Insecticidal compounds

Abstract

The present invention relates to compounds of formula (I) and their N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts, wherein the variables are defined according to the specification. Compounds of formula (I) and their N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts can be used to control or prevent invertebrate pests, especially arthropod pests and nematodes. The present invention also relates to a method for controlling invertebrate pests by using these compounds, as well as plant propagation materials and agricultural and veterinary compositions containing the compounds. #imgabs0#

Description

[0001] Invertebrate pests and especially insects, arachnids and nematodes destroy growing and harvested crops and attack wooden dwellings and commercial structures, causing large economic losses to food supplies and property.Therefore, there remains a need for new agents for controlling invertebrate pests.

[0002] For example, the insecticidal use of carbamoyl and thiocarbamoyl oxime derivatives is known in patent publication WO 2016 / 156076, and the insecticidal use of semicarbazone and thiosemicarbazone derivatives is known in patent publication WO 2016 / 116445.

[0003] Since target pests can develop resistance to insecticidal active agents, there is a continued need to discover additional compounds suitable for controlling invertebrate pests such as insects, arachnids and nematodes. Furthermore, there is a need for new compounds that have high insecticidal activity and exhibit a broad spectrum of activity against a wide variety of invertebrate pests, especially against difficult-to-control insects, arachnids and nematodes.

[0004] Therefore, an object of the present invention is to discover and provide compounds which exhibit high pesticidal activity against invertebrate pests and have a broad spectrum of activity.

[0005] It has been found that these objects are achieved by substituted bicyclic compounds of the formula I shown and defined below, including their stereoisomers, their salts, especially their agriculturally or veterinarily acceptable salts, their tautomers and their N-oxides.

[0006] In a first aspect, the present invention relates to compounds of formula I and their N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts:

[0007]

[0008] in

[0009] A is N or CR A ;

[0010] B 1 N or CR B1 ;

[0011] D is N or CR D ;

[0012] E is N or CR E ;

[0013] A, B 1 , E and D at least one is N; and when A and D are N, B 1 CR B1 ;

[0014] B 2N or CR B2 ;

[0015] B 3 N or CR B3 ;

[0016] B 4 N or CR B4 ;

[0017] Condition B 2 、B 3 and B 4 At least one of them is not N;

[0018] R A 、R D 、R B1 and R E are independently H, halogen, N3, OH, CN, NO2, -SCN, -SF5, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, tri-C1-C6 alkylsilyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 alkoxy-C1-C4 alkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, C3-C6 cycloalkyl-C1-C4 alkyl, C1-C4 alkyl-C3-C6 cycloalkoxy, these structural moieties are unsubstituted or substituted by halogen,

[0019] C(=O)-OR a NR b R c 、C1-C6 alkylene-NR b R c 、O-C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、NH-C1-C6 alkylene-NR b R c 、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c or S(=O) m R e , phenyl, phenoxy, phenylcarbonyl, phenylthio or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0020] R B2 、R B3 and R B4are independently H, halogen, N3, OH, CN, NO2, -SCN, -SF5, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, tri-C1-C6 alkylsilyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 alkoxy-C1-C4 alkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, C3-C6 cycloalkyl-C1-C4 alkyl, C1-C4 alkyl-C3-C6 cycloalkoxy, these structural moieties are unsubstituted or substituted by halogen,

[0021] C(=O)-OR a NR b R c 、C1-C6 alkylene-NR b R c 、O-C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、NH-C1-C6 alkylene-NR b R c 、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c or S(=O) m R e , phenyl, phenoxy, phenylcarbonyl, phenylthio or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0022] Q is -C(R 4 R 5 )-O-, -C(=O)-O-, -S(=O) m -C(R 7 R 8 )-、-N(R 2 )-S(=O) m -、-N(R 2 )-C(R 9 R 10 )-、-C(=O)-C(R 19 R 20 )-、-N(R 2 )-、-N(R 2 )-C(=O)-、-N(R 2 )-C(=S)-、-C(R 13 R 14 )-C(R 15 R 16 )-、-N=C(X)-、-N(R 2)-C(=NR)-or-C(R 17 )=C(R 18 )-; wherein Ar is bonded to either side of Q;

[0023] m is 0, 1, or 2;

[0024] X is H, halogen, SR 7 , OR 8 or N(R 3 )2;

[0025] R is H, CN, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl,

[0026] These moieties are unsubstituted or substituted with halogen,

[0027] OR 8 、N(R 3 )2;

[0028] R 3 is H, C1-C6 alkyl or C1-C6 alkoxy-C1-C4 alkyl;

[0029] R 2 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C4 alkyl, C3-C6 cycloalkoxy-C1-C4 alkyl, these structural moieties are unsubstituted or substituted by halogen,

[0030] C(=O)-OR a 、C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c 、S(=O) m R e , phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0031] R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 13 、R 14 、R 15 、R 16、R 17 、R 18 、R 19 、R 20 the same or different and are H, halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C4 alkyl, C3-C6 cycloalkoxy-C1-C4 alkyl, these structural parts are unsubstituted or substituted by halogen, C(=O)-OR a 、C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c 、S(=O) m R e , phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0032] Ar is unsubstituted or replaced by R Ar substituted phenyl or 5- or 6-membered heteroaryl or 1,3-benzodioxole, wherein

[0033] R Ar is halogen, N3, OH, CN, NO2, -SCN, -SF5, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, tri-C1-C6 alkylsilyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 alkoxy-C1-C4 alkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, C3-C6 cycloalkyl-C1-C4 alkyl, C3-C6 cycloalkoxy-C1-C4 alkyl, these structural parts are unsubstituted or substituted by halogen,

[0034] C(=O)-OR a NR b R c 、C1-C6 alkylene-NR b R c 、O-C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、NH-C1-C6 alkylene-NR b R c 、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b Rc or S(=O) m R e , phenyl, phenoxy, phenylcarbonyl, phenylthio or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0035] R 1 YZTR 11 or YZTR 12 a structural part of

[0036] Y is -CR ya =N-, wherein N is bonded to Z;

[0037] -NR yc -C(=O)-, wherein C(=O) is bonded to Z; or

[0038] -NR yc -C(=S)-, wherein C(=S) is bonded to Z;

[0039] Z is a single bond;

[0040] -NR zc -C(=O)-, wherein C(=O) is bonded to T;

[0041] -NR zc -C(=S)-, wherein C(=S) is bonded to T;

[0042] -N=C(SR za )-, wherein T is bonded to a carbon atom;

[0043] -OC(=O)-, wherein T is bonded to a carbon atom, or

[0044] -NR zc -C(SR za )=, wherein T is bonded to a carbon atom;

[0045] The condition is that when Y is -NR yc -C(=O)- or -NR yc -C(=S)-, then Z is not a single bond;

[0046] T is O, N or NR T ;

[0047] R 11 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C4 alkyl, C1-C4 alkyl-C3-C6 cycloalkoxy,

[0048] These moieties are unsubstituted or substituted with halogen,

[0049] C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、C(=O)-NR b R c 、C(=O)-R d , aryl, arylcarbonyl, aryl-C1-C4 alkyl, aryloxy-C1-C4 alkyl, heteroaryl, carbonylheteroaryl, heteroaryl-C1-C4 alkyl or heteroaryloxy-C1-C4 alkyl, wherein the phenyl and heteroaryl rings are unsubstituted or replaced by R g substituted and wherein heteroaryl is a 5- or 6-membered monocyclic heteroaryl or an 8-, 9- or 10-membered bicyclic heteroaryl;

[0050] R 12 Formula A 1 Groups:

[0051]

[0052] Where # indicates the connection point with T;

[0053] R 121 、R 122 、R 123 the same or different and are H, halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 alkoxy, C2-C6 alkenyloxy, C2-C6 alkynyloxy, C1-C6 alkoxy-C1-C4 alkoxy, C1-C6 alkylcarbonyloxy, C1-C6 alkenylcarbonyloxy, C3-C6 cycloalkylcarbonyloxy, and these structural moieties are unsubstituted

[0054] or halogen or NR b R c Replace or R 121 、R 122 、R 123 One of them may also be oxo; R 124 is H, C1-C6 alkyl, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 alkoxy or C2-C6 alkenyloxy, which are unsubstituted or substituted by halogen;

[0055] And among them

[0056] R yais H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C3-C6 cycloalkyl, C1-C4 alkyl-C3-C6 cycloalkyl, C1-C4 alkyl-C3-C6 cycloalkyloxy, these structural parts are unsubstituted or substituted by halogen,

[0057] C(=O)-OR a 、C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c 、S(=O) m R e , phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0058] R yc 、R zc are the same or different and are H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C4 alkyl-C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C4 alkyl-C3-C6 cycloalkyl or C1-C4 alkyl-C3-C6 cycloalkoxy, which are unsubstituted or substituted by halogen;

[0059] R T is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C4 alkyl-C1-C6 alkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C4 alkyl, C3-C6 cycloalkoxy-C1-C4 alkyl, these structural parts are unsubstituted or substituted by halogen,

[0060] C(=O)-OR a 、C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c 、S(=O) m R e , phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0061] R zc With RT -, if present, together can form a C1-C6-alkylene or a linear C2-C6-alkenylene, wherein in the linear C1-C6-alkylene and the linear C2-C6-alkenylene, the CH2 moiety can be replaced by a carbonyl or C=N-R' and / or wherein 1 or 2 CH2 moieties can be replaced by O or S and / or wherein the linear C1-C6-alkylene and the linear C2-C6-alkenylene can be unsubstituted or replaced by R h replace;

[0062] R za is H, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, tri-C1-C6 alkylsilyl, C2-C6 alkynyl, C1-C4 alkyl-C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C4 alkyl-C3-C6 cycloalkoxy, C1-C4 alkyl-C3-C6 cycloalkyl, these structural parts are unsubstituted or substituted by halogen,

[0063] C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、C(=O)-NR b R c 、C(=O)-R d , phenyl, phenylcarbonyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0064] R za With R T -, if present, together can form a C1-C6-alkylene or a linear C2-C6-alkenylene, wherein in the linear C1-C6-alkylene and the linear C2-C6-alkenylene, the CH2 moiety can be replaced by a carbonyl or C=N-R' and / or wherein 1 or 2 CH2 moieties can be replaced by O or S and / or wherein the linear C1-C6-alkylene and the linear C2-C6-alkenylene can be unsubstituted or replaced by R h replace;

[0065] R a 、R b and R c are the same or different and are H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C4 alkyl, C3-C6 cycloalkoxy-C1-C4 alkyl, these structural moieties are unsubstituted or substituted by halogen,

[0066] C1-C6 alkylene-CN, phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0067] R d is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C4 alkyl, C3-C6 cycloalkoxy-C1-C4 alkyl, these structural moieties are unsubstituted or substituted by halogen,

[0068] Phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0069] R e is C1-C6 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C4 alkyl, these structural parts are unsubstituted or substituted by halogen,

[0070] Phenyl and -CH2-phenyl, where the phenyl ring is unsubstituted or replaced by R f replace;

[0071] R f is halogen, N3, OH, CN, NO2, -SCN, -SF5, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, tri-C1-C6 alkylsilyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 alkoxy-C1-C4 alkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, C3-C6 cycloalkyl-C1-C4 alkyl, C3-C6 cycloalkoxy-C1-C4 alkyl, these structural parts are unsubstituted or substituted by halogen,

[0072] C(=O)-OR a NR b R c 、C1-C6 alkylene-NR b R c 、O-C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、NH-C1-C6 alkylene-NR b R c 、

[0073] C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c or S(=O) m R e ;

[0074] R gis halogen, N3, OH, CN, NO2, -SCN, -SF5, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, tri-C1-C6 alkylsilyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 alkoxy-C1-C4 alkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, C3-C6 cycloalkyl-C1-C4 alkyl, C3-C6 cycloalkoxy-C1-C4 alkyl,

[0075] These moieties are unsubstituted or substituted with halogen,

[0076] C(=O)-OR a NR b R c 、C1-C6 alkylene-NR b R c 、O-C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、NH-C1-C6 alkylene-NR b R c 、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c or S(=O) m R e ;

[0077] R h is halogen, OH, C1-C6 alkyl, C3-C6 cycloalkyl or CN.

[0078] In addition, the present invention also relates to methods and intermediates for preparing compounds of formula I and active compound combinations comprising them. In addition, the present invention relates to agricultural or veterinary compositions comprising compounds of formula I and the use of compounds of formula I or compositions comprising them in preventing or controlling invertebrate pests and / or protecting crops, plants, plant propagation materials and / or growing plants from invertebrate pest infestation and / or infection. The present invention also relates to methods for applying compounds of formula I. The present invention also relates to methods for protecting crops, plants, plant propagation materials and / or growing plants from invertebrate pest infestation or infection, comprising contacting or treating crops, plants, plant propagation materials and growing plants or soil, materials, surfaces, spaces, areas or water bodies in which crops, plants, plant propagation materials are stored or plants are grown with an insecticidal effective amount of at least one compound of formula (I) as defined above or a composition comprising at least one compound of formula (I);

[0079] Furthermore, the present invention relates to seeds comprising compounds of formula I. Compounds of formula I include N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof.

[0080] General procedures:

[0081] Compounds of formula I can be prepared by the procedures given in the following schemes by appropriate modification of the starting compounds.

[0082]

[0083] Compounds of formula S1-2 can be prepared using a coupling agent such as HATU in an amide coupling reaction between an aryl carboxylic acid (ArCOOH) and a compound of formula S1-1, as described in Tobinaga et al., WO2018 / 021447 (Scheme 1). Alternatively, the aryl carboxylic acid (ArCOOH) can be pre-activated to an acyl chloride by reacting with, for example, SOCl2 in the presence of a base (e.g., Et3N) to form a compound of formula S1-2 before reacting with the amine (S1-1). Compounds of formula S1-3 can in turn be prepared by reacting a compound of formula S1-2 with a thioagent such as P2S5, as described in, for example, Carroll et al., WO2008 / 130953. Compounds of formula S1-4 can be prepared by reacting a compound of formula S1-2 with a reducing agent such as BH3 . SMe2 can be synthesized by reaction of SMe2 as described, for example, by Chen et al., WO 2009 / 135299.

[0084] Solution 1

[0085]

[0086] Compounds of formula S2-2 can be prepared from compounds of formula S2-1 by reaction with, for example, hydroxylamine hydrochloride in the presence of a base (e.g., NaOH, pyridine, triethylamine, K2CO3, NaH), as described, for example, by Sanders et al., J.Am.Chem.Soc.2011, 133, 949-957 (Scheme 2). Compounds of formula S2-3 can be prepared from compounds of formula S2-2 by reaction with a chlorinating agent (e.g., N-chlorosuccinimide, NaOCl, tert-butyl hypochlorite), as described, for example, by Sanders et al., J.Am.Chem.Soc.2011, 133, 949-957. Compounds of formula S2-4 can be prepared from compounds of formula S2-3 by reaction with an amine nucleophile (ArNHR 2) reaction, as described, for example, by Altug et al., Tetrahedron Lett. 2009, 50, 7392-7394. The compound of formula S2-5 can be prepared by reacting a compound of formula S2-4 in the presence of a base (e.g., NaOH, pyridine, triethylamine, K2CO3, NaH), as described, for example, by Lui et al., Pest. Manag. Sci. 2009, 65, 229-234.

[0087] Option 2

[0088]

[0089] Compounds of formula S3-2 (R = Me, Et) can be prepared from compounds of formula S3-1 by reaction with, for example, hydrochloric acid in methanol, as described, for example, by Laurent et al., Molecules, 2010, 15, 4283-4293 (Scheme 3). Compounds of formula S3-3 can be prepared from compounds of formula S3-2 by reaction with an amine nucleophile (ArNHR 2 ) reaction as described, for example, by Arnold et al., WO 2008 / 124849.

[0090] Option 3

[0091]

[0092] The compound of formula S4-2 can be prepared by reacting the compound of formula S1-2 with a chlorinating agent (e.g., N-chlorosuccinimide, NaOCl, tert-butyl hypochlorite) and then with hydrazine [H2NN(R 3 2] is prepared via a compound of formula S4-1, as described, for example, in Crimmin et al., Dalton Trans., 2011, 42, 514-522 (Scheme 4). Compounds of formula S4-2 can also be prepared from compounds of formula S1-3 by reacting with, for example, hydrazine [H2NN(R 3 )2] reaction preparation, as described, for example, in Burlison et al., WO2009 / 158026.

[0093] Option 4

[0094]

[0095] Formula S5-3 compound can be prepared by reacting formula S5-1 compound with reducing agent such as LiAlH4. The obtained formula S5-2 compound can then be formed by reacting with aryl alcohol (ArOH) under Mitsonobu conditions to form formula S5-3 compound (Scheme 5). Formula S5-5 compound can be prepared by reacting formula S5-2 compound with chlorination reagent (such as SOCl2, POCl3), as described in, for example, Miyahara et al., WO2017 / 209155. The obtained formula S5-4 compound can then be converted into formula S5-2 compound by reacting with aryl thiol (ArSH). Formula S5-6 compound can be prepared by reacting formula S5-5 compound with oxidant (such as MCPBA). Formula S1-4 compound can also be prepared by reducing formula S5-1 compound with, for example, DIBAL. The obtained formula S2-1 compound can then be reacted with amine (ArNHR 2 ) is reacted in a reductive amination using, for example, Na(CN)BH 3 to form a compound of formula S1-4.

[0096] Option 5

[0097]

[0098] The compound of formula S6-3 can be prepared by treating the compound of formula S6-1 with a halogenating agent (e.g., POCl3, PBr3) (Scheme 6). The resulting compound of formula S6-2 can then be prepared in S N Ar reaction or palladium-catalyzed amination with amines (R 2 Alternatively, the resulting compound of formula S6-3 can be acylated with an aryl acid (or chloride) to form a compound of formula S6-4.

[0099] Option 6

[0100]

[0101] Compounds of formula S7-1, S7-2, S7-3, and S7-4 are isomers of the compounds described in Schemes 1-4 and thus can be synthesized using procedures similar to those described above (Scheme 7).

[0102] Option 7

[0103]

[0104] The compound of formula S8-1 can be prepared similarly to the compound of formula S6-3 (Scheme 8). The compound of formula S8-2 can be prepared from the compound of formula S6-2 by N Ar reaction or copper-catalyzed ether formation with alcohols [ArC(R9 )(R 10 )OH] reaction, as described, for example, by Long et al., WO2018 / 059534 or Gao et al., WO2016 / 150193. The compound of formula S8-3 can be prepared from the compound of formula S6-2 by reacting N Ar reaction or palladium-catalyzed thioether formation with thiols [ArC(R 9 )(R 10 )SH] reaction, as described, for example, by Wang et al., WO2017 / 198196 or Barrow et al., WO2016 / 123577.

[0105] Option 8

[0106]

[0107] Compounds of formula S9-3 can also be prepared by Suzuki-type aryl coupling reactions as described in Scheme 9, wherein X is a halogen such as chlorine or bromine, and Lg is a boron-containing group such as B(OH2) or a corresponding di-C1-C4 alkyl ester. The reaction of compounds of formula S9-1 with compounds of formula S9-2 can be carried out, for example, by reactions similar to those described in WO2014 / 007217 or Org. Lett., 2009, 11(24), 5666-5669 (Scheme 9).

[0108] Option 9

[0109]

[0110] Similarly, compounds of formula S10-3 can also be prepared by a Suzuki-type aryl coupling reaction as described in Scheme 10, wherein X is a halogen such as chlorine or bromine, and Lg is a boron-containing group such as B(OH2) or a corresponding di-C1-C4 alkyl ester. The reaction of compounds of formula S10-1 with compounds of formula S10-2 can be carried out, for example, by a reaction similar to that described in WO2014 / 007217 or Org. Lett., 2009, 11(24), 5666-5669 (Scheme 10).

[0111] Plan 10

[0112]

[0113] Compounds of formula S11-2 (R = Me, Et) can be prepared using CO (g) and MeOH or EtOH in the palladium-catalyzed carbonylation of compounds of formula S11-1, as described, for example, in Evans et al., WO2017 / 214269 (Scheme 11). Compounds of formula S11-4 can in turn be prepared from compounds of formula S11-2, for example, by alkaline hydrolysis. Compounds of formula S11-3 can also be prepared from compounds of formula S11-2, for example, by reduction with DIBAL.

[0114] Plan 11

[0115]

[0116] Compounds of formula S11-4, S11-3 and S12-1 can be converted to compounds of formula (I) in known syntheses, such as those described in Crouse et al., WO2009 / 102736, Crouse et al., WO2010 / 093764, Crouse et al., US2012 / 0202687, Crouse et al., WO2013 / 009791, Baum et al., WO2013 / 116052, Fischer et al., WO2013 / 116053, Crouse et al., WO2014 / 011429, Jeanguenat et al., WO2016 / 116445 and Narine et al., WO2018 / 177781 (Scheme 12).

[0117] Plan 12

[0118]

[0119]

[0120] Individual compounds of formula I may also be prepared by derivatizing other compounds of formula I or intermediates thereof.

[0121] If a mixture of isomers is obtained during synthesis, separation is not generally necessary, since the individual isomers may in some cases be converted into one another during post-processing for use or during application (e.g. under the action of light, acids or bases). Such conversions may also occur after use, for example in the case of plant treatment, in the treated plant or in the harmful fungi to be controlled.

[0122] The skilled worker readily understands that the preferences given herein for the substituents with respect to compound I, in particular also those given for the corresponding substituents in the following table, apply correspondingly to the intermediates. Therefore, the substituents have the meanings given herein in each case independently of one another or more preferably in combination.

[0123] The term "compound of the invention" or "compound of the present invention" or "compound of formula (I)" refers to a compound of formula I, unless otherwise indicated.

[0124] The term "compounds of the present invention" or "compounds of formula I" includes compounds as defined herein and stereoisomers, salts, tautomers or N-oxides thereof. The term "compounds of the present invention" is to be understood as equivalent to the term "compounds of the present invention" and therefore also includes stereoisomers, salts, tautomers or N-oxides thereof.

[0125] The term "composition of the invention" or "composition of the invention" includes compositions comprising at least one compound of the invention as defined above, formula I. The composition of the invention is preferably an agricultural or veterinary composition.

[0126] Depending on the substitution pattern, the compounds of the present invention may have one or more chiral centers, in which case they exist as a mixture of enantiomers or diastereomers. The present invention provides single pure enantiomers or pure diastereomers of the compounds of the present invention and mixtures thereof, as well as the present invention's uses of pure enantiomers or pure diastereomers of the compounds of the present invention or mixtures thereof. Suitable compounds of the present invention also include all possible geometric stereoisomers (cis / trans isomers) and mixtures thereof. Cis / trans isomers may exist for alkenes, carbon-nitrogen double bonds, or amide groups. The term "stereoisomer" includes optical isomers, such as enantiomers or diastereomers, which exist due to more than one chiral center in the molecule, and geometric isomers (cis / trans isomers). The present invention relates to each possible stereoisomer of compounds of formula I, i.e., single enantiomers or diastereomers, and mixtures thereof.

[0127] The compounds of the present invention may be amorphous or may exist in one or more different crystalline states (polymorphs) that may have different macroscopic properties such as stability or exhibit different biological properties such as activity. The present invention relates to amorphous and crystalline compounds of the present invention, mixtures of the corresponding compounds of the present invention in different crystalline states, and amorphous or crystalline salts thereof.

[0128] The term "tautomer" includes isomers derived from compounds of formula I by H atom displacement involving at least one H atom located at a nitrogen, oxygen or sulfur atom. Examples of tautomeric forms are keto-enol forms, imine-enamine forms, urea-isourea forms, thiourea-isothiourea forms, (thio)amide-(thio)imidate forms, and the like.

[0129] The term "stereoisomer" includes both optical isomers such as enantiomers or diastereomers - the latter of which occur due to more than one chiral center in the molecule - and geometric isomers (cis / trans isomers).

[0130] Depending on the substitution pattern, the compounds of the formula I may have one or more chiral centers, in which case they exist as mixtures of enantiomers or diastereomers. A chiral center is a 1 The present invention provides both the pure enantiomers or pure diastereomers of compound I and their mixtures, as well as the use according to the invention of the pure enantiomers or pure diastereomers of compound I or their mixtures. Suitable compounds of formula I also include all possible geometric stereoisomers (cis / trans isomers) and mixtures thereof.

[0131] The term N-oxide relates to a form of compound I in which at least one nitrogen atom is present in oxidized form (as NO). More precisely, it relates to any compound according to the invention which has at least one tertiary nitrogen atom which is oxidized to form an N-oxide moiety. N-oxides of compound I can be obtained, in particular, by oxidizing, for example, an N-heterocycle, such as is present in Ar or R, with a suitable oxidizing agent such as a peroxycarboxylic acid or other peroxide. 11 The compounds of the present invention are prepared from the ring nitrogen atoms of the pyridine or pyrimidine ring or the imino nitrogen present in the central tricyclic nucleus. Those skilled in the art know how and at which positions the compounds of the present invention can form N-oxides.

[0132] The salts of the compounds of formula I are preferably agriculturally and veterinarily acceptable salts. They can be formed in a customary manner, for example by reacting the compound with an acid of the anion in question, if the compound of formula I has a basic function, or by reacting an acidic compound of formula I with a suitable base.

[0133] Suitable agriculturally or veterinarily acceptable salts are in particular salts of cations or acid addition salts of acids whose cations and anions, respectively, are known and accepted in the art of forming agricultural or veterinary salts and which do not have any adverse effect on the action of the compounds of the invention. Suitable cations are in particular alkali metal ions, preferably lithium, sodium and potassium ions; alkaline earth metal ions, preferably calcium, magnesium and barium ions; transition metal ions, preferably manganese, copper, zinc and iron ions; and ammonium (NH4 + ) and substituted ammonium in which 1 to 4 hydrogen atoms are replaced by C1-C4 alkyl, C1-C4 hydroxyalkyl, C1-C4 alkoxy, C1-C4 alkoxy-C1-C4 alkyl, hydroxy-C1-C4 alkoxy-C1-C4 alkyl, phenyl or -CH2-phenyl. Examples of substituted ammonium ions include methylammonium, isopropylammonium, dimethylammonium, diisopropylammonium, trimethylammonium, tetramethylammonium, tetraethylammonium, tetrabutylammonium, 2-hydroxyethylammonium, 2-(2-hydroxyethoxy)ethylammonium, di(2-hydroxyethyl)ammonium, benzyltrimethylammonium and benzyltriethylammonium, in addition to ions, sulfonium ions, preferably tri(C1-C4 alkyl)sulfonium, and sulfoxide ions, preferably tri(C1-C4 alkyl)sulfoxide. Suitable veterinary acid addition salts formed from compounds of formula I containing a basic nitrogen atom, such as an amino group, include salts with inorganic acids, such as hydrochlorides, sulfates, phosphates and nitrates, and salts with organic acids such as acetic acid, maleic acid, dimaleic acid, fumaric acid, difumaric acid, methanesulfenic acid, methanesulfonic acid and succinic acid.

[0134] Anions useful for acid addition salts are primarily chloride, bromide, fluoride, hydrogen sulfate, sulfate, dihydrogen phosphate, hydrogen phosphate, phosphate, nitrate, hydrogen carbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate and anions of C1-C4 alkanoic acids, preferably formate, acetate, propionate and butyrate. These can be formed by reacting a compound of formula I with an acid of the corresponding anion, preferably hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid.

[0135] As used herein, the term "invertebrate pests" includes animal species, such as insects, arachnids and nematodes, which may attack plants, thereby causing significant damage to the attacked plants, and ectoparasites which may infest animals, especially warm-blooded animals such as mammals or birds or other higher animals such as reptiles, amphibians or fish, thereby causing significant damage to the infected animals.

[0136] The term "plant propagation material" should be construed as representing all propagation parts of a plant such as seeds, and asexual plant materials such as cuttings and tubers (e.g., potatoes) that can be used for propagating plants. This includes seeds, roots, fruits, tubers, bulbs, underground stems, branches, buds and other plant parts, including rice seedlings and seedlings transplanted by soil after germination or after emergence. Plant propagation material can be treated with plant protection compounds preventatively when or before planting or transplanting. The seedling can also be protected by the complete or partial treatment via dipping or watering before transplanting.

[0137] The term "plant" comprises any type of plant, including "modified plants" and especially "cultivated plants".

[0138] The term "modified plant" refers to any wild-type variety or related variety or related genus of cultivated plants.

[0139] The term "cultivated plants" is understood to include plants that have been modified by breeding, mutagenesis or genetic engineering, including but not limited to agricultural biotechnology products that are marketed or in development (see http: / / www.bio.org / speeches / pubs / er / agri_products.asp). Genetically modified plants are plants whose genetic material is not readily obtained by hybridization, mutation or natural recombination under natural conditions. One or more genes are typically integrated into the genetic material of a genetically modified plant to improve certain properties of the plant. Such genetic modifications also include but are not limited to targeted post-translational modifications of proteins, oligopeptides or polypeptides, for example by glycosylation or polymer addition such as prenylated, acetylated or farnesylated moieties or PEG moieties.

[0140] Plants modified by breeding, mutagenesis or genetic engineering are, for example, made tolerant by conventional breeding or genetic engineering methods to the application of particular classes of herbicides, such as auxin herbicides, such as dicamba or 2,4-D; bleach herbicides, such as hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors or phytoene desaturase (PDS) inhibitors; acetolactate synthase (ALS) inhibitors, such as sulfonylureas or imidazolinones; enolpyruvylshikimate 3-phosphate synthase (EPSPS) inhibitors, such as glyphosate; glutamine synthase inhibitors. enzyme (GS) inhibitors, such as glufosinate; protoporphyrinogen-IX oxidase inhibitors; lipid biosynthesis inhibitors such as acetyl CoA carboxylase (ACCase) inhibitors; or oxynil (i.e., bromoxynil or ioxynil) herbicides; in addition, plants have been genetically modified multiple times to tolerate various classes of herbicides, such as tolerance to both glyphosate and glufosinate or tolerance to both glyphosate and another class of herbicides selected from ALS inhibitors, HPPD inhibitors, auxin inhibitors or ACCase inhibitors. These herbicide tolerance technologies are described, for example, in Pest Managem. Sci. 61, 2005, 246; 61, 2005, 258; 61, 2005, 277; 61, 2005, 269; 61, 2005, 286; 64, 2008, 326; 64, 2008, 332; Weed Sci. 57, 2009, 108; Austral. J. Agricult. Res. 58, 2007, 708; Science 316, 2007, 1185; and in the literature cited therein. Several cultivated plants have been made tolerant to herbicides by conventional breeding methods (mutagenesis), for example, to imidazolinones such as imazamox. Summer rapeseed (Canola, BASF SE, Germany) or tolerant to sulfonylureas, such as tribenuron Sunflower (DuPont, USA). Genetic engineering methods have been used to confer tolerance to herbicides such as glyphosate and glufosinate in cultivated plants such as soybean, cotton, corn, sugar beet, and rapeseed to herbicides such as glyphosate and glufosinate, some of which are available under the trade names (glyphosate tolerant, Monsanto, USA), (Imidazolinone resistant, BASF SE, Germany) and (Glufosinate-tolerant, Bayer CropScience, Germany) was purchased commercially.

[0141] Furthermore, plants are also encompassed which are capable of synthesizing one or more insecticidal proteins, in particular those known from Bacillus bacteria, in particular Bacillus thuringiensis, by the use of recombinant DNA technology, such as delta-endotoxins, for example CryIA(b), CryIA(c), CryIF, CryIF(a2), CryIIA(b), CryIIIA, CryIIIB(b1) or Cry9c; asexual insecticidal proteins (VIP), for example VIP1, VIP2, VIP3 or VIP3A; insecticidal proteins of nematode-colonizing bacteria, for example Photorhabdus or Xenorhabdus; toxins produced by animals, such as scorpion toxins, spider toxins, wasp toxins or other insect-specific neurotoxins; toxins produced by fungi, for example Streptomycetes toxins; Lectins, such as pea or barley lectins; lectins; protease inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cysteine ​​protease inhibitors or papain inhibitors; ribosome inactivating proteins (RIPs), such as ricin, maize-RIP, abrin, luffa seed protein, saporin or bryodin; steroid metabolizing enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid-IDP glycosyltransferase, cholesterol oxidase, ecdysone inhibitor or HMG-CoA reductase; ion channel blockers, such as sodium channel or calcium channel blockers; juvenile hormone esterase; diuretic hormone receptor (helicokinin receptor); stilbene synthase, bibenzyl synthase, chitinase or glucanase. In the context of the present invention, these insecticidal proteins or toxins are also understood to be protoxins, hybrid proteins, truncated or otherwise modified proteins. Hybrid proteins are characterized by novel combinations of protein domains (e.g., referring to WO 2002 / 015701). Such toxins or other examples of genetically modified plants capable of synthesizing these toxins are disclosed in EP-A 374753, WO 93 / 07278, WO 95 / 34656, EP-A 427 529, EP-A 451 878, WO03 / 18810, and WO 03 / 52073. The method for producing these genetically modified plants is generally known to those skilled in the art and is, for example, described in the above-mentioned publications. These insecticidal proteins contained in genetically modified plants give the plants producing these proteins tolerance to pests that are arthropods in all taxonomies, especially beetles (Coleoptera (Coeleropta)), dipteran insects (Diptera (Diptera)) and moths (Lepidoptera (Lepidoptera)) and nematodes (Nematoda (Nematoda)).Genetically modified plants which are able to synthesize one or more insecticidal proteins are described, for example, in the publications mentioned above, some of which are commercially available, for example. (corn varieties that produce the toxin Cry1Ab), Plus (corn varieties producing toxins Cry1Ab and Cry3Bb1), (corn varieties that produce the toxin Cry9c), RW (a corn variety producing Cry34Ab1, Cry35Ab1, and the enzyme phosphinothricin-N-acetyltransferase [PAT]); 33B (cotton variety producing the toxin Cry1Ac), I (cotton variety producing the toxin Cry1Ac), II (cotton varieties producing toxins Cry1Ac and Cry2Ab2); (cotton varieties that produce VIP toxin); (potato varieties that produce the toxin Cry3A); Bt11 (e.g. CB) and Bt176 of Syngenta Seeds SAS, France (a corn variety producing the toxin Cry1Ab and the PAT enzyme), MIR604 of Syngenta Seeds SAS, France (a corn variety producing a modified version of the toxin Cry3A, see WO 03 / 018810), MON 863 of Monsanto Europe SA, Belgium (a corn variety producing the toxin Cry3Bb1), IPC 531 of Monsanto Europe SA, Belgium (a cotton variety producing a modified version of the toxin Cry1Ac) and 1507 of Pioneer Overseas Corporation, Belgium (a corn variety producing the toxin Cry1F and the PAT enzyme).

[0142] In addition, plants are also included that are capable of synthesizing one or more proteins that enhance resistance or tolerance to bacterial, viral or fungal pathogens by using recombinant DNA technology. Examples of such proteins are so-called "pathogenesis-related proteins" (PR proteins, for example, see EP-A 392 225), plant disease resistance genes (e.g., potato varieties expressing resistance genes that act against Phytophthora infestans from the Mexican wild potato Solanum bulbocastanum) or T4 lysozyme (e.g., potato varieties capable of synthesizing these proteins that enhance resistance to bacteria such as Erwinia amylvora). Methods for producing these genetically modified plants are generally known to those skilled in the art and are described, for example, in the above-mentioned publications.

[0143] Also included are plants that are capable of synthesizing one or more proteins through the use of recombinant DNA technology to increase yield (e.g., biomass production, grain yield, starch content, oil content, or protein content), tolerance to drought, salt, or other growth-limiting environmental factors, or tolerance to pests and fungal, bacterial, and viral pathogens.

[0144] Furthermore, plants are also included which, by using recombinant DNA technology, contain altered amounts of substances or new substances in order to improve, inter alia, human or animal nutrition, such as oil crops which produce health-promoting long-chain ω-3 fatty acids or unsaturated ω-9 fatty acids (e.g. Rapeseed (DOW Agro Sciences, Canada).

[0145] Furthermore, plants are also included which have altered or novel substance contents by the use of recombinant DNA technology, in particular to improve raw material production, such as potatoes which produce increased amounts of amylopectin (e.g. potatoes, BASF SE, Germany).

[0146] The organic moieties mentioned in the above definitions of the variables are, like the term halogen, collective terms for the individual enumerations of the individual members. n -C m In each case it indicates the possible number of carbon atoms in the group.

[0147] The term halogen denotes in each case F, Br, Cl or I, in particular F, Cl or Br.

[0148] As used herein, and in the alkyl moiety of alkoxy, alkylthio, and the like, the term "alkyl" refers to a saturated, straight-chain or branched hydrocarbon radical having 1-2 ("C1-C2 alkyl"), 1-3 ("C1-C3 alkyl"), 1-4 ("C1-C4 alkyl"), or 1-6 ("C1-C6 alkyl") carbon atoms. C1-C2 alkyl is CH3 or C2H5. C1-C3 alkyl is additionally propyl and isopropyl. C1-C4 alkyl is additionally butyl, 1-methylpropyl (sec-butyl), 2-methylpropyl (isobutyl), or 1,1-dimethylethyl (tert-butyl). C1-C6-Alkyl is additionally, for example, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, hexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl or 1-ethyl-2-methylpropyl.

[0149] The term "haloalkyl" as used herein, also denoted as "partially or fully halogenated alkyl", refers to straight-chain or branched alkyl groups (as defined above) having 1-2 ("C1-C2 haloalkyl"), 1-3 ("C1-C3 haloalkyl"), 1-4 ("C1-C4 haloalkyl") or 1-6 ("C1-C6 haloalkyl") carbon atoms, wherein some or all of the hydrogen atoms in these groups are replaced by halogen atoms as defined above: in particular C1-C2 haloalkyl, C1-C3 haloalkyl, C1-C4 haloalkyl, C1-C6 haloalkyl, C1-C6 haloalkyl, C1-C6 haloalkyl, C1-C6 haloalkyl, C1-C6 haloalkyl, C1-C2 ... C2-haloalkyl, such as chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichloromonofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl or pentafluoroethyl. C1-C3-haloalkyl is additionally, for example, 1-fluoropropyl, 2-fluoropropyl, 3-fluoropropyl, 1,1-difluoropropyl, 2,2-difluoropropyl, 1,2-difluoropropyl, 3,3-difluoropropyl, 3,3,3-trifluoropropyl, heptafluoropropyl, 1,1,1-trifluoroprop-2-yl, 3-chloropropyl, etc. Examples of the C1-C4 haloalkyl group include 4-chlorobutyl and the like in addition to those mentioned for the C1-C3 haloalkyl group.

[0150] The term "alkylene" (or alkanediyl) as used herein denotes in each case an alkyl group as defined above, wherein one hydrogen atom at any position of the carbon skeleton is replaced by another bonding position, thereby forming a divalent structural part. Alkylene preferably has 1 to 6 carbon atoms (C1-C6 alkylene), 2 to 6 carbon atoms (C2-C6 alkylene), in particular 1 to 4 carbon atoms (C1-C4 alkylene) or 2 to 4 carbon atoms (C2-C4 alkylene). Examples of alkylene groups are methylene (CH2), 1,1-ethylene, 1,2-ethylene, 1,3-propylene, 1,2-propylene, 2,2-propylene, 1,4-butylene, 1,2-butylene, 1,3-butylene, 2,3-butylene, 2,2-butylene, 1,5-pentylene, 2,2-dimethyl-1,3-propylene, 1,3-dimethyl-1,3-propylene, 1,6-hexylene, and the like.

[0151] As used herein, the term "alkenyl" refers to a monounsaturated straight-chain or branched hydrocarbon group having 2 to 3 ("C2-C3 alkenyl"), 2 to 4 ("C2-C4 alkenyl"), or 2 to 6 ("C2-C6 alkenyl") carbon atoms and a double bond at any position, for example, a C2-C3 alkenyl such as ethenyl, 1-propenyl, 2-propenyl, or 1-methylethenyl; a C2-C4 alkenyl such as ethenyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, or 2-methyl-2-propenyl;C2-C6 alkenyl such as vinyl, 1-propenyl, 2-propenyl, 1-methylvinyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1-butenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3- butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-1-propenyl, 1-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1-pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl, 4-methyl-1-pentenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 1-methyl-3- Pentenyl, 2-methyl-3-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-1-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1,3-dimethyl-1-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl alkenyl, 2,3-dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-1-butenyl, 3,3-dimethyl-2-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl, 1-ethyl-2-methyl-1-propenyl, 1-ethyl-2-methyl-2-propenyl, etc.;

[0152] As used herein, the term "alkynyl" refers to a straight-chain or branched hydrocarbon group having 2-3 ("C2-C3 alkynyl"), 2-4 ("C2-C4 alkynyl") or 2-6 ("C2-C6 alkynyl") carbon atoms and one or two triple bonds at any position, for example, a C2-C3 alkynyl, such as ethynyl, 1-propynyl or 2-propynyl; a C2-C4 alkynyl, such as ethynyl, 1-propynyl, 2-propynyl, 1- butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, etc., C2-C6 alkynyl, such as ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3- methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-1-pentynyl, 3-methyl-4-pentynyl, 4-methyl-1-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl, 1-ethyl-1-methyl-2-propynyl and the like.

[0153] As used herein, the term "cycloalkyl" refers to a monocyclic, bicyclic, or polycyclic saturated hydrocarbon radical having, inter alia, 3-6 ("C3-C6 cycloalkyl"), 3-5 ("C3-C5 cycloalkyl"), or 3-4 ("C3-C4 cycloalkyl") carbon atoms. Examples of monocyclic radicals having 3-4 carbon atoms include cyclopropyl and cyclobutyl. Examples of monocyclic radicals having 3-5 carbon atoms include cyclopropyl, cyclobutyl, and cyclopentyl. Examples of monocyclic radicals having 3-6 carbon atoms include cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl. Examples of monocyclic radicals having 3-8 carbon atoms include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Examples of bicyclic groups having 7 or 8 carbon atoms include bicyclo[2.2.1]heptyl, bicyclo[3.1.1]heptyl, bicyclo[2.2.2]octyl and bicyclo[3.2.1]octyl.Preferably the term cycloalkyl denotes a monocyclic saturated hydrocarbon group.

[0154] The term "cycloalkoxy" as used herein refers to a cycloalkyl group as defined above, especially a monocyclic cycloalkyl group, bonded to the remainder of the molecule via an oxygen atom, especially having 3-6 ("C3-C6 cycloalkoxy"), or 3-5 ("C3-C5 cycloalkoxy"), or 3-4 ("C3-C4 cycloalkoxy") carbon atoms.

[0155] The term "cycloalkyl-C1-C4 alkyl" refers to a C3-C8 cycloalkyl group as defined above ("C3-C8 cycloalkyl-C1-C4 alkyl"), preferably a C3-C6 cycloalkyl group ("C3-C6 cycloalkyl-C1-C4 alkyl"), more preferably a C3-C4 cycloalkyl group ("C3-C4 cycloalkyl-C1-C4 alkyl") (preferably a monocyclic cycloalkyl group). Examples of C3-C4 cycloalkyl-C1-C4 alkyl are cyclopropylmethyl, cyclopropylethyl, cyclopropylpropyl, cyclobutylmethyl, cyclobutylethyl and cyclobutylpropyl. Examples of C3-C6 cycloalkyl-C1-C4 alkyl, in addition to those mentioned for C3-C4 cycloalkyl-C1-C4 alkyl, are cyclopentylmethyl, cyclopentylethyl, cyclopentylpropyl, cyclohexylmethyl, cyclohexylethyl and cyclohexylpropyl.

[0156] The term "C1-C2 alkoxy" is a C1-C2 alkyl group as defined above attached via an oxygen atom. The term "C1-C3 alkoxy" is a C1-C3 alkyl group as defined above attached via an oxygen atom. The term "C1-C4 alkoxy" is a C1-C4 alkyl group as defined above attached via an oxygen atom. The term "C1-C6 alkoxy" is a C1-C6 alkyl group as defined above attached via an oxygen atom. The term "C1-C 10 "Alkoxy" is a C1-C ... 10Alkyl. C1-C2 alkoxy is OCH3 or OC2H5. C1-C3 alkoxy is additionally, for example, n-propoxy and 1-methylethoxy (isopropoxy). C1-C4 alkoxy is additionally, for example, butoxy, 1-methylpropoxy (sec-butoxy), 2-methylpropoxy (isobutoxy), or 1,1-dimethylethoxy (tert-butoxy). C1-C6 alkoxy is additionally, for example, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexyloxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy or 1-ethyl-2-methylpropoxy. C1-C8 alkoxy is additionally, for example, heptoxy, octyloxy, 2-ethylhexyloxy and positional isomers thereof. 10 Alkoxy is additionally exemplified by nonyloxy, decyloxy and positional isomers thereof.

[0157] The term "C1-C2 haloalkoxy" is a C1-C2 haloalkyl group as defined above attached via an oxygen atom. The term "C1-C3 haloalkoxy" is a C1-C3 haloalkyl group as defined above attached via an oxygen atom. The term "C1-C4 haloalkoxy" is a C1-C4 haloalkyl group as defined above attached via an oxygen atom. The term "C1-C6 haloalkoxy" is a C1-C6 haloalkyl group as defined above attached via an oxygen atom. C1-C2-haloalkoxy is, for example, OCH2F, OCHF2, OCF3, OCH2Cl, OCHCl2, OCCl3, chlorofluoromethoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2-bromoethoxy, 2-iodoethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2-trichloroethoxy or OC2F5. C1-C3 haloalkoxy is further exemplified by 2-fluoropropoxy, 3-fluoropropoxy, 2,2-difluoropropoxy, 2,3-difluoropropoxy, 2-chloropropoxy, 3-chloropropoxy, 2,3-dichloropropoxy, 2-bromopropoxy, 3-bromopropoxy, 3,3,3-trifluoropropoxy, 3,3,3-trichloropropoxy, OCH2-C2F5, OCF2-C2F5, 1-(CH2F)-2-fluoroethoxy, 1-(CH2Cl)-2-chloroethoxy or 1-(CH2Br)-2-bromoethoxy. C1-C4 haloalkoxy is further exemplified by 4-fluorobutoxy, 4-chlorobutoxy, 4-bromobutoxy or nonafluorobutoxy. C1-C6-Haloalkoxy is additionally, for example, 5-fluoropentyloxy, 5-chloropentyloxy, 5-bromopentyloxy, 5-iodopentyloxy, undecafluoropentyloxy, 6-fluorohexyloxy, 6-chlorohexyloxy, 6-bromohexyloxy, 6-iodohexyloxy or dodecafluorohexyloxy.

[0158] As used herein, the term "C1-C6 alkoxy-C1-C4 alkyl" refers to a straight-chain or branched alkyl group as defined above having 1 to 4 carbon atoms, in which one hydrogen atom is replaced by a C1-C6 alkoxy group as defined above. Examples are methoxymethyl, ethoxymethyl, propoxymethyl, isopropoxymethyl, n-butoxymethyl, sec-butoxymethyl, isobutoxymethyl, tert-butoxymethyl, 1-methoxyethyl, 1-ethoxyethyl, 1-propoxyethyl, 1-isopropoxyethyl, 1-n-butoxyethyl, 1-sec-butoxyethyl, 1-isobutoxyethyl, 1-tert-butoxyethyl, 2-methoxyethyl, 2-ethoxyethyl, 2-propoxyethyl, 2-isopropoxyethyl, 2-n-butoxyethyl, 2-sec-butoxyethyl, 2-isobutoxyethyl, 2-tert-butoxyethyl, 1-methoxypropyl , 1-ethoxypropyl, 1-propoxypropyl, 1-isopropoxypropyl, 1-n-butoxypropyl, 1-sec-butoxypropyl, 1-isobutoxypropyl, 1-tert-butoxypropyl, 2-methoxypropyl, 2-ethoxypropyl, 2-propoxypropyl, 2-isopropoxypropyl, 2-n-butoxypropyl, 2-sec-butoxypropyl, 2-isobutoxypropyl, 2-tert-butoxypropyl, 3-methoxypropyl, 3-ethoxypropyl, 3-propoxypropyl, 3-isopropoxypropyl, 3-n-butoxypropyl, 3-sec-butoxypropyl, 3-isobutoxypropyl, 3-tert-butoxypropyl, etc.

[0159] As used herein, the term "alkoxyalkoxy" refers to an alkoxyalkyl group as defined above, in particular a C1-C6 alkoxy-C1-C4 alkyl group, which is bound to the remainder of the molecule via an oxygen atom. Examples include OCH2-OCH3, OCH2-OC2H5, n-propoxymethoxy, OCH2-OCH(CH3)2, n-butoxymethoxy, (1-methylpropoxy)methoxy, (2-methylpropoxy)methoxy, OCH2-OC(CH3)3, 2-methoxyethoxy, 2-ethoxyethoxy, 2-n-propoxyethoxy, 2-(1-methylethoxy)ethoxy, 2-(n-butoxy)ethoxy, 2-(1-methylpropoxy)ethoxy, 2-(2-methylpropoxy)ethoxy, 2-(1,1-dimethylethoxy)ethoxy, and the like.

[0160] The substituent "oxo" replaces CH2 by a C(=O) group.

[0161] The term "aryl" refers to a phenyl group that is bound to the rest of the molecule and a bicyclic or polycyclic carbocycle having at least one fused phenylene ring. Examples of bicyclic or polycyclic carbocycles having at least one fused phenylene ring include naphthyl, tetrahydronaphthyl, indanyl, indenyl, anthracenyl, fluorenyl, and the like.

[0162] The term "aryl-C1-C4-alkyl" relates to a C1-C4-alkyl group as defined above in which one hydrogen atom has been replaced by an aryl group, in particular a phenyl group. Specific examples of aryl-C1-C4-alkyl groups include -CH2-phenyl, 1-phenylethyl, 2-phenylethyl, 1-phenylpropyl, 2-phenylpropyl, 3-phenyl-1-propyl and 2-phenyl-2-propyl.

[0163] The term "aryloxy-C1-C4-alkyl" relates to a C1-C4-alkyl group as defined above in which one hydrogen atom has been replaced by an aryloxy group, in particular a phenoxy group. Specific examples of aryloxy-C1-C4-alkyl include phenoxymethyl, 1-phenoxyethyl, 2-phenoxyethyl, 1-phenoxypropyl, 2-phenoxypropyl, 3-phenoxy-1-propyl and 2-phenoxy-2-propyl.

[0164] The term "aryl-C1-C4carbonyl" relates to an aryl group as defined above, especially phenyl, bonded to the remainder of the molecule via a carbonyl group. Specific examples of arylcarbonyl include benzoyl, 1-naphthoyl and 2-naphthoyl.

[0165] The term "heteroaryl" refers to an aromatic heterocycle having 5 or 6 ring atoms (5- or 6-membered heteroaryl) and being monocyclic or having 8, 9 or 10 ring atoms and being bicyclic. A heteroaryl group generally has at least one ring atom selected from O, S and N, which in the case of N may be an imino nitrogen or amino nitrogen bearing a hydrogen or non-hydrogen group. A heteroaryl group may have 1, 2, 3 or 4 further nitrogen atoms which are imino nitrogens as ring members. Examples of 5- or 6-membered heteroaryls include 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, 1-pyrazolyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 2- Azolyl, 4- Azolyl, 5- oxazolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 1-imidazolyl, 2-imidazolyl, 4-imidazolyl, 1,3,4-triazol-1-yl, 1,3,4-triazol-2-yl, 1,3,4- oxadiazole-2-yl, 1,3,4-thiadiazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl and 1,3,5-triazin-2-yl. Examples of 8-, 9- or 10-membered heteroaryl groups include, for example, quinolinyl, isoquinolinyl, monazinyl, indolyl, indolizinyl, isoindolyl, indazolyl, benzofuranyl, benzothiophenyl, benzo[b]thiazolyl ... oxazolyl, benzothiazolyl, benzimidazolyl, imidazo[1,2-a]pyridin-2-yl, thieno[3,2-b]pyridin-5-yl, imidazo[2,1-b]thiazol-6-yl and 1,2,4-triazolo[1,5-a]pyridin-2-yl.

[0166] Examples of N-bonded 5-, 6-, 7- or 8-membered saturated heterocycles include pyrrolidin-1-yl, pyrazolidin-1-yl, imidazolidin-1-yl, Oxazolidin-3-yl, iso oxazolidin-2-yl, thiazolidin-3-yl, isothiazolidin-2-yl, piperidin-1-yl, piperazin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, 1-oxothiomorpholin-4-yl, 1,1-dioxothiomorpholin-4-yl, azepan-1-yl and the like.

[0167] The term "heteroaryl-C1-C4alkyl" relates to a C1-C4alkyl radical as defined above wherein one hydrogen atom has been replaced by a heteroaryl radical, in particular a pyridyl radical. Specific examples of heteroaryl-C1-C4alkyl radicals include 2-pyridylmethyl, 3-pyridylmethyl, 4-pyridylmethyl, 1-(2-pyridyl)ethyl, 2-(2-pyridyl)ethyl, 1-(3-pyridyl)ethyl, 2-(3-pyridyl)ethyl, 1-(4-pyridyl)ethyl, 2-(4-pyridyl)ethyl, and the like.

[0168] The term "heteroaryloxy-Ci-C4-alkyl" relates to a C1-C4-alkyl group as defined above in which one of the hydrogen atoms has been replaced by a heteroaryloxy group, in particular a pyridyloxy group. Specific examples of heteroaryloxy-Ci-C4-alkyl include 2-pyridyloxymethyl, 3-pyridyloxymethyl, 4-pyridyloxymethyl, 1-(2-pyridyloxy)ethyl, 2-(2-pyridyloxy)ethyl, 1-(3-pyridyloxy)ethyl, 2-(3-pyridyloxy)ethyl, 1-(4-pyridyloxy)ethyl, 2-(4-pyridyloxy)ethyl, and the like.

[0169] The term "heteroaryl-C1-C4carbonyl" relates to a heteroaryl as defined above which is bonded to the remainder of the molecule via a carbonyl group, in particular a C-bonded heteroaryl, such as 2-, 3- or 4-pyridyl, 2- or 3-thienyl, 2- or 3-furyl, 1-, 2- or 3-pyrrolyl, 2- or 4-pyrimidinyl, pyridazinyl, 1-, 3- or 4-pyrazolyl, 1-, 2- or 4-imidazolyl.

[0170] If nothing is stated to the contrary, the term "substituted" means substituted by 1, 2 or the maximum possible number of substituents. If more than one substituent is defined in the compound of formula I, they are independently identical or different from one another, unless otherwise stated.

[0171] For each variable, embodiments of compounds of formula I are:

[0172] In a preferred embodiment, A is N;

[0173] In another preferred embodiment, A and D are N;

[0174] In another preferred embodiment, B 1 is N;

[0175] In another preferred embodiment, B 1 and D is N;

[0176] In another preferred embodiment, E and D are N;

[0177] In another preferred embodiment, A is N, B 1 CR B1 、E is CR E And D is CR D ;

[0178] In another preferred embodiment, A and D are N, B 1 CR B1 And E is CR E ;

[0179] In another preferred embodiment, B 1 N, A is CR A 、D is CR D And E is CR E ;

[0180] In another preferred embodiment, B 1 and D is N, A is CR A And E is CR E ;

[0181] In another preferred embodiment, E and D are N, A is CR A And B 1 CR B1 ;

[0182] In a preferred embodiment, B 2 CR B2 、B 3 CR B3 And B 4 CR B4 ;

[0183] In another preferred embodiment, B 2 N, B 3 CR B3 、B 4 CR B4 ;

[0184] In another preferred embodiment, B 2 N, B 3 N, B 4 CR B4 ;

[0185] In another preferred embodiment, B 2 N, B 3 CR B3 、B 4 is N;

[0186] In another preferred embodiment, B 2 CR B2 、B 3 N, B 4 is N;

[0187] In another preferred embodiment, A is N, B 1 CR B1 、E is CR E 、D is CR D 、B 2 CR B2 、B 3 CR B3 And B 4 CR B4 ;

[0188] In another preferred embodiment, A is N, B 1 CR B1 、E is CR E 、D is CR D 、B 2 N, B 3 CR B3 、B 4 CR B4 ;

[0189] In another preferred embodiment, A is N, B 1 CR B1 、E is CR E 、D is CR D 、B 2 N, B 3 N, B 4 CR B4 ;

[0190] In another preferred embodiment, A is N, B 1 CR B1 、E is CR E 、D is CR D 、B 2 N, B3 CR B3 、B 4 is N;

[0191] In another preferred embodiment, A is N, B 1 CR B1 、E is CR E 、D is CR D 、B 2 CR B2 、B 3 N, B 4 is N;

[0192] In another preferred embodiment, A and D are N, B 1 CR B1 、E is CR E 、B 2 CR B2 、B 3 CR B3 And B 4 CR B4 ;

[0193] In another preferred embodiment, A and D are N, B 1 CR B1 、E is CR E 、B 2 N, B 3 CR B3 、B 4 CR B4 ;

[0194] In another preferred embodiment, A and D are N, B 1 CR B1 、E is CR E 、B 2 N, B 3 N, B 4 CR B4 ;

[0195] In another preferred embodiment, A and D are N, B 1 CR B1 、E is CR E 、B 2 N, B 3 CR B3 、B 4 is N;

[0196] In another preferred embodiment, A and D are N, B 1 CR B1 、E is CR E 、B 2 CRB2 、B 3 N, B 4 is N;

[0197] In another preferred embodiment, B 1 N, A is CR A 、D is CR D 、E is CR E 、B 2 CR B2 、B 3 CR B3 And B 4 CR B4 ;

[0198] In another preferred embodiment, B 1 N, A is CR A 、D is CR D 、E is CR E 、B 2 N, B 3 CR B3 、B 4 CR B4 ;

[0199] In another preferred embodiment, B 1 N, A is CR A 、D is CR D 、E is CR E 、B 2 N, B 3 N, B 4 CR B4 ;

[0200] In another preferred embodiment, B 1 N, A is CR A 、D is CR D 、E is CR E 、B 2 N, B 3 CR B3 、B 4 is N;

[0201] In another preferred embodiment, B 1 N, A is CR A 、D is CR D 、E is CR E 、B 2 CR B2 、B 3 N, B 4 is N;

[0202] In another preferred embodiment, B1 and D is N, A is CR A 、E is CR E 、B 2 CR B2 、B 3 CR B3 And B 4 CR B4 ;

[0203] In another preferred embodiment, B 1 and D is N, A is CR A 、E is CR E 、B 2 N, B 3 CR B3 、B 4 CR B4 ;

[0204] In another preferred embodiment, B 1 and D is N, A is CR A 、E is CR E 、B 2 N, B 3 N, B 4 CR B4 ;

[0205] In another preferred embodiment, B 1 and D is N, A is CR A 、E is CR E 、B 2 N, B 3 CR B3 、B 4 is N;

[0206] In another preferred embodiment, B 1 and D is N, A is CR A 、E is CR E 、B 2 CR B2 、B 3 N, B 4 is N;

[0207] In another preferred embodiment, E and D are N, A is CR A 、B 1 CR B1 、B 2 CR B2 、B 3 CR B3 And B 4 CR B4 ;

[0208] In another preferred embodiment, E and D are N, A is CR A 、B 1 CR B1 、B 2 N, B 3 CR B3 、B 4 CR B4 ;

[0209] In another preferred embodiment, E and D are N, A is CR A 、B 1 CR B1 、B 2 N, B 3 N, B 4 CR B4 ;

[0210] In another preferred embodiment, E and D are N, A is CR A 、B 1 CR B1 、B 2 N, B 3 CR B3 、B 4 is N;

[0211] In another preferred embodiment, E and D are N, A is CR A 、B 1 CR B1 、B 2 CR B2 、B 3 N, B 4 is N;

[0212] In a preferred embodiment, R A is H, halogen, OH, CN, C1-C6 alkyl, C1-C6 alkoxy, tri-C1-C6 alkylsilyl, C1-C6 alkoxy-C1-C4 alkyl, C3-C6 cycloalkyl, wherein the alkyl, alkoxy and cycloalkyl moieties are unsubstituted or substituted by halogen,

[0213] C(=O)-OR a NR b R c 、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c or S(=O) m R e ;

[0214] In another preferred embodiment, R A is H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, wherein the alkyl or cycloalkyl moiety is unsubstituted or substituted by halogen.

[0215] In another preferred embodiment, R A It is H, Cl, Br, F, CH3, C2H5, n-C3H7, isopropyl, cyclopropyl, CH2F, CHF2 or CF3.

[0216] In a preferred embodiment, R B1 、R B2 、R B3 and R B4 are independently H, halogen or C1-C6 alkyl;

[0217] In another preferred embodiment, R B1 、R B2 、R B3 and R B4 independently of one another, H, Cl, Br, F, CH3, C2H5, n-C3H7 or isopropyl.

[0218] In a preferred embodiment, Q is -C(R 4 R 5 )-O-, wherein C is bonded to Ar.

[0219] In another preferred embodiment, Q is -C(R 4 R 5 )-O-, wherein O is bonded to Ar.

[0220] In another preferred embodiment, Q is -C(=O)-O-, wherein C is bonded to Ar.

[0221] In another preferred embodiment, Q is -C(=O)-O-, wherein O is bonded to Ar.

[0222] In another preferred embodiment, Q is -S(=O) m -C(R 7 R 8 )-, wherein S is bonded to Ar.

[0223] In another preferred embodiment, Q is -S(=O) m -C(R 7 R 8 )-, wherein C is bonded to Ar.

[0224] In another preferred embodiment, Q is -N(R 2 )-S(=O) m -, wherein N is bonded to Ar.

[0225] In another preferred embodiment, Q is -N(R 2 )-S(=O) m -, wherein S is bonded to Ar.

[0226] In another preferred embodiment, Q is -N(R 2 )-C(R 9 R 10 )-, wherein N is bonded to Ar.

[0227] In another preferred embodiment, Q is -N(R 2 )-C(R 9 R 10 )-, wherein C is bonded to Ar.

[0228] In another preferred embodiment, Q is -C(=O)-C(R 19 R 20 )-, wherein C(=O) is bonded to Ar.

[0229] In another preferred embodiment, Q is -C(=O)-C(R 19 R 20 )-, where C(R 19 R 20 ) is bonded to Ar.

[0230] In another preferred embodiment, Q is -N(R 2 )-C(=O)-, wherein N is bonded to Ar.

[0231] In another preferred embodiment, Q is -N(R 2 )-, wherein N is bonded to Ar.

[0232] In another preferred embodiment, Q is -N(R 2 )-C(=O)-, wherein C is bonded to Ar.

[0233] In another preferred embodiment, Q is -N(R 2 )-C(=S)-, wherein N is bonded to Ar.

[0234] In another preferred embodiment, Q is -N(R 2 )-C(=S)-, wherein C is bonded to Ar.

[0235] In another preferred embodiment, Q is -N=C(X)-, wherein N is bonded to Ar.

[0236] In another preferred embodiment, Q is -N=C(X)-, wherein C is bonded to Ar.

[0237] In another preferred embodiment, Q is -N(R 2 )-C(=NR)-, wherein N is bonded to Ar.

[0238] In another preferred embodiment, Q is -N(R 2 )-C(=NR)-, wherein C is bonded to Ar.

[0239] In another preferred embodiment, Q is -C(R 13 R 14 )-C(R 15 R 16 )-.

[0240] In another preferred embodiment, Q is -C(R 17 )=C(R 18 )-.

[0241] In another preferred embodiment, Q is -C(R 4 R 5 )-O-、-N(R 2 )-S(=O) m -、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-C(=O)-、-N(R 2 )-C(=S)-, -N=C(X)- or -N(R 2 )-C(=NR)-, wherein Ar is bonded to either side of Q;

[0242] In another preferred embodiment, Q is -C(R 4 R 5 )-O-、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-、-N(R 2 )-C(=O)-, -N=C(X)- or -N(R 2 )-C(=NR)-, wherein Ar is bonded to either side of Q;

[0243] In another preferred embodiment, Q is -C(R 4 R 5 )-O-、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-、-N(R 2 )-C(=O)-or-N(R 2)-C(=NR)-, wherein Ar is bonded to either side of Q;

[0244] In another preferred embodiment, Q is -C(R 4 R 5 )-O-、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-C(=O)-、-N(R 2 )-C(=NR)-, wherein Ar is bonded to either side of Q;

[0245] In a preferred embodiment, X is H or N(R 3 )2;

[0246] In another preferred embodiment, X is H;

[0247] In another preferred embodiment, X is N(R 3 )2;

[0248] In a preferred embodiment, R 3 is H, C1-C6 alkyl or C1-C6 alkoxy-C1-C4 alkyl;

[0249] In another preferred embodiment, R 3 is H or C1-C6 alkyl;

[0250] In another preferred embodiment, R 3 is a C1-C6 alkyl group;

[0251] In another preferred embodiment, R 3 is H;

[0252] In a preferred embodiment, R is H, CN, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, OR 8 or N(R 3 )2;

[0253] In another preferred embodiment, R is H, CN, C1-C6 alkyl or OR 8 ;

[0254] In another preferred embodiment, R is H or C1-C6 alkyl;

[0255] In another preferred embodiment, R is H, CH3, C2H5, n-C3H7 or isopropyl;

[0256] In a preferred embodiment, R4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 13 、R 14 、R 15 、R 16 、R 17 、R 18 、R 19 、R 20 are the same or different and are H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C3-C6 cycloalkyl-C1-C4 alkyl, C3-C6 cycloalkoxy-C1-C4 alkyl, C(=O)-OR a 、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c 、S(=O) m R e , phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0257] In another preferred embodiment, R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 13 、R 14 、R 15 、R 16 、R 17 、R 18 、R 19 、R 20 the same or different and are H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C(=O)-OR a 、C(=O)-NR b R c 、C(=O)-R d , phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0258] In another preferred embodiment, R 4 、R 5 、R7 、R 8 、R 9 、R 10 、R 13 、R 14 、R 15 、R 16 、R 17 、R 18 、R 19 、R 20 are the same or different and are H, halogen, C1-C6 alkyl or C1-C6 haloalkyl;

[0259] In another preferred embodiment, R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 13 、R 14 、R 15 、R 16 、R 17 、R 18 、R 19 、R 20 are the same or different and are H, halogen or C1-C6 alkyl;

[0260] In another preferred embodiment, R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 13 、R 14 、R 15 、R 16 、R 17 、R 18 、R 19 、R 20 The same or different and are H or C1-C6 alkyl;

[0261] In a preferred embodiment, Ar is unsubstituted or replaced by R Ar Substituted phenyl.

[0262] In another preferred embodiment, Ar is unsubstituted or replaced by R Ar Substituted 5- or 6-membered heteroaryl.

[0263] In a more preferred embodiment, Ar is unsubstituted or replaced by R Ar substituted phenyl, pyrimidinyl, pyridazinyl or pyridinyl.

[0264] In a preferred embodiment, RAr is halogen, OH, CN, NO2, SCN, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy or SR e .

[0265] In a more preferred embodiment, R Ar is F, Cl, Br, OH, CN, NO2, SCN, CH3, C2H5, n-C3H7, isopropyl, CH2F, CHF2, CF3, CH2CF3, CF2CHF2, C2F5, CH2CH2CF3, CH2CF2CHF2, CH2CF2CF3, OCH3, OC2H5, n-propoxy, isopropoxy, OCH2F, OCHF2, OCF3, OCH2CF3, OCF2CHF2, OC2F5, OCH2CH2CF3, OCH2CF2CHF2, OCH2CF2CF3, or SR e , where R e It is C1-C6 alkyl, especially C1-C3 alkyl such as CH3, C2H5, n-C3H7 or isopropyl, or C1-C6 haloalkyl, especially fluorinated C1-C3 alkyl such as CH2F, CHF2, CF3, CH2CF3, CF2CHF2, C2F5, CH2CH2CF3, CH2CF2CHF2 or CH2CF2CF3.

[0266] Particularly preferred Ar are listed in Table A below.

[0267] Table A:

[0268]

[0269] Particularly preferred Ar is selected from Ar-1 to Ar-20;

[0270] It is also particularly preferred that Ar is selected from Ar-1 to Ar-13;

[0271] Also particularly preferred is Ar selected from Ar-1 to Ar-13 and Ar-17 to Ar-18;

[0272] Also particularly preferred is Ar selected from Ar-1, Ar-2, Ar-3, Ar-4, Ar-10, Ar-17 and Ar-18.

[0273] It is also particularly preferred that Ar is selected from Ar-17 and Ar-18;

[0274] It is also particularly preferred that Ar is selected from Ar-1, Ar-2, Ar-5, Ar-21 and Ar-22;

[0275] Also particularly preferred is Ar-17;

[0276] Also particularly preferred is Ar-18;

[0277] In a preferred embodiment, R 1 For YZTR 11 .

[0278] In another preferred embodiment, R 1 For YZTR 12 .

[0279] In a preferred embodiment, Y is -CR ya =N-, wherein N is bonded to Z.

[0280] In another preferred embodiment, Y is -NR yc -C(=S)-, wherein C(=S) is bonded to Z.

[0281] In another preferred embodiment, Y is -NR yc -C(=O)-, wherein C(=O) is bonded to Z.

[0282] In a preferred embodiment, Y is -CR ya =N- and Z is a single bond;

[0283] -NR zc -C(=O)-, wherein C(=O) is bonded to T;

[0284] -NR zc -C(=S)-, wherein C(=S) is bonded to T;

[0285] -N=C(SR za )-, wherein T is bonded to a carbon atom; or

[0286] -NR zc -C(SR za )=, wherein T is bonded to a carbon atom;

[0287] In another preferred embodiment, Z is -NR zc -C(=S)-, wherein C(=S) is bonded to T.

[0288] In another preferred embodiment, Z is -NR zc -C(=O)-, wherein C(=O) is bonded to T.

[0289] In another preferred embodiment, Z is -N=C(SR za )-, where T is bonded to a carbon atom.

[0290] In another preferred embodiment, Z is -NR zc -C(SRza )=, wherein T is bonded to a carbon atom.

[0291] In another preferred embodiment, Z is -OC(=O)-, wherein T is bonded to a carbon atom;

[0292] In another preferred embodiment, Z is a single bond.

[0293] In a preferred embodiment, T is O.

[0294] In another preferred embodiment, T is NR T .

[0295] In another preferred embodiment, T is N.

[0296] In a preferred embodiment, R ya is H, halogen, C1-C6 alkyl, C1-C6 alkoxy, which is unsubstituted or substituted by halogen, phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or substituted by R f replace.

[0297] In a more preferred embodiment, R ya is H, halogen, C1-C6 alkyl, C1-C6 alkoxy, which is unsubstituted or substituted by halogen, or is unsubstituted or substituted by R f Substituted phenyl.

[0298] In the most preferred embodiment, R ya is H, F, Cl, Br, CH3, C2H5, n-C3H7, isopropyl, CH2F, CHF2, CF3, CH2CF3, CF2CHF2, C2F5, CH2CH2CF3, CH2CF2CHF2, CH2CF2CF3, OCH3, OC2H5, n-propoxy, isopropoxy, OCH2F, OCHF2, OCF3, OCH2CF3, OCF2CHF2, OC2F5, OCH2CH2CF3, OCH2CF2CHF2, OCH2CF2CF3, or is unsubstituted or replaced by R f Substituted phenyl.

[0299] In another most preferred embodiment, R ya is H or CH3;

[0300] In one embodiment, R yc 、R zc is H, C1-C6 alkyl, C3-C6 cycloalkyl, which is unsubstituted or substituted by halogen, phenyl or -CH2-phenyl, wherein each ring is unsubstituted or substituted by R f replace.

[0301] In a more preferred embodiment, R yc and R zc is H, C1-C6 alkyl, C1-C6 haloalkyl or unsubstituted or replaced by R f Substituted phenyl.

[0302] In the most preferred embodiment, R yc and R zc is H, CH3, C2H5, n-C3H7, isopropyl, CH2F, CHF2, CF3, CH2CF3, CF2CHF2, C2F5, CH2CH2CF3, CH2CF2CHF2, CH2CF2CF3 or is unsubstituted or replaced by R f Substituted phenyl.

[0303] In another most preferred embodiment, R yc and R zc is H or CH3;

[0304] In a preferred embodiment, R T is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C4 alkyl-C1-C6 alkoxy, which is unsubstituted or substituted by halogen, C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c 、S(=O) m R e , phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace.

[0305] In a more preferred embodiment, R T is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C4 alkyl-C1-C6 alkoxy, which is unsubstituted or substituted by halogen.

[0306] In the most preferred embodiment, R T is H or C1-C6 alkyl.

[0307] In another preferred embodiment, R zc With R T - if present - together form a C1-C6-alkylene or a linear C2-C6-alkenylene, wherein in the linear C1-C6-alkylene and the linear C2-C6-alkenylene, the CH2 moiety may be replaced by a carbonyl group or C=N-R' and / or wherein one or two CH2 moieties may be replaced by O or S and / or wherein the linear C1-C6-alkylene and the linear C2-C6-alkenylene may be unsubstituted or replaced by R hreplace.

[0308] In a more preferred embodiment, R zc With R T -if present-together form a C1-C6-alkylene or a linear C2-C6-alkenylene, wherein in the linear C1-C6-alkylene and the linear C2-C6-alkenylene the CH2 moiety is replaced by a carbonyl group.

[0309] In another more preferred embodiment, R zc With R T - if present - together form a C1-C6-alkylene or a linear C2-C6-alkenylene, wherein in the linear C1-C6-alkylene and the linear C2-C6-alkenylene, the CH2 moiety is replaced by C=N-R' and wherein 1 or 2 CH2 moieties may be replaced by O or S and / or wherein the linear C1-C6-alkylene and the linear C2-C6-alkenylene may be unsubstituted or replaced by R h replace.

[0310] In another more preferred embodiment, R zc With R T - if present - together form a C1-C6-alkylene or a linear C2-C6-alkenylene, wherein in the linear C1-C6-alkylene and the linear C2-C6-alkenylene, 1 or 2 CH2 moieties are replaced by O or S and / or wherein the linear C1-C6-alkylene and the linear C2-C6-alkenylene may be unsubstituted or replaced by R h replace.

[0311] In a preferred embodiment, R za is H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkylene-NR b R c 、C1-C6-C(=O)-R d , phenyl, phenylcarbonyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0312] In a more preferred embodiment, R za is H, C1-C6 alkyl or C1-C6 haloalkyl;

[0313] In the most preferred embodiment, R za It is H, C1-C6 alkyl.

[0314] In another preferred embodiment, R za With R T- if present - together form a C1-C6-alkylene or a linear C2-C6-alkenylene, wherein in the linear C1-C6-alkylene and the linear C2-C6-alkenylene, the CH2 moiety may be replaced by a carbonyl group or C=N-R' and / or wherein one or two CH2 moieties may be replaced by O or S and / or wherein the linear C1-C6-alkylene and the linear C2-C6-alkenylene may be unsubstituted or replaced by R h replace;

[0315] In a more preferred embodiment, R za With R T -if present-together form a C1-C6-alkylene or a linear C2-C6-alkenylene, wherein in the linear C1-C6-alkylene and the linear C2-C6-alkenylene the CH2 moiety is replaced by a carbonyl group.

[0316] In another more preferred embodiment, R za With R T - if present - together form a C1-C6-alkylene or a linear C2-C6-alkenylene, wherein in the linear C1-C6-alkylene and the linear C2-C6-alkenylene, the CH2 moiety is replaced by C=N-R' and wherein 1 or 2 CH2 moieties may be replaced by O or S and / or wherein the linear C1-C6-alkylene and the linear C2-C6-alkenylene may be unsubstituted or replaced by R h replace.

[0317] In another more preferred embodiment, R za With R T - if present - together form a C1-C6-alkylene or a linear C2-C6-alkenylene, wherein in the linear C1-C6-alkylene and the linear C2-C6-alkenylene, 1 or 2 CH2 moieties are replaced by O or S and / or wherein the linear C1-C6-alkylene and the linear C2-C6-alkenylene may be unsubstituted or replaced by R h replace.

[0318] In a preferred embodiment, R a 、R b and R c is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, which is unsubstituted or substituted by halogen,

[0319] C1-C6 alkylene-CN, phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace;

[0320] In a more preferred embodiment, R a 、R b and R cis H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, which is unsubstituted or substituted by halogen,

[0321] Phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace.

[0322] In a preferred embodiment, R d is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, which is unsubstituted or substituted by halogen, phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or substituted by R f replace.

[0323] In a more preferred embodiment, R d is H, C1-C6 alkyl, C1-C6 haloalkyl or unsubstituted or replaced by R f Substituted phenyl.

[0324] In a preferred embodiment, R e is C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, phenyl or -CH2-phenyl, wherein the phenyl ring is unsubstituted or replaced by R f replace.

[0325] In a more preferred embodiment, R e is H, C1-C6 alkyl, C1-C6 haloalkyl or unsubstituted or replaced by R f Substituted phenyl.

[0326] In a preferred embodiment, R f is halogen, N3, OH, CN, NO2, -SCN, -SF5, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, which is unsubstituted or substituted by halogen, C(=O)-OR a NR b R c 、C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c or S(=O) m R e .

[0327] In a more preferred embodiment, R fis halogen, N3, OH, CN, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, which is unsubstituted or substituted by halogen,

[0328] C(=O)-OR a NR b R c 、C1-C6 alkylene-NR b R c 、C1-C6 alkylene-CN、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c or S(=O) m R e .

[0329] In a preferred embodiment, R g is halogen, N3, OH, CN, NO2, -SCN, -SF5, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, which is unsubstituted or substituted by halogen,

[0330] C(=O)-OR a NR b R c 、C1-C6 alkylene-NR b R c , NH-C1-C6 alkylene-NR b R c 、C(=O)-NR b R c 、C(=O)-R d 、SO2NR b R c or S(=O) m R e .

[0331] In a more preferred embodiment, R g is halogen, N3, OH, CN, NO2, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, which is unsubstituted or substituted by halogen,

[0332] C(=O)-OR a NR b R c 、C1-C6 alkylene-NR b R c、C(=O)-NR b R c 、C(=O)-R d 、

[0333] SO2NR b R c or S(=O) m R e .

[0334] In one embodiment, m is 0.

[0335] In another embodiment, m is 1.

[0336] In another embodiment, m is 2.

[0337] In another embodiment, m is 0 or 1.

[0338] In another embodiment, m is 1 or 2.

[0339] In a more preferred embodiment, R 1 is of formula Y-1 to Y-9, wherein Indicates the connection to the rest of the compound, D is R 11 or R 12 And where R T 、R 11 、R 12 、R ya 、R yc 、R za and R zc As defined in the compounds of formula I.

[0340]

[0341] In a more preferred embodiment, R 1 is the formula Y-1 to Y-8, wherein Indicates the connection to the rest of the compound, D is R 11 or R 12 And where R T 、R 11 、R 12 、R ya 、R yc 、R za and R zc As defined in the compounds of formula I.

[0342] In a more preferred embodiment, R 1 is of formula Y-1, Y-5 or Y-6, wherein Indicates the connection to the rest of the compound, D is R 11 or R 12 And where RT 、R 11 、R 12 、R ya 、R yc 、R za and R zc As defined in the compounds of formula I.

[0343] In another more preferred embodiment, R 1 is the following formula YZT-1 to YZT-9, where represents the connection to the rest of the compound and R 11 、R 12 、R T 、R ya 、R za and R zc As defined in the compounds of formula I.

[0344]

[0345] In another more preferred embodiment, R 1 is the formula YZT-1 to YZT-8, wherein represents the connection to the rest of the compound and R 11 、R 12 、R T 、R ya 、R za and R zc As defined in the compounds of formula I.

[0346] In the most preferred embodiment, R 1 is of the formula Y-1A to Y-9A, wherein Indicates the connection to the rest of the compound, D is R 11 or R 12 .

[0347]

[0348] In the most preferred embodiment, R 1 is of the formula Y-1A to Y-8B, wherein Indicates the connection to the rest of the compound, D is R 11 or R 12 .

[0349] In a preferred embodiment, R 11 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy-C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C4 alkyl, C1-C4 alkyl-C3-C6 cycloalkoxy, which is unsubstituted or substituted by halogen,

[0350] Aryl, arylcarbonyl, aryl-C1-C4 alkyl, aryloxy-C1-C4 alkyl, heteroaryl, carbonylheteroaryl, C1-C4 alkylheteroaryl and C1-C4 alkylheteroaryloxy, wherein the aryl or heteroaryl ring is unsubstituted or replaced by R g substituted and wherein heteroaryl is a 5- or 6-membered monocyclic heteroaryl or an 8-, 9- or 10-membered bicyclic heteroaryl.

[0351] In a more preferred embodiment, R 11 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, which is unsubstituted or substituted by halogen,

[0352] Aryl, arylcarbonyl, aryl-C1-C4 alkyl, aryloxy-C1-C4 alkyl, heteroaryl, carbonylheteroaryl, C1-C4 alkylheteroaryl and C1-C4 alkylheteroaryloxy, wherein each ring is unsubstituted or replaced by R g substituted and wherein heteroaryl is a 5- or 6-membered monocyclic heteroaryl or an 8-, 9- or 10-membered bicyclic heteroaryl.

[0353] In the most preferred embodiment, R 11 is aryl, aryl-C1-C4 alkyl, heteroaryl or heteroaryl-C1-C4 alkyl, wherein each ring is unsubstituted or replaced by R g and wherein the heteroaryl or heteroaryl-C1-C4 alkyl group is preferably unsubstituted or replaced by R g Substituted 5- or 6-membered monocyclic heteroaryl, such as pyridyl, pyrimidinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, iso oxazolyl or isothiazolyl.

[0354] Particularly preferred groups R 11 Examples of groups R are summarized in Table A-1 below 11 -1 to R 11 -29.

[0355] Table A-1.

[0356]

[0357]

[0358] In another preferred embodiment of the present invention, R 11 R 11 -1, R 11 -10 or R 11 -29;

[0359] In one embodiment, R 12 Formula (A1 ) group:

[0360]

[0361] where # denotes the point of connection to T and where R 121 、R 122 、R 123 and R 124 As defined above and wherein R 121 、R 122 、R 123 and R 124 Independently of one another and in particular in combination preferably have the following meanings:

[0362] R 121 is C1-C4 alkoxy, especially OCH3, OC2H5;

[0363] R 122 is a C1-C4 alkoxy group such as OCH3, OC2H5, n-propoxy or isopropoxy, or a C3-C4 alkenyloxy group such as allyloxy, R 122 Especially OCH3, OC2H5 or n-propoxy;

[0364] R 123 is OH, C1-C4 alkoxy, such as OCH3, OC2H5, or C3-C4 alkenyloxy, such as allyloxy, R 123 Especially OCH3, OC2H5;

[0365] R 124 is C1-C4 alkyl, such as CH3 or C2H5, or C1-C4 alkoxy-C1-C4 alkyl, such as methoxymethyl, ethoxymethyl, 2-methoxyethyl or 2-ethoxyethyl, R 124 Especially methyl.

[0366] In a more preferred embodiment, R 12 Especially the formula (A 11 ) groups, for example (A 11 -a) or (A 11 -b):

[0367]

[0368] where # denotes the point of connection to T and where R 121 、R 122 、R 123 and R 124 As defined above and wherein R 121 、R 122 、R 123 and R 124Independently of one another and in particular in combination preferably have the following meanings:

[0369] R 121 is C1-C4alkoxy, especially OCH3 or OC2H5;

[0370] R 122 is a C1-C4 alkoxy group such as OCH3, OC2H5, n-propoxy or isopropoxy, or a C3-C4 alkenyloxy group such as allyloxy, R 122 Especially OCH3, OC2H5 or n-propoxy;

[0371] R 123 is OH, C1-C4 alkoxy, such as OCH3 or OC2H5, or C3-C4 alkenyloxy, such as allyloxy, R 123 Especially OCH3 or OC2H5;

[0372] R 124 is C1-C4 alkyl, such as CH3 or C2H5, or C1-C4 alkoxy-C1-C4 alkyl, such as methoxymethyl, ethoxymethyl, 2-methoxyethyl or 2-ethoxyethyl, R 124 Especially methyl.

[0373] Group R 12 A special example is the following group A 11 -1, A 11 -1a, A 11 -1b, A 11 -2, A 11 -2a, A 11 -2b, A 11 -3, A 11 -3a and A 11 -3b:

[0374]

[0375] In a more preferred embodiment, the compound of formula I is selected from the group consisting of compounds of formulae A.1-A.36:

[0376]

[0377] Where Ar is R Ar substituted phenyl or 5- or 6-membered heteroaryl ring;

[0378] R Ar Halogen, OH, CN, NO2, SCN, C1-C6 alkyl, C1-C6 alkoxy or SR e ,

[0379] wherein the alkyl and alkoxy groups are unsubstituted or substituted with halogen;

[0380] R A is H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl or C3-C6 halocycloalkyl;

[0381] R B1 、R B2 、R B3 and R B4 are independently H, halogen or C1-C6 alkyl;

[0382] Q is -C(R 4 R 5 )-O-、-N(R 2 )-S(=O) m -、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-C(=O)-、-N(R 2 )-C(=S)-, -N=C(X)-, -N(R 2 )-C(=NR)-; wherein Ar is bonded to either side of Q;

[0383] X is N(R 3 )2;

[0384] and R 1 is YZTR as defined in Formula I 11 or YZTR 12 .

[0385] More preferred compounds of formula I are compounds of formulae I.1-I.48, wherein R 1 Selected from Y-1A, Y-1B, Y-2A, Y-2B, Y-3A, Y-3B, Y-3C, Y-3D, Y-4A, Y-4B, Y-4C, Y-4D, Y-5A, Y-5B, Y-6A, Y-6B, Y-8A and Y-8B; wherein D is R 11 or R 12 and other variables are as defined herein.

[0386]

[0387]

[0388]

[0389] Still more preferred are compounds of formula I, wherein

[0390] A is N, B 1 CR B1、E is CR E 、D is CR D 、B 2 CR B2 、B 3 CR B3 And B 4 CR B4 ;

[0391] R B1 、R E 、R D are independently H, halogen or C1-C6 alkyl;

[0392] R B2 、R B3 and R B4 are independently H, halogen, C1-C6 alkyl;

[0393] Q is -C(R 4 R 5 )-O-、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-、-N(R 2 )-C(=O)-or-N(R 2 )-C(=NR)-; wherein Ar is bonded to either side of Q;

[0394] m is 0, 1, or 2;

[0395] R is H, CN or C1-C6 alkyl;

[0396] R 2 is H or C1-C6 alkyl;

[0397] R 4 、R 5 、R 9 、R 10 The same or different and are H or C1-C6 alkyl;

[0398] Ar is Ar 1 、Ar 2 、Ar 3 、Ar 4 、Ar 10 、Ar 17 or Ar 18 ;

[0399] R 1 Is Y-1A, Y-3C, Y-5A, Y-6A, Y-8A or Y-9A;

[0400] D is R 11 or R12 ;

[0401] R 11 R 11 -1 or R 11 -10;

[0402] R 12 A 11 -1b or A 11 -3b;

[0403] Still more preferred are compounds of formula I, wherein

[0404] A and D are N, B 1 CR B1 、E is CR E 、B 2 CR B2 、B 3 CR B3 And B 4 CR B4 ; R B1 、R E are independently H, halogen or C1-C6 alkyl;

[0405] R B2 、R B3 and R B4 are independently H, halogen, C1-C6 alkyl;

[0406] Q is -C(R 4 R 5 )-O-、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-、-N(R 2 )-C(=O)-or-N(R 2 )-C(=NR)-; wherein Ar is bonded to either side of Q;

[0407] m is 0, 1, or 2;

[0408] R is H, CN or C1-C6 alkyl;

[0409] R 2 is H or C1-C6 alkyl;

[0410] R 4 、R 5 、R 9 、R 10 The same or different and are H or C1-C6 alkyl;

[0411] Ar is Ar 1 、Ar2 、Ar 3 、Ar 4 、Ar 10 、Ar 17 or Ar 18 ;

[0412] R 1 Is Y-1A, Y-3C, Y-5A, Y-6A, Y-8A or Y-9A;

[0413] D is R 11 or R 12 ;

[0414] R 11 R 11 -1 or R 11 -10;

[0415] R 12 A 11 -1b or A 11 -3b;

[0416] Still more preferred are compounds of formula I, wherein

[0417] B 1 N, A is CR A 、D is CR D 、E is CR E 、B 2 CR B2 、B 3 CR B3 And B 4 CR B4 ;

[0418] R A 、R E 、R D are independently H, halogen or C1-C6 alkyl;

[0419] R B2 、R B3 and R B4 are independently H, halogen, C1-C6 alkyl;

[0420] Q is -C(R 4 R 5 )-O-、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-、-N(R 2 )-C(=O)-or-N(R 2 )-C(=NR)-; wherein Ar is bonded to either side of Q;

[0421] m is 0, 1, or 2;

[0422] R is H, CN or C1-C6 alkyl;

[0423] R 2 is H or C1-C6 alkyl;

[0424] R 4 、R 5 、R 9 、R 10 The same or different and are H or C1-C6 alkyl;

[0425] Ar is Ar 1 、Ar 2 、Ar 3 、Ar 4 、Ar 10 、Ar 17 or Ar 18 ;

[0426] R 1 Is Y-1A, Y-3C, Y-5A, Y-6A, Y-8A or Y-9A;

[0427] D is R 11 or R 12 ;

[0428] R 11 R 11 -1 or R 11 -10;

[0429] R 12 A 11 -1b or A 11 -3b;

[0430] Still more preferred are compounds of formula I, wherein

[0431] B 1 and D is N, A is CR A 、E is CR E 、B 2 CR B2 、B 3 CR B3 And B 4 CR B4 ; R A 、R E are independently H, halogen or C1-C6 alkyl;

[0432] R B2 、R B3 and R B4 are independently H, halogen, C1-C6 alkyl;

[0433] Q is -C(R 4 R 5 )-O-、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-、-N(R 2 )-C(=O)-or-N(R 2 )-C(=NR)-; wherein Ar is bonded to either side of Q;

[0434] m is 0, 1, or 2;

[0435] R is H, CN or C1-C6 alkyl;

[0436] R 2 is H or C1-C6 alkyl;

[0437] R 4 、R 5 、R 9 、R 10 The same or different and are H or C1-C6 alkyl;

[0438] Ar is Ar 1 、Ar 2 、Ar 3 、Ar 4 、Ar 10 、Ar 17 or Ar 18 ;

[0439] R 1 Is Y-1A, Y-3C, Y-5A, Y-6A, Y-8A or Y-9A;

[0440] D is R 11 or R 12 ;

[0441] R 11 R 11 -1 or R 11 -10;

[0442] R 12 A 11 -1b or A 11 -3b;

[0443] Still more preferred are compounds of formula I, wherein

[0444] E and D are N, A is CR A 、B 1 CR B1 、B 2 CR B2 、B3 CR B3 And B 4 CR B4 ; R A 、R B1 are independently H, halogen or C1-C6 alkyl;

[0445] R B2 、R B3 and R B4 are independently H, halogen, C1-C6 alkyl;

[0446] Q is -C(R 4 R 5 )-O-、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-、-N(R 2 )-C(=O)-or-N(R 2 )-C(=NR)-; wherein Ar is bonded to either side of Q;

[0447] m is 0, 1, or 2;

[0448] R is H, CN or C1-C6 alkyl;

[0449] R 2 is H or C1-C6 alkyl;

[0450] R 4 、R 5 、R 9 、R 10 The same or different and are H or C1-C6 alkyl;

[0451] Ar is Ar 1 、Ar 2 、Ar 3 、Ar 4 、Ar 10 、Ar 17 or Ar 18 ;

[0452] R 1 Is Y-1A, Y-3C, Y-5A, Y-6A, Y-8A or Y-9A;

[0453] D is R 11 or R 12 ;

[0454] R 11 R 11 -1 or R 11 -10;

[0455] R12 A 11 -1b or A 11 -3b;

[0456] Still more preferred are compounds of formula I, wherein

[0457] A, B 1 , E, D are independently selected from N or CH, wherein A, B 1 , E and D at least one is N; and when A and D are N, B 1 for CH;

[0458] B 2 、B 3 、B 4 for CH;

[0459] Q is -C(R 4 R 5 )-O-、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-、-N(R 2 )-C(=O)-, -N=C(X)- or -N(R 2 )-C(=NR)-; wherein Ar is bonded to either side of Q.

[0460] Ar is Ar-1 or Ar-2;

[0461] m is 0, 1, or 2;

[0462] R is H, CN or C1-C6 alkyl;

[0463] R 2 is H or C1-C6 alkyl;

[0464] R 4 、R 5 、R 9 、R 10 The same or different and are H or C1-C6 alkyl;

[0465] Ar is Ar 1 、Ar 2 、Ar 3 、Ar 4 、Ar 10 、Ar 17 or Ar 18 ;

[0466] R 1 Y-1A, Y-5A, Y-6A or Y-8A;

[0467] D is R 11 or R12 ;

[0468] R 11 R 11 -1 or R 11 -29;

[0469] R 12 A 11 -1b or A 11 -3b;

[0470] In another preferred embodiment, the compound of formula I is a compound of formula I.1-I.48, wherein Ar is Ar 1 、Ar 2 、Ar 3 、Ar 4 、Ar 10 、Ar 17 or Ar 18 ;

[0471] B 4 N or CH;

[0472] B 2 N or CH;

[0473] B 3 N or CH;

[0474] R 1 is Y-1A, Y-1B, Y-2A, Y-2B, Y-3A, Y-3B, Y-3C, Y-3D, Y-4A, Y-4B, Y-4C, Y-4D, Y-5A, Y-5B, Y-6A, Y-6B, Y-8A or Y-8B; where D is R 11 or R 12 ;

[0475] R 11 R 11 -1, R 11 -2, R 11 -3, R 11 -5, R 11 -6, R 11 -7, R 11 -8, R 11 -9, R 11 -10, R 11 -11, R 11 -12, R 11 -13, R 11 -14, R 11 -15, R 11 -16, R 11 -17, R 11 -18, R 11 -19, R11 -20, R 11 -21, R 11 -22, R 11 -23, R 11 -25, R 11 -26, R 11 -27, R 11 -28 or R 11 -29; R 12 For (A 11 -1)、(A 11 -2) or (A 11 -3).

[0476] R 4 and R 5 are independently H or CH3,

[0477] R 9 and R 10 are independently H or CH3,

[0478] R 2 H, CH3 or c-C3H5

[0479] R is NH, NCH3 or NCN;

[0480] Specific compounds of formula I are the compounds of formulae I.1 to I.48 compiled in Tables 1-3888 below, wherein for each compound in Tables 1-3888, the variable B 2 、B 3 、B 4 The combination of Ar, Ar and D corresponds to each row of Table B. Each radical mentioned in the table for a substituent is, by itself, independent of the combination mentioned, a particularly preferred aspect of said substituent.

[0481] Table 1. Compounds of formula I.7, wherein R 1 Y-1A, R 4 H and R 5 For H.

[0482] Table 2. Compounds of formula I.7, wherein R 1 For Y-1B, R 4 H and R 5 For H.

[0483] Table 3. Compounds of formula I.7, wherein R 1 For Y-2A, R 4 H and R 5 For H.

[0484] Table 4. Compounds of formula I.7, wherein R 1 For Y-2B, R 4 H and R5 For H.

[0485] Table 5. Compounds of formula I.7, wherein R 1 For Y-3A, R 4 H and R 5 For H.

[0486] Table 6. Compounds of formula I.7, wherein R 1 For Y-3B, R 4 H and R 5 For H.

[0487] Table 7. Compounds of formula I.7, wherein R 1 For Y-3C, R 4 H and R 5 For H.

[0488] Table 8. Compounds of formula I.7, wherein R 1 For Y-3D, R 4 H and R 5 For H.

[0489] Table 9. Compounds of formula I.7, wherein R 1 For Y-4A, R 4 H and R 5 For H.

[0490] Table 10. Compounds of formula I.7, wherein R 1 For Y-4B, R 4 H and R 5 For H.

[0491] Table 11. Compounds of formula I.7, wherein R 1 For Y-4C, R 4 H and R 5 For H.

[0492] Table 12. Compounds of formula I.7, wherein R 1 For Y-4D, R 4 H and R 5 For H.

[0493] Table 13. Compounds of formula I.7, wherein R 1 For Y-5A, R 4 H and R 5 For H.

[0494] Table 14. Compounds of formula I.7, wherein R 1 For Y-5B, R 4 H and R 5 For H.

[0495] Table 15. Compounds of formula I.7, wherein R 1For Y-6A, R 4 H and R 5 For H.

[0496] Table 16. Compounds of formula I.7, wherein R 1 For Y-6B, R 4 H and R 5 For H.

[0497] Table 17. Compounds of formula I.7, wherein R 1 For Y-8A, R 4 H and R 5 For H.

[0498] Table 18. Compounds of formula I.7, wherein R 1 For Y-8B, R 4 H and R 5 For H.

[0499] Table 19. Compounds of formula I.7, wherein R 1 Y-1A, R 4 is CH3 and R 5 For H.

[0500] Table 20. Compounds of formula I.7, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For H.

[0501] Table 21. Compounds of formula I.7, wherein R 1 For Y-2A, R 4 is CH3 and R 5 For H.

[0502] Table 22. Compounds of formula I.7, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For H.

[0503] Table 23. Compounds of formula I.7, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For H.

[0504] Table 24. Compounds of formula I.7, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For H.

[0505] Table 25. Compounds of formula I.7, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For H.

[0506] Table 26. Compounds of formula I.7, wherein R 1 For Y-3D, R 4 is CH3 and R 5 For H.

[0507] Table 27. Compounds of formula I.7, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For H.

[0508] Table 28. Compounds of formula I.7, wherein R 1 For Y-4B, R 4 is CH3 and R 5 For H.

[0509] Table 29. Compounds of formula I.7, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For H.

[0510] Table 30. Compounds of formula I.7, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For H.

[0511] Table 31. Compounds of formula I.7, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For H.

[0512] Table 32. Compounds of formula I.7, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For H.

[0513] Table 33. Compounds of formula I.7, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For H.

[0514] Table 34. Compounds of formula I.7, wherein R 1 For Y-6B, R 4 is CH3 and R 5 For H.

[0515] Table 35. Compounds of formula I.7, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For H.

[0516] Table 36. Compounds of formula I.7, wherein R1 For Y-8B, R 4 is CH3 and R 5 For H.

[0517] Table 37. Compounds of formula I.7, wherein R 1 Y-1A, R 4 is CH3 and R 5 For CH3.

[0518] Table 38. Compounds of formula I.7, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For CH3.

[0519] Table 39. Compounds of formula I.7, wherein R 1 For Y-2A, R 4 is CH3 and R 5 For CH3.

[0520] Table 40. Compounds of formula I.7, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For CH3.

[0521] Table 41. Compounds of formula I.7, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For CH3.

[0522] Table 42. Compounds of formula I.7, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For CH3.

[0523] Table 43. Compounds of formula I.7, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For CH3.

[0524] Table 44. Compounds of formula I.7, wherein R 1 For Y-3D, R 4 is CH3 and R 5 For CH3.

[0525] Table 45. Compounds of formula I.7, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For CH3.

[0526] Table 46. Compounds of formula I.7, wherein R 1 For Y-4B, R4 is CH3 and R 5 For CH3.

[0527] Table 47. Compounds of formula I.7, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For CH3.

[0528] Table 48. Compounds of formula I.7, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For CH3.

[0529] Table 49. Compounds of formula I.7, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For CH3.

[0530] Table 50. Compounds of formula I.7, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For CH3.

[0531] Table 51. Compounds of formula I.7, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For CH3.

[0532] Table 52. Compounds of formula I.7, wherein R 1 For Y-6B, R 4 is CH3 and R 5 For CH3.

[0533] Table 53. Compounds of formula I.7, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For CH3.

[0534] Table 54. Compounds of formula I.7, wherein R 1 For Y-8B, R 4 is CH3 and R 5 For CH3.

[0535] Table 55. Compounds of formula I.8, wherein R 1 Y-1A, R 4 H and R 5 For H.

[0536] Table 56. Compounds of formula I.8, wherein R 1 For Y-1B, R 4 H and R5 For H.

[0537] Table 57. Compounds of formula I.8, wherein R 1 For Y-2A, R 4 H and R 5 For H.

[0538] Table 58. Compounds of formula I.8, wherein R 1 For Y-2B, R 4 H and R 5 For H.

[0539] Table 59. Compounds of formula I.8, wherein R 1 For Y-3A, R 4 H and R 5 For H.

[0540] Table 60. Compounds of formula I.8, wherein R 1 For Y-3B, R 4 H and R 5 For H.

[0541] Table 61. Compounds of formula I.8, wherein R 1 For Y-3C, R 4 H and R 5 For H.

[0542] Table 62. Compounds of formula I.8, wherein R 1 For Y-3D, R 4 H and R 5 For H.

[0543] Table 63. Compounds of formula I.8, wherein R 1 For Y-4A, R 4 H and R 5 For H.

[0544] Table 64. Compounds of formula I.8, wherein R 1 For Y-4B, R 4 H and R 5 For H.

[0545] Table 65. Compounds of formula I.8, wherein R 1 For Y-4C, R 4 H and R 5 For H.

[0546] Table 66. Compounds of formula I.8, wherein R 1 For Y-4D, R 4 H and R 5 For H.

[0547] Table 67. Compounds of formula I.8, wherein R1 For Y-5A, R 4 H and R 5 For H.

[0548] Table 68. Compounds of formula I.8, wherein R 1 For Y-5B, R 4 H and R 5 For H.

[0549] Table 69. Compounds of formula I.8, wherein R 1 For Y-6A, R 4 H and R 5 For H.

[0550] Table 70. Compounds of formula I.8, wherein R 1 For Y-6B, R 4 H and R 5 For H.

[0551] Table 71. Compounds of formula I.8, wherein R 1 For Y-8A, R 4 H and R 5 For H.

[0552] Table 72. Compounds of formula I.8, wherein R 1 For Y-8B, R 4 H and R 5 For H.

[0553] Table 73. Compounds of formula I.8, wherein R 1 Y-1A, R 4 is CH3 and R 5 For H.

[0554] Table 74. Compounds of formula I.8, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For H.

[0555] Table 75. Compounds of formula I.8, wherein R 1 For Y-2A, R 4 is CH3 and R 5 For H.

[0556] Table 76. Compounds of formula I.8, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For H.

[0557] Table 77. Compounds of formula I.8, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For H.

[0558] Table 78. Compounds of formula I.8, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For H.

[0559] Table 79. Compounds of formula I.8, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For H.

[0560] Table 80. Compounds of formula I.8, wherein R 1 For Y-3D, R 4 is CH3 and R 5 For H.

[0561] Table 81. Compounds of formula I.8, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For H.

[0562] Table 82. Compounds of formula I.8, wherein R 1 For Y-4B, R 4 is CH3 and R 5 For H.

[0563] Table 83. Compounds of formula I.8, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For H.

[0564] Table 84. Compounds of formula I.8, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For H.

[0565] Table 85. Compounds of formula I.8, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For H.

[0566] Table 86. Compounds of formula I.8, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For H.

[0567] Table 87. Compounds of formula I.8, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For H.

[0568] Table 88. Compounds of formula I.8, wherein R1 For Y-6B, R 4 is CH3 and R 5 For H.

[0569] Table 89. Compounds of formula I.8, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For H.

[0570] Table 90. Compounds of formula I.8, wherein R 1 For Y-8B, R 4 is CH3 and R 5 For H.

[0571] Table 91. Compounds of formula I.8, wherein R 1 Y-1A, R 4 is CH3 and R 5 For CH3.

[0572] Table 92. Compounds of formula I.8, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For CH3.

[0573] Table 93. Compounds of formula I.8, wherein R 1 For Y-2A, R 4 is CH3 and R 5 For CH3.

[0574] Table 94. Compounds of formula I.8, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For CH3.

[0575] Table 95. Compounds of formula I.8, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For CH3.

[0576] Table 96. Compounds of formula I.8, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For CH3.

[0577] Table 97. Compounds of formula I.8, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For CH3.

[0578] Table 98. Compounds of formula I.8, wherein R 1 For Y-3D, R4 is CH3 and R 5 For CH3.

[0579] Table 99. Compounds of formula I.8, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For CH3.

[0580] Table 100. Compounds of formula I.8, wherein R 1 For Y-4B, R 4 is CH3 and R 5 For CH3.

[0581] Table 101. Compounds of formula I.8, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For CH3.

[0582] Table 102. Compounds of formula I.8, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For CH3.

[0583] Table 103. Compounds of formula I.8, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For CH3.

[0584] Table 104. Compounds of formula I.8, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For CH3.

[0585] Table 105. Compounds of formula I.8, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For CH3.

[0586] Table 106. Compounds of formula I.8, wherein R 1 For Y-6B, R 4 is CH3 and R 5 For CH3.

[0587] Table 107. Compounds of formula I.8, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For CH3.

[0588] Table 108. Compounds of formula I.8, wherein R 1 For Y-8B, R 4is CH3 and R 5 For CH3.

[0589] Table 109. Compounds of formula I.9, wherein R 1 Y-1A, R 4 H and R 5 For H.

[0590] Table 110. Compounds of formula I.9, wherein R 1 For Y-1B, R 4 H and R 5 For H.

[0591] Table 111. Compounds of formula I.9, wherein R 1 For Y-2A, R 4 H and R 5 For H.

[0592] Table 112. Compounds of formula I.9, wherein R 1 For Y-2B, R 4 H and R 5 For H.

[0593] Table 113. Compounds of formula I.9, wherein R 1 For Y-3A, R 4 H and R 5 For H.

[0594] Table 114. Compounds of formula I.9, wherein R 1 For Y-3B, R 4 H and R 5 For H.

[0595] Table 115. Compounds of formula I.9, wherein R 1 For Y-3C, R 4 H and R 5 For H.

[0596] Table 116. Compounds of formula I.9, wherein R 1 For Y-3D, R 4 H and R 5 For H.

[0597] Table 117. Compounds of formula I.9, wherein R 1 For Y-4A, R 4 H and R 5 For H.

[0598] Table 118. Compounds of formula I.9, wherein R 1 For Y-4B, R 4 H and R 5 For H.

[0599] Table 119. Compounds of formula I.9, wherein R 1 For Y-4C, R 4 H and R 5 For H.

[0600] Table 120. Compounds of formula I.9, wherein R 1 For Y-4D, R 4 H and R 5 For H.

[0601] Table 121. Compounds of formula I.9, wherein R 1 For Y-5A, R 4 H and R 5 For H.

[0602] Table 122. Compounds of formula I.9, wherein R 1 For Y-5B, R 4 H and R 5 For H.

[0603] Table 123. Compounds of formula I.9, wherein R 1 For Y-6A, R 4 H and R 5 For H.

[0604] Table 124. Compounds of formula I.9, wherein R 1 For Y-6B, R 4 H and R 5 For H.

[0605] Table 125. Compounds of formula I.9, wherein R 1 For Y-8A, R 4 H and R 5 For H.

[0606] Table 126. Compounds of formula I.9, wherein R 1 For Y-8B, R 4 H and R 5 For H.

[0607] Table 127. Compounds of formula I.9, wherein R 1 Y-1A, R 4 is CH3 and R 5 For H.

[0608] Table 128. Compounds of formula I.9, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For H.

[0609] Table 129. Compounds of formula I.9, wherein R 1 For Y-2A, R 4is CH3 and R 5 For H.

[0610] Table 130. Compounds of formula I.9, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For H.

[0611] Table 131. Compounds of formula I.9, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For H.

[0612] Table 132. Compounds of formula I.9, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For H.

[0613] Table 133. Compounds of formula I.9, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For H.

[0614] Table 134. Compounds of formula I.9, wherein R 1 For Y-3D, R 4 is CH3 and R 5 For H.

[0615] Table 135. Compounds of formula I.9, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For H.

[0616] Table 136. Compounds of formula I.9, wherein R 1 For Y-4B, R 4 is CH3 and R 5 For H.

[0617] Table 137. Compounds of formula I.9, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For H.

[0618] Table 138. Compounds of formula I.9, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For H.

[0619] Table 139. Compounds of formula I.9, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For H.

[0620] Table 140. Compounds of formula I.9, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For H.

[0621] Table 141. Compounds of formula I.9, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For H.

[0622] Table 142. Compounds of formula I.9, wherein R 1 For Y-6B, R 4 is CH3 and R 5 For H.

[0623] Table 143. Compounds of formula I.9, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For H.

[0624] Table 144. Compounds of formula I.9, wherein R 1 For Y-8B, R 4 is CH3 and R 5 For H.

[0625] Table 145. Compounds of formula I.9, wherein R 1 Y-1A, R 4 is CH3 and R 5 For CH3.

[0626] Table 146. Compounds of formula I.9, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For CH3.

[0627] Table 147. Compounds of formula I.9, wherein R 1 For Y-2A, R 4 is CH3 and R 5 For CH3.

[0628] Table 148. Compounds of formula I.9, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For CH3.

[0629] Table 149. Compounds of formula I.9, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For CH3.

[0630] Table 150. Compounds of formula I.9, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For CH3.

[0631] Table 151. Compounds of formula I.9, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For CH3.

[0632] Table 152. Compounds of formula I.9, wherein R 1 For Y-3D, R 4 is CH3 and R 5 For CH3.

[0633] Table 153. Compounds of formula I.9, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For CH3.

[0634] Table 154. Compounds of formula I.9, wherein R 1 For Y-4B, R 4 is CH3 and R 5 For CH3.

[0635] Table 155. Compounds of formula I.9, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For CH3.

[0636] Table 156. Compounds of formula I.9, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For CH3.

[0637] Table 157. Compounds of formula I.9, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For CH3.

[0638] Table 158. Compounds of formula I.9, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For CH3.

[0639] Table 159. Compounds of formula I.9, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For CH3.

[0640] Table 160. Compounds of formula I.9, wherein R 1 For Y-6B, R 4 is CH3 and R 5 For CH3.

[0641] Table 161. Compounds of formula I.9, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For CH3.

[0642] Table 162. Compounds of formula I.9, wherein R 1 For Y-8B, R 4 is CH3 and R 5 For CH3.

[0643] Table 163. Compounds of formula I.10, wherein R 1 Y-1A, R 4 H and R 5 For H.

[0644] Table 164. Compounds of formula I.10, wherein R 1 For Y-1B, R 4 H and R 5 For H.

[0645] Table 165. Compounds of formula I.10, wherein R 1 For Y-2A, R 4 H and R 5 For H.

[0646] Table 166. Compounds of formula I.10, wherein R 1 For Y-2B, R 4 H and R 5 For H.

[0647] Table 167. Compounds of formula I.10, wherein R 1 For Y-3A, R 4 H and R 5 For H.

[0648] Table 168. Compounds of formula I.10, wherein R 1 For Y-3B, R 4 H and R 5 For H.

[0649] Table 169. Compounds of formula I.10, wherein R 1 For Y-3C, R 4 H and R 5 For H.

[0650] Table 170. Compounds of formula I.10, wherein R 1For Y-3D, R 4 H and R 5 For H.

[0651] Table 171. Compounds of formula I.10, wherein R 1 For Y-4A, R 4 H and R 5 For H.

[0652] Table 172. Compounds of formula I.10, wherein R 1 For Y-4B, R 4 H and R 5 For H.

[0653] Table 173. Compounds of formula I.10, wherein R 1 For Y-4C, R 4 H and R 5 For H.

[0654] Table 174. Compounds of formula I.10, wherein R 1 For Y-4D, R 4 H and R 5 For H.

[0655] Table 175. Compounds of formula I.10, wherein R 1 For Y-5A, R 4 H and R 5 For H.

[0656] Table 176. Compounds of formula I.10, wherein R 1 For Y-5B, R 4 H and R 5 For H.

[0657] Table 177. Compounds of formula I.10, wherein R 1 For Y-6A, R 4 H and R 5 For H.

[0658] Table 178. Compounds of formula I.10, wherein R 1 For Y-6B, R 4 H and R 5 For H.

[0659] Table 179. Compounds of formula I.10, wherein R 1 For Y-8A, R 4 H and R 5 For H.

[0660] Table 180. Compounds of formula I.10, wherein R 1 For Y-8B, R 4 H and R 5 For H.

[0661] Table 181. Compounds of formula I.10, wherein R 1 Y-1A, R 4 is CH3 and R 5 For H.

[0662] Table 182. Compounds of formula I.10, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For H.

[0663] Table 183. Compounds of formula I.10, wherein R 1 For Y-2A, R 4 is CH3 and R 5 For H.

[0664] Table 184. Compounds of formula I.10, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For H.

[0665] Table 185. Compounds of formula I.10, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For H.

[0666] Table 186. Compounds of formula I.10, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For H.

[0667] Table 187. Compounds of formula I.10, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For H.

[0668] Table 188. Compounds of formula I.10, wherein R 1 For Y-3D, R 4 is CH3 and R 5 For H.

[0669] Table 189. Compounds of formula I.10, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For H.

[0670] Table 190. Compounds of formula I.10, wherein R 1 For Y-4B, R 4 is CH3 and R 5 For H.

[0671] Table 191. Compounds of formula I.10, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For H.

[0672] Table 192. Compounds of formula I.10, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For H.

[0673] Table 193. Compounds of formula I.10, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For H.

[0674] Table 194. Compounds of formula I.10, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For H.

[0675] Table 195. Compounds of formula I.10, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For H.

[0676] Table 196. Compounds of formula I.10, wherein R 1 For Y-6B, R 4 is CH3 and R 5 For H.

[0677] Table 197. Compounds of formula I.10, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For H.

[0678] Table 198. Compounds of formula I.10, wherein R 1 For Y-8B, R 4 is CH3 and R 5 For H.

[0679] Table 199. Compounds of formula I.10, wherein R 1 Y-1A, R 4 is CH3 and R 5 For CH3.

[0680] Table 200. Compounds of formula I.10, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For CH3.

[0681] Table 201. Compounds of formula I.10, wherein R 1 For Y-2A, R 4 is CH3 and R 5 For CH3.

[0682] Table 202. Compounds of formula I.10, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For CH3.

[0683] Table 203. Compounds of formula I.10, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For CH3.

[0684] Table 204. Compounds of formula I.10, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For CH3.

[0685] Table 205. Compounds of formula I.10, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For CH3.

[0686] Table 206. Compounds of formula I.10, wherein R 1 For Y-3D, R 4 is CH3 and R 5 For CH3.

[0687] Table 207. Compounds of formula I.10, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For CH3.

[0688] Table 208. Compounds of formula I.10, wherein R 1 For Y-4B, R 4 is CH3 and R 5 For CH3.

[0689] Table 209. Compounds of formula I.10, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For CH3.

[0690] Table 210. Compounds of formula I.10, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For CH3.

[0691] Table 211. Compounds of formula I.10, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For CH3.

[0692] Table 212. Compounds of formula I.10, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For CH3.

[0693] Table 213. Compounds of formula I.10, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For CH3.

[0694] Table 214. Compounds of formula I.10, wherein R 1 For Y-6B, R 4 is CH3 and R 5 For CH3.

[0695] Table 215. Compounds of formula I.10, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For CH3.

[0696] Table 216. Compounds of formula I.10, wherein R 1 For Y-8B, R 4 is CH3 and R 5 For CH3.

[0697] Table 217. Compounds of formula I.11, wherein R 1 Y-1A, R 4 H and R 5 For H.

[0698] Table 218. Compounds of formula I.11, wherein R 1 For Y-1B, R 4 H and R 5 For H.

[0699] Table 219. Compounds of formula I.11, wherein R 1 For Y-2A, R 4 H and R 5 For H.

[0700] Table 220. Compounds of formula I.11, wherein R 1 For Y-2B, R 4 H and R 5 For H.

[0701] Table 221. Compounds of formula I.11, wherein R1 For Y-3A, R 4 H and R 5 For H.

[0702] Table 222. Compounds of formula I.11, wherein R 1 For Y-3B, R 4 H and R 5 For H.

[0703] Table 223. Compounds of formula I.11, wherein R 1 For Y-3C, R 4 H and R 5 For H.

[0704] Table 224. Compounds of formula I.11, wherein R 1 For Y-3D, R 4 H and R 5 For H.

[0705] Table 225. Compounds of formula I.11, wherein R 1 For Y-4A, R 4 H and R 5 For H.

[0706] Table 226. Compounds of formula I.11, wherein R 1 For Y-4B, R 4 H and R 5 For H.

[0707] Table 227. Compounds of formula I.11, wherein R 1 For Y-4C, R 4 H and R 5 For H.

[0708] Table 228. Compounds of formula I.11, wherein R 1 For Y-4D, R 4 H and R 5 For H.

[0709] Table 229. Compounds of formula I.11, wherein R 1 For Y-5A, R 4 H and R 5 For H.

[0710] Table 230. Compounds of formula I.11, wherein R 1 For Y-5B, R 4 H and R 5 For H.

[0711] Table 231. Compounds of formula I.11, wherein R 1 For Y-6A, R 4 H and R5 For H.

[0712] Table 232. Compounds of formula I.11, wherein R 1 For Y-6B, R 4 H and R 5 For H.

[0713] Table 233. Compounds of formula I.11, wherein R 1 For Y-8A, R 4 H and R 5 For H.

[0714] Table 234. Compounds of formula I.11, wherein R 1 For Y-8B, R 4 H and R 5 For H.

[0715] Table 235. Compounds of formula I.11, wherein R 1 Y-1A, R 4 is CH3 and R 5 For H.

[0716] Table 236. Compounds of formula I.11, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For H.

[0717] Table 237. Compounds of formula I.11, wherein R 1 For Y-2A, R 4 is CH3 and R 5 For H.

[0718] Table 238. Compounds of formula I.11, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For H.

[0719] Table 239. Compounds of formula I.11, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For H.

[0720] Table 240. Compounds of formula I.11, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For H.

[0721] Table 241. Compounds of formula I.11, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For H.

[0722] Table 242. Compounds of formula I.11, wherein R 1 For Y-3D, R 4 is CH3 and R 5 For H.

[0723] Table 243. Compounds of formula I.11, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For H.

[0724] Table 244. Compounds of formula I.11, wherein R 1 For Y-4B, R 4 is CH3 and R 5 For H.

[0725] Table 245. Compounds of formula I.11, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For H.

[0726] Table 246. Compounds of formula I.11, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For H.

[0727] Table 247. Compounds of formula I.11, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For H.

[0728] Table 248. Compounds of formula I.11, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For H.

[0729] Table 249. Compounds of formula I.11, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For H.

[0730] Table 250. Compounds of formula I.11, wherein R 1 For Y-6B, R 4 is CH3 and R 5 For H.

[0731] Table 251. Compounds of formula I.11, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For H.

[0732] Table 252. Compounds of formula I.11, wherein R 1 For Y-8B, R 4 is CH3 and R 5 For H.

[0733] Table 253. Compounds of formula I.11, wherein R 1 Y-1A, R 4 is CH3 and R 5 For CH3.

[0734] Table 254. Compounds of formula I.11, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For CH3.

[0735] Table 255. Compounds of formula I.11, wherein R 1 For Y-2A, R 4 is CH3 and R 5 For CH3.

[0736] Table 256. Compounds of formula I.11, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For CH3.

[0737] Table 257. Compounds of formula I.11, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For CH3.

[0738] Table 258. Compounds of formula I.11, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For CH3.

[0739] Table 259. Compounds of formula I.11, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For CH3.

[0740] Table 260. Compounds of formula I.11, wherein R 1 For Y-3D, R 4 is CH3 and R 5 For CH3.

[0741] Table 261. Compounds of formula I.11, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For CH3.

[0742] Table 262. Compounds of formula I.11, wherein R 1 For Y-4B, R 4 is CH3 and R 5 For CH3.

[0743] Table 263. Compounds of formula I.11, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For CH3.

[0744] Table 264. Compounds of formula I.11, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For CH3.

[0745] Table 265. Compounds of formula I.11, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For CH3.

[0746] Table 266. Compounds of formula I.11, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For CH3.

[0747] Table 267. Compounds of formula I.11, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For CH3.

[0748] Table 268. Compounds of formula I.11, wherein R 1 For Y-6B, R 4 is CH3 and R 5 For CH3.

[0749] Table 269. Compounds of formula I.11, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For CH3.

[0750] Table 270. Compounds of formula I.11, wherein R 1 For Y-8B, R 4 is CH3 and R 5 For CH3.

[0751] Table 271. Compounds of formula I.12, wherein R 1 Y-1A, R 4 H and R 5 For H.

[0752] Table 272. Compounds of formula I.12, wherein R 1 For Y-1B, R 4 H and R 5 For H.

[0753] Table 273. Compounds of formula I.12, wherein R 1 For Y-2A, R 4 H and R 5 For H.

[0754] Table 274. Compounds of formula I.12, wherein R 1 For Y-2B, R 4 H and R 5 For H.

[0755] Table 275. Compounds of formula I.12, wherein R 1 For Y-3A, R 4 H and R 5 For H.

[0756] Table 276. Compounds of formula I.12, wherein R 1 For Y-3B, R 4 H and R 5 For H.

[0757] Table 277. Compounds of formula I.12, wherein R 1 For Y-3C, R 4 H and R 5 For H.

[0758] Table 278. Compounds of formula I.12, wherein R 1 For Y-3D, R 4 H and R 5 For H.

[0759] Table 279. Compounds of formula I.12, wherein R 1 For Y-4A, R 4 H and R 5 For H.

[0760] Table 280. Compounds of formula I.12, wherein R 1 For Y-4B, R 4 H and R 5 For H.

[0761] Table 281. Compounds of formula I.12, wherein R 1 For Y-4C, R 4 H and R 5 For H.

[0762] Table 282. Compounds of formula I.12, wherein R 1 For Y-4D, R4 H and R 5 For H.

[0763] Table 283. Compounds of formula I.12, wherein R 1 For Y-5A, R 4 H and R 5 For H.

[0764] Table 284. Compounds of formula I.12, wherein R 1 For Y-5B, R 4 H and R 5 For H.

[0765] Table 285. Compounds of formula I.12, wherein R 1 For Y-6A, R 4 H and R 5 For H.

[0766] Table 286. Compounds of formula I.12, wherein R 1 For Y-6B, R 4 H and R 5 For H.

[0767] Table 287. Compounds of formula I.12, wherein R 1 For Y-8A, R 4 H and R 5 For H.

[0768] Table 288. Compounds of formula I.12, wherein R 1 For Y-8B, R 4 H and R 5 For H.

[0769] Table 289. Compounds of formula I.12, wherein R 1 Y-1A, R 4 is CH3 and R 5 For H.

[0770] Table 290. Compounds of formula I.12, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For H.

[0771] Table 291. Compounds of formula I.12, wherein R 1 For Y-2A, R 4 is CH3 and R 5 For H.

[0772] Table 292. Compounds of formula I.12, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For H.

[0773] Table 293. Compounds of formula I.12, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For H.

[0774] Table 294. Compounds of formula I.12, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For H.

[0775] Table 295. Compounds of formula I.12, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For H.

[0776] Table 296. Compounds of formula I.12, wherein R 1 For Y-3D, R 4 is CH3 and R 5 For H.

[0777] Table 297. Compounds of formula I.12, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For H.

[0778] Table 298. Compounds of formula I.12, wherein R 1 For Y-4B, R 4 is CH3 and R 5 For H.

[0779] Table 299. Compounds of formula I.12, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For H.

[0780] Table 300. Compounds of formula I.12, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For H.

[0781] Table 301. Compounds of formula I.12, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For H.

[0782] Table 302. Compounds of formula I.12, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For H.

[0783] Table 303. Compounds of formula I.12, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For H.

[0784] Table 304. Compounds of formula I.12, wherein R 1 For Y-6B, R 4 is CH3 and R 5 For H.

[0785] Table 305. Compounds of formula I.12, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For H.

[0786] Table 306. Compounds of formula I.12, wherein R 1 For Y-8B, R 4 is CH3 and R 5 For H.

[0787] Table 307. Compounds of formula I.12, wherein R 1 Y-1A, R 4 is CH3 and R 5 For CH3.

[0788] Table 308. Compounds of formula I.12, wherein R 1 For Y-1B, R 4 is CH3 and R 5 For CH3.

[0789] Table 309. Compounds of formula I.12, wherein R 1 For Y-2A, R 4 is CH3 and R 5 For CH3.

[0790] Table 310. Compounds of formula I.12, wherein R 1 For Y-2B, R 4 is CH3 and R 5 For CH3.

[0791] Table 311. Compounds of formula I.12, wherein R 1 For Y-3A, R 4 is CH3 and R 5 For CH3.

[0792] Table 312. Compounds of formula I.12, wherein R 1 For Y-3B, R 4 is CH3 and R 5 For CH3.

[0793] Table 313. Compounds of formula I.12, wherein R 1 For Y-3C, R 4 is CH3 and R 5 For CH3.

[0794] Table 314. Compounds of formula I.12, wherein R 1 For Y-3D, R 4 is CH3 and R 5 For CH3.

[0795] Table 315. Compounds of formula I.12, wherein R 1 For Y-4A, R 4 is CH3 and R 5 For CH3.

[0796] Table 316. Compounds of formula I.12, wherein R 1 For Y-4B, R 4 is CH3 and R 5 For CH3.

[0797] Table 317. Compounds of formula I.12, wherein R 1 For Y-4C, R 4 is CH3 and R 5 For CH3.

[0798] Table 318. Compounds of formula I.12, wherein R 1 For Y-4D, R 4 is CH3 and R 5 For CH3.

[0799] Table 319. Compounds of formula I.12, wherein R 1 For Y-5A, R 4 is CH3 and R 5 For CH3.

[0800] Table 320. Compounds of formula I.12, wherein R 1 For Y-5B, R 4 is CH3 and R 5 For CH3.

[0801] Table 321. Compounds of formula I.12, wherein R 1 For Y-6A, R 4 is CH3 and R 5 For CH3.

[0802] Table 322. Compounds of formula I.12, wherein R 1 For Y-6B, R 4 is CH3 and R 5 For CH3.

[0803] Table 323. Compounds of formula I.12, wherein R 1 For Y-8A, R 4 is CH3 and R 5 For CH3.

[0804] Table 324. Compounds of formula I.12, wherein R 1 For Y-8B, R 4 is CH3 and R 5 For CH3.

[0805] Table 325. Compounds of formula I.13, wherein R 1 Y-1A, R 2 H, R 9 H and R 10 For H.

[0806] Table 326. Compounds of formula I.13, wherein R 1 Y-1A, R 2 H, R 9 CH3 and R 10 For H.

[0807] Table 327. Compounds of formula I.13, wherein R 1 Y-1A, R 2 H, R 9 is CH3 and R 10 For CH3.

[0808] Table 328. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 H, R 9 H and R 10 For H.

[0809] Table 329. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For H.

[0810] Table 330. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For CH3.

[0811] Table 331. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 H, R 9 H and R 10 For H.

[0812] Table 332. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 H, R 9 is CH3 and R 10 For H.

[0813] Table 333. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 H, R 9 is CH3 and R 10 For CH3.

[0814] Table 334. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 H, R 9 H and R 10 For H.

[0815] Table 335. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For H.

[0816] Table 336. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For CH3.

[0817] Table 337. Compounds of formula I.13, wherein R 1 For Y-3A, R 2 H, R 9 H and R 10 For H.

[0818] Table 338. Compounds of formula I.13, wherein R 1 For Y-3A, R 2 H, R 9 is CH3 and R 10 For H.

[0819] Table 339. Compounds of formula I.13, wherein R 1 For Y-3A, R 2 H, R 9 is CH3 and R 10 For CH3.

[0820] Table 340. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 H, R 9H and R 10 For H.

[0821] Table 341. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 H, R 9 is CH3 and R 10 For H.

[0822] Table 342. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 H, R 9 is CH3 and R 10 For CH3.

[0823] Table 343. Compounds of formula I.13, wherein R 1 For Y-3C, R 2 H, R 9 H and R 10 For H.

[0824] Table 344. Compounds of formula I.13, wherein R 1 For Y-3C, R 2 H, R 9 is CH3 and R 10 For H.

[0825] Table 345. Compounds of formula I.13, wherein R 1 For Y-3C, R 2 H, R 9 is CH3 and R 10 For CH3.

[0826] Table 346. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 H, R 9 H and R 10 For H.

[0827] Table 347. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For H.

[0828] Table 348. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For CH3.

[0829] Table 349. Compounds of formula I.13, wherein R 1For Y-4A, R 2 H, R 9 H and R 10 For H.

[0830] Table 350. Compounds of formula I.13, wherein R 1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For H.

[0831] Table 351. Compounds of formula I.13, wherein R 1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For CH3.

[0832] Table 352. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 H, R 9 H and R 10 For H.

[0833] Table 353. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 H, R 9 is CH3 and R 10 For H.

[0834] Table 354. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 H, R 9 is CH3 and R 10 For CH3.

[0835] Table 355. Compounds of formula I.13, wherein R 1 For Y-4C, R 2 H, R 9 H and R 10 For H.

[0836] Table 356. Compounds of formula I.13, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For H.

[0837] Table 357. Compounds of formula I.13, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For CH3.

[0838] Table 358. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 H, R 9 H and R 10 For H.

[0839] Table 359. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 H, R 9 is CH3 and R 10 For H.

[0840] Table 360. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 H, R 9 is CH3 and R 10 For CH3.

[0841] Table 361. Compounds of formula I.13, wherein R 1 For Y-5A, R 2 H, R 9 H and R 10 For H.

[0842] Table 362. Compounds of formula I.13, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For H.

[0843] Table 363. Compounds of formula I.13, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For CH3.

[0844] Table 364. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 H, R 9 H and R 10 For H.

[0845] Table 365. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 H, R 9 is CH3 and R 10 For H.

[0846] Table 366. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 H, R 9is CH3 and R 10 For CH3.

[0847] Table 367. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 H, R 9 H and R 10 For H.

[0848] Table 368. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 H, R 9 is CH3 and R 10 For H.

[0849] Table 369. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 H, R 9 is CH3 and R 10 For CH3.

[0850] Table 370. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 H, R 9 H and R 10 For H.

[0851] Table 371. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R 10 For H.

[0852] Table 372. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R 10 For CH3.

[0853] Table 373. Compounds of formula I.13, wherein R 1 For Y-8A, R 2 H, R 9 H and R 10 For H.

[0854] Table 374. Compounds of formula I.13, wherein R 1 For Y-8A, R 2 H, R 9 is CH3 and R 10 For H.

[0855] Table 375. Compounds of formula I.13, wherein R 1For Y-8A, R 2 H, R 9 is CH3 and R 10 For CH3.

[0856] Table 376. Compounds of formula I.13, wherein R 1 For Y-8B, R 2 H, R 9 H and R 10 For H.

[0857] Table 377. Compounds of formula I.13, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For H.

[0858] Table 378. Compounds of formula I.13, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For CH3.

[0859] Table 379. Compounds of formula I.13, wherein R 1 Y-1A, R 2 CH3, R 9 H and R 10 For H.

[0860] Table 380. Compounds of formula I.13, wherein R 1 Y-1A, R 2 CH3, R 9 is CH3 and R 10 For H.

[0861] Table 381. Compounds of formula I.13, wherein R 1 Y-1A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0862] Table 382. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 CH3, R 9 H and R 10 For H.

[0863] Table 383. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 CH3, R 9 is CH3 and R 10 For H.

[0864] Table 384. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0865] Table 385. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 CH3, R 9 H and R 10 For H.

[0866] Table 386. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 CH3, R 9 is CH3 and R 10 For H.

[0867] Table 387. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0868] Table 388. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 CH3, R 9 H and R 10 For H.

[0869] Table 389. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For H.

[0870] Table 390. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0871] Table 391. Compounds of formula I.13, wherein R 1 For Y-3A, R 2 CH3, R 9 H and R 10 For H.

[0872] Table 392. Compounds of formula I.13, wherein R 1 For Y-3A, R 2CH3, R 9 is CH3 and R 10 For H.

[0873] Table 393. Compounds of formula I.13, wherein R 1 For Y-3A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0874] Table 394. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 CH3, R 9 H and R 10 For H.

[0875] Table 395. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For H.

[0876] Table 396. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0877] Table 397. Compounds of formula I.13, wherein R 1 For Y-3C, R 2 CH3, R 9 H and R 10 For H.

[0878] Table 398. Compounds of formula I.13, wherein R 1 For Y-3C, R 2 CH3, R 9 is CH3 and R 10 For H.

[0879] Table 399. Compounds of formula I.13, wherein R 1 For Y-3C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0880] Table 400. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 CH3, R 9 H and R 10 For H.

[0881] Table 401. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 CH3, R 9 is CH3 and R 10 For H.

[0882] Table 402. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0883] Table 403. Compounds of formula I.13, wherein R 1 For Y-4A, R 2 CH3, R 9 H and R 10 For H.

[0884] Table 404. Compounds of formula I.13, wherein R 1 For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For H.

[0885] Table 405. Compounds of formula I.13, wherein R 1 For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0886] Table 406. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 CH3, R 9 H and R 10 For H.

[0887] Table 407. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For H.

[0888] Table 408. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0889] Table 409. Compounds of formula I.13, wherein R 1 For Y-4C, R 2 CH3, R9 H and R 10 For H.

[0890] Table 410. Compounds of formula I.13, wherein R 1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For H.

[0891] Table 411. Compounds of formula I.13, wherein R 1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0892] Table 412. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 CH3, R 9 H and R 10 For H.

[0893] Table 413. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 CH3, R 9 is CH3 and R 10 For H.

[0894] Table 414. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0895] Table 415. Compounds of formula I.13, wherein R 1 For Y-5A, R 2 CH3, R 9 H and R 10 For H.

[0896] Table 416. Compounds of formula I.13, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For H.

[0897] Table 417. Compounds of formula I.13, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0898] Table 418. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 CH3, R 9 H and R 10 For H.

[0899] Table 419. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R 10 For H.

[0900] Table 420. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0901] Table 421. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 CH3, R 9 H and R 10 For H.

[0902] Table 422. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For H.

[0903] Table 423. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0904] Table 424. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 CH3, R 9 H and R 10 For H.

[0905] Table 425. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 CH3, R 9 is CH3 and R 10 For H.

[0906] Table 426. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 CH3, R 9is CH3 and R 10 For CH3. CH3.

[0907] Table 427. Compounds of formula I.13, wherein R 1 For Y-8A, R 2 CH3, R 9 H and R 10 For H.

[0908] Table 428. Compounds of formula I.13, wherein R 1 For Y-8A, R 2 CH3, R 9 is CH3 and R 10 For H.

[0909] Table 429. Compounds of formula I.13, wherein R 1 For Y-8A, R 2 CH3, R 9 is CH3 and R 10 Table 430. Compounds of formula I.13, wherein R 1 For Y-8B, R 2 CH3, R 9 H and R 10 For H.

[0910] Table 431. Compounds of formula I.13, wherein R 1 For Y-8B, R 2 CH3, R 9 is CH3 and R 10 For H.

[0911] Table 432. Compounds of formula I.13, wherein R 1 For Y-8B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[0912] Table 433. Compounds of formula I.13, wherein R 1 Y-1A, R 2 For C2H5, R 9 H and R 10 For H.

[0913] Table 434. Compounds of formula I.13, wherein R 1 Y-1A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0914] Table 435. Compounds of formula I.13, wherein R 1 Y-1A, R2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0915] Table 436. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 For C2H5, R 9 H and R 10 For H.

[0916] Table 437. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0917] Table 438. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0918] Table 439. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 For C2H5, R 9 H and R 10 For H.

[0919] Table 440. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0920] Table 441. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0921] Table 442. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 For C2H5, R 9 H and R 10 For H.

[0922] Table 443. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0923] Table 444. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0924] Table 445. Compounds of formula I.13, wherein R 1 For Y-3A, R 2 For C2H5, R 9 H and R 10 For H.

[0925] Table 446. Compounds of formula I.13, wherein R 1 For Y-3A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0926] Table 447. Compounds of formula I.13, wherein R 1 For Y-3A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0927] Table 448. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 For C2H5, R 9 H and R 10 For H.

[0928] Table 449. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0929] Table 450. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0930] Table 451. Compounds of formula I.13, wherein R 1 For Y-3C, R 2 For C2H5, R 9 H and R 10 For H.

[0931] Table 452. Compounds of formula I.13, wherein R 1For Y-3C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0932] Table 453. Compounds of formula I.13, wherein R 1 For Y-3C, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0933] Table 454. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 For C2H5, R 9 H and R 10 For H.

[0934] Table 455. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0935] Table 456. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0936] Table 457. Compounds of formula I.13, wherein R 1 For Y-4A, R 2 For C2H5, R 9 H and R 10 For H.

[0937] Table 458. Compounds of formula I.13, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0938] Table 459. Compounds of formula I.13, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0939] Table 460. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 For C2H5, R 9 H and R 10For H.

[0940] Table 461. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0941] Table 462. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0942] Table 463. Compounds of formula I.13, wherein R 1 For Y-4C, R 2 For C2H5, R 9 H and R 10 For H.

[0943] Table 464. Compounds of formula I.13, wherein R 1 For Y-4C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0944] Table 465. Compounds of formula I.13, wherein R 1 For Y-4C, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0945] Table 466. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 For C2H5, R 9 H and R 10 For H.

[0946] Table 467. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0947] Table 468. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0948] Table 469. Compounds of formula I.13, wherein R1 For Y-5A, R 2 For C2H5, R 9 H and R 10 For H.

[0949] Table 470. Compounds of formula I.13, wherein R 1 For Y-5A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0950] Table 471. Compounds of formula I.13, wherein R 1 For Y-5A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0951] Table 472. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 For C2H5, R 9 H and R 10 For H.

[0952] Table 473. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0953] Table 474. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0954] Table 475. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 For C2H5, R 9 H and R 10 For H.

[0955] Table 476. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0956] Table 477. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R10 For CH3.

[0957] Table 478. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 For C2H5, R 9 H and R 10 For H.

[0958] Table 479. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0959] Table 480. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0960] Table 481. Compounds of formula I.13, wherein R 1 For Y-8A, R 2 For C2H5, R 9 H and R 10 For H.

[0961] Table 482. Compounds of formula I.13, wherein R 1 For Y-8A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0962] Table 483. Compounds of formula I.13, wherein R 1 For Y-8A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0963] Table 484. Compounds of formula I.13, wherein R 1 For Y-8B, R 2 For C2H5, R 9 H and R 10 For H.

[0964] Table 485. Compounds of formula I.13, wherein R 1 For Y-8B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[0965] Table 486. Compounds of formula I.13, wherein R1 For Y-8B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[0966] Table 487. Compounds of formula I.13, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 H and R 10 For H.

[0967] Table 488. Compounds of formula I.13, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[0968] Table 489. Compounds of formula I.13, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[0969] Table 490. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 H and R 10 For H.

[0970] Table 491. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 CH3, R 10 For H.

[0971] Table 492. Compounds of formula I.13, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[0972] Table 493. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 H and R 10 For H.

[0973] Table 494. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 For c-C3H5, R9 is CH3 and R 10 For H.

[0974] Table 495. Compounds of formula I.13, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[0975] Table 496. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 H and R 10 For H.

[0976] Table 497. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[0977] Table 498. Compounds of formula I.13, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[0978] Table 499. Compounds of formula I.13, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 H and R 10 For H.

[0979] Table 500. Compounds of formula I.13, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[0980] Table 501. Compounds of formula I.13, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[0981] Table 502. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 H and R 10 For H.

[0982] Table 503. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[0983] Table 504. Compounds of formula I.13, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[0984] Table 505. Compounds of formula I.13, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 H and R 10 For H.

[0985] Table 506. Compounds of formula I.13, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[0986] Table 507. Compounds of formula I.13, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[0987] Table 508. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 H and R 10 For H.

[0988] Table 509. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[0989] Table 510. Compounds of formula I.13, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[0990] Table 511. Compounds of formula I.13, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 H and R 10 For H.

[0991] Table 512. Compounds of formula I.13, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[0992] Table 513. Compounds of formula I.13, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[0993] Table 514. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 H and R 10 For H.

[0994] Table 515. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[0995] Table 516. Compounds of formula I.13, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[0996] Table 517. Compounds of formula I.13, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 H and R 10 For H.

[0997] Table 518. Compounds of formula I.13, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[0998] Table 519. Compounds of formula I.13, wherein R 1 For Y-4C, R2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[0999] Table 520. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 H and R 10 For H.

[1000] Table 521. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1001] Table 522. Compounds of formula I.13, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1002] Table 523. Compounds of formula I.13, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1003] Table 524. Compounds of formula I.13, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1004] Table 525. Compounds of formula I.13, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1005] Table 526. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1006] Table 527. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R10 For H.

[1007] Table 528. Compounds of formula I.13, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1008] Table 529. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1009] Table 530. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1010] Table 531. Compounds of formula I.13, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1011] Table 532. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1012] Table 533. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1013] Table 534. Compounds of formula I.13, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1014] Table 535. Compounds of formula I.13, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1015] Table 536. Compounds of formula I.13, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1016] Table 537. Compounds of formula I.13, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1017] Table 538. Compounds of formula I.13, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1018] Table 539. Compounds of formula I.13, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1019] Table 540. Compounds of formula I.13, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1020] Table 541. Compounds of formula I.14, wherein R 1 Y-1A, R 2 H, R 9 H and R 10 For H.

[1021] Table 542. Compounds of formula I.14, wherein R 1 Y-1A, R 2 H, R 9 CH3 and R 10 For H.

[1022] Table 543. Compounds of formula I.14, wherein R 1 Y-1A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1023] Table 544. Compounds of formula I.14, wherein R 1 For Y-1B, R 2H, R 9 H and R 10 For H.

[1024] Table 545. Compounds of formula I.14, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For H.

[1025] Table 546. Compounds of formula I.14, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1026] Table 547. Compounds of formula I.14, wherein R 1 For Y-2A, R 2 H, R 9 H and R 10 For H.

[1027] Table 548. Compounds of formula I.14, wherein R 1 For Y-2A, R 2 H, R 9 is CH3 and R 10 For H.

[1028] Table 549. Compounds of formula I.14, wherein R 1 For Y-2A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1029] Table 550. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 H, R 9 H and R 10 For H.

[1030] Table 551. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For H.

[1031] Table 552. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1032] Table 553. Compounds of formula I.14, wherein R 1 For Y-3A, R 2 H, R 9 H and R 10 For H.

[1033] Table 554. Compounds of formula I.14, wherein R 1 For Y-3A, R 2 H, R 9 is CH3 and R 10 For H.

[1034] Table 555. Compounds of formula I.14, wherein R 1 For Y-3A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1035] Table 556. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 H, R 9 H and R 10 For H.

[1036] Table 557. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 H, R 9 is CH3 and R 10 For H.

[1037] Table 558. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1038] Table 559. Compounds of formula I.14, wherein R 1 For Y-3C, R 2 H, R 9 H and R 10 For H.

[1039] Table 560. Compounds of formula I.14, wherein R 1 For Y-3C, R 2 H, R 9 is CH3 and R 10 For H.

[1040] Table 561. Compounds of formula I.14, wherein R 1 For Y-3C, R 2 H, R 9 is CH3 and R10 For CH3.

[1041] Table 562. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 H, R 9 H and R 10 For H.

[1042] Table 563. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For H.

[1043] Table 564. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For CH3.

[1044] Table 565. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 H, R 9 H and R 10 For H.

[1045] Table 566. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For H.

[1046] Table 567. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1047] Table 568. Compounds of formula I.14, wherein R 1 For Y-4B, R 2 H, R 9 H and R 10 For H.

[1048] Table 569. Compounds of formula I.14, wherein R 1 For Y-4B, R 2 H, R 9 is CH3 and R 10 For H.

[1049] Table 570. Compounds of formula I.14, wherein R 1 For Y-4B, R2 H, R 9 is CH3 and R 10 For CH3.

[1050] Table 571. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 H, R 9 H and R 10 For H.

[1051] Table 572. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For H.

[1052] Table 573. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For CH3.

[1053] Table 574. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 H, R 9 H and R 10 For H.

[1054] Table 575. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 H, R 9 is CH3 and R 10 For H.

[1055] Table 576. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 H, R 9 is CH3 and R 10 For CH3.

[1056] Table 577. Compounds of formula I.14, wherein R 1 For Y-5A, R 2 H, R 9 H and R 10 For H.

[1057] Table 578. Compounds of formula I.14, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For H.

[1058] Table 579. Compounds of formula I.14, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1059] Table 580. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 H, R 9 H and R 10 For H.

[1060] Table 581. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 H, R 9 is CH3 and R 10 For H.

[1061] Table 582. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1062] Table 583. Compounds of formula I.14, wherein R 1 For Y-6A, R 2 H, R 9 H and R 10 For H.

[1063] Table 584. Compounds of formula I.14, wherein R 1 For Y-6A, R 2 H, R 9 is CH3 and R 10 For H.

[1064] Table 585. Compounds of formula I.14, wherein R 1 For Y-6A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1065] Table 586. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 H, R 9 H and R 10 For H.

[1066] Table 587. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R10 For H.

[1067] Table 588. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1068] Table 589. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 H, R 9 H and R 10 For H.

[1069] Table 590. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 H, R 9 is CH3 and R 10 For H.

[1070] Table 591. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1071] Table 592. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 H, R 9 H and R 10 For H.

[1072] Table 593. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For H.

[1073] Table 594. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1074] Table 595. Compounds of formula I.14, wherein R 1 Y-1A, R 2 CH3, R 9 H and R 10 For H.

[1075] Table 596. Compounds of formula I.14, wherein R 1 Y-1A, R2 CH3, R 9 is CH3 and R 10 For H.

[1076] Table 597. Compounds of formula I.14, wherein R 1 Y-1A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1077] Table 598. Compounds of formula I.14, wherein R 1 For Y-1B, R 2 CH3, R 9 H and R 10 For H.

[1078] Table 599. Compounds of formula I.14, wherein R 1 For Y-1B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1079] Table 600. Compounds of formula I.14, wherein R 1 For Y-1B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1080] Table 601. Compounds of formula I.14, wherein R 1 For Y-2A, R 2 CH3, R 9 H and R 10 For H.

[1081] Table 602. Compounds of formula I.14, wherein R 1 For Y-2A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1082] Table 603. Compounds of formula I.14, wherein R 1 For Y-2A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1083] Table 604. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 CH3, R 9 H and R 10 For H.

[1084] Table 605. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1085] Table 606. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1086] Table 607. Compounds of formula I.14, wherein R 1 For Y-3A, R 2 CH3, R 9 H and R 10 For H.

[1087] Table 608. Compounds of formula I.14, wherein R 1 For Y-3A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1088] Table 609. Compounds of formula I.14, wherein R 1 For Y-3A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1089] Table 610. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 CH3, R 9 H and R 10 For H.

[1090] Table 611. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1091] Table 612. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1092] Table 613. Compounds of formula I.14, wherein R 1 For Y-3C, R 2CH3, R 9 H and R 10 For H.

[1093] Table 614. Compounds of formula I.14, wherein R 1 For Y-3C, R 2 CH3, R 9 is CH3 and R 10 For H.

[1094] Table 615. Compounds of formula I.14, wherein R 1 For Y-3C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1095] Table 616. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 CH3, R 9 H and R 10 For H.

[1096] Table 617. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 CH3, R 9 is CH3 and R 10 For H.

[1097] Table 618. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1098] Table 619. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 CH3, R 9 H and R 10 For H.

[1099] Table 620. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1100] Table 621. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1101] Table 622. Compounds of formula I.14, wherein R 1 For Y-4B, R 2 CH3, R 9 H and R 10 For H.

[1102] Table 623. Compounds of formula I.14, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1103] Table 624. Compounds of formula I.14, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1104] Table 625. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 CH3, R 9 H and R 10 For H.

[1105] Table 626. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For H.

[1106] Table 627. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1107] Table 628. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 CH3, R 9 H and R 10 For H.

[1108] Table 629. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 CH3, R 9 is CH3 and R 10 For H.

[1109] Table 630. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 CH3, R 9is CH3 and R 10 For CH3.

[1110] Table 631. Compounds of formula I.14, wherein R 1 For Y-5A, R 2 CH3, R 9 H and R 10 For H.

[1111] Table 632. Compounds of formula I.14, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1112] Table 633. Compounds of formula I.14, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1113] Table 634. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 CH3, R 9 H and R 10 For H.

[1114] Table 635. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1115] Table 636. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1116] Table 637. Compounds of formula I.14, wherein R 1 For Y-6A, R 2 CH3, R 9 H and R 10 For H.

[1117] Table 638. Compounds of formula I.14, wherein R 1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1118] Table 639. Compounds of formula I.14, wherein R1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1119] Table 640. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 CH3, R 9 H and R 10 For H.

[1120] Table 641. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1121] Table 642. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1122] Table 643. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 CH3, R 9 H and R 10 For H.

[1123] Table 644. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1124] Table 645. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1125] Table 646. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 CH3, R 9 H and R 10 For H.

[1126] Table 647. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 CH3, R 9 is CH3 and R10 For H.

[1127] Table 648. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1128] Table 649. Compounds of formula I.14, wherein R 1 Y-1A, R 2 For C2H5, R 9 H and R 10 For H.

[1129] Table 650. Compounds of formula I.14, wherein R 1 Y-1A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1130] Table 651. Compounds of formula I.14, wherein R 1 Y-1A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1131] Table 652. Compounds of formula I.14, wherein R 1 For Y-1B, R 2 For C2H5, R 9 H and R 10 For H.

[1132] Table 653. Compounds of formula I.14, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1133] Table 654. Compounds of formula I.14, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1134] Table 655. Compounds of formula I.14, wherein R 1 For Y-2A, R 2 For C2H5, R 9 H and R 10 For H.

[1135] Table 656. Compounds of formula I.14, wherein R1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1136] Table 657. Compounds of formula I.14, wherein R 1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1137] Table 658. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 For C2H5, R 9 H and R 10 For H.

[1138] Table 659. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1139] Table 660. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1140] Table 661. Compounds of formula I.14, wherein R 1 For Y-3A, R 2 For C2H5, R 9 H and R 10 For H.

[1141] Table 662. Compounds of formula I.14, wherein R 1 For Y-3A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1142] Table 663. Compounds of formula I.14, wherein R 1 For Y-3A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1143] Table 664. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 For C2H5, R 9 H and R10 For H.

[1144] Table 665. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1145] Table 666. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1146] Table 667. Compounds of formula I.14, wherein R 1 For Y-3C, R 2 For C2H5, R 9 H and R 10 For H.

[1147] Table 668. Compounds of formula I.14, wherein R 1 For Y-3C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1148] Table 669. Compounds of formula I.14, wherein R 1 For Y-3C, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1149] Table 670. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 For C2H5, R 9 H and R 10 For H.

[1150] Table 671. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1151] Table 672. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1152] Table 673. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 For C2H5, R 9 H and R 10 For H.

[1153] Table 674. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1154] Table 675. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1155] Table 676. Compounds of formula I.14, wherein R 1 For Y-4B, R 2 For C2H5, R 9 H and R 10 For H.

[1156] Table 677. Compounds of formula I.14, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1157] Table 678. Compounds of formula I.14, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1158] Table 679. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 For C2H5, R 9 H and R 10 For H.

[1159] Table 680. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1160] Table 681. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 For C2H5, R9 is CH3 and R 10 For CH3.

[1161] Table 682. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 For C2H5, R 9 H and R 10 For H.

[1162] Table 683. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1163] Table 684. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1164] Table 685. Compounds of formula I.14, wherein R 1 For Y-5A, R 2 For C2H5, R 9 H and R 10 For H.

[1165] Table 686. Compounds of formula I.14, wherein R 1 For Y-5A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1166] Table 687. Compounds of formula I.14, wherein R 1 For Y-5A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1167] Table 688. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 For C2H5, R 9 H and R 10 For H.

[1168] Table 689. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1169] Table 690. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1170] Table 691. Compounds of formula I.14, wherein R 1 For Y-6A, R 2 For C2H5, R 9 H and R 10 For H.

[1171] Table 692. Compounds of formula I.14, wherein R 1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1172] Table 693. Compounds of formula I.14, wherein R 1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1173] Table 694. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 For C2H5, R 9 H and R 10 For H.

[1174] Table 695. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1175] Table 696. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1176] Table 697. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 For C2H5, R 9 H and R 10 For H.

[1177] Table 698. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 For C2H5, R9 is CH3 and R 10 For H.

[1178] Table 699. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1179] Table 700. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 For C2H5, R 9 H and R 10 For H.

[1180] Table 701. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1181] Table 702. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1182] Table 703. Compounds of formula I.14, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1183] Table 704. Compounds of formula I.14, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1184] Table 705. Compounds of formula I.14, wherein R 1 Y-1A, R 2 c-C3H5, R 9 is CH3 and R 10 For CH3.

[1185] Table 706. Compounds of formula I.14, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1186] Table 707. Compounds of formula I.14, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 CH3, R 10 For H.

[1187] Table 708. Compounds of formula I.14, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1188] Table 709. Compounds of formula I.14, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1189] Table 710. Compounds of formula I.14, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1190] Table 711. Compounds of formula I.14, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1191] Table 712. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1192] Table 713. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1193] Table 714. Compounds of formula I.14, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1194] Table 715. Compounds of formula I.14, wherein R 1For Y-3A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1195] Table 716. Compounds of formula I.14, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1196] Table 717. Compounds of formula I.14, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1197] Table 718. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1198] Table 719. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1199] Table 720. Compounds of formula I.14, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1200] Table 721. Compounds of formula I.14, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 H and R 10 For H.

[1201] Table 722. Compounds of formula I.14, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1202] Table 723. Compounds of formula I.14, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9is CH3 and R 10 For CH3.

[1203] Table 724. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 H and R 10 For H.

[1204] Table 725. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1205] Table 726. Compounds of formula I.14, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1206] Table 727. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1207] Table 728. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1208] Table 729. Compounds of formula I.14, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1209] Table 730. Compounds of formula I.14, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1210] Table 731. Compounds of formula I.14, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1211] Table 732. Compounds of formula I.14, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1212] Table 733. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 H and R 10 For H.

[1213] Table 734. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1214] Table 735. Compounds of formula I.14, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1215] Table 736. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 H and R 10 For H.

[1216] Table 737. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1217] Table 738. Compounds of formula I.14, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1218] Table 739. Compounds of formula I.14, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1219] Table 740. Compounds of formula I.14, wherein R 1For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1220] Table 741. Compounds of formula I.14, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1221] Table 742. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1222] Table 743. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1223] Table 744. Compounds of formula I.14, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1224] Table 745. Compounds of formula I.14, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1225] Table 746. Compounds of formula I.14, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1226] Table 747. Compounds of formula I.14, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1227] Table 748. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 For c-C3H5, R9 H and R 10 For H.

[1228] Table 749. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1229] Table 750. Compounds of formula I.14, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1230] Table 751. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1231] Table 752. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1232] Table 753. Compounds of formula I.14, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1233] Table 754. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1234] Table 755. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1235] Table 756. Compounds of formula I.14, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1236] Table 757. Compounds of formula I.15, wherein R 1 Y-1A, R 2 H, R 9 H and R 10 For H.

[1237] Table 758. Compounds of formula I.15, wherein R 1 Y-1A, R 2 H, R 9 CH3 and R 10 For H.

[1238] Table 759. Compounds of formula I.15, wherein R 1 Y-1A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1239] Table 760. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 H, R 9 H and R 10 For H.

[1240] Table 761. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For H.

[1241] Table 762. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1242] Table 763. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 H, R 9 H and R 10 For H.

[1243] Table 764. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 H, R 9 is CH3 and R 10 For H.

[1244] Table 765. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 H, R9 is CH3 and R 10 For CH3.

[1245] Table 766. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 H, R 9 H and R 10 For H.

[1246] Table 767. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For H.

[1247] Table 768. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1248] Table 769. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 H, R 9 H and R 10 For H.

[1249] Table 770. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 H, R 9 is CH3 and R 10 For H.

[1250] Table 771. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1251] Table 772. Compounds of formula I.15, wherein R 1 For Y-3B, R 2 H, R 9 H and R 10 For H.

[1252] Table 773. Compounds of formula I.15, wherein R 1 For Y-3B, R 2 H, R 9 is CH3 and R 10 For H.

[1253] Table 774. Compounds of formula I.15, wherein R1 For Y-3B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1254] Table 775. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 H, R 9 H and R 10 For H.

[1255] Table 776. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 H, R 9 is CH3 and R 10 For H.

[1256] Table 777. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 H, R 9 is CH3 and R 10 For CH3.

[1257] Table 778. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 H, R 9 H and R 10 For H.

[1258] Table 779. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For H.

[1259] Table 780. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For CH3.

[1260] Table 781. Compounds of formula I.15, wherein R 1 For Y-4A, R 2 H, R 9 H and R 10 For H.

[1261] Table 782. Compounds of formula I.15, wherein R 1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For H.

[1262] Table 783. Compounds of formula I.15, wherein R 1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1263] Table 784. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 H, R 9 H and R 10 For H.

[1264] Table 785. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 H, R 9 is CH3 and R 10 For H.

[1265] Table 786. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1266] Table 787. Compounds of formula I.15, wherein R 1 For Y-4C, R 2 H, R 9 H and R 10 For H.

[1267] Table 788. Compounds of formula I.15, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For H.

[1268] Table 789. Compounds of formula I.15, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For CH3.

[1269] Table 790. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 H, R 9 H and R 10 For H.

[1270] Table 791. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 H, R 9is CH3 and R 10 For H.

[1271] Table 792. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 H, R 9 is CH3 and R 10 For CH3.

[1272] Table 793. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 H, R 9 H and R 10 For H.

[1273] Table 794. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For H.

[1274] Table 795. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1275] Table 796. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 H, R 9 H and R 10 For H.

[1276] Table 797. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 H, R 9 is CH3 and R 10 For H.

[1277] Table 798. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1278] Table 799. Compounds of formula I.15, wherein R 1 For Y-6A, R 2 H, R 9 H and R 10 For H.

[1279] Table 800. Compounds of formula I.15, wherein R 1For Y-6A, R 2 H, R 9 is CH3 and R 10 For H.

[1280] Table 801. Compounds of formula I.15, wherein R 1 For Y-6A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1281] Table 802. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 H, R 9 H and R 10 For H.

[1282] Table 803. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R 10 For H.

[1283] Table 804. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1284] Table 805. Compounds of formula I.15, wherein R 1 For Y-8A, R 2 H, R 9 H and R 10 For H.

[1285] Table 806. Compounds of formula I.15, wherein R 1 For Y-8A, R 2 H, R 9 is CH3 and R 10 For H.

[1286] Table 807. Compounds of formula I.15, wherein R 1 For Y-8A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1287] Table 808. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 H, R 9 H and R 10 For H.

[1288] Table 809. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For H.

[1289] Table 810. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1290] Table 811. Compounds of formula I.15, wherein R 1 Y-1A, R 2 CH3, R 9 H and R 10 For H.

[1291] Table 812. Compounds of formula I.15, wherein R 1 Y-1A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1292] Table 813. Compounds of formula I.15, wherein R 1 Y-1A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1293] Table 814. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 CH3, R 9 H and R 10 For H.

[1294] Table 815. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1295] Table 816. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1296] Table 817. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 CH3, R9 H and R 10 For H.

[1297] Table 818. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1298] Table 819. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1299] Table 820. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 CH3, R 9 H and R 10 For H.

[1300] Table 821. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1301] Table 822. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1302] Table 823. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 CH3, R 9 H and R 10 For H.

[1303] Table 824. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1304] Table 825. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1305] Table 826. Compounds of formula I.15, wherein R 1 For Y-3B, R 2 CH3, R 9 H and R 10 For H.

[1306] Table 827. Compounds of formula I.15, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1307] Table 828. Compounds of formula I.15, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1308] Table 829. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 CH3, R 9 H and R 10 For H.

[1309] Table 830. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 CH3, R 9 is CH3 and R 10 For H.

[1310] Table 831. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1311] Table 832. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 CH3, R 9 H and R 10 For H.

[1312] Table 833. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 CH3, R 9 is CH3 and R 10 For H.

[1313] Table 834. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 CH3, R 9is CH3 and R 10 For CH3.

[1314] Table 835. Compounds of formula I.15, wherein R 1 For Y-4A, R 2 CH3, R 9 H and R 10 For H.

[1315] Table 836. Compounds of formula I.15, wherein R 1 For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1316] Table 837. Compounds of formula I.15, wherein R 1 For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1317] Table 838. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 CH3, R 9 H and R 10 For H.

[1318] Table 839. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1319] Table 840. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1320] Table 841. Compounds of formula I.15, wherein R 1 For Y-4C, R 2 CH3, R 9 H and R 10 For H.

[1321] Table 842. Compounds of formula I.15, wherein R 1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For H.

[1322] Table 843. Compounds of formula I.15, wherein R1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1323] Table 844. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 CH3, R 9 H and R 10 For H.

[1324] Table 845. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 CH3, R 9 is CH3 and R 10 For H.

[1325] Table 846. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1326] Table 847. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 CH3, R 9 H and R 10 For H.

[1327] Table 848. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1328] Table 849. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1329] Table 850. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 CH3, R 9 H and R 10 For H.

[1330] Table 851. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R10 For H.

[1331] Table 852. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1332] Table 853. Compounds of formula I.15, wherein R 1 For Y-6A, R 2 CH3, R 9 H and R 10 For H.

[1333] Table 854. Compounds of formula I.15, wherein R 1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1334] Table 855. Compounds of formula I.15, wherein R 1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1335] Table 856. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 CH3, R 9 H and R 10 For H.

[1336] Table 857. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1337] Table 858. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1338] Table 859. Compounds of formula I.15, wherein R 1 For Y-8A, R 2 CH3, R 9 H and R 10 For H.

[1339] Table 860. Compounds of formula I.15, wherein R1 For Y-8A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1340] Table 861. Compounds of formula I.15, wherein R 1 For Y-8A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1341] Table 862. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 CH3, R 9 H and R 10 For H.

[1342] Table 863. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1343] Table 864. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1344] Table 865. Compounds of formula I.15, wherein R 1 Y-1A, R 2 For C2H5, R 9 H and R 10 For H.

[1345] Table 866. Compounds of formula I.15, wherein R 1 Y-1A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1346] Table 867. Compounds of formula I.15, wherein R 1 Y-1A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1347] Table 868. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 For C2H5, R 9 H and R10 For H.

[1348] Table 869. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1349] Table 870. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1350] Table 871. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 For C2H5, R 9 H and R 10 For H.

[1351] Table 872. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1352] Table 873. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1353] Table 874. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 For C2H5, R 9 H and R 10 For H.

[1354] Table 875. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1355] Table 876. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1356] Table 877. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 For C2H5, R 9 H and R 10 For H.

[1357] Table 878. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1358] Table 879. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1359] Table 880. Compounds of formula I.15, wherein R 1 For Y-3B, R 2 For C2H5, R 9 H and R 10 For H.

[1360] Table 881. Compounds of formula I.15, wherein R 1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1361] Table 882. Compounds of formula I.15, wherein R 1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1362] Table 883. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 For C2H5, R 9 H and R 10 For H.

[1363] Table 884. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1364] Table 885. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 For C2H5, R9 is CH3 and R 10 For CH3.

[1365] Table 886. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 For C2H5, R 9 H and R 10 For H.

[1366] Table 887. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1367] Table 888. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1368] Table 889. Compounds of formula I.15, wherein R 1 For Y-4A, R 2 For C2H5, R 9 H and R 10 For H.

[1369] Table 890. Compounds of formula I.15, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1370] Table 891. Compounds of formula I.15, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1371] Table 892. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 For C2H5, R 9 H and R 10 For H.

[1372] Table 893. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1373] Table 894. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1374] Table 895. Compounds of formula I.15, wherein R 1 For Y-4C, R 2 For C2H5, R 9 H and R 10 For H.

[1375] Table 896. Compounds of formula I.15, wherein R 1 For Y-4C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1376] Table 897. Compounds of formula I.15, wherein R 1 For Y-4C, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1377] Table 898. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 For C2H5, R 9 H and R 10 For H.

[1378] Table 899. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1379] Table 900. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1380] Table 901. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 For C2H5, R 9 H and R 10 For H.

[1381] Table 902. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 For C2H5, R9 is CH3 and R 10 For H.

[1382] Table 903. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1383] Table 904. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 For C2H5, R 9 H and R 10 For H.

[1384] Table 905. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1385] Table 906. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1386] Table 907. Compounds of formula I.15, wherein R 1 For Y-6A, R 2 For C2H5, R 9 H and R 10 For H.

[1387] Table 908. Compounds of formula I.15, wherein R 1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1388] Table 909. Compounds of formula I.15, wherein R 1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1389] Table 910. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 For C2H5, R 9 H and R 10 For H.

[1390] Table 911. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1391] Table 912. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1392] Table 913. Compounds of formula I.15, wherein R 1 For Y-8A, R 2 For C2H5, R 9 H and R 10 For H.

[1393] Table 914. Compounds of formula I.15, wherein R 1 For Y-8A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1394] Table 915. Compounds of formula I.15, wherein R 1 For Y-8A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1395] Table 916. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 For C2H5, R 9 H and R 10 For H.

[1396] Table 917. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1397] Table 918. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1398] Table 919. Compounds of formula I.15, wherein R 1 Y-1A, R 2For c-C3H5, R 9 H and R 10 For H.

[1399] Table 920. Compounds of formula I.15, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1400] Table 921. Compounds of formula I.15, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1401] Table 922. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1402] Table 923. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 CH3, R 10 For H.

[1403] Table 924. Compounds of formula I.15, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1404] Table 925. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1405] Table 926. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1406] Table 927. Compounds of formula I.15, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 is CH3 and R 10For CH3.

[1407] Table 928. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1408] Table 929. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1409] Table 930. Compounds of formula I.15, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1410] Table 931. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1411] Table 932. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1412] Table 933. Compounds of formula I.15, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1413] Table 934. Compounds of formula I.15, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1414] Table 935. Compounds of formula I.15, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1415] Table 936. Compounds of formula I.15, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1416] Table 937. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 H and R 10 For H.

[1417] Table 938. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1418] Table 939. Compounds of formula I.15, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1419] Table 940. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 H and R 10 For H.

[1420] Table 941. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1421] Table 942. Compounds of formula I.15, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1422] Table 943. Compounds of formula I.15, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1423] Table 944. Compounds of formula I.15, wherein R 1 For Y-4A, R2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1424] Table 945. Compounds of formula I.15, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1425] Table 946. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1426] Table 947. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1427] Table 948. Compounds of formula I.15, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1428] Table 949. Compounds of formula I.15, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 H and R 10 For H.

[1429] Table 950. Compounds of formula I.15, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1430] Table 951. Compounds of formula I.15, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1431] Table 952. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 H and R10 For H.

[1432] Table 953. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1433] Table 954. Compounds of formula I.15, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1434] Table 955. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1435] Table 956. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1436] Table 957. Compounds of formula I.15, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1437] Table 958. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1438] Table 959. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1439] Table 960. Compounds of formula I.15, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1440] Table 961. Compounds of formula I.15, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1441] Table 962. Compounds of formula I.15, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1442] Table 963. Compounds of formula I.15, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1443] Table 964. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1444] Table 965. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1445] Table 966. Compounds of formula I.15, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1446] Table 967. Compounds of formula I.15, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1447] Table 968. Compounds of formula I.15, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1448] Table 969. Compounds of formula I.15, wherein R 1 For Y-8A, R2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1449] Table 970. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1450] Table 971. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1451] Table 972. Compounds of formula I.15, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1452] Table 973. Compounds of formula I.16, wherein R 1 Y-1A, R 2 H, R 9 H and R 10 For H.

[1453] Table 974. Compounds of formula I.16, wherein R 1 Y-1A, R 2 H, R 9 CH3 and R 10 For H.

[1454] Table 975. Compounds of formula I.16, wherein R 1 Y-1A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1455] Table 976. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 H, R 9 H and R 10 For H.

[1456] Table 977. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For H.

[1457] Table 978. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1458] Table 979. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 H, R 9 H and R 10 For H.

[1459] Table 980. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 H, R 9 is CH3 and R 10 For H.

[1460] Table 981. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1461] Table 982. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 H, R 9 H and R 10 For H.

[1462] Table 983. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For H.

[1463] Table 984. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1464] Table 985. Compounds of formula I.16, wherein R 1 For Y-3A, R 2 H, R 9 H and R 10 For H.

[1465] Table 986. Compounds of formula I.16, wherein R 1 For Y-3A, R 2 H, R9 is CH3 and R 10 For H.

[1466] Table 987. Compounds of formula I.16, wherein R 1 For Y-3A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1467] Table 988. Compounds of formula I.16, wherein R 1 For Y-3B, R 2 H, R 9 H and R 10 For H.

[1468] Table 989. Compounds of formula I.16, wherein R 1 For Y-3B, R 2 H, R 9 is CH3 and R 10 For H.

[1469] Table 990. Compounds of formula I.16, wherein R 1 For Y-3B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1470] Table 991. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 H, R 9 H and R 10 For H.

[1471] Table 992. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 H, R 9 is CH3 and R 10 For H.

[1472] Table 993. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 H, R 9 is CH3 and R 10 For CH3.

[1473] Table 994. Compounds of formula I.16, wherein R 1 For Y-3D, R 2 H, R 9 H and R 10 For H.

[1474] Table 995. Compounds of formula I.16, wherein R1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For H.

[1475] Table 996. Compounds of formula I.16, wherein R 1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For CH3.

[1476] Table 997. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 H, R 9 H and R 10 For H.

[1477] Table 998. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For H.

[1478] Table 999. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1479] Table 1000. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 H, R 9 H and R 10 For H.

[1480] Table 1001. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 H, R 9 is CH3 and R 10 For H.

[1481] Table 1002. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1482] Table 1003. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 H, R 9 H and R 10 For H.

[1483] Table 1004. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For H.

[1484] Table 1005. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For CH3.

[1485] Table 1006. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 H, R 9 H and R 10 For H.

[1486] Table 1007. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 H, R 9 is CH3 and R 10 For H.

[1487] Table 1008. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 H, R 9 is CH3 and R 10 For CH3.

[1488] Table 1009. Compounds of formula I.16, wherein R 1 For Y-5A, R 2 H, R 9 H and R 10 For H.

[1489] Table 1010. Compounds of formula I.16, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For H.

[1490] Table 1011. Compounds of formula I.16, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1491] Table 1012. Compounds of formula I.16, wherein R 1 For Y-5B, R2 H, R 9 H and R 10 For H.

[1492] Table 1013. Compounds of formula I.16, wherein R 1 For Y-5B, R 2 H, R 9 is CH3 and R 10 For H.

[1493] Table 1014. Compounds of formula I.16, wherein R 1 For Y-5B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1494] Table 1015. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 H, R 9 H and R 10 For H.

[1495] Table 1016. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 H, R 9 is CH3 and R 10 For H.

[1496] Table 1017. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1497] Table 1018. Compounds of formula I.16, wherein R 1 For Y-6B, R 2 H, R 9 H and R 10 For H.

[1498] Table 1019. Compounds of formula I.16, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R 10 For H.

[1499] Table 1020. Compounds of formula I.16, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1500] Table 1021. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 H, R 9 H and R 10 For H.

[1501] Table 1022. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 H, R 9 is CH3 and R 10 For H.

[1502] Table 1023. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1503] Table 1024. Compounds of formula I.16, wherein R 1 For Y-8B, R 2 H, R 9 H and R 10 For H.

[1504] Table 1025. Compounds of formula I.16, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For H.

[1505] Table 1026. Compounds of formula I.16, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1506] Table 1027. Compounds of formula I.16, wherein R 1 Y-1A, R 2 CH3, R 9 H and R 10 For H.

[1507] Table 1028. Compounds of formula I.16, wherein R 1 Y-1A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1508] Table 1029. Compounds of formula I.16, wherein R 1 Y-1A, R 2 CH3, R9 is CH3 and R 10 For CH3.

[1509] Table 1030. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 CH3, R 9 H and R 10 For H.

[1510] Table 1031. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1511] Table 1032. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1512] Table 1033. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 CH3, R 9 H and R 10 For H.

[1513] Table 1034. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1514] Table 1035. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1515] Table 1036. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 CH3, R 9 H and R 10 For H.

[1516] Table 1037. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1517] Table 1038. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1518] Table 1039. Compounds of formula I.16, wherein R 1 For Y-3A, R 2 CH3, R 9 H and R 10 For H.

[1519] Table 1040. Compounds of formula I.16, wherein R 1 For Y-3A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1520] Table 1041. Compounds of formula I.16, wherein R 1 For Y-3A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1521] Table 1042. Compounds of formula I.16, wherein R 1 For Y-3B, R 2 CH3, R 9 H and R 10 For H.

[1522] Table 1043. Compounds of formula I.16, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1523] Table 1044. Compounds of formula I.16, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1524] Table 1045. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 CH3, R 9 H and R 10 For H.

[1525] Table 1046. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 CH3, R9 is CH3 and R 10 For H.

[1526] Table 1047. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1527] Table 1048. Compounds of formula I.16, wherein R 1 For Y-3D, R 2 CH3, R 9 H and R 10 For H.

[1528] Table 1049. Compounds of formula I.16, wherein R 1 For Y-3D, R 2 CH3, R 9 is CH3 and R 10 For H.

[1529] Table 1050. Compounds of formula I.16, wherein R 1 For Y-3D, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1530] Table 1051. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 CH3, R 9 H and R 10 For H.

[1531] Table 1052. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1532] Table 1053. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1533] Table 1054. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 CH3, R 9 H and R 10 For H.

[1534] Table 1055. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1535] Table 1056. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1536] Table 1057. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 CH3, R 9 H and R 10 For H.

[1537] Table 1058. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For H.

[1538] Table 1059. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1539] Table 1060. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 CH3, R 9 H and R 10 For H.

[1540] Table 1061. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 CH3, R 9 is CH3 and R 10 For H.

[1541] Table 1062. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1542] Table 1063. Compounds of formula I.16, wherein R 1 For Y-5A, R 2CH3, R 9 H and R 10 For H.

[1543] Table 1064. Compounds of formula I.16, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1544] Table 1065. Compounds of formula I.16, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1545] Table 1066. Compounds of formula I.16, wherein R 1 For Y-5B, R 2 CH3, R 9 H and R 10 For H.

[1546] Table 1067. Compounds of formula I.16, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1547] Table 1068. Compounds of formula I.16, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1548] Table 1069. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 CH3, R 9 H and R 10 For H.

[1549] Table 1070. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1550] Table 1071. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1551] Table 1072. Compounds of formula I.16, wherein R 1 For Y-6B, R 2 CH3, R 9 H and R 10 For H.

[1552] Table 1073. Compounds of formula I.16, wherein R 1 For Y-6B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1553] Table 1074. Compounds of formula I.16, wherein R 1 For Y-6B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1554] Table 1075. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 CH3, R 9 H and R 10 For H.

[1555] Table 1076. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1556] Table 1077. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1557] Table 1078. Compounds of formula I.16, wherein R 1 For Y-8B, R 2 CH3, R 9 H and R 10 For H.

[1558] Table 1079. Compounds of formula I.16, wherein R 1 For Y-8B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1559] Table 1080. Compounds of formula I.16, wherein R 1 For Y-8B, R2 CH3, R 9 is CH3 and R 10 For CH3.

[1560] Table 1081. Compounds of formula I.16, wherein R 1 Y-1A, R 2 For C2H5, R 9 H and R 10 For H.

[1561] Table 1082. Compounds of formula I.16, wherein R 1 Y-1A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1562] Table 1083. Compounds of formula I.16, wherein R 1 Y-1A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1563] Table 1084. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 For C2H5, R 9 H and R 10 For H.

[1564] Table 1085. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1565] Table 1086. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1566] Table 1087. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 For C2H5, R 9 H and R 10 For H.

[1567] Table 1088. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10For H.

[1568] Table 1089. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1569] Table 1090. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 For C2H5, R 9 H and R 10 For H.

[1570] Table 1091. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1571] Table 1092. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1572] Table 1093. Compounds of formula I.16, wherein R 1 For Y-3A, R 2 For C2H5, R 9 H and R 10 For H.

[1573] Table 1094. Compounds of formula I.16, wherein R 1 For Y-3A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1574] Table 1095. Compounds of formula I.16, wherein R 1 For Y-3A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1575] Table 1096. Compounds of formula I.16, wherein R 1 For Y-3B, R 2 For C2H5, R 9 H and R 10 For H.

[1576] Table 1097. Compounds of formula I.16, wherein R1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1577] Table 1098. Compounds of formula I.16, wherein R 1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1578] Table 1099. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 For C2H5, R 9 H and R 10 For H.

[1579] Table 1100. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1580] Table 1101. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1581] Table 1102. Compounds of formula I.16, wherein R 1 For Y-3D, R 2 For C2H5, R 9 H and R 10 For H.

[1582] Table 1103. Compounds of formula I.16, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1583] Table 1104. Compounds of formula I.16, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1584] Table 1105. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 For C2H5, R9 H and R 10 For H.

[1585] Table 1106. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1586] Table 1107. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1587] Table 1108. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 For C2H5, R 9 H and R 10 For H.

[1588] Table 1109. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1589] Table 1110. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1590] Table 1111. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 For C2H5, R 9 H and R 10 For H.

[1591] Table 1112. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1592] Table 1113. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1593] Table 1114. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 For C2H5, R 9 H and R 10 For H.

[1594] Table 1115. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1595] Table 1116. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1596] Table 1117. Compounds of formula I.16, wherein R 1 For Y-5A, R 2 For C2H5, R 9 H and R 10 For H.

[1597] Table 1118. Compounds of formula I.16, wherein R 1 For Y-5A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1598] Table 1119. Compounds of formula I.16, wherein R 1 For Y-5A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1599] Table 1120. Compounds of formula I.16, wherein R 1 For Y-5B, R 2 For C2H5, R 9 H and R 10 For H.

[1600] Table 1121. Compounds of formula I.16, wherein R 1 For Y-5B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1601] Table 1122. Compounds of formula I.16, wherein R 1 For Y-5B, R2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1602] Table 1123. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 For C2H5, R 9 H and R 10 For H.

[1603] Table 1124. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1604] Table 1125. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1605] Table 1126. Compounds of formula I.16, wherein R 1 For Y-6B, R 2 For C2H5, R 9 H and R 10 For H.

[1606] Table 1127. Compounds of formula I.16, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1607] Table 1128. Compounds of formula I.16, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1608] Table 1129. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 For C2H5, R 9 H and R 10 For H.

[1609] Table 1130. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 For C2H5, R 9 is CH3 and R 10For H.

[1610] Table 1131. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1611] Table 1132. Compounds of formula I.16, wherein R 1 For Y-8B, R 2 For C2H5, R 9 H and R 10 For H.

[1612] Table 1133. Compounds of formula I.16, wherein R 1 For Y-8B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1613] Table 1134. Compounds of formula I.16, wherein R 1 For Y-8B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1614] Table 1135. Compounds of formula I.16, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1615] Table 1136. Compounds of formula I.16, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1616] Table 1137. Compounds of formula I.16, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1617] Table 1138. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1618] Table 1139. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 CH3, R 10 For H.

[1619] Table 1140. Compounds of formula I.16, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1620] Table 1141. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1621] Table 1142. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1622] Table 1143. Compounds of formula I.16, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1623] Table 1144. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1624] Table 1145. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1625] Table 1146. Compounds of formula I.16, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1626] Table 1147. Compounds of formula I.16, wherein R 1For Y-3A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1627] Table 1148. Compounds of formula I.16, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1628] Table 1149. Compounds of formula I.16, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1629] Table 1150. Compounds of formula I.16, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1630] Table 1151. Compounds of formula I.16, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1631] Table 1152. Compounds of formula I.16, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1632] Table 1153. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 H and R 10 For H.

[1633] Table 1154. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1634] Table 1155. Compounds of formula I.16, wherein R 1 For Y-3C, R 2 For c-C3H5, R9 is CH3 and R 10 For CH3.

[1635] Table 1156. Compounds of formula I.16, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 H and R 10 For H.

[1636] Table 1157. Compounds of formula I.16, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1637] Table 1158. Compounds of formula I.16, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1638] Table 1159. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1639] Table 1160. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1640] Table 1161. Compounds of formula I.16, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1641] Table 1162. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1642] Table 1163. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1643] Table 1164. Compounds of formula I.16, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1644] Table 1165. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 H and R 10 For H.

[1645] Table 1166. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1646] Table 1167. Compounds of formula I.16, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1647] Table 1168. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 H and R 10 For H.

[1648] Table 1169. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1649] Table 1170. Compounds of formula I.16, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1650] Table 1171. Compounds of formula I.16, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1651] Table 1172. Compounds of formula I.16, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1652] Table 1173. Compounds of formula I.16, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1653] Table 1174. Compounds of formula I.16, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1654] Table 1175. Compounds of formula I.16, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1655] Table 1176. Compounds of formula I.16, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1656] Table 1177. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1657] Table 1178. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1658] Table 1179. Compounds of formula I.16, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1659] Table 1180. Compounds of formula I.16, wherein R 1For Y-6B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1660] Table 1181. Compounds of formula I.16, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1661] Table 1182. Compounds of formula I.16, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1662] Table 1183. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1663] Table 1184. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1664] Table 1185. Compounds of formula I.16, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1665] Table 1186. Compounds of formula I.16, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1666] Table 1187. Compounds of formula I.16, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1667] Table 1188. Compounds of formula I.16, wherein R 1 For Y-8B, R 2 For c-C3H5, R9 is CH3 and R 10 For CH3.

[1668] Table 1189. Compounds of formula I.17, wherein R 1 Y-1A, R 2 H, R 9 H and R 10 For H.

[1669] Table 1190. Compounds of formula I.17, wherein R 1 Y-1A, R 2 H, R 9 CH3 and R 10 For H.

[1670] Table 1191. Compounds of formula I.17, wherein R 1 Y-1A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1671] Table 1192. Compounds of formula I.17, wherein R 1 For Y-1B, R 2 H, R 9 H and R 10 For H.

[1672] Table 1193. Compounds of formula I.17, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For H.

[1673] Table 1194. Compounds of formula I.17, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1674] Table 1195. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 H, R 9 H and R 10 For H.

[1675] Table 1196. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 H, R 9 is CH3 and R 10 For H.

[1676] Table 1197. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1677] Table 1198. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 H, R 9 H and R 10 For H.

[1678] Table 1199. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For H.

[1679] Table 1200. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1680] Table 1201. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 H, R 9 H and R 10 For H.

[1681] Table 1202. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 H, R 9 is CH3 and R 10 For H.

[1682] Table 1203. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1683] Table 1204. Compounds of formula I.17, wherein R 1 For Y-3B, R 2 H, R 9 H and R 10 For H.

[1684] Table 1205. Compounds of formula I.17, wherein R 1 For Y-3B, R 2 H, R 9is CH3 and R 10 For H.

[1685] Table 1206. Compounds of formula I.17, wherein R 1 For Y-3B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1686] Table 1207. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 H, R 9 H and R 10 For H.

[1687] Table 1208. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 H, R 9 is CH3 and R 10 For H.

[1688] Table 1209. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 H, R 9 is CH3 and R 10 For CH3.

[1689] Table 1210. Compounds of formula I.17, wherein R 1 For Y-3D, R 2 H, R 9 H and R 10 For H.

[1690] Table 1211. Compounds of formula I.17, wherein R 1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For H.

[1691] Table 1212. Compounds of formula I.17, wherein R 1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For CH3.

[1692] Table 1213. Compounds of formula I.17, wherein R 1 For Y-4A, R 2 H, R 9 H and R 10 For H.

[1693] Table 1214. Compounds of formula I.17, wherein R1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For H.

[1694] Table 1215. Compounds of formula I.17, wherein R 1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1695] Table 1216. Compounds of formula I.17, wherein R 1 For Y-4B, R 2 H, R 9 H and R 10 For H.

[1696] Table 1217. Compounds of formula I.17, wherein R 1 For Y-4B, R 2 H, R 9 is CH3 and R 10 For H.

[1697] Table 1218. Compounds of formula I.17, wherein R 1 For Y-4B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1698] Table 1219. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 H, R 9 H and R 10 For H.

[1699] Table 1220. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For H.

[1700] Table 1221. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For CH3.

[1701] Table 1222. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 H, R 9 H and R 10 For H.

[1702] Table 1223. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 H, R 9 is CH3 and R 10 For H.

[1703] Table 1224. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 H, R 9 is CH3 and R 10 For CH3.

[1704] Table 1225. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 H, R 9 H and R 10 For H.

[1705] Table 1226. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For H.

[1706] Table 1227. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1707] Table 1228. Compounds of formula I.17, wherein R 1 For Y-5B, R 2 H, R 9 H and R 10 For H.

[1708] Table 1229. Compounds of formula I.17, wherein R 1 For Y-5B, R 2 H, R 9 is CH3 and R 10 For H.

[1709] Table 1230. Compounds of formula I.17, wherein R 1 For Y-5B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1710] Table 1231. Compounds of formula I.17, wherein R 1 For Y-6A, R2 H, R 9 H and R 10 For H.

[1711] Table 1232. Compounds of formula I.17, wherein R 1 For Y-6A, R 2 H, R 9 is CH3 and R 10 For H.

[1712] Table 1233. Compounds of formula I.17, wherein R 1 For Y-6A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1713] Table 1234. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 H, R 9 H and R 10 For H.

[1714] Table 1235. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R 10 For H.

[1715] Table 1236. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1716] Table 1237. Compounds of formula I.17, wherein R 1 For Y-8A, R 2 H, R 9 H and R 10 For H.

[1717] Table 1238. Compounds of formula I.17, wherein R 1 For Y-8A, R 2 H, R 9 is CH3 and R 10 For H.

[1718] Table 1239. Compounds of formula I.17, wherein R 1 For Y-8A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1719] Table 1240. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 H, R 9 H and R 10 For H.

[1720] Table 1241. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For H.

[1721] Table 1242. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1722] Table 1243. Compounds of formula I.17, wherein R 1 Y-1A, R 2 CH3, R 9 H and R 10 For H.

[1723] Table 1244. Compounds of formula I.17, wherein R 1 Y-1A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1724] Table 1245. Compounds of formula I.17, wherein R 1 Y-1A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1725] Table 1246. Compounds of formula I.17, wherein R 1 For Y-1B, R 2 CH3, R 9 H and R 10 For H.

[1726] Table 1247. Compounds of formula I.17, wherein R 1 For Y-1B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1727] Table 1248. Compounds of formula I.17, wherein R 1 For Y-1B, R 2CH3, R 9 is CH3 and R 10 For CH3.

[1728] Table 1249. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 CH3, R 9 H and R 10 For H.

[1729] Table 1250. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1730] Table 1251. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1731] Table 1252. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 CH3, R 9 H and R 10 For H.

[1732] Table 1253. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1733] Table 1254. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1734] Table 1255. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 CH3, R 9 H and R 10 For H.

[1735] Table 1256. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1736] Table 1257. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1737] Table 1258. Compounds of formula I.17, wherein R 1 For Y-3B, R 2 CH3, R 9 H and R 10 For H.

[1738] Table 1259. Compounds of formula I.17, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1739] Table 1260. Compounds of formula I.17, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1740] Table 1261. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 CH3, R 9 H and R 10 For H.

[1741] Table 1262. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 CH3, R 9 is CH3 and R 10 For H.

[1742] Table 1263. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1743] Table 1264. Compounds of formula I.17, wherein R 1 For Y-3D, R 2 CH3, R 9 H and R 10 For H.

[1744] Table 1265. Compounds of formula I.17, wherein R 1 For Y-3D, R2 CH3, R 9 is CH3 and R 10 For H.

[1745] Table 1266. Compounds of formula I.17, wherein R 1 For Y-3D, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1746] Table 1267. Compounds of formula I.17, wherein R 1 For Y-4A, R 2 CH3, R 9 H and R 10 For H.

[1747] Table 1268. Compounds of formula I.17, wherein R 1 For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1748] Table 1269. Compounds of formula I.17, wherein R 1 For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1749] Table 1270. Compounds of formula I.17, wherein R 1 For Y-4B, R 2 CH3, R 9 H and R 10 For H.

[1750] Table 1271. Compounds of formula I.17, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1751] Table 1272. Compounds of formula I.17, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1752] Table 1273. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 CH3, R 9 H and R 10 For H.

[1753] Table 1274. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For H.

[1754] Table 1275. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1755] Table 1276. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 CH3, R 9 H and R 10 For H.

[1756] Table 1277. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 CH3, R 9 is CH3 and R 10 For H.

[1757] Table 1278. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1758] Table 1279. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 CH3, R 9 H and R 10 For H.

[1759] Table 1280. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1760] Table 1281. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1761] Table 1282. Compounds of formula I.17, wherein R 1For Y-5B, R 2 CH3, R 9 H and R 10 For H.

[1762] Table 1283. Compounds of formula I.17, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1763] Table 1284. Compounds of formula I.17, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1764] Table 1285. Compounds of formula I.17, wherein R 1 For Y-6A, R 2 CH3, R 9 H and R 10 For H.

[1765] Table 1286. Compounds of formula I.17, wherein R 1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1766] Table 1287. Compounds of formula I.17, wherein R 1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1767] Table 1288. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 CH3, R 9 H and R 10 For H.

[1768] Table 1289. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1769] Table 1290. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 CH3, R 9 is CH3 and R 10For CH3.

[1770] Table 1291. Compounds of formula I.17, wherein R 1 For Y-8A, R 2 CH3, R 9 H and R 10 For H.

[1771] Table 1292. Compounds of formula I.17, wherein R 1 For Y-8A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1772] Table 1293. Compounds of formula I.17, wherein R 1 For Y-8A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1773] Table 1294. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 CH3, R 9 H and R 10 For H.

[1774] Table 1295. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1775] Table 1296. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1776] Table 1297. Compounds of formula I.17, wherein R 1 Y-1A, R 2 For C2H5, R 9 H and R 10 For H.

[1777] Table 1298. Compounds of formula I.17, wherein R 1 Y-1A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1778] Table 1299. Compounds of formula I.17, wherein R1 Y-1A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1779] Table 1300. Compounds of formula I.17, wherein R 1 For Y-1B, R 2 For C2H5, R 9 H and R 10 For H.

[1780] Table 1301. Compounds of formula I.17, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1781] Table 1302. Compounds of formula I.17, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1782] Table 1303. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 For C2H5, R 9 H and R 10 For H.

[1783] Table 1304. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1784] Table 1305. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1785] Table 1306. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 For C2H5, R 9 H and R 10 For H.

[1786] Table 1307. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 For C2H5, R 9is CH3 and R 10 For H.

[1787] Table 1308. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1788] Table 1309. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 For C2H5, R 9 H and R 10 For H.

[1789] Table 1310. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1790] Table 1311. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1791] Table 1312. Compounds of formula I.17, wherein R 1 For Y-3B, R 2 For C2H5, R 9 H and R 10 For H.

[1792] Table 1313. Compounds of formula I.17, wherein R 1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1793] Table 1314. Compounds of formula I.17, wherein R 1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1794] Table 1315. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 For C2H5, R 9 H and R 10 For H.

[1795] Table 1316. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1796] Table 1317. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1797] Table 1318. Compounds of formula I.17, wherein R 1 For Y-3D, R 2 For C2H5, R 9 H and R 10 For H.

[1798] Table 1319. Compounds of formula I.17, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1799] Table 1320. Compounds of formula I.17, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1800] Table 1321. Compounds of formula I.17, wherein R 1 For Y-4A, R 2 For C2H5, R 9 H and R 10 For H.

[1801] Table 1322. Compounds of formula I.17, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1802] Table 1323. Compounds of formula I.17, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1803] Table 1324. Compounds of formula I.17, wherein R 1 For Y-4B, R2 For C2H5, R 9 H and R 10 For H.

[1804] Table 1325. Compounds of formula I.17, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1805] Table 1326. Compounds of formula I.17, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1806] Table 1327. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 For C2H5, R 9 H and R 10 For H.

[1807] Table 1328. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1808] Table 1329. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1809] Table 1330. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 For C2H5, R 9 H and R 10 For H.

[1810] Table 1331. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1811] Table 1332. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10For CH3.

[1812] Table 1333. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 For C2H5, R 9 H and R 10 For H.

[1813] Table 1334. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1814] Table 1335. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1815] Table 1336. Compounds of formula I.17, wherein R 1 For Y-5B, R 2 For C2H5, R 9 H and R 10 For H.

[1816] Table 1337. Compounds of formula I.17, wherein R 1 For Y-5B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1817] Table 1338. Compounds of formula I.17, wherein R 1 For Y-5B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1818] Table 1339. Compounds of formula I.17, wherein R 1 For Y-6A, R 2 For C2H5, R 9 H and R 10 For H.

[1819] Table 1340. Compounds of formula I.17, wherein R 1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1820] Table 1341. Compounds of formula I.17, wherein R1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1821] Table 1342. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 For C2H5, R 9 H and R 10 For H.

[1822] Table 1343. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1823] Table 1344. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1824] Table 1345. Compounds of formula I.17, wherein R 1 For Y-8A, R 2 For C2H5, R 9 H and R 10 For H.

[1825] Table 1346. Compounds of formula I.17, wherein R 1 For Y-8A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1826] Table 1347. Compounds of formula I.17, wherein R 1 For Y-8A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1827] Table 1348. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 For C2H5, R 9 H and R 10 For H.

[1828] Table 1349. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 For C2H5, R 9is CH3 and R 10 For H.

[1829] Table 1350. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1830] Table 1351. Compounds of formula I.17, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1831] Table 1352. Compounds of formula I.17, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1832] Table 1353. Compounds of formula I.17, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1833] Table 1354. Compounds of formula I.17, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1834] Table 1355. Compounds of formula I.17, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 CH3, R 10 For H.

[1835] Table 1356. Compounds of formula I.17, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1836] Table 1357. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1837] Table 1358. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1838] Table 1359. Compounds of formula I.17, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1839] Table 1360. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1840] Table 1361. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1841] Table 1362. Compounds of formula I.17, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1842] Table 1363. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1843] Table 1364. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1844] Table 1365. Compounds of formula I.17, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1845] Table 1366. Compounds of formula I.17, wherein R1 For Y-3B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1846] Table 1367. Compounds of formula I.17, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1847] Table 1368. Compounds of formula I.17, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1848] Table 1369. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 H and R 10 For H.

[1849] Table 1370. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1850] Table 1371. Compounds of formula I.17, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1851] Table 1372. Compounds of formula I.17, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 H and R 10 For H.

[1852] Table 1373. Compounds of formula I.17, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1853] Table 1374. Compounds of formula I.17, wherein R 1 For Y-3D, R 2For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1854] Table 1375. Compounds of formula I.17, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1855] Table 1376. Compounds of formula I.17, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1856] Table 1377. Compounds of formula I.17, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1857] Table 1378. Compounds of formula I.17, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1858] Table 1379. Compounds of formula I.17, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1859] Table 1380. Compounds of formula I.17, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1860] Table 1381. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 H and R 10 For H.

[1861] Table 1382. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 is CH3 and R10 For H.

[1862] Table 1383. Compounds of formula I.17, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1863] Table 1384. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 H and R 10 For H.

[1864] Table 1385. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1865] Table 1386. Compounds of formula I.17, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1866] Table 1387. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1867] Table 1388. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1868] Table 1389. Compounds of formula I.17, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1869] Table 1390. Compounds of formula I.17, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1870] Table 1391. Compounds of formula I.17, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1871] Table 1392. Compounds of formula I.17, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1872] Table 1393. Compounds of formula I.17, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1873] Table 1394. Compounds of formula I.17, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1874] Table 1395. Compounds of formula I.17, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1875] Table 1396. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1876] Table 1397. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1877] Table 1398. Compounds of formula I.17, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1878] Table 1399. Compounds of formula I.17, wherein R1 For Y-8A, R 2 For c-C3H5, R 9 H and R 10 For H.

[1879] Table 1400. Compounds of formula I.17, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1880] Table 1401. Compounds of formula I.17, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1881] Table 1402. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 H and R 10 For H.

[1882] Table 1403. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[1883] Table 1404. Compounds of formula I.17, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[1884] Table 1405. Compounds of formula I.18, wherein R 1 Y-1A, R 2 H, R 9 H and R 10 For H.

[1885] Table 1406. Compounds of formula I.18, wherein R 1 Y-1A, R 2 H, R 9 CH3 and R 10 For H.

[1886] Table 1407. Compounds of formula I.18, wherein R 1 Y-1A, R 2 H, R9 is CH3 and R 10 For CH3.

[1887] Table 1408. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 H, R 9 H and R 10 For H.

[1888] Table 1409. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For H.

[1889] Table 1410. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1890] Table 1411. Compounds of formula I.18, wherein R 1 For Y-2A, R 2 H, R 9 H and R 10 For H.

[1891] Table 1412. Compounds of formula I.18, wherein R 1 For Y-2A, R 2 H, R 9 is CH3 and R 10 For H.

[1892] Table 1413. Compounds of formula I.18, wherein R 1 For Y-2A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1893] Table 1414. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 H, R 9 H and R 10 For H.

[1894] Table 1415. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For H.

[1895] Table 1416. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1896] Table 1417. Compounds of formula I.18, wherein R 1 For Y-3A, R 2 H, R 9 H and R 10 For H.

[1897] Table 1418. Compounds of formula I.18, wherein R 1 For Y-3A, R 2 H, R 9 is CH3 and R 10 For H.

[1898] Table 1419. Compounds of formula I.18, wherein R 1 For Y-3A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1899] Table 1420. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 H, R 9 H and R 10 For H.

[1900] Table 1421. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 H, R 9 is CH3 and R 10 For H.

[1901] Table 1422. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1902] Table 1423. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 H, R 9 H and R 10 For H.

[1903] Table 1424. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 H, R 9is CH3 and R 10 For H.

[1904] Table 1425. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 H, R 9 is CH3 and R 10 For CH3.

[1905] Table 1426. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 H, R 9 H and R 10 For H.

[1906] Table 1427. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For H.

[1907] Table 1428. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 H, R 9 is CH3 and R 10 For CH3.

[1908] Table 1429. Compounds of formula I.18, wherein R 1 For Y-4A, R 2 H, R 9 H and R 10 For H.

[1909] Table 1430. Compounds of formula I.18, wherein R 1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For H.

[1910] Table 1431. Compounds of formula I.18, wherein R 1 For Y-4A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1911] Table 1432. Compounds of formula I.18, wherein R 1 For Y-4B, R 2 H, R 9 H and R 10 For H.

[1912] Table 1433. Compounds of formula I.18, wherein R1 For Y-4B, R 2 H, R 9 is CH3 and R 10 For H.

[1913] Table 1434. Compounds of formula I.18, wherein R 1 For Y-4B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1914] Table 1435. Compounds of formula I.18, wherein R 1 For Y-4C, R 2 H, R 9 H and R 10 For H.

[1915] Table 1436. Compounds of formula I.18, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For H.

[1916] Table 1437. Compounds of formula I.18, wherein R 1 For Y-4C, R 2 H, R 9 is CH3 and R 10 For CH3.

[1917] Table 1438. Compounds of formula I.18, wherein R 1 For Y-4D, R 2 H, R 9 H and R 10 For H.

[1918] Table 1439. Compounds of formula I.18, wherein R 1 For Y-4D, R 2 H, R 9 is CH3 and R 10 For H.

[1919] Table 1440. Compounds of formula I.18, wherein R 1 For Y-4D, R 2 H, R 9 is CH3 and R 10 For CH3.

[1920] Table 1441. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 H, R 9 H and R 10 For H.

[1921] Table 1442. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For H.

[1922] Table 1443. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1923] Table 1444. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 H, R 9 H and R 10 For H.

[1924] Table 1445. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 H, R 9 is CH3 and R 10 For H.

[1925] Table 1446. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1926] Table 1447. Compounds of formula I.18, wherein R 1 For Y-6A, R 2 H, R 9 H and R 10 For H.

[1927] Table 1448. Compounds of formula I.18, wherein R 1 For Y-6A, R 2 H, R 9 is CH3 and R 10 For H.

[1928] Table 1449. Compounds of formula I.18, wherein R 1 For Y-6A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1929] Table 1450. Compounds of formula I.18, wherein R 1 For Y-6B, R2 H, R 9 H and R 10 For H.

[1930] Table 1451. Compounds of formula I.18, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R 10 For H.

[1931] Table 1452. Compounds of formula I.18, wherein R 1 For Y-6B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1932] Table 1453. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 H, R 9 H and R 10 For H.

[1933] Table 1454. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 H, R 9 is CH3 and R 10 For H.

[1934] Table 1455. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 H, R 9 is CH3 and R 10 For CH3.

[1935] Table 1456. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 H, R 9 H and R 10 For H.

[1936] Table 1457. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For H.

[1937] Table 1458. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 H, R 9 is CH3 and R 10 For CH3.

[1938] Table 1459. Compounds of formula I.18, wherein R 1 Y-1A, R 2 CH3, R 9 H and R 10 For H.

[1939] Table 1460. Compounds of formula I.18, wherein R 1 Y-1A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1940] Table 1461. Compounds of formula I.18, wherein R 1 Y-1A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1941] Table 1462. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 CH3, R 9 H and R 10 For H.

[1942] Table 1463. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1943] Table 1464. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1944] Table 1465. Compounds of formula I.18, wherein R 1 For Y-2A, R 2 CH3, R 9 H and R 10 For H.

[1945] Table 1466. Compounds of formula I.18, wherein R 1 For Y-2A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1946] Table 1467. Compounds of formula I.18, wherein R 1 For Y-2A, R2 CH3, R 9 is CH3 and R 10 For CH3.

[1947] Table 1468. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 CH3, R 9 H and R 10 For H.

[1948] Table 1469. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1949] Table 1470. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1950] Table 1471. Compounds of formula I.18, wherein R 1 For Y-3A, R 2 CH3, R 9 H and R 10 For H.

[1951] Table 1472. Compounds of formula I.18, wherein R 1 For Y-3A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1952] Table 1473. Compounds of formula I.18, wherein R 1 For Y-3A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1953] Table 1474. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 CH3, R 9 H and R 10 For H.

[1954] Table 1475. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1955] Table 1476. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1956] Table 1477. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 CH3, R 9 H and R 10 For H.

[1957] Table 1478. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 CH3, R 9 is CH3 and R 10 For H.

[1958] Table 1479. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1959] Table 1480. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 CH3, R 9 H and R 10 For H.

[1960] Table 1481. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 CH3, R 9 is CH3 and R 10 For H.

[1961] Table 1482. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1962] Table 1483. Compounds of formula I.18, wherein R 1 For Y-4A, R 2 CH3, R 9 H and R 10 For H.

[1963] Table 1484. Compounds of formula I.18, wherein R 1For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1964] Table 1485. Compounds of formula I.18, wherein R 1 For Y-4A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1965] Table 1486. ​​Compounds of formula I.18, wherein R 1 For Y-4B, R 2 CH3, R 9 H and R 10 For H.

[1966] Table 1487. Compounds of formula I.18, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1967] Table 1488. Compounds of formula I.18, wherein R 1 For Y-4B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1968] Table 1489. Compounds of formula I.18, wherein R 1 For Y-4C, R 2 CH3, R 9 H and R 10 For H.

[1969] Table 1490. Compounds of formula I.18, wherein R 1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For H.

[1970] Table 1491. Compounds of formula I.18, wherein R 1 For Y-4C, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1971] Table 1492. Compounds of formula I.18, wherein R 1 For Y-4D, R 2 CH3, R 9 H and R 10For H.

[1972] Table 1493. Compounds of formula I.18, wherein R 1 For Y-4D, R 2 CH3, R 9 is CH3 and R 10 For H.

[1973] Table 1494. Compounds of formula I.18, wherein R 1 For Y-4D, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1974] Table 1495. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 CH3, R 9 H and R 10 For H.

[1975] Table 1496. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1976] Table 1497. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1977] Table 1498. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 CH3, R 9 H and R 10 For H.

[1978] Table 1499. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1979] Table 1500. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1980] Table 1501. Compounds of formula I.18, wherein R1 For Y-6A, R 2 CH3, R 9 H and R 10 For H.

[1981] Table 1502. Compounds of formula I.18, wherein R 1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1982] Table 1503. Compounds of formula I.18, wherein R 1 For Y-6A, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1983] Table 1504. Compounds of formula I.18, wherein R 1 For Y-6B, R 2 CH3, R 9 H and R 10 For H.

[1984] Table 1505. Compounds of formula I.18, wherein R 1 For Y-6B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1985] Table 1506. Compounds of formula I.18, wherein R 1 For Y-6B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1986] Table 1507. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 CH3, R 9 H and R 10 For H.

[1987] Table 1508. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 CH3, R 9 is CH3 and R 10 For H.

[1988] Table 1509. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 CH3, R 9 is CH3 and R10 For CH3.

[1989] Table 1510. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 CH3, R 9 H and R 10 For H.

[1990] Table 1511. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 CH3, R 9 is CH3 and R 10 For H.

[1991] Table 1512. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 CH3, R 9 is CH3 and R 10 For CH3.

[1992] Table 1513. Compounds of formula I.18, wherein R 1 Y-1A, R 2 For C2H5, R 9 H and R 10 For H.

[1993] Table 1514. Compounds of formula I.18, wherein R 1 Y-1A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1994] Table 1515. Compounds of formula I.18, wherein R 1 Y-1A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1995] Table 1516. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 For C2H5, R 9 H and R 10 For H.

[1996] Table 1517. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[1997] Table 1518. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[1998] Table 1519. Compounds of formula I.18, wherein R 1 For Y-2A, R 2 For C2H5, R 9 H and R 10 For H.

[1999] Table 1520. Compounds of formula I.18, wherein R 1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2000] Table 1521. Compounds of formula I.18, wherein R 1 For Y-2A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2001] Table 1522. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 For C2H5, R 9 H and R 10 For H.

[2002] Table 1523. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2003] Table 1524. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2004] Table 1525. Compounds of formula I.18, wherein R 1 For Y-3A, R 2 For C2H5, R 9 H and R 10 For H.

[2005] Table 1526. Compounds of formula I.18, wherein R 1 For Y-3A, R 2For C2H5, R 9 is CH3 and R 10 For H.

[2006] Table 1527. Compounds of formula I.18, wherein R 1 For Y-3A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2007] Table 1528. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 For C2H5, R 9 H and R 10 For H.

[2008] Table 1529. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2009] Table 1530. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2010] Table 1531. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 For C2H5, R 9 H and R 10 For H.

[2011] Table 1532. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2012] Table 1533. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2013] Table 1534. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 For C2H5, R 9 H and R 10 For H.

[2014] Table 1535. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2015] Table 1536. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2016] Table 1537. Compounds of formula I.18, wherein R 1 For Y-4A, R 2 For C2H5, R 9 H and R 10 For H.

[2017] Table 1538. Compounds of formula I.18, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2018] Table 1539. Compounds of formula I.18, wherein R 1 For Y-4A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2019] Table 1540. Compounds of formula I.18, wherein R 1 For Y-4B, R 2 For C2H5, R 9 H and R 10 For H.

[2020] Table 1541. Compounds of formula I.18, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2021] Table 1542. Compounds of formula I.18, wherein R 1 For Y-4B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2022] Table 1543. Compounds of formula I.18, wherein R1 For Y-4C, R 2 For C2H5, R 9 H and R 10 For H.

[2023] Table 1544. Compounds of formula I.18, wherein R 1 For Y-4C, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2024] Table 1545. Compounds of formula I.18, wherein R 1 For Y-4C, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2025] Table 1546. Compounds of formula I.18, wherein R 1 For Y-4D, R 2 For C2H5, R 9 H and R 10 For H.

[2026] Table 1547. Compounds of formula I.18, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2027] Table 1548. Compounds of formula I.18, wherein R 1 For Y-4D, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2028] Table 1549. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 For C2H5, R 9 H and R 10 For H.

[2029] Table 1550. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2030] Table 1551. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 For C2H5, R 9is CH3 and R 10 For CH3.

[2031] Table 1552. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 For C2H5, R 9 H and R 10 For H.

[2032] Table 1553. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2033] Table 1554. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2034] Table 1555. Compounds of formula I.18, wherein R 1 For Y-6A, R 2 For C2H5, R 9 H and R 10 For H.

[2035] Table 1556. Compounds of formula I.18, wherein R 1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2036] Table 1557. Compounds of formula I.18, wherein R 1 For Y-6A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2037] Table 1558. Compounds of formula I.18, wherein R 1 For Y-6B, R 2 For C2H5, R 9 H and R 10 For H.

[2038] Table 1559. Compounds of formula I.18, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2039] Table 1560. Compounds of formula I.18, wherein R 1 For Y-6B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2040] Table 1561. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 For C2H5, R 9 H and R 10 For H.

[2041] Table 1562. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2042] Table 1563. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2043] Table 1564. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 For C2H5, R 9 H and R 10 For H.

[2044] Table 1565. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 For C2H5, R 9 is CH3 and R 10 For H.

[2045] Table 1566. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 For C2H5, R 9 is CH3 and R 10 For CH3.

[2046] Table 1567. Compounds of formula I.18, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 H and R 10 For H.

[2047] Table 1568. Compounds of formula I.18, wherein R 1 Y-1A, R2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2048] Table 1569. Compounds of formula I.18, wherein R 1 Y-1A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2049] Table 1570. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 H and R 10 For H.

[2050] Table 1571. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 CH3, R 10 For H.

[2051] Table 1572. Compounds of formula I.18, wherein R 1 For Y-1B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2052] Table 1573. Compounds of formula I.18, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 H and R 10 For H.

[2053] Table 1574. Compounds of formula I.18, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2054] Table 1575. Compounds of formula I.18, wherein R 1 For Y-2A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2055] Table 1576. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9H and R 10 For H.

[2056] Table 1577. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2057] Table 1578. Compounds of formula I.18, wherein R 1 For Y-2B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2058] Table 1579. Compounds of formula I.18, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 H and R 10 For H.

[2059] Table 1580. Compounds of formula I.18, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2060] Table 1581. Compounds of formula I.18, wherein R 1 For Y-3A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2061] Table 1582. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 H and R 10 For H.

[2062] Table 1583. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2063] Table 1584. Compounds of formula I.18, wherein R 1 For Y-3B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2064] Table 1585. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 H and R 10 For H.

[2065] Table 1586. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2066] Table 1587. Compounds of formula I.18, wherein R 1 For Y-3C, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2067] Table 1588. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 H and R 10 For H.

[2068] Table 1589. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2069] Table 1590. Compounds of formula I.18, wherein R 1 For Y-3D, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2070] Table 1591. Compounds of formula I.18, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 H and R 10 For H.

[2071] Table 1592. Compounds of formula I.18, wherein R 1 For Y-4A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2072] Table 1593. Compounds of formula I.18, wherein R1 For Y-4A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2073] Table 1594. Compounds of formula I.18, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 H and R 10 For H.

[2074] Table 1595. Compounds of formula I.18, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2075] Table 1596. Compounds of formula I.18, wherein R 1 For Y-4B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2076] Table 1597. Compounds of formula I.18, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 H and R 10 For H.

[2077] Table 1598. Compounds of formula I.18, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2078] Table 1599. Compounds of formula I.18, wherein R 1 For Y-4C, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2079] Table 1600. Compounds of formula I.18, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 H and R 10 For H.

[2080] Table 1601. Compounds of formula I.18, wherein R 1 For Y-4D, R 2For c-C3H5, R 9 is CH3 and R 10 For H.

[2081] Table 1602. Compounds of formula I.18, wherein R 1 For Y-4D, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2082] Table 1603. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 H and R 10 For H.

[2083] Table 1604. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2084] Table 1605. Compounds of formula I.18, wherein R 1 For Y-5A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2085] Table 1606. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 H and R 10 For H.

[2086] Table 1607. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2087] Table 1608. Compounds of formula I.18, wherein R 1 For Y-5B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2088] Table 1609. Compounds of formula I.18, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 H and R10 For H.

[2089] Table 1610. Compounds of formula I.18, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2090] Table 1611. Compounds of formula I.18, wherein R 1 For Y-6A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2091] Table 1612. Compounds of formula I.18, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 H and R 10 For H.

[2092] Table 1613. Compounds of formula I.18, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2093] Table 1614. Compounds of formula I.18, wherein R 1 For Y-6B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2094] Table 1615. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 H and R 10 For H.

[2095] Table 1616. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2096] Table 1617. Compounds of formula I.18, wherein R 1 For Y-8A, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2097] Table 1618. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 H and R 10 For H.

[2098] Table 1619. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 is CH3 and R 10 For H.

[2099] Table 1620. Compounds of formula I.18, wherein R 1 For Y-8B, R 2 For c-C3H5, R 9 is CH3 and R 10 For CH3.

[2100] Table 1621. Compounds of formula I.25, wherein R 1 Y-1A and R 2 For H.

[2101] Table 1622. Compounds of formula I.25, wherein R 1 Y-1B and R 2 For H.

[2102] Table 1623. Compounds of formula I.25, wherein R 1 Y-2A and R 2 For H.

[2103] Table 1624. Compounds of formula I.25, wherein R 1 Y-2B and R 2 For H.

[2104] Table 1625. Compounds of formula I.25, wherein R 1 Y-3A and R 2 For H.

[2105] Table 1626. Compounds of formula I.25, wherein R 1 Y-3B and R 2 For H.

[2106] Table 1627. Compounds of formula I.25, wherein R 1 Y-3C and R 2 For H.

[2107] Table 1628. Compounds of formula I.25, wherein R 1 Y-3D and R 2 For H.

[2108] Table 1629. Compounds of formula I.25, wherein R 1 Y-4A and R 2 For H.

[2109] Table 1630. Compounds of formula I.25, wherein R 1 Y-4B and R 2 For H.

[2110] Table 1631. Compounds of formula I.25, wherein R 1 Y-4C and R 2 For H.

[2111] Table 1632. Compounds of formula I.25, wherein R 1 Y-4D and R 2 For H.

[2112] Table 1633. Compounds of formula I.25, wherein R 1 Y-5A and R 2 For H.

[2113] Table 1634. Compounds of formula I.25, wherein R 1 Y-5B and R 2 For H.

[2114] Table 1635. Compounds of formula I.25, wherein R 1 Y-6A and R 2 For H.

[2115] Table 1636. Compounds of formula I.25, wherein R 1 Y-6B and R 2 For H.

[2116] Table 1637. Compounds of formula I.25, wherein R 1 Y-8A and R 2 For H.

[2117] Table 1638. Compounds of formula I.25, wherein R 1 Y-8B and R 2 For H.

[2118] Table 1639. Compounds of formula I.25, wherein R 1 Y-1A and R 2 For CH3.

[2119] Table 1640. Compounds of formula I.25, wherein R 1 Y-1B and R 2 For CH3.

[2120] Table 1641. Compounds of formula I.25, wherein R1 Y-2A and R 2 For CH3.

[2121] Table 1642. Compounds of formula I.25, wherein R 1 Y-2B and R 2 For CH3.

[2122] Table 1643. Compounds of formula I.25, wherein R 1 Y-3A and R 2 For CH3.

[2123] Table 1644. Compounds of formula I.25, wherein R 1 Y-3B and R 2 For CH3.

[2124] Table 1645. Compounds of formula I.25, wherein R 1 Y-3C and R 2 For CH3.

[2125] Table 1646. Compounds of formula I.25, wherein R 1 Y-3D and R 2 For CH3.

[2126] Table 1647. Compounds of formula I.25, wherein R 1 Y-4A and R 2 For CH3.

[2127] Table 1648. Compounds of formula I.25, wherein R 1 Y-4B and R 2 For CH3.

[2128] Table 1649. Compounds of formula I.25, wherein R 1 Y-4C and R 2 For CH3.

[2129] Table 1650. Compounds of formula I.25, wherein R 1 Y-4D and R 2 For CH3.

[2130] Table 1651. Compounds of formula I.25, wherein R 1 Y-5A and R 2 For CH3.

[2131] Table 1652. Compounds of formula I.25, wherein R 1 Y-5B and R 2 For CH3.

[2132] Table 1653. Compounds of formula I.25, wherein R 1Y-6A and R 2 For CH3.

[2133] Table 1654. Compounds of formula I.25, wherein R 1 Y-6B and R 2 For CH3.

[2134] Table 1655. Compounds of formula I.25, wherein R 1 Y-8A and R 2 For CH3.

[2135] Table 1656. Compounds of formula I.25, wherein R 1 Y-8B and R 2 For CH3.

[2136] Table 1657. Compounds of formula I.25, wherein R 1 Y-1A and R 2 It is c-C3H5.

[2137] Table 1658. Compounds of formula I.25, wherein R 1 Y-1B and R 2 It is c-C3H5.

[2138] Table 1659. Compounds of formula I.25, wherein R 1 Y-2A and R 2 It is c-C3H5.

[2139] Table 1660. Compounds of formula I.25, wherein R 1 Y-2B and R 2 It is c-C3H5.

[2140] Table 1661. Compounds of formula I.25, wherein R 1 Y-3A and R 2 It is c-C3H5.

[2141] Table 1662. Compounds of formula I.25, wherein R 1 Y-3B and R 2 It is c-C3H5.

[2142] Table 1663. Compounds of formula I.25, wherein R 1 Y-3C and R 2 It is c-C3H5.

[2143] Table 1664. Compounds of formula I.25, wherein R 1 Y-3D and R 2 It is c-C3H5.

[2144] Table 1665. Compounds of formula I.25, wherein R1 Y-4A and R 2 It is c-C3H5.

[2145] Table 1666. Compounds of formula I.25, wherein R 1 Y-4B and R 2 It is c-C3H5.

[2146] Table 1667. Compounds of formula I.25, wherein R 1 Y-4C and R 2 It is c-C3H5.

[2147] Table 1668. Compounds of formula I.25, wherein R 1 Y-4D and R 2 It is c-C3H5.

[2148] Table 1669. Compounds of formula I.25, wherein R 1 Y-5A and R 2 It is c-C3H5.

[2149] Table 1670. Compounds of formula I.25, wherein R 1 Y-5B and R 2 It is c-C3H5.

[2150] Table 1671. Compounds of formula I.25, wherein R 1 Y-6A and R 2 It is c-C3H5.

[2151] Table 1672. Compounds of formula I.25, wherein R 1 Y-6B and R 2 It is c-C3H5.

[2152] Table 1673. Compounds of formula I.25, wherein R 1 Y-8A and R 2 It is c-C3H5.

[2153] Table 1674. Compounds of formula I.25, wherein R 1 Y-8B and R 2 It is c-C3H5.

[2154] Table 1675. Compounds of formula I.26, wherein R 1 Y-1A and R 2 For H.

[2155] Table 1676. Compounds of formula I.26, wherein R 1 Y-1B and R 2 For H.

[2156] Table 1677. Compounds of formula I.26, wherein R 1 Y-2A and R 2 For H.

[2157] Table 1678. Compounds of formula I.26, wherein R 1 Y-2B and R 2 For H.

[2158] Table 1679. Compounds of formula I.26, wherein R 1 Y-3A and R 2 For H.

[2159] Table 1680. Compounds of formula I.26, wherein R 1 Y-3B and R 2 For H.

[2160] Table 1681. Compounds of formula I.26, wherein R 1 Y-3C and R 2 For H.

[2161] Table 1682. Compounds of formula I.26, wherein R 1 Y-3D and R 2 For H.

[2162] Table 1683. Compounds of formula I.26, wherein R 1 Y-4A and R 2 For H.

[2163] Table 1684. Compounds of formula I.26, wherein R 1 Y-4B and R 2 For H.

[2164] Table 1685. Compounds of formula I.26, wherein R 1 Y-4C and R 2 For H.

[2165] Table 1686. Compounds of formula I.26, wherein R 1 Y-4D and R 2 For H.

[2166] Table 1687. Compounds of formula I.26, wherein R 1 Y-5A and R 2 For H.

[2167] Table 1688. Compounds of formula I.26, wherein R 1 Y-5B and R 2 For H.

[2168] Table 1689. Compounds of formula I.26, wherein R 1 Y-6A and R2 For H.

[2169] Table 1690. Compounds of formula I.26, wherein R 1 Y-6B and R 2 For H.

[2170] Table 1691. Compounds of formula I.26, wherein R 1 Y-8A and R 2 For H.

[2171] Table 1692. Compounds of formula I.26, wherein R 1 Y-8B and R 2 For H.

[2172] Table 1693. Compounds of formula I.26, wherein R 1 Y-1A and R 2 For CH3.

[2173] Table 1694. Compounds of formula I.26, wherein R 1 Y-1B and R 2 For CH3.

[2174] Table 1695. Compounds of formula I.26, wherein R 1 Y-2A and R 2 For CH3.

[2175] Table 1696. Compounds of formula I.26, wherein R 1 Y-2B and R 2 For CH3.

[2176] Table 1697. Compounds of formula I.26, wherein R 1 Y-3A and R 2 For CH3.

[2177] Table 1698. Compounds of formula I.26, wherein R 1 Y-3B and R 2 For CH3.

[2178] Table 1699. Compounds of formula I.26, wherein R 1 Y-3C and R 2 For CH3.

[2179] Table 1700. Compounds of formula I.26, wherein R 1 Y-3D and R 2 For CH3.

[2180] Table 1701. Compounds of formula I.26, wherein R 1 Y-4A and R 2 For CH3.

[2181] Table 1702. Compounds of formula I.26, wherein R 1 Y-4B and R 2 For CH3.

[2182] Table 1703. Compounds of formula I.26, wherein R 1 Y-4C and R 2 For CH3.

[2183] Table 1704. Compounds of formula I.26, wherein R 1 Y-4D and R 2 For CH3.

[2184] Table 1705. Compounds of formula I.26, wherein R 1 Y-5A and R 2 For CH3.

[2185] Table 1706. Compounds of formula I.26, wherein R 1 Y-5B and R 2 For CH3.

[2186] Table 1707. Compounds of formula I.26, wherein R 1 Y-6A and R 2 For CH3.

[2187] Table 1708. Compounds of formula I.26, wherein R 1 Y-6B and R 2 For CH3.

[2188] Table 1709. Compounds of formula I.26, wherein R 1 Y-8A and R 2 For CH3.

[2189] Table 1710. Compounds of formula I.26, wherein R 1 Y-8B and R 2 For CH3.

[2190] Table 1711. Compounds of formula I.26, wherein R 1 Y-1A and R 2 It is c-C3H5.

[2191] Table 1712. Compounds of formula I.26, wherein R 1 Y-1B and R 2 It is c-C3H5.

[2192] Table 1713. Compounds of formula I.26, wherein R 1 Y-2A and R 2 It is c-C3H5.

[2193] Table 1714. Compounds of formula I.26, wherein R 1 Y-2B and R 2 It is c-C3H5.

[2194] Table 1715. Compounds of formula I.26, wherein R 1 Y-3A and R 2 It is c-C3H5.

[2195] Table 1716. Compounds of formula I.26, wherein R 1 Y-3B and R 2 It is c-C3H5.

[2196] Table 1717. Compounds of formula I.26, wherein R 1 Y-3C and R 2 It is c-C3H5.

[2197] Table 1718. Compounds of formula I.26, wherein R 1 Y-3D and R 2 It is c-C3H5.

[2198] Table 1719. Compounds of formula I.26, wherein R 1 Y-4A and R 2 It is c-C3H5.

[2199] Table 1720. Compounds of formula I.26, wherein R 1 Y-4B and R 2 It is c-C3H5.

[2200] Table 1721. Compounds of formula I.26, wherein R 1 Y-4C and R 2 It is c-C3H5.

[2201] Table 1722. Compounds of formula I.26, wherein R 1 Y-4D and R 2 It is c-C3H5.

[2202] Table 1723. Compounds of formula I.26, wherein R 1 Y-5A and R 2 It is c-C3H5.

[2203] Table 1724. Compounds of formula I.26, wherein R 1 Y-5B and R 2 It is c-C3H5.

[2204] Table 1725. Compounds of formula I.26, wherein R 1 Y-6A and R2 It is c-C3H5.

[2205] Table 1726. Compounds of formula I.26, wherein R 1 Y-6B and R 2 It is c-C3H5.

[2206] Table 1727. Compounds of formula I.26, wherein R 1 Y-8A and R 2 It is c-C3H5.

[2207] Table 1728. Compounds of formula I.26, wherein R 1 Y-8B and R 2 It is c-C3H5.

[2208] Table 1729. Compounds of formula I.27, wherein R 1 Y-1A and R 2 For H.

[2209] Table 1730. Compounds of formula I.27, wherein R 1 Y-1B and R 2 For H.

[2210] Table 1731. Compounds of formula I.27, wherein R 1 Y-2A and R 2 For H.

[2211] Table 1732. Compounds of formula I.27, wherein R 1 Y-2B and R 2 For H.

[2212] Table 1733. Compounds of formula I.27, wherein R 1 Y-3A and R 2 For H.

[2213] Table 1734. Compounds of formula I.27, wherein R 1 Y-3B and R 2 For H.

[2214] Table 1735. Compounds of formula I.27, wherein R 1 Y-3C and R 2 For H.

[2215] Table 1736. Compounds of formula I.27, wherein R 1 Y-3D and R 2 For H.

[2216] Table 1737. Compounds of formula I.27, wherein R 1 Y-4A and R 2 For H.

[2217] Table 1738. Compounds of formula I.27, wherein R 1 Y-4B and R 2 For H.

[2218] Table 1739. Compounds of formula I.27, wherein R 1 Y-4C and R 2 For H.

[2219] Table 1740. Compounds of formula I.27, wherein R 1 Y-4D and R 2 For H.

[2220] Table 1741. Compounds of formula I.27, wherein R 1 Y-5A and R 2 For H.

[2221] Table 1742. Compounds of formula I.27, wherein R 1 Y-5B and R 2 For H.

[2222] Table 1743. Compounds of formula I.27, wherein R 1 Y-6A and R 2 For H.

[2223] Table 1744. Compounds of formula I.27, wherein R 1 Y-6B and R 2 For H.

[2224] Table 1745. Compounds of formula I.27, wherein R 1 Y-8A and R 2 For H.

[2225] Table 1746. Compounds of formula I.27, wherein R 1 Y-8B and R 2 For H.

[2226] Table 1747. Compounds of formula I.27, wherein R 1 Y-1A and R 2 For CH3.

[2227] Table 1748. Compounds of formula I.27, wherein R 1 Y-1B and R 2 For CH3.

[2228] Table 1749. Compounds of formula I.27, wherein R 1 Y-2A and R 2 For CH3.

[2229] Table 1750. Compounds of formula I.27, wherein R 1 Y-2B and R 2 For CH3.

[2230] Table 1751. Compounds of formula I.27, wherein R 1 Y-3A and R 2 For CH3.

[2231] Table 1752. Compounds of formula I.27, wherein R 1 Y-3B and R 2 For CH3.

[2232] Table 1753. Compounds of formula I.27, wherein R 1 Y-3C and R 2 For CH3.

[2233] Table 1754. Compounds of formula I.27, wherein R 1 Y-3D and R 2 For CH3.

[2234] Table 1755. Compounds of formula I.27, wherein R 1 Y-4A and R 2 For CH3.

[2235] Table 1756. Compounds of formula I.27, wherein R 1 Y-4B and R 2 For CH3.

[2236] Table 1757. Compounds of formula I.27, wherein R 1 Y-4C and R 2 For CH3.

[2237] Table 1758. Compounds of formula I.27, wherein R 1 Y-4D and R 2 For CH3.

[2238] Table 1759. Compounds of formula I.27, wherein R 1 Y-5A and R 2 For CH3.

[2239] Table 1760. Compounds of formula I.27, wherein R 1 Y-5B and R 2 For CH3.

[2240] Table 1761. Compounds of formula I.27, wherein R 1 Y-6A and R 2 For CH3.

[2241] Table 1762. Compounds of formula I.27, wherein R 1 Y-6B and R 2 For CH3.

[2242] Table 1763. Compounds of formula I.27, wherein R 1 Y-8A and R 2 For CH3.

[2243] Table 1764. Compounds of formula I.27, wherein R 1 Y-8B and R 2 For CH3.

[2244] Table 1765. Compounds of formula I.27, wherein R 1 Y-1A and R 2 It is c-C3H5.

[2245] Table 1766. Compounds of formula I.27, wherein R 1 Y-1B and R 2 It is c-C3H5.

[2246] Table 1767. Compounds of formula I.27, wherein R 1 Y-2A and R 2 It is c-C3H5.

[2247] Table 1768. Compounds of formula I.27, wherein R 1 Y-2B and R 2 It is c-C3H5.

[2248] Table 1769. Compounds of formula I.27, wherein R 1 Y-3A and R 2 It is c-C3H5.

[2249] Table 1770. Compounds of formula I.27, wherein R 1 Y-3B and R 2 It is c-C3H5.

[2250] Table 1771. Compounds of formula I.27, wherein R 1 Y-3C and R 2 It is c-C3H5.

[2251] Table 1772. Compounds of formula I.27, wherein R 1 Y-3D and R 2 It is c-C3H5.

[2252] Table 1773. Compounds of formula I.27, wherein R 1 Y-4A and R 2 It is c-C3H5.

[2253] Table 1774. Compounds of formula I.27, wherein R 1 Y-4B and R 2 It is c-C3H5.

[2254] Table 1775. Compounds of formula I.27, wherein R 1 Y-4C and R 2 It is c-C3H5.

[2255] Table 1776. Compounds of formula I.27, wherein R 1 Y-4D and R 2 It is c-C3H5.

[2256] Table 1777. Compounds of formula I.27, wherein R 1 Y-5A and R 2 It is c-C3H5.

[2257] Table 1778. Compounds of formula I.27, wherein R 1 Y-5B and R 2 It is c-C3H5.

[2258] Table 1779. Compounds of formula I.27, wherein R 1 Y-6A and R 2 It is c-C3H5.

[2259] Table 1780. Compounds of formula I.27, wherein R 1 Y-6B and R 2 It is c-C3H5.

[2260] Table 1781. Compounds of formula I.27, wherein R 1 Y-8A and R 2 It is c-C3H5.

[2261] Table 1782. Compounds of formula I.27, wherein R 1 Y-8B and R 2 It is c-C3H5.

[2262] Table 1783. Compounds of formula I.28, wherein R 1 Y-1A and R 2 For H.

[2263] Table 1784. Compounds of formula I.28, wherein R 1 Y-1B and R 2 For H.

[2264] Table 1785. Compounds of formula I.28, wherein R 1 Y-2A and R 2 For H.

[2265] Table 1786. Compounds of formula I.28, wherein R 1 Y-2B and R 2 For H.

[2266] Table 1787. Compounds of formula I.28, wherein R 1 Y-3A and R 2 For H.

[2267] Table 1788. Compounds of formula I.28, wherein R 1 Y-3B and R 2 For H.

[2268] Table 1789. Compounds of formula I.28, wherein R 1 Y-3C and R 2 For H.

[2269] Table 1790. Compounds of formula I.28, wherein R 1 Y-3D and R 2 For H.

[2270] Table 1791. Compounds of formula I.28, wherein R 1 Y-4A and R 2 For H.

[2271] Table 1792. Compounds of formula I.28, wherein R 1 Y-4B and R 2 For H.

[2272] Table 1793. Compounds of formula I.28, wherein R 1 Y-4C and R 2 For H.

[2273] Table 1794. Compounds of formula I.28, wherein R 1 Y-4D and R 2 For H.

[2274] Table 1795. Compounds of formula I.28, wherein R 1 Y-5A and R 2 For H.

[2275] Table 1796. Compounds of formula I.28, wherein R 1 Y-5B and R 2 For H.

[2276] Table 1797. Compounds of formula I.28, wherein R 1 Y-6A and R 2 For H.

[2277] Table 1798. Compounds of formula I.28, wherein R1 Y-6B and R 2 For H.

[2278] Table 1799. Compounds of formula I.28, wherein R 1 Y-8A and R 2 For H.

[2279] Table 1800. Compounds of formula I.28, wherein R 1 Y-8B and R 2 For H.

[2280] Table 1801. Compounds of formula I.28, wherein R 1 Y-1A and R 2 For CH3.

[2281] Table 1802. Compounds of formula I.28, wherein R 1 Y-1B and R 2 For CH3.

[2282] Table 1803. Compounds of formula I.28, wherein R 1 Y-2A and R 2 For CH3.

[2283] Table 1804. Compounds of formula I.28, wherein R 1 Y-2B and R 2 For CH3.

[2284] Table 1805. Compounds of formula I.28, wherein R 1 Y-3A and R 2 For CH3.

[2285] Table 1806. Compounds of formula I.28, wherein R 1 Y-3B and R 2 For CH3.

[2286] Table 1807. Compounds of formula I.28, wherein R 1 Y-3C and R 2 For CH3.

[2287] Table 1808. Compounds of formula I.28, wherein R 1 Y-3D and R 2 For CH3.

[2288] Table 1809. Compounds of formula I.28, wherein R 1 Y-4A and R 2 For CH3.

[2289] Table 1810. Compounds of formula I.28, wherein R 1 Y-4B and R2 For CH3.

[2290] Table 1811. Compounds of formula I.28, wherein R 1 Y-4C and R 2 For CH3.

[2291] Table 1812. Compounds of formula I.28, wherein R 1 Y-4D and R 2 For CH3.

[2292] Table 1813. Compounds of formula I.28, wherein R 1 Y-5A and R 2 For CH3.

[2293] Table 1814. Compounds of formula I.28, wherein R 1 Y-5B and R 2 For CH3.

[2294] Table 1815. Compounds of formula I.28, wherein R 1 Y-6A and R 2 For CH3.

[2295] Table 1816. Compounds of formula I.28, wherein R 1 Y-6B and R 2 For CH3.

[2296] Table 1817. Compounds of formula I.28, wherein R 1 Y-8A and R 2 For CH3.

[2297] Table 1818. Compounds of formula I.28, wherein R 1 Y-8B and R 2 For CH3.

[2298] Table 1819. Compounds of formula I.28, wherein R 1 Y-1A and R 2 It is c-C3H5.

[2299] Table 1820. Compounds of formula I.28, wherein R 1 Y-1B and R 2 It is c-C3H5.

[2300] Table 1821. Compounds of formula I.28, wherein R 1 Y-2A and R 2 It is c-C3H5.

[2301] Table 1822. Compounds of formula I.28, wherein R 1 Y-2B and R2 It is c-C3H5.

[2302] Table 1823. Compounds of formula I.28, wherein R 1 Y-3A and R 2 It is c-C3H5.

[2303] Table 1824. Compounds of formula I.28, wherein R 1 Y-3B and R 2 It is c-C3H5.

[2304] Table 1825. Compounds of formula I.28, wherein R 1 Y-3C and R 2 It is c-C3H5.

[2305] Table 1826. Compounds of formula I.28, wherein R 1 Y-3D and R 2 It is c-C3H5.

[2306] Table 1827. Compounds of formula I.28, wherein R 1 Y-4A and R 2 It is c-C3H5.

[2307] Table 1828. Compounds of formula I.28, wherein R 1 Y-4B and R 2 It is c-C3H5.

[2308] Table 1829. Compounds of formula I.28, wherein R 1 Y-4C and R 2 It is c-C3H5.

[2309] Table 1830. Compounds of formula I.28, wherein R 1 Y-4D and R 2 It is c-C3H5.

[2310] Table 1831. Compounds of formula I.28, wherein R 1 Y-5A and R 2 It is c-C3H5.

[2311] Table 1832. Compounds of formula I.28, wherein R 1 Y-5B and R 2 It is c-C3H5.

[2312] Table 1833. Compounds of formula I.28, wherein R 1 Y-6A and R 2 It is c-C3H5.

[2313] Table 1834. Compounds of formula I.28, wherein R1 Y-6B and R 2 It is c-C3H5.

[2314] Table 1835. Compounds of formula I.28, wherein R 1 Y-8A and R 2 It is c-C3H5.

[2315] Table 1836. Compounds of formula I.28, wherein R 1 Y-8B and R 2 It is c-C3H5.

[2316] Table 1837. Compounds of formula I.29, wherein R 1 Y-1A and R 2 For H.

[2317] Table 1838. Compounds of formula I.29, wherein R 1 Y-1B and R 2 For H.

[2318] Table 1839. Compounds of formula I.29, wherein R 1 Y-2A and R 2 For H.

[2319] Table 1840. Compounds of formula I.29, wherein R 1 Y-2B and R 2 For H.

[2320] Table 1841. Compounds of formula I.29, wherein R 1 Y-3A and R 2 For H.

[2321] Table 1842. Compounds of formula I.29, wherein R 1 Y-3B and R 2 For H.

[2322] Table 1843. Compounds of formula I.29, wherein R 1 Y-3C and R 2 For H.

[2323] Table 1844. Compounds of formula I.29, wherein R 1 Y-3D and R 2 For H.

[2324] Table 1845. Compounds of formula I.29, wherein R 1 Y-4A and R 2 For H.

[2325] Table 1846. Compounds of formula I.29, wherein R 1 Y-4B and R2 For H.

[2326] Table 1847. Compounds of formula I.29, wherein R 1 Y-4C and R 2 For H.

[2327] Table 1848. Compounds of formula I.29, wherein R 1 Y-4D and R 2 For H.

[2328] Table 1849. Compounds of formula I.29, wherein R 1 Y-5A and R 2 For H.

[2329] Table 1850. Compounds of formula I.29, wherein R 1 Y-5B and R 2 For H.

[2330] Table 1851. Compounds of formula I.29, wherein R 1 Y-6A and R 2 For H.

[2331] Table 1852. Compounds of formula I.29, wherein R 1 Y-6B and R 2 For H.

[2332] Table 1853. Compounds of formula I.29, wherein R 1 Y-8A and R 2 For H.

[2333] Table 1854. Compounds of formula I.29, wherein R 1 Y-8B and R 2 For H.

[2334] Table 1855. Compounds of formula I.29, wherein R 1 Y-1A and R 2 For CH3.

[2335] Table 1856. Compounds of formula I.29, wherein R 1 Y-1B and R 2 For CH3.

[2336] Table 1857. Compounds of formula I.29, wherein R 1 Y-2A and R 2 For CH3.

[2337] Table 1858. Compounds of formula I.29, wherein R 1 Y-2B and R 2 For CH3.

[2338] Table 1859. Compounds of formula I.29, wherein R 1 Y-3A and R 2 For CH3.

[2339] Table 1860. Compounds of formula I.29, wherein R 1 Y-3B and R 2 For CH3.

[2340] Table 1861. Compounds of formula I.29, wherein R 1 Y-3C and R 2 For CH3.

[2341] Table 1862. Compounds of formula I.29, wherein R 1 Y-3D and R 2 For CH3.

[2342] Table 1863. Compounds of formula I.29, wherein R 1 Y-4A and R 2 For CH3.

[2343] Table 1864. Compounds of formula I.29, wherein R 1 Y-4B and R 2 For CH3.

[2344] Table 1865. Compounds of formula I.29, wherein R 1 Y-4C and R 2 For CH3.

[2345] Table 1866. Compounds of formula I.29, wherein R 1 Y-4D and R 2 For CH3.

[2346] Table 1867. Compounds of formula I.29, wherein R 1 Y-5A and R 2 For CH3.

[2347] Table 1868. Compounds of formula I.29, wherein R 1 Y-5B and R 2 For CH3.

[2348] Table 1869. Compounds of formula I.29, wherein R 1 Y-6A and R 2 For CH3.

[2349] Table 1870. Compounds of formula I.29, wherein R 1 Y-6B and R 2 For CH3.

[2350] Table 1871. Compounds of formula I.29, wherein R 1 Y-8A and R 2 For CH3.

[2351] Table 1872. Compounds of formula I.29, wherein R 1 Y-8B and R 2 For CH3.

[2352] Table 1873. Compounds of formula I.29, wherein R 1 Y-1A and R 2 It is c-C3H5.

[2353] Table 1874. Compounds of formula I.29, wherein R 1 Y-1B and R 2 It is c-C3H5.

[2354] Table 1875. Compounds of formula I.29, wherein R 1 Y-2A and R 2 It is c-C3H5.

[2355] Table 1876. Compounds of formula I.29, wherein R 1 Y-2B and R 2 It is c-C3H5.

[2356] Table 1877. Compounds of formula I.29, wherein R 1 Y-3A and R 2 It is c-C3H5.

[2357] Table 1878. Compounds of formula I.29, wherein R 1 Y-3B and R 2 It is c-C3H5.

[2358] Table 1879. Compounds of formula I.29, wherein R 1 Y-3C and R 2 It is c-C3H5.

[2359] Table 1880. Compounds of formula I.29, wherein R 1 Y-3D and R 2 It is c-C3H5.

[2360] Table 1881. Compounds of formula I.29, wherein R 1 Y-4A and R 2 It is c-C3H5.

[2361] Table 1882. Compounds of formula I.29, wherein R 1 Y-4B and R 2 It is c-C3H5.

[2362] Table 1883. Compounds of formula I.29, wherein R 1 Y-4C and R 2 It is c-C3H5.

[2363] Table 1884. Compounds of formula I.29, wherein R 1 Y-4D and R 2 It is c-C3H5.

[2364] Table 1885. Compounds of formula I.29, wherein R 1 Y-5A and R 2 It is c-C3H5.

[2365] Table 1886. Compounds of formula I.29, wherein R 1 Y-5B and R 2 It is c-C3H5.

[2366] Table 1887. Compounds of formula I.29, wherein R 1 Y-6A and R 2 It is c-C3H5.

[2367] Table 1888. Compounds of formula I.29, wherein R 1 Y-6B and R 2 It is c-C3H5.

[2368] Table 1889. Compounds of formula I.29, wherein R 1 Y-8A and R 2 It is c-C3H5.

[2369] Table 1890. Compounds of formula I.29, wherein R 1 Y-8B and R 2 It is c-C3H5.

[2370] Table 1891. Compounds of formula I.30, wherein R 1 Y-1A and R 2 For H.

[2371] Table 1892. Compounds of formula I.30, wherein R 1 Y-1B and R 2 For H.

[2372] Table 1893. Compounds of formula I.30, wherein R 1 Y-2A and R 2 For H.

[2373] Table 1894. Compounds of formula I.30, wherein R 1 Y-2B and R 2 For H.

[2374] Table 1895. Compounds of formula I.30, wherein R 1 Y-3A and R 2 For H.

[2375] Table 1896. Compounds of formula I.30, wherein R 1 Y-3B and R 2 For H.

[2376] Table 1897. Compounds of formula I.30, wherein R 1 Y-3C and R 2 For H.

[2377] Table 1898. Compounds of formula I.30, wherein R 1 Y-3D and R 2 For H.

[2378] Table 1899. Compounds of formula I.30, wherein R 1 Y-4A and R 2 For H.

[2379] Table 1900. Compounds of formula I.30, wherein R 1 Y-4B and R 2 For H.

[2380] Table 1901. Compounds of formula I.30, wherein R 1 Y-4C and R 2 For H.

[2381] Table 1902. Compounds of formula I.30, wherein R 1 Y-4D and R 2 For H.

[2382] Table 1903. Compounds of formula I.30, wherein R 1 Y-5A and R 2 For H.

[2383] Table 1904. Compounds of formula I.30, wherein R 1 Y-5B and R 2 For H.

[2384] Table 1905. Compounds of formula I.30, wherein R 1 Y-6A and R 2 For H.

[2385] Table 1906. Compounds of formula I.30, wherein R 1 Y-6B and R 2 For H.

[2386] Table 1907. Compounds of formula I.30, wherein R 1Y-8A and R 2 For H.

[2387] Table 1908. Compounds of formula I.30, wherein R 1 Y-8B and R 2 For H.

[2388] Table 1909. Compounds of formula I.30, wherein R 1 Y-1A and R 2 For CH3.

[2389] Table 1910. Compounds of formula I.30, wherein R 1 Y-1B and R 2 For CH3.

[2390] Table 1911. Compounds of formula I.30, wherein R 1 Y-2A and R 2 For CH3.

[2391] Table 1912. Compounds of formula I.30, wherein R 1 Y-2B and R 2 For CH3.

[2392] Table 1913. Compounds of formula I.30, wherein R 1 Y-3A and R 2 For CH3.

[2393] Table 1914. Compounds of formula I.30, wherein R 1 Y-3B and R 2 For CH3.

[2394] Table 1915. Compounds of formula I.30, wherein R 1 Y-3C and R 2 For CH3.

[2395] Table 1916. Compounds of formula I.30, wherein R 1 Y-3D and R 2 For CH3.

[2396] Table 1917. Compounds of formula I.30, wherein R 1 Y-4A and R 2 For CH3.

[2397] Table 1918. Compounds of formula I.30, wherein R 1 Y-4B and R 2 For CH3.

[2398] Table 1919. Compounds of formula I.30, wherein R 1 Y-4C and R 2For CH3.

[2399] Table 1920. Compounds of formula I.30, wherein R 1 Y-4D and R 2 For CH3.

[2400] Table 1921. Compounds of formula I.30, wherein R 1 Y-5A and R 2 For CH3.

[2401] Table 1922. Compounds of formula I.30, wherein R 1 Y-5B and R 2 For CH3.

[2402] Table 1923. Compounds of formula I.30, wherein R 1 Y-6A and R 2 For CH3.

[2403] Table 1924. Compounds of formula I.30, wherein R 1 Y-6B and R 2 For CH3.

[2404] Table 1925. Compounds of formula I.30, wherein R 1 Y-8A and R 2 For CH3.

[2405] Table 1926. Compounds of formula I.30, wherein R 1 Y-8B and R 2 For CH3.

[2406] Table 1927. Compounds of formula I.30, wherein R 1 Y-1A and R 2 It is c-C3H5.

[2407] Table 1928. Compounds of formula I.30, wherein R 1 Y-1B and R 2 It is c-C3H5.

[2408] Table 1929. Compounds of formula I.30, wherein R 1 Y-2A and R 2 It is c-C3H5.

[2409] Table 1930. Compounds of formula I.30, wherein R 1 Y-2B and R 2 It is c-C3H5.

[2410] Table 1931. Compounds of formula I.30, wherein R 1 Y-3A and R 2It is c-C3H5.

[2411] Table 1932. Compounds of formula I.30, wherein R 1 Y-3B and R 2 It is c-C3H5.

[2412] Table 1933. Compounds of formula I.30, wherein R 1 Y-3C and R 2 It is c-C3H5.

[2413] Table 1934. Compounds of formula I.30, wherein R 1 Y-3D and R 2 It is c-C3H5.

[2414] Table 1935. Compounds of formula I.30, wherein R 1 Y-4A and R 2 It is c-C3H5.

[2415] Table 1936. Compounds of formula I.30, wherein R 1 Y-4B and R 2 It is c-C3H5.

[2416] Table 1937. Compounds of formula I.30, wherein R 1 Y-4C and R 2 It is c-C3H5.

[2417] Table 1938. Compounds of formula I.30, wherein R 1 Y-4D and R 2 It is c-C3H5.

[2418] Table 1939. Compounds of formula I.30, wherein R 1 Y-5A and R 2 It is c-C3H5.

[2419] Table 1940. Compounds of formula I.30, wherein R 1 Y-5B and R 2 It is c-C3H5.

[2420] Table 1941. Compounds of formula I.30, wherein R 1 Y-6A and R 2 It is c-C3H5.

[2421] Table 1942. Compounds of formula I.30, wherein R 1 Y-6B and R 2 It is c-C3H5.

[2422] Table 1943. Compounds of formula I.30, wherein R 1Y-8A and R 2 It is c-C3H5.

[2423] Table 1944. Compounds of formula I.30, wherein R 1 Y-8B and R 2 It is c-C3H5.

[2424] Table 1945. Compounds of formula I.37, wherein R 1 is Y-1A, R is NH and R 2 For H.

[2425] Table 1946. Compounds of formula I.37, wherein R 1 is Y-1B, R is NH and R 2 For H.

[2426] Table 1947. Compounds of formula I.37, wherein R 1 is Y-2A, R is NH and R 2 For H.

[2427] Table 1948. Compounds of formula I.37, wherein R 1 is Y-2B, R is NH and R 2 For H.

[2428] Table 1949. Compounds of formula I.37, wherein R 1 is Y-3A, R is NH and R 2 For H.

[2429] Table 1950. Compounds of formula I.37, wherein R 1 is Y-3B, R is NH and R 2 For H.

[2430] Table 1951. Compounds of formula I.37, wherein R 1 is Y-3C, R is NH and R 2 For H.

[2431] Table 1952. Compounds of formula I.37, wherein R 1 is Y-3D, R is NH and R 2 For H.

[2432] Table 1953. Compounds of formula I.37, wherein R 1 is Y-4A, R is NH and R 2 For H.

[2433] Table 1954. Compounds of formula I.37, wherein R 1 is Y-4B, R is NH and R 2 For H.

[2434] Table 1955. Compounds of formula I.37, wherein R 1 is Y-4C, R is NH and R 2 For H.

[2435] Table 1956. Compounds of formula I.37, wherein R 1 is Y-4D, R is NH and R 2 For H.

[2436] Table 1957. Compounds of formula I.37, wherein R 1 is Y-5A, R is NH and R 2 For H.

[2437] Table 1958. Compounds of formula I.37, wherein R 1 is Y-5B, R is NH and R 2 For H.

[2438] Table 1959. Compounds of formula I.37, wherein R 1 is Y-6A, R is NH and R 2 For H.

[2439] Table 1960. Compounds of formula I.37, wherein R 1 is Y-6B, R is NH and R 2 For H.

[2440] Table 1961. Compounds of formula I.37, wherein R 1 is Y-8A, R is NH and R 2 For H.

[2441] Table 1962. Compounds of formula I.37, wherein R 1 is Y-8B, R is NH and R 2 For H.

[2442] Table 1963. Compounds of formula I.37, wherein R 1 is Y-1A, R is NH and R 2 For CH3.

[2443] Table 1964. Compounds of formula I.37, wherein R 1 is Y-1B, R is NH and R 2 For CH3.

[2444] Table 1965. Compounds of formula I.37, wherein R 1 is Y-2A, R is NH and R 2 For CH3.

[2445] Table 1966. Compounds of formula I.37, wherein R 1 is Y-2B, R is NH and R 2For CH3.

[2446] Table 1967. Compounds of formula I.37, wherein R 1 is Y-3A, R is NH and R 2 For CH3.

[2447] Table 1968. Compounds of formula I.37, wherein R 1 is Y-3B, R is NH and R 2 For CH3.

[2448] Table 1969. Compounds of formula I.37, wherein R 1 is Y-3C, R is NH and R 2 For CH3.

[2449] Table 1970. Compounds of formula I.37, wherein R 1 is Y-3D, R is NH and R 2 For CH3.

[2450] Table 1971. Compounds of formula I.37, wherein R 1 is Y-4A, R is NH and R 2 For CH3.

[2451] Table 1972. Compounds of formula I.37, wherein R 1 is Y-4B, R is NH and R 2 For CH3.

[2452] Table 1973. Compounds of formula I.37, wherein R 1 is Y-4C, R is NH and R 2 For CH3.

[2453] Table 1974. Compounds of formula I.37, wherein R 1 is Y-4D, R is NH and R 2 For CH3.

[2454] Table 1975. Compounds of formula I.37, wherein R 1 is Y-5A, R is NH and R 2 For CH3.

[2455] Table 1976. Compounds of formula I.37, wherein R 1 is Y-5B, R is NH and R 2 For CH3.

[2456] Table 1977. Compounds of formula I.37, wherein R 1 is Y-6A, R is NH and R 2 For CH3.

[2457] Table 1978. Compounds of formula I.37, wherein R 1 is Y-6B, R is NH and R 2 For CH3.

[2458] Table 1979. Compounds of formula I.37, wherein R 1 is Y-8A, R is NH and R 2 For CH3.

[2459] Table 1980. Compounds of formula I.37, wherein R 1 is Y-8B, R is NH and R 2 For CH3.

[2460] Table 1981. Compounds of formula I.37...

Claims

1. Compounds of formula I and their stereoisomers, tautomers and agriculturally or veterinarily acceptable salts: in A is N or CR A ; B 1 N or CR B1 ; D is N or CR D ; E is N or CR E ; A, B 1 , E and D at least one is N; and when A and D are N, B 1 CR B1 ; B 2 CR B2 ; B 3 CR B3 ; B 4 CR B4 ; R A 、R D 、R B1 and R E are independently H, halogen, CN, C1-C6 alkyl, and these structural moieties are unsubstituted or substituted by halogen; R B2 、R B3 and R B4 are independently H, halogen, CN, C1-C6 alkyl, and these structural moieties are unsubstituted or substituted by halogen; Q is -C(R 4 R 5 )-O-, -N(R 2 )-C(R 9 R 10 )-, -N(R 2 )-, -N(R 2 )-C(=O)-, -N=C(X)-, -N(R 2 )-C(=NR)-; wherein Ar is bonded to either side of Q; X is N(R 3 )2; R is H, C1-C6 alkyl, these structural parts are unsubstituted or substituted by halogen; R 3 is H, C1-C6 alkyl; R 2 is H, C1-C6 alkyl, these structural moieties are unsubstituted or substituted by halogen; R 4 、R 5 、R 9 、R 10 are the same or different and are H, halogen, C1-C6 alkyl, these structural parts are unsubstituted or substituted by halogen; Ar is unsubstituted or replaced by R Ar Substituted phenyl, wherein R Ar is halogen, CN, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy-C1-C4 alkyl, These moieties are unsubstituted or substituted with halogen; R 1 It is a structural part of the formula YZT-1, YZT-2, YZT-5, YZT-6 or YZT-8: R 11 is phenyl, wherein the phenyl ring is unsubstituted or replaced by R g replace; R 12 Formula A 1 Groups: Where # represents a connection point; R 121 、R 122 、R 123 The same or different and are C1-C6 alkyl, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 alkoxy, these structural moieties are unsubstituted or substituted by halogen; R 124 C1-C6 alkyl, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 alkoxy, these structural moieties are unsubstituted or substituted by halogen; And among them R ya is H, halogen, C1-C6 alkyl, and these structural moieties are unsubstituted or substituted by halogen; R zc is H, C1-C6 alkyl, these structural moieties are unsubstituted or substituted by halogen; R T is H, C1-C6 alkyl, these structural moieties are unsubstituted or substituted by halogen; R g It is halogen or C1-C6 alkyl.

2. A compound of formula I according to claim 1, wherein A is N.

3. A compound of formula I according to claim 1, wherein A and D are N.

4. A compound of formula I according to claim 1, wherein B 1 is N.

5. A compound of formula I according to claim 1, wherein B 1 and D is N.

6. A compound of formula I according to claim 1, wherein E and D are N.

7. A compound of formula I according to any one of claims 1 to 6, wherein Q is -C(R 4 R 5 )-O-、-N(R 2 )-C(R 9 R 10 )-、-N(R 2 )-C(=O)-, -N=C(X)- or -N(R 2 )-C(=NR)-, wherein Ar is bonded to either side of Q.

8. A compound of formula I according to claim 1, wherein Ar is any one of the following formulae:

9. A composition comprising a compound of the formula I according to any one of claims 1 to 8, an agriculturally acceptable salt and another active substance.

10. A method for the non-therapeutic control or prevention of invertebrate pests, which method comprises contacting the pests or their food supply, habitat or breeding grounds with a pesticidally effective amount of at least one compound according to any one of claims 1 to 8 or a composition according to claim 9.

11. A method of protecting growing plants from attack or infestation by invertebrate pests, which method comprises contacting the plants or the soil or water in which the plants are growing with a pesticidally effective amount of at least one compound according to any one of claims 1 to 8 or a composition according to claim 9.

12. A method for treating seeds with a compound according to any one of claims 1 to 8 or an enantiomer, diastereomer or salt thereof, or a composition according to claim 9, wherein the seeds contain the compound or an enantiomer, diastereomer or salt thereof, or the composition, in an amount of 0.1 g to 10 kg per 100 kg of seeds.

13. Use of a compound of formula I according to any one of claims 1 to 8 and its agriculturally acceptable salts or a composition according to claim 9 for protecting growing plants from attack or infestation by invertebrate pests.

14. Use of a compound of formula I according to any one of claims 1 to 8, its stereoisomers and / or its veterinarily acceptable salts for the preparation of a medicament for treating or protecting an animal against attack or infestation by invertebrate pests, comprising contacting the animal with a pesticidally effective amount of at least one compound of formula I according to any one of claims 1 to 8, its stereoisomers and / or at least one veterinarily acceptable salt thereof.

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