask extends between the first and third arcuate boundary segments, and the third boundary segment of the compartment mask extends between the second arcuate boundary segment and the second linear boundary segment. Figure 9 In the embodiment shown, due to the curvature around the imaging region of the magnet, the radius of curvature of the third arcuate segment of the partition mask 951 adjacent to the arcuate wall segment 956 is smaller than the radius of curvature of the first and second arcuate boundaries of the partition mask 951 and the other masks.

[0107] Continue to refer to Figure 8 and 9 At 826, the image processor 160 executes an imaging algorithm including a partial structural mask 952 on a portion of the respective walls (inner wall 727 and outer / inner sidewalls 736i, 736o) of the specimen tray 720 and storage compartment 728 depicted in the X-ray image 150. The boundary of the partial structural mask 952 extends around or covers the compartment mask 951.

[0108] The boundary of the partial structure mask 952 extends along the respective lengths of the respective walls 727, 736 of the specimen tray 720 and partially passes through the respective walls 727, 736 of the specimen tray 720 to capture the respective inner wall segments of the respective walls of the specimen tray 720 and the remaining portions of the storage compartment 728 beyond the boundary of the specimen image mask 951. Therefore, the partial structure mask 952 is applied to a portion of the X-ray image 150 depicting the specimen wall structure, which is determined, for example, based on the image portion within lines OB 912 and OC 913 or based on a predetermined distance from the boundary of the compartment mask 951. The partial structure mask 952 is performed to mask the image portion or reduce at least one of the brightness and contrast of the pixels of the X-ray image 150, the pixels of which depict the outer portions of the respective specimen tray walls 727a, b and 736i, o, thereby leaving only the inner portions of the specimen tray walls 727a, b and 736i, o. In other words, part of the structural mask 952 cuts the thickness of the wall, for example, keeping 25%, 33%, or 50% of the wall thickness, while another part of the wall is processed by reducing its brightness and / or contrast.

[0109] In this way, in the X-ray image 150 excluding the magnet being imaged, similar to the boundary of the compartment mask 951, the boundary of the partial structure mask 952 includes a pair of linear boundary segments and a pair of arcuate boundary segments extending between the linear boundary segments, such that the partial structure mask can have substantially the same shape as the compartment mask 951, but encompass the compartment mask 951. In the X-ray image 150 including a portion of the magnet being imaged, as... Figure 9 As shown, the compartment mask 951 and the partial structure mask 952 can have different shapes because the compartment mask 951 includes additional curvature as a result of the imaged magnet and the resulting wall portion 956. Additionally, for the imaged magnet, such as... Figure 9 As shown, a portion of the partial structural mask 952 may extend through a portion of the X-ray image 150 generated by imaging through a magnet or other unrelated object, or in other embodiments, follow the curvature of the compartment mask 951 through the wall portion 956, such that the compartment mask 951 and the partial structural mask have similar shapes.

[0110] At 828, the image processor 160 identifies or receives a user's selection of a portion of the X-ray image 150 for "irrelevant" objects located outside the storage compartment 728 area, such as magnets and printed markings. At 830, the image processor 160 identifies and executes the corresponding irrelevant object image masks 953, 954 for the identified objects. A portion of the X-ray image 150 generated by imaging a metallic magnet can be, for example,... Figure 9The bright spot 960 or high-attenuation object depicted in the image will, in this case, be significantly reduced in brightness and contrast by the metal mask 953, or this area will be deleted and filled with pixel values ​​from adjacent image areas. Other objects may be handled differently. For example, it may be desirable to preserve the imaged printed markings 750, such that the object mask 954 for these marking objects selects the ROI that includes the printed markings 750 to be included in the modified X-ray image 150m. Such character objects can be identified by the user via UI 182 or via character recognition. Therefore, portions of the X-ray image 150 for different types of irrelevant objects can be processed with different types of irrelevant object masks 953, 954 that do not emphasize or delete portions of the X-ray image 150, or preserve and / or enhance portions of the X-ray image 150.

[0111] At 832, the image processor 160 performs a background image mask 955 on other portions of other areas of the depicting specimen tray 420 of the X-ray image 150. This may involve, for example, other plastic specimen tray structures or plastic structures used for fluid management and located outside of or between the boundaries of the partial structure mask 952 and the ROI mask boundary. These background structures, which may include various additional structures for enhanced fluid management control, may be masked or not emphasized.

[0112] At 834, the image processor 160 determines contrast and / or brightness adjustments to adapt pixel values ​​to the corresponding thickness of the tissue specimen 123. Statistical analysis of portions of the X-ray image 150 depicting the tissue specimen 123 can be performed using one or more statistical analyses such as mean, standard deviation, and threshold to identify portions of the X-ray image 150 depicting thinner portions of the specimen 123, compared to thicker portions, allowing pixel adjustments based on different specimen thicknesses. For example, the brightness values ​​of pixels in thinner and thicker portions of the specimen 132 are enhanced with respect to corresponding brightness and contrast, so that the specimen edges of the thinner and thicker portions of the specimen 132 can be depicted, while the thicker portion of the specimen 132 is less bright. Therefore, pixel values ​​can be selectively adapted to the thickness of the specimen 123.

[0113] At position 836, the modified X-ray image 150m is generated based on the corresponding results of performing various image masks 170 or based on the corresponding results of performing various image masks 170 and specimen thickness adjustments.

[0114] Figure 10A The X-ray image 150 is generated by the X-ray imaging device 141 (before processing in the embodiment) and depicts the magnet (imaged as a high-attenuation / bright spot). Figure 10BThe image is a modified X-ray image of 150m generated according to the embodiment.

[0115] For example, through comparison Figure 10A (Unprocessed X-ray image 150) and Figure 10B (As can be seen from the modified X-ray image 150m generated according to the embodiment), the modified X-ray image 150m generated according to the embodiment is cleaner, smaller, and more focused, and includes a more consistent or flatter brightness profile or fewer brightness variations. The modified X-ray image 150m does not include bright, high-attenuation image portions (e.g., generated by imaging the metallic magnet or plastic portion of the specimen tray 720). The embodiment also does not emphasize or eliminate image portions used for the additional tray structure, such as those used for the above references. Figure 7E -M describes the additional plastic structure for fluid management in the tissue filter assembly 100. Figure 10B The modified X-ray image 150m is significantly more pleasing to the eye with a substantial reduction in interfering elements. The modified X-ray image 150m generated according to the example is significantly better than... Figure 10A The X-ray images shown 150 are less distracting and less likely to cause eye strain, while providing a more productive and efficient review experience.

[0116] Figure 11A -B provides another example of a modified X-ray image 150m generated according to an embodiment for different tissue storage compartments 728 (identified by the printed mark "G") that are not adjacent to the magnet and include tissue specimens 123 stored therein. Figure 11B The modified X-ray image in 150m is compared to, for example Figure 11A The similar advantages of the unprocessed X-ray image 150 shown are visually apparent, including enhancing the tissue specimen 123 within the tissue storage compartment 728 without emphasizing or eliminating image portions of other plastic specimen tray areas.

[0117] Refer again Figure 8 At 838, the modified 150m pixel data of the X-ray image is incorporated into a Medical Digital Imaging and Communication (DICOM) object, which can be exported at 840 to be displayed to the user or transmitted to another system or via a network.

[0118] Therefore, as described above, the embodiments provide improved tissue specimen imaging and enhanced X-ray images that selectively emphasize certain image portions while eliminating or de-emphasizing other image portions through selective image masking based on the structure or geometry of the specimen tray being imaged. These embodiments achieve these significant imaging improvements in tissue image processing, which can be performed in real time during or after a biopsy procedure, allowing improved imaging results to be presented to the operator for more accurate and efficient analysis and determination, for example, whether additional tissue specimens should be obtained. The embodiments are also applicable to various system component configurations and tissue specimen and biopsy procedures, one example being a breast biopsy procedure.

[0119] While specific embodiments of the disclosed invention have been shown and described, it should be understood that the above description is provided for illustrative purposes only. Therefore, various changes and modifications can be made without departing from the scope of the disclosed invention.

[0120] For example, not all components depicted and described in the disclosed embodiments are necessary for implementing the embodiments, and various additional embodiments of the disclosed invention may include appropriate combinations of the described components, including different numbers and combinations of imaging masks.

[0121] Additionally, while embodiments have described tissue filter assemblies, specimen trays, and associated imaging masks having certain shapes (with linear and / or curved / arc walls), it will be understood that embodiments are not limited thereto, and embodiments may involve specimen trays with different configurations and compartment configurations, and image masks with different corresponding shapes for different configurations, which may include different combinations of linear and curved / arc walls and / or walls of other shapes for other specimen storage compartment shapes and specimen tray constructions.

[0122] Examples can be implemented to generate modified X-ray images that mask or de-emphasize different portions of the tissue filter assembly and specimen tray based on the specific structural construction used. For example, examples can be implemented to mask or de-emphasize additional plastic or other material structures, as referenced. Figure 7E As described in -M, these additional plastic or other material structures are added for fluid management, and the organization filter assembly can include different fluid management structures.

[0123] Although the system and methods have been described with reference to imaging of breast tissue samples obtained during biopsy procedures, the embodiments can also be configured and used with other types of tissue specimens.

[0124] Furthermore, although imaging algorithms have been described with respect to various imaging masks, embodiments may involve some or all of these masks and different combinations thereof, which may be executed in different orders.

[0125] Therefore, the embodiments are intended to illustrate alternatives, modifications, and equivalents that may fall within the scope of the claims.

Claims

1. A computer-implemented method executed by a biopsy tissue processing device, the computer-implemented method comprising: X-ray images of tissue specimens in the storage compartment of a specimen tray are acquired by the X-ray imaging system of the biopsy tissue processing device; A modified X-ray image is generated by an image processor in communication with an X-ray imaging system, wherein the modified X-ray image is generated by performing multiple image masks based at least partially on the geometry of at least a portion of a specimen tray, the specimen tray including a storage compartment having a tissue specimen depicted in the X-ray image, the multiple image masks including: A compartment mask, performed on a portion of an X-ray image depicting the storage compartment and including the cut tissue specimen, has boundaries that substantially correspond to the contours of the interior of the storage compartment defined by the multiple walls of the specimen tray. A partial structural mask is applied to a portion of an X-ray image that depicts the corresponding walls of a specimen tray and a storage compartment. The boundaries of the partial structural mask extend along the corresponding length and partially penetrate the corresponding walls of the specimen tray, such that the outer portions of the walls of the specimen tray are eliminated or not emphasized, while the inner portions of the walls are maintained or enhanced.

2. The method of claim 1, wherein the compartment mask enhances at least one of the brightness and contrast of the pixels depicting the X-ray image of the tissue specimen.

3. The method of claim 1, wherein the compartment mask does not include the walls of the storage compartment, the imaged portion of the collimator of the X-ray imaging system, and the magnet for rotating the specimen tray about the axis.

4. The method of claim 1, wherein the boundary of the partial structure mask is based on a predetermined distance from the boundary of the compartment mask.

5. The method of claim 1, wherein a partial structural mask is performed to mask or reduce at least one of the brightness and contrast of pixels in an X-ray image, the pixels of which are depicted on the outer portion of the corresponding plastic wall of the specimen tray outside the boundary of the partial structural mask.

6. The method of claim 1, wherein the boundaries of the partial structural mask and the boundaries of the compartment mask have substantially similar shapes.

7. The method of claim 6, wherein the boundary of the compartment mask comprises a pair of linear boundary segments and a pair of arcuate boundary segments extending between the linear boundary segments.

8. The method of claim 1, wherein the plurality of image masks further includes an unrelated object mask performed on a portion of the X-ray image, the portion depicting an object embedded or fixed to a specimen tray.

9. A biopsy tissue processing device, comprising: Specimen trays, with designated storage compartments; A tube, defining a vacuum lumen in communication with a storage compartment, is configured to receive excised tissue specimens and deliver the excised tissue specimens along with fluids through the vacuum lumen, thereby storing the excised tissue specimens and fluids in the storage compartment; An X-ray imaging system is arranged relative to a tissue storage compartment to acquire X-ray images of tissue specimens cut out in the storage compartment; An image processor, which communicates with the X-ray imaging system, is configured to... Modified X-ray images are generated by performing multiple image masks based at least partially on the geometry of at least a portion of a specimen tray, the specimen tray including storage compartments having tissue specimens depicted in the X-ray images, the multiple image masks comprising: A compartment mask, performed on a portion of an X-ray image depicting the storage compartment and including the excised tissue specimen, has boundaries that substantially correspond to the contours of the interior of the storage compartment defined by the corresponding walls of the specimen tray. A partial structural mask is applied to a portion of an X-ray image that depicts the corresponding walls of a specimen tray and a storage compartment. The boundaries of the partial structural mask extend along the corresponding length and partially penetrate the corresponding walls of the specimen tray, such that the outer portions of the walls of the specimen tray are eliminated or not emphasized, while the inner portions of the walls are maintained or enhanced. as well as The display communicates with the image processor and is operable to present modified images to the user of the biopsy tissue processing device.

10. A non-transitory computer-readable medium that tangibly implements one or more sequences of instructions, wherein one or more processors included in one or more computing systems of a biopsy tissue disposal apparatus execute the one or more sequences of instructions such that the one or more computing systems acquire and modify X-ray images by performing computer-implemented methods, comprising: X-ray images of tissue specimens in the storage compartment of the specimen tray are acquired by the X-ray imaging system of the biopsy tissue processing device; Modified X-ray images are generated by an image processor that communicates with the X-ray imaging system. The modified X-ray image is generated by performing multiple image masks based at least partially on the geometry of at least a portion of a specimen tray, which includes storage compartments with tissue specimens depicted in the X-ray image. The plurality of image masks includes: A compartment mask, performed on a portion of an X-ray image depicting the storage compartment and including the excised tissue specimen, has boundaries that substantially correspond to the contours of the interior of the storage compartment defined by the corresponding walls of the specimen tray. A partial structural mask is applied to a portion of an X-ray image that depicts the corresponding walls of a specimen tray and a storage compartment. The boundaries of the partial structural mask extend along the corresponding length and partially penetrate the corresponding walls of the specimen tray, such that the outer portions of the walls of the specimen tray are eliminated or not emphasized, while the inner portions of the walls are maintained or enhanced.

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