A fluorescent probe for detecting the coexistence and alternating existence of endogenous H2O2 and H2S, and its preparation method and application
By designing an organic fluorescence probe that can turn on fluorescence emission when H2O2 and H2S coexist and turn on fluorescence in sequence when alternate existence, the problem that the prior art cannot effectively monitor the interaction between H2O2 and H2S is solved, and the fluorescence visualization of the coexistence and alternating existence of endogenous H2O2 and H2S in cells is realized.
Patent Information
- Application Number
- CN202210995123.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-08-18
- Publication Date
- 2025-03-28
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Existing fluorescent probes cannot effectively elucidate the interaction of H2O2 and H2S in organisms, especially when they coexist or alternately exist, and cannot achieve a response to dynamic and alternating existence.
An organic fluorescent probe with excellent responsiveness is designed that enables fluorescent emission when H2O2 and H2S coexist and turns off and turn on fluorescent emission in sequence when the subsequent H2O2 and H2S alternately exist. This probe visualizes the fluorescence of the coexistence and alternation of endogenous H2O2 and H2S in cells through near-infrared fluorescence analysis.
The fluorescence visualization of the coexistence and alternating presence of endogenous H2O2 and H2S in cells is achieved, providing direct visual evidence of the interaction of H2O2 and H2S, filling the gap in the prior art that cannot monitor coexistence and alternating presence.